Monitoring online biomass with a capacitance sensor during scale-up of industrially relevant CHO cell culture fed-batch processes in single-use bioreactors

Case study: The characterization and implementation of dielectric spectroscopy (biocapacitance) for process control in a commercial GMP CHO manufacturing process

(2019) Brandon Moore et al.   BIOTECHNOLOGY PROGRESS

Dielectric Spectroscopy and Optical Density Measurement for the Online Monitoring and Control of Recombinant Protein Production in Stably Transformed Drosophila melanogaster S2 Cells

(2018) Jan Zitzmann et al.   SENSORS

Development of Capacitance Tools: At-Line Method for Assessing Biomass of Mammalian Cell Culture and Fixed Cell Calibration Standard

(2018) Juhi Fernandes et al.   Biotechnology Journal

Quality by control: Towards model predictive control of mammalian cell culture bioprocesses

(2017) Wolfgang Sommeregger et al.   Biotechnology Journal

Process analytical technology tools for perfusion cell culture

(2015) Sarah M. Mercier et al.   ENGINEERING IN LIFE SCIENCES

Universal Capacitance Model for Real-Time Biomass in Cell Culture

(2015) Viktor Konakovsky et al.   SENSORS

QbD/PAT for bioprocessing: moving from theory to implementation

(2014) Anurag S Rathore   Current Opinion in Chemical Engineering

Application of dielectric spectroscopy for monitoring high cell density in monoclonal antibody producing CHO cell cultivations

(2013) László Párta et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

A novel approach for using dielectric spectroscopy to predict viable cell volume (VCV) in early process development

(2013) Brandon J. Downey et al.   BIOTECHNOLOGY PROGRESS

Process analytical technology (PAT) tools for the cultivation step in biopharmaceutical production

(2013) Mathieu Streefland et al.   ENGINEERING IN LIFE SCIENCES

Single-use disposable technologies for biopharmaceutical manufacturing

(2012) Abhinav A. Shukla et al.   TRENDS IN BIOTECHNOLOGY

Monitoring lentiviral vector production kinetics using online permittivity measurements

(2011) Sven Ansorge et al.   BIOCHEMICAL ENGINEERING JOURNAL

Process control in cell culture technology using dielectric spectroscopy

(2011) C. Justice et al.   BIOTECHNOLOGY ADVANCES

Disposable bioreactors: the current state-of-the-art and recommended applications in biotechnology

(2010) Regine Eibl et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quantitative modeling of viable cell density, cell size, intracellular conductivity, and membrane capacitance in batch and fed-batch CHO processes using dielectric spectroscopy

(2010) Cary F. Opel et al.   BIOTECHNOLOGY PROGRESS

On-line monitoring of responses to nutrient feed additions by multi-frequency permittivity measurements in fed-batch cultivations of CHO cells

(2010) Sven Ansorge et al.   CYTOTECHNOLOGY

Scale-up analysis for a CHO cell culture process in large-scale bioreactors

(2009) Zizhuo Xing et al.   BIOTECHNOLOGY AND BIOENGINEERING

Case study and application of process analytical technology (PAT) towards bioprocessing: Use of on-line high-performance liquid chromatography (HPLC) for making real-time pooling decisions for process chromatography

(2007) Anurag S. Rathore et al.   BIOTECHNOLOGY AND BIOENGINEERING