Expanding the Toolbox of Upconversion Nanoparticles for In Vivo Optogenetics and Neuromodulation

Near-Infrared-Light Activatable Nanoparticles for Deep-Tissue-Penetrating Wireless Optogenetics

(2019) Nuo Yu et al.   Advanced Healthcare Materials

Energy-Transfer Editing in Lanthanide-Activated Upconversion Nanocrystals: A Toolbox for Emerging Applications

(2019) Xian Qin et al.   ACS Central Science

Large Timescale Interrogation of Neuronal Function by Fiberless Optogenetics Using Lanthanide Micro-particles

(2019) Toh Miyazaki et al.   Cell Reports

Mammalian Near-Infrared Image Vision through Injectable and Self-Powered Retinal Nanoantennae

(2019) Yuqian Ma et al.   CELL

Suppression of Defect-Induced Quenching via Chemical Potential Tuning: A Theoretical Solution for Enhancing Lanthanide Luminescence

(2019) Xian Qin et al.   Journal of Physical Chemistry C

Core–Shell–Shell Upconversion Nanoparticles with Enhanced Emission for Wireless Optogenetic Inhibition

(2018) Xudong Lin et al.   NANO LETTERS

Microscale optoelectronic infrared-to-visible upconversion devices and their use as injectable light sources

(2018) He Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

(2018) Shuo Chen et al.   SCIENCE

Advances in highly doped upconversion nanoparticles

(2018) Shihui Wen et al.   Nature Communications

Energy Flux Manipulation in Upconversion Nanosystems

(2018) Liangliang Liang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Multiplexed Optogenetic Stimulation of Neurons with Spectrum-Selective Upconversion Nanoparticles

(2017) Xudong Lin et al.   Advanced Healthcare Materials

Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications

(2016) Xiang Wu et al.   ACS Nano

Unraveling Epitaxial Habits in the NaLnF4System for Color Multiplexing at the Single-Particle Level

(2016) Yuhai Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Designing Upconversion Nanocrystals Capable of 745 nm Sensitization and 803 nm Emission for Deep-Tissue Imaging

(2016) Liangliang Liang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Quasi-Continuous Wave Near-Infrared Excitation of Upconversion Nanoparticles for Optogenetic Manipulation ofC. elegans

(2016) Akshaya Bansal et al.   Small

Photon Upconversion Through Tb3+-Mediated Interfacial Energy Transfer

(2015) Bo Zhou et al.   ADVANCED MATERIALS

A novel analgesic approach to optogenetically and specifically inhibit pain transmission using TRPV1 promoter

(2015) Bei Li et al.   BRAIN RESEARCH

Vagal Sensory Neuron Subtypes that Differentially Control Breathing

(2015) Rui B. Chang et al.   CELL

The biosafety of lanthanide upconversion nanomaterials

(2015) Yun Sun et al.   CHEMICAL SOCIETY REVIEWS

Optogenetic control of insulin secretion by pancreatic β-cells in vitro and in vivo

(2015) T Kushibiki et al.   GENE THERAPY

Intracellular Adenosine Triphosphate Deprivation through Lanthanide-Doped Nanoparticles

(2015) Jing Tian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Energy-Cascaded Upconversion in an Organic Dye-Sensitized Core/Shell Fluoride Nanocrystal

(2015) Guanying Chen et al.   NANO LETTERS

Tailoring dye-sensitized upconversion nanoparticle excitation bands towards excitation wavelength selective imaging

(2015) Xiang Wu et al.   Nanoscale

Hybrid upconversion nanomaterials for optogenetic neuronal control

(2015) Shreyas Shah et al.   Nanoscale

Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics

(2015) Sung Il Park et al.   NATURE BIOTECHNOLOGY

Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice

(2015) Kate L Montgomery et al.   NATURE METHODS

Controlling upconversion nanocrystals for emerging applications

(2015) Bo Zhou et al.   Nature Nanotechnology

Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch

(2015) Edmund Foster et al.   NEURON

Single-band upconversion nanoprobes for multiplexed simultaneous in situ molecular mapping of cancer biomarkers

(2015) Lei Zhou et al.   Nature Communications

Near-infrared (NIR) up-conversion optogenetics

(2015) Shoko Hososhima et al.   Scientific Reports

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

(2015) Kaoru Yamamoto et al.   Cell Reports

Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

(2015) Lian He et al.   eLife

Dual-Targeting Upconversion Nanoprobes across the Blood–Brain Barrier for Magnetic Resonance/Fluorescence Imaging of Intracranial Glioblastoma

(2014) Dalong Ni et al.   ACS Nano

An Upconversion Nanoparticle with Orthogonal Emissions Using Dual NIR Excitations for Controlled Two-Way Photoswitching

(2014) Jinping Lai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhancing Luminescence in Lanthanide-Doped Upconversion Nanoparticles

(2014) Sanyang Han et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Epitaxial Seeded Growth of Rare-Earth Nanocrystals with Efficient 800 nm Near-Infrared to 1525 nm Short-Wavelength Infrared Downconversion Photoluminescence for In Vivo Bioimaging

(2014) Rui Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multicolor Barcoding in a Single Upconversion Crystal

(2014) Yuhai Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

Engineering bright sub-10-nm upconverting nanocrystals for single-molecule imaging

(2014) Daniel J. Gargas et al.   Nature Nanotechnology

Through-skull fluorescence imaging of the brain in a new near-infrared window

(2014) Guosong Hong et al.   Nature Photonics

Optogenetic Patterning of Whisker-Barrel Cortical System in Transgenic Rat Expressing Channelrhodopsin-2

(2014) Tatsuya Honjoh et al.   PLoS One

Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans

(2014) Frederick B. Shipley et al.   Frontiers in Neural Circuits

Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2

(2014) Thomas M Reinbothe et al.   Islets

Biodistribution of sub-10 nm PEG-modified radioactive/upconversion nanoparticles

(2013) Tianye Cao et al.   BIOMATERIALS

Targeting CCL21–folic acid–upconversion nanoparticles conjugates to folate receptor-α expressing tumor cells in an endothelial-tumor cell bilayer model

(2013) Kim Yee Lee et al.   BIOMATERIALS

Optogenetic manipulation of neural and non-neural functions

(2013) Hiromu Yawo et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Remote Optogenetic Activation and Sensitization of Pain Pathways in Freely Moving Mice

(2013) I. Daou et al.   JOURNAL OF NEUROSCIENCE

Mechanistic Investigation of Photon Upconversion in Nd3+-Sensitized Core–Shell Nanoparticles

(2013) Xiaoji Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-nanocrystal sensitivity achieved by enhanced upconversion luminescence

(2013) Jiangbo Zhao et al.   Nature Nanotechnology

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation

(2013) John Y Lin et al.   NATURE NEUROSCIENCE

Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics

(2013) Jordan G McCall et al.   Nature Protocols

Optical properties of biological tissues: a review

(2013) Steven L Jacques   PHYSICS IN MEDICINE AND BIOLOGY

Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion

(2013) M. Hagglund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering the Upconversion Nanoparticle Excitation Wavelength: Cascade Sensitization of Tri-doped Upconversion Colloidal Nanoparticles at 800 nm

(2013) Jie Shen et al.   Advanced Optical Materials

Ag2S Quantum Dot: A Bright and Biocompatible Fluorescent Nanoprobe in the Second Near-Infrared Window

(2012) Yan Zhang et al.   ACS Nano

Mn2+ Dopant-Controlled Synthesis of NaYF4:Yb/Er Upconversion Nanoparticles for in vivo Imaging and Drug Delivery

(2012) Gan Tian et al.   ADVANCED MATERIALS

Central Amygdala Metabotropic Glutamate Receptor 5 in the Modulation of Visceral Pain

(2012) L. W. Crock et al.   JOURNAL OF NEUROSCIENCE

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury

(2012) Jeanne T Paz et al.   NATURE NEUROSCIENCE

A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

(2012) Linda Madisen et al.   NATURE NEUROSCIENCE

Broadband dye-sensitized upconversion of near-infrared light

(2012) Wenqiang Zou et al.   Nature Photonics

Light-evoked Somatosensory Perception of Transgenic Rats That Express Channelrhodopsin-2 in Dorsal Root Ganglion Cells

(2012) Zhi-Gang Ji et al.   PLoS One

Upconverting Nanoparticles

(2011) Markus Haase et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optically controlled contraction of photosensitive skeletal muscle cells

(2011) Toshifumi Asano et al.   BIOTECHNOLOGY AND BIOENGINEERING

Upconversion nanophosphors for small-animal imaging

(2011) Jing Zhou et al.   CHEMICAL SOCIETY REVIEWS

A wirelessly powered and controlled device for optical neural control of freely-behaving animals

(2011) Christian T Wentz et al.   Journal of Neural Engineering

In vivopharmacokinetics, long-term biodistribution and toxicology study of functionalized upconversion nanoparticles in mice

(2011) Liang Cheng et al.   Nanomedicine

Upconversion nanoparticles: synthesis, surface modification and biological applications

(2011) Meng Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Tuning upconversion through energy migration in core–shell nanoparticles

(2011) Feng Wang et al.   NATURE MATERIALS

Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function

(2011) Shengli Zhao et al.   NATURE METHODS

Optogenetics in Neural Systems

(2011) Ofer Yizhar et al.   NEURON

Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window

(2011) K. Welsher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antidepressant Effect of Optogenetic Stimulation of the Medial Prefrontal Cortex

(2010) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping

(2010) Feng Wang et al.   NATURE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Optogenetics

(2010) Karl Deisseroth   NATURE METHODS

Optogenetic control of heart muscle in vitro and in vivo

(2010) Tobias Bruegmann et al.   NATURE METHODS

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

(2010) Feng Zhang et al.   Nature Protocols

Cholinergic Interneurons Control Local Circuit Activity and Cocaine Conditioning

(2010) I. B. Witten et al.   SCIENCE

The Active-Core/Active-Shell Approach: A Strategy to Enhance the Upconversion Luminescence in Lanthanide-Doped Nanoparticles

(2009) Fiorenzo Vetrone et al.   ADVANCED FUNCTIONAL MATERIALS

High Contrast Upconversion Luminescence Targeted Imaging in Vivo Using Peptide-Labeled Nanophosphors

(2009) Liqin Xiong et al.   ANALYTICAL CHEMISTRY

Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals

(2009) Feng Wang et al.   CHEMICAL SOCIETY REVIEWS

NIR dyes for bioimaging applications

(2009) Jorge O Escobedo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Surface Modification of Upconverting NaYF4Nanoparticles with PEG−Phosphate Ligands for NIR (800 nm) Biolabeling within the Biological Window

(2009) John-Christopher Boyer et al.   LANGMUIR

Second window for in vivo imaging

(2009) Andrew M. Smith et al.   Nature Nanotechnology

Bi-stable neural state switches

(2009) André Berndt et al.   NATURE NEUROSCIENCE

Optical Deconstruction of Parkinsonian Neural Circuitry

(2009) V. Gradinaru et al.   SCIENCE

Synthesis and Optical Properties of KYF4/Yb, Er Nanocrystals, and their Surface Modification with Undoped KYF4

(2008) Helmut Schäfer et al.   ADVANCED FUNCTIONAL MATERIALS

Multicolor Core/Shell-Structured Upconversion Fluorescent Nanoparticles

(2008) Zhengquan Li et al.   ADVANCED MATERIALS

Molecular Determinants Differentiating Photocurrent Properties of Two Channelrhodopsins fromChlamydomonas

(2008) Hongxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light-Induced Rescue of Breathing after Spinal Cord Injury

(2008) W. J. Alilain et al.   JOURNAL OF NEUROSCIENCE

Upconversion Emission Enhancement in Yb3+/Er3+-Codoped Y2O3 Nanocrystals by Tridoping with Li+ Ions

(2008) Guanying Chen et al.   Journal of Physical Chemistry C

Upconversion Multicolor Fine-Tuning: Visible to Near-Infrared Emission from Lanthanide-Doped NaYF4Nanoparticles

(2008) Feng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An efficient and user-friendly method for the synthesis of hexagonal-phase NaYF4:Yb, Er/Tm nanocrystals with controllable shape and upconversion fluorescence

(2008) Zhengquan Li et al.   NANOTECHNOLOGY

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri

(2008) Feng Zhang et al.   NATURE NEUROSCIENCE

Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals

(2007) D CHATTERJEE et al.   BIOMATERIALS