Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects

EWAS: epigenome-wide association study software 2.0

(2018) Jing Xu et al.   BIOINFORMATICS

From genome-wide associations to candidate causal variants by statistical fine-mapping

(2018) Daniel J. Schaid et al.   NATURE REVIEWS GENETICS

Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania

(2018) Matt Ravenhall et al.   PLoS Genetics

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia

(2018) D Herbert Opi et al.   eLife

Epigenetics and Malaria Susceptibility/Protection: A Missing Piece of the Puzzle

(2018) Charles Arama et al.   Frontiers in Immunology

An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility

(2017) Samuel Lessard et al.   JOURNAL OF CLINICAL INVESTIGATION

Reevaluation of SNP heritability in complex human traits

(2017) Doug Speed et al.   NATURE GENETICS

Genetic and epigenetic changes in host ABCB1 influences malaria susceptibility to Plasmodium falciparum

(2017) Himanshu Gupta et al.   PLoS One

Resistance to malaria through structural variation of red blood cell invasion receptors

(2017) Ellen M. Leffler et al.   SCIENCE

Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections

(2017) Chao Tian et al.   Nature Communications

Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria

(2017) Jaclyn E Quin et al.   eLife

Pathway-wide association study identifies five shared pathways associated with schizophrenia in three ancestral distinct populations

(2017) C Liu et al.   Translational Psychiatry

The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?

(2017) Matthew D Hall et al.   BMC BIOLOGY

Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome

(2017) Henry Richard Johnston et al.   Scientific Reports

Polygenic Epidemiology

(2016) Frank Dudbridge   GENETIC EPIDEMIOLOGY

Genomics is failing on diversity

(2016) Alice B. Popejoy et al.   NATURE

Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study

(2016) Susan E. Martelle et al.   Brain and Behavior

ancGWAS: a post genome-wide association study method for interaction, pathway and ancestry analysis in homogeneous and admixed populations

(2015) Emile R. Chimusa et al.   BIOINFORMATICS

Strategies for fine-mapping complex traits

(2015) Sarah L. Spain et al.   HUMAN MOLECULAR GENETICS

USP38, FREM3, SDC1, DDC,andLOC727982Gene Polymorphisms and Differential Susceptibility to Severe Malaria in Tanzania

(2015) Alphaxard Manjurano et al.   JOURNAL OF INFECTIOUS DISEASES

A novel locus of resistance to severe malaria in a region of ancient balancing selection

(2015)   NATURE

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

Systems genetics: From GWAS to disease pathways

(2014) Marijke R. van der Sijde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Epistasis between the haptoglobin common variant and α+thalassemia influences risk of severe malaria in Kenyan children

(2014) Sarah H. Atkinson et al.   BLOOD

Erratum to “Improving accuracy of genomic predictions within and between dairy cattle breeds with imputed high-density single nucleotide polymorphism panels” (J. Dairy Sci. 95:4114–4129)

(2014) M. Erbe et al.   JOURNAL OF DAIRY SCIENCE

The African Genome Variation Project shapes medical genetics in Africa

(2014) Deepti Gurdasani et al.   NATURE

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Advantages and pitfalls in the application of mixed-model association methods

(2014) Jian Yang et al.   NATURE GENETICS

Reappraisal of known malaria resistance loci in a large multicenter study

(2014) Kirk A Rockett et al.   NATURE GENETICS

Detecting epistasis in human complex traits

(2014) Wen-Hua Wei et al.   NATURE REVIEWS GENETICS

Natural selection and infectious disease in human populations

(2014) Elinor K. Karlsson et al.   NATURE REVIEWS GENETICS

Measuring missing heritability: Inferring the contribution of common variants

(2014) David Golan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ATP2B4 Polymorphism Protects Against Malaria in Pregnancy

(2013) George Bedu-Addo et al.   JOURNAL OF INFECTIOUS DISEASES

A Panel of Ancestry Informative Markers for the Complex Five-Way Admixed South African Coloured Population

(2013) Michelle Daya et al.   PLoS One

The distribution of haemoglobin C and its prevalence in newborns in Africa

(2013) Frédéric B. Piel et al.   Scientific Reports

Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations

(2013) Gavin Band et al.   PLoS Genetics

Improved Heritability Estimation from Genome-wide SNPs

(2012) Doug Speed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance

(2012) Gregory LaMonte et al.   Cell Host & Microbe

GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children

(2012) Jin Li et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study indicates two novel resistance loci for severe malaria

(2012) Christian Timmann et al.   NATURE

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Effects of Natural Selection and Gene Conversion on the Evolution of Human Glycophorins Coding for MNS Blood Polymorphisms in Malaria-Endemic African Populations

(2011) Wen-Ya Ko et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Interleukin-23: A key cytokine in inflammatory diseases

(2011) Emilie Duvallet et al.   ANNALS OF MEDICINE

Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genesBANK1andBLK

(2011) Casimiro Castillejo-López et al.   ANNALS OF THE RHEUMATIC DISEASES

Population genetics of malaria resistance in humans

(2011) P W Hedrick   HEREDITY

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

A Dopa Decarboxylase Modulating the Immune Response of Scallop Chlamys farreri

(2011) Zhi Zhou et al.   PLoS One

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Malaria, a Journey in Time: In Search of the Lost Myths and Forgotten Stories

(2010) Raul Neghina et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Redox Regulation of SCO Protein Function: Controlling Copper at a Mitochondrial Crossroad

(2010) Scot C. Leary   ANTIOXIDANTS & REDOX SIGNALING

Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility

(2010) C O'Dushlaine et al.   MOLECULAR PSYCHIATRY

Integrating common and rare genetic variation in diverse human populations

(2010)   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3

(2010) Zi-Jiang Chen et al.   NATURE GENETICS

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation

(2010) Geneviève Galarneau et al.   NATURE GENETICS

Common SNPs explain a large proportion of the heritability for human height

(2010) Jian Yang et al.   NATURE GENETICS

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Methodological challenges of genome-wide association analysis in Africa

(2010) Yik-Ying Teo et al.   NATURE REVIEWS GENETICS

Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family

(2009) Emily Steed et al.   BMC CELL BIOLOGY

Common vs. rare allele hypotheses for complex diseases

(2009) Nicholas J Schork et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility

(2009) Taane G Clark et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

(2009) Shaun M. Purcell et al.   NATURE

Genome-wide and fine-resolution association analysis of malaria in West Africa

(2009) Muminatou Jallow et al.   NATURE GENETICS

Detecting gene–gene interactions that underlie human diseases

(2009) Heather J Cordell   NATURE REVIEWS GENETICS

Genetics of susceptibility toPlasmodium falciparum: from classical malaria resistance genes towards genome-wide association studies

(2009) F. VERRA et al.   PARASITE IMMUNOLOGY

Meta-analysis in genome-wide association studies

(2009) Eleftheria Zeggini et al.   PHARMACOGENOMICS

Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1

(2009) D. C. G. Mayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

African Genetic Diversity: Implications for Human Demographic History, Modern Human Origins, and Complex Disease Mapping

(2008) Michael C. Campbell et al.   Annual Review of Genomics and Human Genetics

The genetic architecture of susceptibility to parasites

(2008) Lena Wilfert et al.   BMC EVOLUTIONARY BIOLOGY

Malaria Parasite Pre-Erythrocytic Stage Infection: Gliding and Hiding

(2008) Ashley M. Vaughan et al.   Cell Host & Microbe

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants

(2008) Itsik Pe'er et al.   GENETIC EPIDEMIOLOGY

Human Genetics and Malaria: Relevance for the Design of Clinical Trials

(2008) Sunil Parikh et al.   JOURNAL OF INFECTIOUS DISEASES

A global network for investigating the genomic epidemiology of malaria

(2008) Eric Akum Achidi et al.   NATURE

Linkage disequilibrium — understanding the evolutionary past and mapping the medical future

(2008) Montgomery Slatkin   NATURE REVIEWS GENETICS

An Integrated Approach for the Analysis of Biological Pathways using Mixed Models

(2008) Lily Wang et al.   PLoS Genetics