Topical Diclofenac Reprograms Metabolism and Immune Cell Infiltration in Actinic Keratosis

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

(2019) Shuo Qie et al.   Nature Communications

Immunometabolism in cancer at a glance

(2018) Katrin Singer et al.   Disease Models & Mechanisms

Nonmelanoma skin cancer - from actinic keratosis to cutaneous squamous cell carcinoma

(2018) Lutz Schmitz et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells

(2018) Kathrin Renner et al.   Frontiers in Pharmacology

Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance

(2017) Marc Hennequart et al.   Cancer Immunology Research

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

(2017) Kathrin Renner et al.   Frontiers in Immunology

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target

(2016) Icard Philippe et al.   DRUG RESISTANCE UPDATES

Tumor-Preferential Induction of Immune Responses and Epidermal Cell Death in Actinic Keratoses by Ingenol Mebutate

(2016) Steffen Emmert et al.   PLoS One

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the V600EBRAF oncogene

(2015) Arnaldur Hall et al.   Oncotarget

Prevalence of Actinic Keratosis and Its Risk Factors in the General Population: The Rotterdam Study

(2013) Sophie C. Flohil et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Prevalence and risk factors of actinic keratoses in Germany - analysis of multisource data

(2013) I. Schaefer et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells

(2013) Eva Gottfried et al.   PLoS One

Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy

(2012) R.M. Szeimies et al.   BRITISH JOURNAL OF DERMATOLOGY

EWS-FLI-1-Targeted Cytotoxic T-cell Killing of Multiple Tumor Types Belonging to the Ewing Sarcoma Family of Tumors

(2012) C. H. Evans et al.   CLINICAL CANCER RESEARCH

Activation of mitochondrial apoptosis pathways in cutaneous squamous cell carcinoma cells by diclofenac/hyaluronic acid is related to upregulation of Bad as well as downregulation of Mcl-1 and Bcl-w

(2012) Paul M. Rodust et al.   EXPERIMENTAL DERMATOLOGY

Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model

(2012) Sridhar R. Chirasani et al.   INTERNATIONAL JOURNAL OF CANCER

Down-Regulation of Glucose-Regulated Protein (GRP) 78 Potentiates Cytotoxic Effect of Celecoxib in Human Urothelial Carcinoma Cells

(2012) Kuo-How Huang et al.   PLoS One

Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation

(2012) A. T. van der Goot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diclofenac gel in the treatment of actinic keratoses

(2012) Chris Nelson   Therapeutics and Clinical Risk Management

Quantitative profiling of tryptophan metabolites in serum, urine, and cell culture supernatants by liquid chromatography–tandem mass spectrometry

(2011) Wentao Zhu et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Different expression of cyclooxygenase-2 (COX-2) in selected nonmelanocytic human cutaneous lesions

(2011) Łukasz Kuźbicki et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Modes of action of diclofenac 3%/hyaluronic acid 2.5% in the treatment of actinic keratosis

(2011) Adrienne Maltusch et al.   JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT

Open label randomized study comparing 3 months vs. 6 months treatment of actinic keratoses with 3% diclofenac in 2.5% hyaluronic acid gel: a trial of the German Dermatologic Cooperative Oncology Group

(2011) A. Pflugfelder et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Metabolite extraction from adherently growing mammalian cells for metabolomics studies: optimization of harvesting and extraction protocols

(2010) Katja Dettmer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Enhanced Death Ligand-Induced Apoptosis in Cutaneous SCC Cells by Treatment with Diclofenac/Hyaluronic Acid Correlates with Downregulation of c-FLIP

(2010) Lothar F. Fecker et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stromal CD10 expression, as well as increased dermal macrophages and decreased Langerhans cells, are associated with malignant transformation of keratinocytes

(2009) Masakazu Takahara et al.   JOURNAL OF CUTANEOUS PATHOLOGY