Dietary n-6 and n-3 PUFA alter the free oxylipin profile differently in male and female rat hearts

Dietary ALA, EPA and DHA have distinct effects on oxylipin profiles in female and male rat kidney, liver and serum

(2018) Shan Leng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Distinct effects of dietary ALA, EPA and DHA on rat adipose oxylipins vary by depot location and sex

(2018) Anne M. Mendonça et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Heart failure–induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore

(2017) Sung Ho Moon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary LA and sex effects on oxylipin profiles in rat kidney, liver, and serum differ from their effects on PUFAs

(2017) Shan Leng et al.   JOURNAL OF LIPID RESEARCH

Distinct effects of dietary flax compared to fish oil, soy protein compared to casein, and sex on the renal oxylipin profile in models of polycystic kidney disease

(2017) Jessay G. Devassy et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters

(2017) Gregory C. Shearer et al.   JOURNAL OF LIPID RESEARCH

15-hydroxyprostaglandin dehydrogenase (15-PGDH) prevents lipopolysaccharide (LPS)-induced acute liver injury

(2017) Lu Yao et al.   PLoS One

Prostaglandin E2 Reduces Cardiac Contractility via EP3 ReceptorCLINICAL PERSPECTIVE

(2016) Xiaosong Gu et al.   Circulation-Heart Failure

Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid

(2016) James F. Markworth et al.   FASEB JOURNAL

Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)

(2016) Christopher E Ramsden et al.   BMJ-British Medical Journal

Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)

(2016) Christopher E Ramsden et al.   BMJ-British Medical Journal

5-, 12- and 15-Hydroxyeicosatetraenoic acids induce cellular hypertrophy in the human ventricular cardiomyocyte, RL-14 cell line, through MAPK- and NF-κB-dependent mechanism

(2015) Zaid H. Maayah et al.   ARCHIVES OF TOXICOLOGY

Characterization of changes in plasma and tissue oxylipin levels in LPS and CLP induced murine sepsis

(2015) Ina Willenberg et al.   INFLAMMATION RESEARCH

Epoxyeicosatrienoic Acids Regulate Macrophage Polarization and Prevent LPS-Induced Cardiac Dysfunction

(2015) Meiyan Dai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

How Can Linoleic Acid Be the Preferential Substrate of the Enzyme 15-Lipoxygenase-1? A QM/MM Approach

(2015) Jordi Soler et al.   JOURNAL OF PHYSICAL CHEMISTRY B

19-Hydroxyeicosatetraenoic acid and isoniazid protect against angiotensin II-induced cardiac hypertrophy

(2015) Samya Elkhatali et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs

(2015) Melissa Gabbs et al.   Advances in Nutrition

18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling

(2014) Jin Endo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway

(2014) Robert Fischer et al.   JOURNAL OF LIPID RESEARCH

Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipins

(2014) Nils Helge Schebb et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Role of cytochrome P450–mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy

(2013) Abdulaziz M. S. Alsaad et al.   DRUG METABOLISM REVIEWS

Dietary Linoleic Acid and α-Linolenic Acid Differentially Affect Renal Oxylipins and Phospholipid Fatty Acids in Diet-Induced Obese Rats

(2013) Stephanie P. B. Caligiuri et al.   JOURNAL OF NUTRITION

Renal cyclooxygenase and lipoxygenase products are altered in polycystic kidneys and by dietary soy protein and fish oil treatment in the Han:SPRD-Cyrat

(2013) Naser H. M. Ibrahim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response

(2013) V Samokhvalov et al.   Cell Death & Disease

Tissue-specific sex differences in docosahexaenoic acid and Δ6-desaturase in rats fed a standard chow diet

(2012) Alex P. Kitson et al.   Applied Physiology Nutrition and Metabolism

New families of bioactive oxidized phospholipids generated by immune cells: identification and signaling actions

(2012) V. B. O'Donnell et al.   BLOOD

Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury

(2012) Gang Zhao et al.   JOURNAL OF LIPID RESEARCH

Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation

(2012) Kenneth N. Ikei et al.   JOURNAL OF LIPID RESEARCH

Fish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues

(2012) Michiel G. J. Balvers et al.   Metabolomics

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes

(2011) Carlo Pergola et al.   FASEB JOURNAL

Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart

(2011) Matthew L. Edin et al.   FASEB JOURNAL

CYP-eicosanoids—A new link between omega-3 fatty acids and cardiac disease?

(2011) Christina Westphal et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Resolvin E1 protects the rat heart against reperfusion injury

(2010) K. T. Keyes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Arachidonic Acid-metabolizing Cytochrome P450 Enzymes Are Targets of ω-3 Fatty Acids

(2010) Cosima Arnold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docosahexanoic Acid-Induced Coronary Arterial Dilation: Actions of 17S-Hydroxy Docosahexanoic Acid on K+ Channel Activity

(2010) X. Li et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effect of sex and dietary fat intake on the fatty acid composition of phospholipids and triacylglycerol in rat heart

(2010) Joanne L. Slater-Jefferies et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Omega-6 Fatty Acids and Risk for Cardiovascular Disease

(2009) William S. Harris et al.   CIRCULATION

Rat heart cannot synthesize docosahexaenoic acid from circulating α-linolenic acid because it lacks elongase-2

(2008) Miki Igarashi et al.   JOURNAL OF LIPID RESEARCH

Epoxyeicosatrienoic acid prevents postischemic electrocardiogram abnormalities in an isolated heart model

(2008) S.N. Batchu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY