Article
Materials Science, Biomaterials
Gangchen Lu, Xin Shen, Dongdong Xiao, Liduo Rong, Zhiping Mao, Bijia Wang, Xiaofeng Sui, Meixin Zhao, Xueling Feng
Summary: Emulsion hydrogels are composite materials that can accommodate hydrophobic and hydrophilic components, promising for the encapsulation and delivery of bioactive ingredients. The ternary enzyme-mediated polymerization is an efficient strategy to encapsulate hydrophobic bioactive ingredients.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Medicine, Research & Experimental
Seyed Farzad Baniahmad, Romane Oliverio, Ines Obregon-Gomez, Alma Robert, Anne E. G. Lenferink, Elena Pazos, Nick Virgilio, Xavier Banquy, Gregory De Crescenzo, Yves Durocher
Summary: Long-term delivery is a successful strategy to reduce adverse effects of mAb-based treatments. Macroporous hydrogels and affinity-based strategies are effective in sustained and localized delivery of mAbs. The Ecoil and Kcoil peptides have high-affinity binding and can be used for controlled release of Ecoil-tagged trastuzumab from macroporous hydrogels.
Article
Biochemistry & Molecular Biology
Chih-Hsiang Hu, Remi Veneziano
Summary: This study developed a responsive controlled release system using DNA nanotechnology tools and strand displacement circuit, allowing precise control over the release of biomolecules. The system was successfully incorporated within a gelatin hydrogel and demonstrated the ability to release multiple model cargos with temporal specificity.
Article
Chemistry, Physical
Si Yu Zheng, Shihua Mao, Jingfeng Yuan, Shuaibing Wang, Xiaomin He, Xinning Zhang, Cong Du, Dong Zhang, Zi Liang Wu, Jintao Yang
Summary: A new class of zwitterionic hydrogels, developed from a structurally ameliorated sulfobetaine monomer VBIPS, show significantly enhanced mechanical properties including excellent tensile toughness and fracture toughness. The toughness originates from the formation of a two-phase structure at room temperature, and the gel's mechanical properties can be tuned by changing the pH, with self-healing achieved through acid treatment.
CHEMISTRY OF MATERIALS
(2021)
Article
Polymer Science
Shengwei Xiao, Xiaomin He, Zhiqiang Zhao, Guobo Huang, Zhenzhong Yan, Zhicai He, Zhengping Zhao, Feng Chen, Jintao Yang
Summary: Salt-responsive hydrogels with zwitterionic monomer VBIPS were prepared, showing strong mechanical properties and recoverability. They exhibit different properties in water and salt solution, and after complexing with multivalent cations, a decreased freezing point was observed.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Physical
George Newham, Stephen D. Evans, Zhan Yuin Ong
Summary: Research has shown a facile method for synthesizing organic-inorganic hybrid poly(ethylenimine) functionalised silica nanoparticles (PEI-SiNPs) using poly-electrolyte complex (PEC) templated synthesis, and their use as multifunctional electrostatic crosslinkers with hyaluronic acid (HA) to form nanocomposite hydrogels. The electrostatic interactions between PEI-SiNPs and HA resulted in a coacervate nanocomposite hydrogel with enhanced mechanical stiffness and self-healing properties. This method offers a simpler and more versatile strategy for the fabrication of nanocomposite hydrogels with tuneable mechanical stiffness and self-healing properties for drug delivery applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Vincent Huynh, Nazanin Tatari, April Marple, Neil Savage, Dillon McKenna, Chitra Venugopal, Sheila K. Singh, Ryan Wylie
Summary: This study demonstrates the use of displacement affinity release (DAR) to tune the release of a CD133 targeting dual antigen T cell engager (DATE) within a hydrogel. The sustained release enhances T cell mediated killing of cancer spheroids, and the addition of anti-PD1 antibody further enhances the killing effect. The development of a multi-cellular embedded spheroid model with automated microscopy facilitates the identification and translation of delivery vehicles for immunotherapeutics.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Kai Jiang, Xuesong Zhou, Tong He
Summary: The composite hydrogels composed of partially oxidated bacterial cellulose and chitosan showed good mechanical properties and pH responsive performance, making them potential drug carriers for clinical therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Analytical
Chae Hwan Cho, Se-Young Son, Jeong Kyu Bang, Young Ho Jeon, Jong Pil Park
Summary: Allergy-causing inflammatory diseases have become a global health problem. This study identified specific peptides that bind to IL-33 and described their molecular interactions. The peptide with the highest binding affinity was identified as FGLEPRANLHFT. The study also investigated the primary peptide binding site of IL-33 and suggested potential applications in drug development and allergy diagnosis.
ANALYTICA CHIMICA ACTA
(2022)
Article
Polymer Science
Shubhra Goel, Tejinder Kaur, Neetu Singh, Josemon Jacob
Summary: This article reports the preparation of novel D-galactose based hydrogels for biomedical applications. The hydrogels exhibit porous morphology with tunable properties such as swelling ratio and drug release. The cytocompatibility of the material shows its potential for various biomedical applications.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Applied
Sonita A. P. Siboro, Daru S. B. Anugrah, Kalyan Ramesh, Sang-Hyug Park, Hyeung-Rak Kim, Kwon Taek Lim
Summary: The study demonstrates that the drug release behavior of alginate hydrogels is significantly influenced by the proportion of crosslinkers and porosity. Porous hydrogels lead to faster drug release, while non-porous hydrogels result in slow release. Furthermore, porous alginate hydrogels can sustainably release doxorubicin for up to 35 days.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Carter J. Teal, Marian H. Hettiaratchi, Margaret T. Ho, Arturo Ortin-Martinez, Ahil N. Ganesh, Andrew J. Pickering, Alex W. Golinski, Benjamin J. Hackel, Valerie A. Wallace, Molly S. Shoichet
Summary: By using directed evolution, specific affibody binding partners have been engineered to independently control the release rates of therapeutic proteins. In vivo testing on mice demonstrated the sustained activity of the controlled release, leading to improved efficacy.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Emily K. Makowski, Tiexin Wang, Jennifer M. Zupancic, Jie Huang, Lina Wu, John S. Schardt, Anne S. De Groot, Stephanie L. Elkins, William D. Martin, Peter M. Tessier
Summary: Interpretable machine-learning models can identify clinical-stage monoclonal antibodies with optimal combinations of low off-target binding and low self-association in physiological and antibody-formulation conditions.
NATURE BIOMEDICAL ENGINEERING
(2023)
Review
Pharmacology & Pharmacy
Stephane Bernhard, Mark W. Tibbitt
Summary: Supramolecular binding motifs are increasingly utilized in the design of biomaterials, particularly in drug delivery systems. Rational engineering of specific associations enables injectable or sprayable hydrogels, achieving minimally invasive administration in drug delivery.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Monessha Nambiar, Joel P. Schneider
Summary: The development of devices for precise and controlled delivery of therapeutics has grown rapidly over decades, with materials needing to provide delivery profiles that satisfy pharmacodynamic and pharmacokinetic requirements. Therapeutic efficacy is limited by short half-life and poor stability, but can potentially be improved by using materials that control drug release rates. Affinity-based release strategies can modulate drug release profiles to meet pharmacokinetic benchmarks.
JOURNAL OF PEPTIDE SCIENCE
(2022)