Review
Biochemistry & Molecular Biology
Xiaolin Hou, Jiaqi Li, Yongyu Hong, Hang Ruan, Meng Long, Nianping Feng, Yongtai Zhang
Summary: Transdermal drug delivery (TDD) is a key approach for treating diseases and improving patient compliance. Microneedling is a relatively simple and efficient means of drug delivery, and is often used to improve the efficiency of TDD.
Article
Pharmacology & Pharmacy
Majd Kittaneh, Moammal Qurt, Numan Malkieh, Hani Naseef, Ramzi Muqedi
Summary: This study prepared various film-forming solutions for transdermal delivery of vitamin D3. The release of vitamin D3 from the solution was greater compared to the dry film. In vitro permeation studies showed that after 24 hours, around 800 IU of vitamin D3 permeated through the artificial skin membrane.
Review
Biotechnology & Applied Microbiology
Yanghui Xing, Buhui Zeng, Wang Yang
Summary: Light responsive hydrogels are an important drug delivery system that can accurately control drug release by incorporating photosensitive moieties into their structures. Advances in photosensitizers have enabled the use of different light sources, and hydrogels with photosensitizers have improved therapeutic effects. Existing light responsive drug delivery systems have been applied in chemotherapy, immunotherapy, photodynamic therapy, gene therapy, and other fields.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Haojie Zhang, Yinping Pan, Yao Hou, Minghui Li, Jia Deng, Bochu Wang, Shilei Hao
Summary: Transdermal drug delivery systems based on physical principles have provided a stable, efficient, and safe strategy for disease therapy. Intelligent design and concepts have enabled real-time monitoring and precise drug release. The combination with pharmaceutical dosage forms can achieve better transdermal effects and facilitate the development of smart medical devices.
Review
Biochemistry & Molecular Biology
Zhenzhen Qi, Zheng Yan, Guohongfang Tan, Subhas C. Kundu, Shenzhou Lu
Summary: Research on smart responsive polymer microneedles aims to achieve local accurate drug release, which have advantages such as painless administration, good biocompatibility, and ease of self-administration, and hold significant research implications in transdermal drug administration.
Article
Biochemistry & Molecular Biology
Chengdian He, Xiong He, Yi Zhang, Xiaofeng Han, Yujun Yang, Yong Shen, Teng Wang, Qing Wu, Yukun Yang, Wei Xu, Jin Bai, Zhenyu Wang
Summary: This study presents an ultrasound-controlled monodisperse lipid vesicles (U-CMLVs) hydrogel dressing that combines with ultrasound to form a transdermal drug delivery system (TDDS). Utilizing microfluidic technology, size controllable U-CMLVs with high drug encapsulation efficiency and quantitative encapsulation of ultrasonic response materials are prepared and mixed with hydrogel to create the desired thickness of dressings. The use of high and low frequency ultrasound controls the movement and rupture of U-CMLVs, enabling the drugs to penetrate the epidermis and dermis, achieving deep, controllable, efficient, and safe drug delivery through TDDS.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Joseph G. Turner, Leah R. White, Pedro Estrela, Hannah S. Leese
Summary: Hydrogel-forming microneedles offer enhanced transdermal drug delivery effectiveness and potential for passive extraction of interstitial fluid from the skin, making them suitable for biocompatible minimally invasive monitoring devices.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Na Qiao, Yufan Zhang, Ying Fang, Heli Deng, Desuo Zhang, Hong Lin, Yuyue Chen, Ken Tye Yong, Jiaqing Xiong
Summary: A silk fabric-based medical dressing decorated by a thermo-responsive hydrogel is proposed for sustained release of paracetamol, effectively avoiding the drawbacks of oral ingestion.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Elka Touitou, Hiba Natsheh, Jana Zailer
Summary: This study investigates delivery systems that can form a structured matrix film on the skin. Previous research has shown that these systems enhance skin delivery of molecules. The study further explores factors affecting delivery properties, such as component concentration and application mode on the skin.
Article
Chemistry, Physical
Soledad Stagnoli, Cintia Garro, Ozlem Ertekin, Susanne Heid, Stefan Seyferth, Gaston Soria, N. Mariano Correa, Aldo Leal-Egana, Aldo R. Boccaccini
Summary: This study developed a system for delivering water-insoluble drugs, which can efficiently load drugs and increase the likelihood of drug uptake by cancer cells instead of healthy cells. The system also demonstrates high efficiency and stability during topical application, and it is less invasive compared to alternative methods.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Jiuyu Cui, Jun Huang, Yonggan Yan, Wenqian Chen, Jie Wen, Xunwei Wu, Jikai Liu, Hanlian Liu, Chuanzhen Huang
Summary: A Fe3O4-loaded photothermal microneedle patch (Fe3O4@MN) has been developed for controlled drug delivery, achieving enhanced drug release efficiency. The Fe3O4@MN has sufficient mechanical strength to penetrate the skin, and its temperature can rapidly increase under NIR irradiation. In vitro experiments showed high drug release rates and increased penetration depth compared to a patch without Fe3O4 nanoparticles, indicating the potential application of the synthesized microneedle patch for transdermal drug delivery.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Applied
Yu Cai, Liying Xin, Peng Sun, Hui Li, Chao Liu, Liang Fang
Summary: A temperature-sensitive multifunctional intelligent hydrogel patch has been developed for wound healing, which can accelerate wound closure through controlling drug release, providing analgesia, antioxidation, and hemostasis.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Shubhra Goel, Tejinder Kaur, Neetu Singh, Josemon Jacob
Summary: This article reports the preparation of novel D-galactose based hydrogels for biomedical applications. The hydrogels exhibit porous morphology with tunable properties such as swelling ratio and drug release. The cytocompatibility of the material shows its potential for various biomedical applications.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Biotechnology & Applied Microbiology
Xue Jiang, Huanhuan Zhao, Wei Li
Summary: This paper discusses the importance of drug-carrying nanoparticles in disease treatments and the advantages of microneedle-mediated delivery of nanoparticles. It provides an overview of several methods for nanoparticle delivery and the potential clinical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Chen Li, Fayong Li, Ke Wang, Qing Wang, Hailu Liu, Xiaoyan Sun, Dong Xie
Summary: In this study, a functionalized carboxymethyl chitosan-graphene oxide-gelatin composite hydrogel with excellent swelling property, high biocompatibility, and drug delivery efficiency was prepared by ionic crosslinking. The composite hydrogel exhibited porous structures with randomly distributed but regularly arranged pores in the cross section. The thermal stability and swelling ratio of the composite hydrogel were improved, leading to improved drug delivery efficiency and prolonged drug administration.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Chau T. M. Tran, Phuong H. L. Tran, Thao T. D. Tran
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2019)
Article
Pharmacology & Pharmacy
Minh N. U. Nguyen, Phuong H. L. Tran, Thao T. D. Tran
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Pharmacology & Pharmacy
Chulhun Park, Nileshkumar M. Meghani, Yongkwan Shin, Euichaul Oh, Jun-Born Park, Jing-Hao Cui, Qing-Ri Cao, Thao Truong-Dinh Tran, Phuong Ha-Lien Tran, Beom-Jin Lee
Article
Pharmacology & Pharmacy
Hai Ngo, Phuong H. L. Tran, Beom-Jin Lee, Thao T. D. Tran
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Review
Biochemistry & Molecular Biology
Phuong H. L. Tran, Wei Duan, Beom-Jin Lee, Thao T. D. Tran
CURRENT DRUG METABOLISM
(2019)
Review
Pharmacology & Pharmacy
Phuong H. L. Tran, Wei Duan, Beom-Jin Lee, Thao T. D. Tran
CURRENT PHARMACEUTICAL DESIGN
(2019)
Article
Pharmacology & Pharmacy
Phuong H. L. Tran, Wei Dian, Beom-Jin Lee, Thao T. D. Tran
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Pharmacology & Pharmacy
Phuong H. L. Tran, Tao Wang, Wang Yin, Thao T. D. Tran, Hridika T. Barua, Yumei Zhang, Snehal B. Midge, Tuong N. G. Nguyen, Beom-Jin Lee, Wei Duan
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Pharmacology & Pharmacy
Chulhun Park, Nileshkumar Meghani, Hardik Amin, Phuong H-L Tran, Thao T-D Tran, Van H. Nguyen, Beom-Jin Lee
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Nanoscience & Nanotechnology
Hai Ngo, Phuong H. L. Tran, Beom-Jin Lee, Thao T. D. Tran
Article
Chemistry, Multidisciplinary
Phuong H. L. Tran, Dongxi Xiang, Thao T. D. Tran, Wang Yin, Yumei Zhang, Lingxue Kong, Kuisheng Chen, Miaomiao Sun, Yong Li, Yingchun Hou, Yimin Zhu, Wei Duan
ADVANCED MATERIALS
(2020)
Article
Pharmacology & Pharmacy
Ngan D. T. Le, Phuong H. L. Tran, Beom-Jin Lee, Thao T. D. Tran
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Article
Pharmacology & Pharmacy
Duong T. T. Pham, Phuong H. L. Tran, Thao T. D. Tran
SAUDI PHARMACEUTICAL JOURNAL
(2019)
Article
Pharmacology & Pharmacy
Phuong H. L. Tran, Wei Duan, Beom-Jin Lee, Thao T. D. Tran
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)