Article
Immunology
Courtney Mowat, Jasmine Dhatt, Ilsa Bhatti, Angela Hamie, Kristi Baker
Summary: Colorectal cancer (CRC) growth can be influenced by the metabolic activities of intestinal microbiota, specifically short chain fatty acids (SCFAs). This study investigates how SCFA treatment directly regulates immune modulating pathways in CRC cells and found that SCFAs can significantly activate CD8+ T cells. The response to SCFAs was subtype-dependent, with MSI CRCs being more sensitive and showing better activation of CD8+ T cells compared to CIN CRCs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Qingqing Zhang, Qing Zhao, Tao Li, Longya Lu, Fei Wang, Hong Zhang, Zhi Liu, Huihui Ma, Qihui Zhu, Jingjing Wang, Xuemei Zhang, Yang Pei, Qisha Liu, Yuyu Xu, Jinlong Qie, Xiaoting Luan, Zhibin Hu, Xingyin Liu
Summary: Previous studies have shown that probiotics can ameliorate colorectal cancer in a mouse model, but the underlying mechanisms are still unclear. In this study, the researchers found that a specific probiotic strain and its metabolite could improve intestinal inflammation, tumor growth, and gut dysbiosis. Further investigation revealed that the metabolite enhanced the production of IL12a in dendritic cells, priming CD8+ T cell immunity against tumor growth, and also regulated cholesterol metabolism in CD8+ T cells. These findings provide new insights into the epigenetic regulation of probiotics-mediated anti-tumor immunity and suggest potential therapeutic strategies for colorectal cancer patients.
Article
Pharmacology & Pharmacy
Sara Gomes, Fatima Baltazar, Elisabete Silva, Ana Preto
Summary: The composition of colon microbiota affects the development of colorectal cancer and has an impact on cellular phenotypes. Short-chain fatty acids (SCFAs) exhibit selective and anticancer effects on colon cancer cells and could be a potential therapy for CRC by modulating the composition of colon microbiota.
Review
Oncology
Huiqin Hou, Danfeng Chen, Kexin Zhang, Wanru Zhang, Tianyu Liu, Xin Dai, Bangmao Wang, Weilong Zhong, Hailong Cao
Summary: Colorectal cancer is the third most common cancer worldwide, and its development is closely related to changes in the gut microbiota and metabolites. Short-chain fatty acids play a crucial role in promoting intestinal health, inhibiting tumor development, and enhancing responses to chemotherapy and immunotherapy.
Article
Agronomy
Qixiu Huang, Lijun Xiang, Li Zhang, Yushanjiang Maimaiti, Wenfang Luo, Zhonghua Lei
Summary: This study analyzed the fatty acid content of five varieties of oilseed sunflower and sequenced the transcriptome of seed embryos from one high oleic acid variety at different stages. The results showed that oleic acid synthesis dominated the pathways of unsaturated fatty acid synthesis in seed embryos. Differential expression genes were detected at various post-flowering stages, with the highest number of up-regulated genes at 10 days after flowering and most genes being down-regulated at 20 days after flowering. The enriched genes were consistent with the FAD2 gene in almost all experimental groups. The expression of FAD2 was negatively correlated with the expressions of FAD6, FAD3, and FAD7. The expression level of FAD2 was highly negatively correlated with the final oleic acid content and highly positively correlated with the final linoleic acid content during seed embryo development, suggesting that FAD2 is a key enzyme catalyzing the conversion of oleic acid to linoleic acid.
Article
Cardiac & Cardiovascular Systems
Marine De Loof, Edith Renguet, Audrey Ginion, Caroline Bouzin, Sandrine Horman, Christophe Beauloye, Luc Bertrand, Laurent Bultot
Summary: Fatty acids inhibit cardiac glucose uptake by enhancing protein acetylation, leading to impaired glucose absorption.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cell Biology
Zuzanna Tracz-Gaszewska, Adrian Sowka, Pawel Dobrzyn
Summary: This study reveals the impact of SCD1 on glucose and lipid metabolism in colorectal cancer cells and its significant role in promoting cancer development and progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Federica Rubbino, Valentina Garlatti, Valeria Garzarelli, Luca Massimino, Salvatore Spano, Paolo Iadarola, Maddalena Cagnone, Martin Giera, Marieke Heijink, Simone Guglielmetti, Vincenzo Arena, Alberto Malesci, Luigi Laghi, Silvio Danese, Stefania Vetrano
Summary: This study highlights the role of GPR120 in the progression of colorectal cancer. Loss of GPR120 in the gut leads to increased intestinal permeability, microbiota translocation, and dysbiosis, which results in hyperproliferation of epithelial cells through the activation of beta-catenin signaling. Therefore, the loss of GPR120 is an early event in CRC development but does not promote invasive cancer.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Lijin Song, Qinghua Sun, Haonan Zheng, Yiming Zhang, Yujing Wang, Shuangjiang Liu, Liping Duan
Summary: The potential probiotic Roseburia hominis shows anti-neuroinflammatory effects by inhibiting microglial activation and reducing proinflammatory cytokines in the brain. Treatment with propionate or butyrate also leads to decreased neuroinflammation. This study suggests that R. hominis could be a potential psychoprobiotic to reduce neuroinflammation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Joan Bestard-Escalas, Rebeca Reigada, Jose Reyes, Paloma de la Torre, Gerhard Liebisch, Gwendolyn Barcelo-Coblijn
Summary: The analysis of plasma exosome lipid fingerprint can provide new non-invasive biomarkers for CRC. The lipid composition in pathological patients shows significant changes, and a certain ratio has the potential to discriminate between healthy and pathological patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Jibraan A. Fawad, Deborah H. Luzader, Gabriel F. Hanson, Thomas J. Moutinho Jr, Craig A. McKinney, Paul G. Mitchell, Kathleen Brown-Steinke, Ajay Kumar, Miri Park, Suengwon Lee, David T. Bolick, Greg L. Medlock, Jesse Y. Zhao, Andrew E. Rosselot, C. James Chou, Emily M. Eshleman, Theresa Alenghat, Christian Hong, Jason A. Papin, Sean R. Moore
Summary: Short-chain fatty acids (SCFAs) produced by gut microbiota entrain intestinal epithelial circadian rhythms via an HDACi-dependent mechanism, which is critical for the regulation of intestinal epithelial homeostasis by microbial and circadian networks.
Review
Biochemistry & Molecular Biology
Sara Gomes, Ana Catarina Rodrigues, Valerio Pazienza, Ana Preto
Summary: Finding new therapeutic approaches to colorectal cancer is crucial due to its high prevalence. Current standard therapies have limitations in terms of side effects and resistance. Microbiota-derived short-chain fatty acids have shown antitumorigenic properties and can modulate the tumor microenvironment. Manipulating the gut microbiota to increase the production of these fatty acids may be an important strategy in colorectal cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Javier Fernandez, Paolo Saettone, Mauro Comes Franchini, Claudio J. Villar, Felipe Lombo
Summary: Polyhydroxybutyrate (PHB), a non-toxic polymer, has been tested in an animal model for colorectal cancer. In this study, PHB was able to reduce the number of polyps and the tumoral extension area. It also induced an increase in beneficial gut bacteria and a reduction in pro-inflammatory bacteria. This antitumor effect is caused by the gut production of 3-hydroxybutyrate and butyrate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Shiqing Nie, Jichen Wang, Ye Deng, Zheng Ye, Yuan Ge
Summary: This study conducted a large-scale meta-analysis of the gut microbiome in Parkinson's disease (PD), revealing the changes in potential pro-inflammatory and anti-inflammatory bacteria, genes, and pathways associated with PD. It also established models based on the gut microbiome that can predict PD occurrence. The study provides further insights into the potential mechanisms of inflammation-based prediction and treatment of PD.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Gastroenterology & Hepatology
Lingling Zhang, Yanqiu Li, Ying Wang, Yugang Qiu, Hanchuan Mou, Yuanyao Deng, Jiyuan Yao, Zhiqing Xia, Wenzhe Zhang, Di Zhu, Zeyu Qiu, Zhongjie Lu, Jirong Wang, Zhouxin Yang, GenXiang Mao, Dan Chen, Leimin Sun, Leiming Liu, Zhenyu Ju
Summary: During liver regeneration, mTORC2 plays a role in lipid metabolism by facilitating FA transportation into hepatocytes through the GluCer-PPAR-alpha pathway.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)