Traceless aptamer-mediated isolation of CD8+ T cells for chimeric antigen receptor T-cell therapy

Individually addressable and dynamic DNA gates for multiplexed cell sorting

(2018) Shreyas N. Dahotre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomanufacturing for clinically advanced cell therapies

(2018) Ayesha Aijaz et al.   Nature Biomedical Engineering

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

(2018) Marco Ruella et al.   NATURE MEDICINE

Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

(2017) Shuaijian Ni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   MOLECULAR THERAPY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Selection of DNA aptamers with two modified bases

(2017) Bharat N. Gawande et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aptamers for CD Antigens: From Cell Profiling to Activity Modulation

(2017) Amin Nozari et al.   Molecular Therapy-Nucleic Acids

Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications

(2017) Hamid R. Mirzaei et al.   Frontiers in Immunology

Analysis of aptamer discovery and technology

(2017) Matthew R. Dunn et al.   Nature Reviews Chemistry

Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies

(2016) M. Sabatino et al.   BLOOD

A ternary complex comprising transportin1, Rab8 and the ciliary targeting signal directs proteins to ciliary membranes

(2016) Viswanadh Madugula et al.   JOURNAL OF CELL SCIENCE

CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

(2016) Cameron J. Turtle et al.   JOURNAL OF CLINICAL INVESTIGATION

Aptamer and Antisense-Mediated Two-Dimensional Isolation of Specific Cancer Cell Subpopulations

(2016) Mahmoud Labib et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aptamers as targeted therapeutics: current potential and challenges

(2016) Jiehua Zhou et al.   NATURE REVIEWS DRUG DISCOVERY

Chitosan Nanofibers for Specific Capture and Nondestructive Release of CTCs Assisted by pCBMA Brushes

(2016) Na Sun et al.   Small

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells

(2015) Zeguo Zhao et al.   CANCER CELL

Aptamers Overview: Selection, Features and Applications

(2015) Luiza Hernandez et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo

(2015) D Sommermeyer et al.   LEUKEMIA

Isolation of Foreign Material-Free Endothelial Progenitor Cells Using CD31 Aptamer and Therapeutic Application for Ischemic Injury

(2015) Jung Won Yoon et al.   PLoS One

FASTAptamer: A Bioinformatic Toolkit for High-throughput Sequence Analysis of Combinatorial Selections

(2015) Khalid K Alam et al.   Molecular Therapy-Nucleic Acids

Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy

(2014) A. Heczey et al.   BLOOD

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

(2014) M. L. Davila et al.   Science Translational Medicine

A new nucleic acid–based agent inhibits cytotoxic T lymphocyte–mediated immune disorders

(2013) Chuang-Wei Wang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

(2013) R. J. Brentjens et al.   Science Translational Medicine

Endonuclease-responsive aptamer-functionalized hydrogel coating for sequential catch and release of cancer cells

(2012) Shihui Li et al.   BIOMATERIALS

Phenotypic and Functional Attributes of Lentivirus-modified CD19-specific Human CD8+ Central Memory T Cells Manufactured at Clinical Scale

(2012) Xiuli Wang et al.   JOURNAL OF IMMUNOTHERAPY

Programmable Hydrogels for Controlled Cell Catch and Release Using Hybridized Aptamers and Complementary Sequences

(2012) Zhaoyang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Capture, isolation and release of cancer cells with aptamer-functionalized glass bead array

(2012) Yuan Wan et al.   LAB ON A CHIP

Specific capture and temperature-mediated release of cells in an aptamer-based microfluidic device

(2012) Jing Zhu et al.   LAB ON A CHIP

Novel Serial Positive Enrichment Technology Enables Clinical Multiparameter Cell Sorting

(2012) Christian Stemberger et al.   PLoS One

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

(2012) J. Scholler et al.   Science Translational Medicine

Aptamer-Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces

(2011) Li Chen et al.   ADVANCED MATERIALS

Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells

(2011) S. Terakura et al.   BLOOD

Rapid Multitarget Immunomagnetic Separation through Programmable DNA Linker Displacement

(2011) Christine E. Probst et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic DNA nanotechnology using strand-displacement reactions

(2011) David Yu Zhang et al.   Nature Chemistry

NUPACK: Analysis and design of nucleic acid systems

(2010) Joseph N. Zadeh et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Development of DNA aptamers using Cell-SELEX

(2010) Kwame Sefah et al.   Nature Protocols

Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation

(2010) Anita Schmitt et al.   TRANSFUSION

Aptamer-Based Microfluidic Device for Enrichment, Sorting, and Detection of Multiple Cancer Cells

(2009) Ye Xu et al.   ANALYTICAL CHEMISTRY

Control of DNA Strand Displacement Kinetics Using Toehold Exchange

(2009) David Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MEME SUITE: tools for motif discovery and searching

(2009) T. L. Bailey et al.   NUCLEIC ACIDS RESEARCH