Article
Chemistry, Analytical
Shuzhen Gao, Jia-Ling Zhang, Jin-Ling Zhang, Mei-Ling Lu, Wen-Bin Liang, Ruo Yuan, Dong-Rong Xiao
Summary: Polycyclic aromatic hydrocarbons (PAHs) are limited in their electrochemiluminescence (ECL) performance in water due to the aggregation-induced quenching (ACQ) effect. To overcome this, PAH derivative ligands were assembled into metal-organic framework nanosheets (MONs) to separate ACQphores and enhance ECL performance. The Hf-DEADB MON prepared using this strategy showed a 5.71-fold improvement in ECL intensity compared to H2DEADB aggregates. The enlarged distance between ACQphores and the ultrathin porous Hf-DEADB MON shortened diffusion pathways, boosting electrochemical activation and enabling the fabrication of a hypersensitive biosensor for microRNA-21 detection with a broad response range and ultralow detection limit.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Xianzhen Song, Siqi Yu, Lu Zhao, Yujian Guo, Xiang Ren, Hongmin Ma, Shoufeng Wang, Chuannan Luo, Yuyang Li, Qin Wei
Summary: A signal-amplified electrochemiluminescent (ECL) sensor chip has been developed for sensitive analysis of procalcitonin (PCT). By introducing a self-enhanced luminophore, Au-Pd bimetallic nanocrystals, mixed-valence Ce-based metal-organic frameworks (MOFs), affinity peptide ligands, and microfluidic technology, the sensor showed high sensitivity for PCT detection with positive significance for clinical diagnosis of sepsis.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Wenting Wei, Han Lin, Tingting Hao, Xiurong Su, Xiaohua Jiang, Sui Wang, Yufang Hu, Zhiyong Guo
Summary: The dual-mode ECL/SERS immunoassay developed in this study offers a high detection sensitivity through increasing signal tags, electrochemically activating them, and introducing AuNRs for signal enhancement. The linear range and limit of quantification for ECL were 1-10^8 CFU/mL and 1 CFU/mL, while those for SERS were 10^2-10^8 CFU/mL and 10^2 CFU/mL respectively under optimal conditions.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biophysics
Weiwei Cao, Linlei Liu, Ruo Yuan, Haijun Wang
Summary: In this study, the electrochemiluminescence phenomenon of 3D g-C3N4 was reported. A sensitive biosensor was constructed for miRNA-21 detection using 3D g-C3N4-O-2 ECL system.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Applied
Mohammad Ali Kamyabi, Mohsen Moharramnezhad
Summary: An innovative enzyme free electrochemiluminescence chlorpyrifos sensor was developed using a ternary nanocomposite for signal enhancement. The modified electrode showed superior electrocatalytic performance and successfully allowed for trace analysis of chlorpyrifos with wide linear range and low detection limit.
Article
Chemistry, Analytical
Weiwei Luo, Hongyu Chu, Xinzhao Wu, Pinyi Ma, Qiong Wu, Daqian Song
Summary: A highly sensitive disposable self-enhanced off-on electrochemiluminescence (ECL) biosensor was developed to detect the biomarker caspase-3 activity, which is related to cancer cell apoptosis. This biosensor has a low detection limit, enhanced ECL emission and stability, and utilizes a solid-state ECL strategy to overcome weak emission issues. Introducing disposable screen-printed electrodes enables on-site rapid detection capabilities, laying the foundation for the development of advanced portable ECL devices for biosensing various bioanalytes.
Article
Chemistry, Analytical
Xiao Zhao, Rong Liao, Yueming Tan, Wenfang Deng, Qingji Xie
Summary: In this study, a highly sensitive self-powered biosensing platform for miRNA detection was developed. The platform integrates a glucose/O2 biofuel cell, CRISPR-Cas12a cleavage, and DSN-assisted target recycling, enabling ultrasensitive sensing of miRNA-155.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Nanoscience & Nanotechnology
Tong Wu, Hui Zheng, Yichuan Kou, Xinyue Su, Naveen Reddy Kadasala, Ming Gao, Lei Chen, Donglai Han, Yang Liu, Jinghai Yang
Summary: In this work, ternary Au@Cu2O-Ag NCs were successfully designed and prepared, and a possible SERS enhancement mechanism was proposed based on the investigation of SERS activity and electromagnetic field simulations. These NCs achieved highly sensitive SERS detection of MG and catalyzed its degradation driven by visible light.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Chemistry, Analytical
Chao Yan, Jianguo Xu, Lijun Yang, Bangben Yao, Guodong Liu, Wei Chen
Summary: A DG-TIS-based electrochemical biosensor was developed for the ultrasensitive detection of miRNA-21, showing wide linear response range, low detection limit, and excellent specificity. The biosensor could effectively interrogate the expression levels of miRNA-21 in cancer cells and spiked human serum, making it an ideal analytical tool for diagnostic applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Shi-Yun Cen, Xin-Yue Ge, Yao Chen, Ai-Jun Wang, Jiu-Ju Feng
Summary: Enhancement of electrochemical immunosensors using advanced nanomaterials is beneficial for developing high-sensitivity and high-selectivity immunoassays for cardiac troponin I (cTnI). By utilizing trimetallic alloyed AuPtPd porous fluffy-like nanodendrites (AuPtPd FNDs) as the assembly point for the antibody (Ab), the sensor displayed a wide linear range (0.01 to 100.0 ng/mL) and a low detection limit (LOD = 3 pg/mL), showing great potential for detecting cTnI in serum samples and providing an effective platform for analysis of other cardiac markers in practical samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Jingjing Zhang, Weijie Liu, Wei Gong, Ning Liu, Yiting Jia, Ding Ding, Zhanwu Ning
Summary: The ECL immunosensor developed based on dual signal amplification strategy utilizing MoS2-Au hybrid nanocomposite and graphene nanosheets for CdSe QDs capture successfully achieved trace microcystins detection in water with wide linear response range, as well as good selectivity, stability, and reproducibility for MCLR.
ANALYTICAL LETTERS
(2021)