CREB3 Transcription Factors: ER-Golgi Stress Transducers as Hubs for Cellular Homeostasis

A homozygous pathogenic missense variant broadens the phenotypic and mutational spectrum of CREB3L1-related osteogenesis imperfecta

(2019) Brecht Guillemyn et al.   HUMAN MOLECULAR GENETICS

Axotomy Induces Phasic Alterations in Luman/CREB3 Expression and Nuclear Localization in Injured and Contralateral Uninjured Sensory Neurons: Correlation With Intrinsic Axon Growth Capacity

(2019) Jovan C D Hasmatali et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Inhibition of Luman/CREB3 expression leads to the upregulation of testosterone synthesis in mouse Leydig cells

(2019) Lei Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα

(2019) Philip M. M. Ruppert et al.   BMC GENOMICS

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

CREBH Regulates Systemic Glucose and Lipid Metabolism

(2018) Yoshimi Nakagawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Golgi stress–induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing

(2018) Jan Baumann et al.   MOLECULAR BIOLOGY OF THE CELL

CREB3L1 as a potential biomarker predicting response of triple negative breast cancer to doxorubicin-based chemotherapy

(2018) Bray Denard et al.   BMC CANCER

Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity

(2018) Muna Al-Maskari et al.   Scientific Reports

LUMAN/CREB3 Plays a Dual Role in Stress Responses as a Cofactor of the Glucocorticoid Receptor and a Regulator of Secretion

(2018) Jenna Penney et al.   Frontiers in Molecular Neuroscience

The endoplasmic reticulum stress transducer old astrocyte specifically induced substance positively regulates glial scar formation in spinal cord injury

(2018) Yoshikazu Sumida et al.   NEUROREPORT

Monoallelic and biallelic CREB3L1 variant causes mild and severe osteogenesis imperfecta, respectively

(2017) Rachel B Keller et al.   GENETICS IN MEDICINE

UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage–specific manner

(2017) Tokiro Ishikawa et al.   JOURNAL OF CELL BIOLOGY

CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells

(2017) Iris A. García et al.   JOURNAL OF CELL SCIENCE

A CREB3-regulated ER–Golgi trafficking signature promotes metastatic progression in breast cancer

(2017) Breege V. Howley et al.   ONCOGENE

Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

(2017) Yu-Xiong Feng et al.   Nature Communications

Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons

(2017) Chang Geon Chung et al.   Cell Reports

Regulation of cAMP Responsive Element Binding Protein 3-Like 1 (Creb3l1) Expression by Orphan Nuclear Receptor Nr4a1

(2017) Michael P. Greenwood et al.   Frontiers in Molecular Neuroscience

Chlamydia pneumoniae inclusion membrane protein Cpn0147 interacts with host protein CREB3

(2017) Xia Zhao et al.   PLoS One

CREB3L2-mediated expression of Sec23A/Sec24D is involved in hepatic stellate cell activation through ER-Golgi transport

(2017) Shotaro Tomoishi et al.   Scientific Reports

MLX Is a Transcriptional Repressor of the Mammalian Golgi Stress Response

(2016) Mai Taniguchi et al.   CELL STRUCTURE AND FUNCTION

ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the HeartNovelty and Significance

(2016) Jung-Kang Jin et al.   CIRCULATION RESEARCH

Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease

(2016) José R. Naranjo et al.   JOURNAL OF CLINICAL INVESTIGATION

The CREB3-Herp signalling module limits the cytosolic calcium concentration increase and apoptosis induced by poliovirus

(2016) Carmen Mirabelli et al.   JOURNAL OF GENERAL VIROLOGY

Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination

(2016) Danyang He et al.   NATURE NEUROSCIENCE

The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression

(2016) Xiang Cui et al.   Scientific Reports

Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression

(2016) Takuya Kikuchi et al.   Molecular Metabolism

Knockdown of CREB3/Luman by shRNA in Mouse Granulosa Cells Results in Decreased Estradiol and Progesterone Synthesis and Promotes Cell Proliferation

(2016) Fan Zhao et al.   PLoS One

TFE3 Is a bHLH-ZIP-type Transcription Factor that Regulates the Mammalian Golgi Stress Response

(2015) Mai Taniguchi et al.   CELL STRUCTURE AND FUNCTION

Organelle autoregulation--stress responses in the ER, Golgi, mitochondria and lysosome

(2015) K. Sasaki et al.   JOURNAL OF BIOCHEMISTRY

Dickkopf Homolog 3 Induces Stem Cell Differentiation into Smooth Muscle Lineage via ATF6 Signalling

(2015) Xiaocong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells

(2015) Wei Shi et al.   NATURE IMMUNOLOGY

Transcription Factor CREB3L1 Regulates Endoplasmic Reticulum Stress Response Genes in the Osmotically Challenged Rat Hypothalamus

(2015) Mingkwan Greenwood et al.   PLoS One

OASIS modulates hypoxia pathway activity to regulate bone angiogenesis

(2015) Min Cui et al.   Scientific Reports

The Golgi complex in stress and death

(2015) Carolyn E. Machamer   Frontiers in Neuroscience

OASIS/CREB3L1is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migrationin vitro

(2015) Michael Rose et al.   Epigenetics

Master Regulator for Chondrogenesis, Sox9, Regulates Transcriptional Activation of the Endoplasmic Reticulum Stress Transducer BBF2H7/CREB3L2 in Chondrocytes

(2014) Kenta Hino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cloning and Characterization of Rat Luman/CREB3, A Transcription Factor Highly Expressed in Nervous System Tissue

(2014) Zhengxin Ying et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

OASIS regulates chondroitin 6-O-sulfotransferase 1 gene transcription in the injured adult mouse cerebral cortex

(2014) Hiroaki Okuda et al.   JOURNAL OF NEUROCHEMISTRY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Transcription Factor CREB3L1 Regulates Vasopressin Gene Expression in the Rat Hypothalamus

(2014) M. Greenwood et al.   JOURNAL OF NEUROSCIENCE

Orphan Nuclear Receptor Errγ Induces C-Reactive Protein Gene Expression through Induction of ER-Bound Bzip Transmembrane Transcription Factor CREBH

(2014) Jagannath Misra et al.   PLoS One

Sensing nerve injury at the axonal ER: Activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal

(2014) Zhengxin Ying et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Creb3l4 as an essential negative regulator of adipogenesis

(2014) T-H Kim et al.   Cell Death & Disease

VEGF-A Is Necessary and Sufficient for Retinal Neuroprotection in Models of Experimental Glaucoma

(2013) Richard H. Foxton et al.   AMERICAN JOURNAL OF PATHOLOGY

F-box and WD Repeat Domain-containing-7 (Fbxw7) Protein Targets Endoplasmic Reticulum-anchored Osteogenic and Chondrogenic Transcriptional Factors for Degradation

(2013) Kanae Yumimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chondrocyte Proliferation Regulated by Secreted Luminal Domain of ER Stress Transducer BBF2H7/CREB3L2

(2013) Atsushi Saito et al.   MOLECULAR CELL

A CREB3–ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

(2013) Jan H. Reiling et al.   NATURE CELL BIOLOGY

Deficiency for the ER-stress transducer OASIS causes severe recessive osteogenesis imperfecta in humans

(2013) Sofie Symoens et al.   Orphanet Journal of Rare Diseases

Transcriptional Regulation of VEGFA by the Endoplasmic Reticulum Stress Transducer OASIS in ARPE-19 Cells

(2013) Hidetaka Miyagi et al.   PLoS One

The Endoplasmic Reticulum-Resident Chaperone Heat Shock Protein 47 Protects the Golgi Apparatus from the Effects of O-Glycosylation Inhibition

(2013) Shingo Miyata et al.   PLoS One

Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons

(2012) S.-Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Orchestrated Program Regulating Secretory Pathway Genes and Cargos by the Transmembrane Transcription Factor CREB-H

(2012) Sónia Barbosa et al.   TRAFFIC

Unfolded protein response, activated by OASIS family transcription factors, promotes astrocyte differentiation

(2012) Atsushi Saito et al.   Nature Communications

Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1

(2012) Bray Denard et al.   eLife

Regulation of ADP-ribosylation factor 4 expression by small leucine zipper protein and involvement in breast cancer cell migration

(2011) Soon Young Jang et al.   CANCER LETTERS

The Membrane-Bound Transcription Factor CREB3L1 Is Activated in Response to Virus Infection to Inhibit Proliferation of Virus-Infected Cells

(2011) Bray Denard et al.   Cell Host & Microbe

FUS-CREB3L2/L1-Positive Sarcomas Show a Specific Gene Expression Profile with Upregulation of CD24 and FOXL1

(2011) E. Moller et al.   CLINICAL CANCER RESEARCH

The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis

(2011) D. B. Melville et al.   Disease Models & Mechanisms

Analysis of genes regulated by the transcription factor LUMAN identifies ApoA4 as a target gene in dendritic cells

(2011) Anna Sanecka et al.   MOLECULAR IMMUNOLOGY

The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism

(2011) Jung Hoon Lee et al.   NATURE MEDICINE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models

(2011) Chi-Ping Chan et al.   Cell and Bioscience

Fusion of the FUS and CREB3L2 genes in a supernumerary ring chromosome in low-grade fibromyxoid sarcoma

(2010) Hammurabi Bartuma et al.   CANCER GENETICS AND CYTOGENETICS

Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH

(2010) Min-Woo Lee et al.   Cell Metabolism

Novel Cis-acting Element GASE Regulates Transcriptional Induction by the Golgi Stress Response

(2010) Masaya Oku et al.   CELL STRUCTURE AND FUNCTION

HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells

(2010) Han-Cheon Kim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

OASIS/CREB3L1 Induces Expression of Genes Involved in Extracellular Matrix Production But Not Classical Endoplasmic Reticulum Stress Response Genes in Pancreatic β-Cells

(2010) Ravi N. Vellanki et al.   ENDOCRINOLOGY

The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity

(2010) Rebecca M. Fox et al.   JOURNAL OF CELL BIOLOGY

Genome-wide gene expression and promoter binding analysis identifies NFIL3 as a repressor of C/EBP target genes in neuronal outgrowth

(2010) Harold D. MacGillavry et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications

(2010) Zhi Sheng et al.   NATURE MEDICINE

The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARα

(2009) Hirosuke Danno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Coordinated activation of the secretory pathway during notochord formation in the Xenopus embryo

(2009) K. Tanegashima et al.   DEVELOPMENT

Increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid inOASIS-deficient mice

(2009) Kazuyasu Chihara et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis

(2009) Atsushi Saito et al.   NATURE CELL BIOLOGY

Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation

(2009) Tomohiko Murakami et al.   NATURE CELL BIOLOGY

ER Stress Controls Iron Metabolism Through Induction of Hepcidin

(2009) C. Vecchi et al.   SCIENCE

Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration

(2008) Ho Joong Sung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Hepatocyte nuclear factor 4α is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H

(2008) Jennifer Luebke-Wheeler et al.   HEPATOLOGY

Association of the Cellular Coactivator HCF-1 with the Golgi Apparatus in Sensory Neurons

(2008) G. Kolb et al.   JOURNAL OF VIROLOGY