Article
Biophysics
Syed Harris Hussain, Cesar S. Huertas, Arnan Mitchell, Anne-Laure Deman, Emmanuelle Laurenceau
Summary: Analysis of circulating tumor cells (CTCs) and their associated biomarkers can provide valuable information for lung and prostate cancer, aiding in early detection and personalized treatment selection. Biosensors offer an elegant alternative to conventional methods for real-time, multiplexed analysis of cancer biomarkers at lower concentrations.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Xuming Sun, Mingyan Zhang, Linyan Xie, Qiongqiong Ren, Jinlong Chang, Wenshuai Jiang
Summary: This article summarizes the application of advanced materials in cancer biomarker sensing. The unique structures and tunable properties of advanced materials make them ideal for developing various sensing systems and improving the detection of cancer biomarkers.
MICROCHEMICAL JOURNAL
(2023)
Article
Medical Laboratory Technology
Sepideh Sadighbathi, Ahmad Mobed
Summary: MicroRNAs are small non-coding RNAs, with miR21 being highly expressed in many mammalian cells and regulating various biological functions. Accurate detection of miR-21 is crucial, and conventional methods have limitations. Advanced techniques such as nanotechnology and biosensors have gained attention in recent years.
CLINICA CHIMICA ACTA
(2022)
Article
Medical Laboratory Technology
Yinyu Mu, Jing Li, Fuyi Xie, Lin Xu, Guodong Xu
Summary: This study investigated the detection value of seven autoantibodies and three tumor markers in the diagnosis of lung cancer. The combined detection of these markers showed potential for early diagnosis of lung cancer.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Materials Science, Biomaterials
Shanchuan Chen, Minghan Li, Ting Weng, Deqiang Wang, Jia Geng
Summary: Lung cancer, as one of the most common cancers worldwide, is the leading cause of death. Early screening is vital for later treatment. This review focuses on cutting-edge methods for detecting lung cancer tumor markers using biosensors, specifically DNA biosensors, RNA biosensors, and protein biosensors. Different electrochemical and optical sensors, as well as novel sensing platforms, are discussed, providing important insights for developing optoelectronic biosensors for the early diagnosis of lung cancer.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Characterization & Testing
Nan Ouyang, Lei Hong, Yuanshuai Zhou, Jingzhong Zhang, Shaheryar Shafi, Jinlin Pan, Rongchuan Zhao, Ying Yang, Wenya Hou
Summary: Fluorescent sensors based on nano-materials have been widely used in cancer medical sensing research due to their unique properties. This article provides an overview of different nano-materials and their uses, as well as the principles and functions of fluorescent nano-biosensor detection for cancer bio-macromolecular markers. It also discusses the prospects and challenges of translating this diagnostic method into clinical application.
Article
Chemistry, Analytical
Yang Xu, Huiqiang Wang
Summary: A portable glucometer-based immunosensor was designed for quantitative detection of tumor markers, showing advantages of low cost, high efficiency, and simple operation, with potential for home use in tracking treatment effects in a timely manner.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Ory Wiesel, Sook-Whan Sung, Amit Katz, Raya Leibowitz, Jair Bar, Iris Kamer, Itay Berger, Inbal Nir-Ziv, Michal Mark Danieli
Summary: Lung cancer is the main cause of cancer-related deaths worldwide. The BSP urine test, using trained rats as biosensors, shows high accuracy in recognizing lung cancer VOCs. It is safe, rapid, objective, and repeatable, and has the potential to increase detection rates and curability rates with lower healthcare expenditure.
Article
Surgery
Su-Ju Wei, Li-Ping Wang, Jun-Yan Wang, Jing-Xu Ma, Feng-Bin Chuan, Yu-Dong Zhang
Summary: The study demonstrates that the combination of tumor markers and imaging has significant value in the early detection of lung cancer, with high sensitivity and specificity, particularly in differentiating between various types of lung cancer.
FRONTIERS IN SURGERY
(2021)
Review
Chemistry, Applied
Mbugua Simon Ngigi
Summary: Although current cancer treatment technologies have advanced quickly, the patient's chance of recovering is still poor. Early detection enhances cancer prognosis and can considerably lower cancer-related fatalities. Non-invasive liquid biopsy becomes a significant option that may solve the limitations of traditional tumor imaging and specimen biopsy, offering benefits such as minimal risk, non-invasiveness, lower cost, and faster diagnosis.
Article
Biochemistry & Molecular Biology
Yan Zhou, Ming Li, Hui Wang, ShuXiang Sun
Summary: An electrochemical biosensor was developed for highly sensitive detection of CEA, using dual signal amplification of electrically mediated atom transfer radical polymerization (eATRP) and polyethyleneimine (PEI). The biosensor showed a wide linear detection range and low limit of detection. Compared to other sensors, this biosensor used a simpler and more environmentally friendly technique and improved electron transfer rate with the use of PEI. It demonstrated superior analytical performance in clinical serums and holds great promise for early lung cancer diagnosis applications.
BIOELECTROCHEMISTRY
(2022)
Article
Oncology
Sumin Guo, Jingyu Chen, Po Hu, Chen Li, Xiang Wang, Ning Chen, Jiale Sun, Yongfeng Wang, Jianling Wang, Weikuan Gu, Shucai Wu
Summary: The detection of circulating tumor cells using a conical micro filter integrated microfluidic system can improve the accuracy of lung cancer diagnosis. The combination of circulating tumor cells and the conventional 4 lung cancer markers can enhance the clinical application accuracy. Venous blood should be used as a routine sample for circulating tumor cells detection.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Review
Chemistry, Analytical
Zhi-Fang Sun, Yong Chang, Ning Xia
Summary: This review summarizes the recent development of nanomaterials-based optical and electrochemical analytical techniques for CTCs detection, aiming at amplifying the signal and enhancing the sensitivity.
Article
Chemistry, Analytical
Chunhua Wang, Yu Zhang, Wei Tang, Chao Wang, Yingkuan Han, Le Qiang, Jianwei Gao, Hong Liu, Lin Han
Summary: The developed universal biosensing platform combines the unique nanostructure and biochemistry properties of graphene oxide quantum dots with the high throughput and low cost of microfluidic chips, enabling reliable and simultaneous detection of multiple cancer biomarkers. This platform has a wide linear quantification range and ultra-low detection limits, allowing for simultaneous detection of multiple biomarkers from multiple individuals in a short time, significantly reducing detection costs and time.
ANALYTICA CHIMICA ACTA
(2021)
Article
Endocrinology & Metabolism
Jun Jin, Haihong Liu, Haiyan Yang, Guanghui Xu, Xinkuan Chen
Summary: This study demonstrates that combined detection of serum tumor markers CEA, CA125, CA724, and CYFRA211 has clinical value in diagnosing advanced non-small cell lung cancer (NSCLC). Compared to the control group, the lung cancer group had elevated levels of serum CEA, CA125, CA724, and CYFRA211. ROC curve analysis confirms that combined detection is the most effective method for diagnosing advanced NSCLC, with high sensitivity and specificity.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)