Potential Role of the Microbiome in Acne: A Comprehensive Review

Acne, the Skin Microbiome, and Antibiotic Treatment

(2019) Haoxiang Xu et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Association of Systemic Antibiotic Treatment of Acne With Skin Microbiota Characteristics

(2019) Anna L. Chien et al.   JAMA Dermatology

From pathogenesis of acne vulgaris to anti-acne agents

(2019) Tian-Xin Cong et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Investigation of the skin microbiome: swabs vs. biopsies

(2019) S. Prast‐Nielsen et al.   BRITISH JOURNAL OF DERMATOLOGY

Research Techniques Made Simple: Profiling the Skin Microbiota

(2019) Max D. Grogan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A systematic literature review of the human skin microbiome as biomarker for dermatological drug development

(2018) T. Niemeyer - van der Kolk et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Isolation and Identification of the Follicular Microbiome: Implications for Acne Research

(2018) Jacob B. Hall et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Phenotype and Antimicrobial Activity of Th17 Cells Induced by Propionibacterium acnes Strains Associated with Healthy and Acne Skin

(2018) George W. Agak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Susceptibility of Enterococcus faecalis and Propionibacterium acnes to antimicrobial photodynamic therapy

(2018) Sarah Raquel de Annunzio et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Practical management of acne for clinicians: An international consensus from the Global Alliance to Improve Outcomes in Acne

(2018) Diane M. Thiboutot et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The Gut Microbiome as a Major Regulator of the Gut-Skin Axis

(2018) Iman Salem et al.   Frontiers in Microbiology

Patients with Acne Vulgaris Have a Distinct Gut Microbiota in Comparison with Healthy Controls

(2018) Y Deng et al.   ACTA DERMATO-VENEREOLOGICA

Gut microbiota alterations in moderate to severe acne vulgaris patients

(2018) Hui-Min Yan et al.   JOURNAL OF DERMATOLOGY

Skin Ecology During Sebaceous Drought—How Skin Microbes Respond to Isotretinoin

(2018) William H. McCoy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Skin microbiome and acne vulgaris : Staphylococcus , a new actor in acne

(2017) Brigitte Dreno et al.   EXPERIMENTAL DERMATOLOGY

Isotretinoin and lymecycline treatments modify the skin microbiota in acne

(2017) Hanna-Leena Kelhälä et al.   EXPERIMENTAL DERMATOLOGY

Effects of oral antibiotics and isotretinoin on the murine gut microbiota

(2017) Eugenia Becker et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Edible Plants and Their Influence on the Gut Microbiome and Acne

(2017) Ashley Clark et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Corrigendum: Proposal to reclassify Propionibacterium acnes type I as Propionibacterium acnes subsp. acnes subsp. nov. and Propionibacterium acnes type II as Propionibacterium acnes subsp. defendens subsp. nov.

(2017) Andrew McDowell et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

The Short-Chain Fatty Acid Sodium Butyrate Functions as a Regulator of the Skin Immune System

(2017) Agatha Schwarz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Propionibacterium acnes is developing gradual increase in resistance to oral tetracyclines

(2017) Keisuke Nakase et al.   JOURNAL OF MEDICAL MICROBIOLOGY

The preadolescent acne microbiome: A prospective, randomized, pilot study investigating characterization and effects of acne therapy

(2017) Carrie C. Coughlin et al.   PEDIATRIC DERMATOLOGY

Non-antibiotic Isotretinoin Treatment Differentially Controls Propionibacterium acnes on Skin of Acne Patients

(2017) Angela E. Ryan-Kewley et al.   Frontiers in Microbiology

Increase of Skin-Ceramide Levels in Aged Subjects following a Short-Term Topical Application of Bacterial Sphingomyelinase from Streptococcus Thermophilus

(2017) L. Dimarzio et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

The gut-skin axis in health and disease: A paradigm with therapeutic implications

(2016) Catherine A. O'Neill et al.   BIOESSAYS

Antagonism between Staphylococcus epidermidis and Propionibacterium acnes and its genomic basis

(2016) Gitte J. M. Christensen et al.   BMC GENOMICS

Skin expression of mammalian target of rapamycin and forkhead box transcription factor O1, and serum insulin-like growth factor-1 in patients with acne vulgaris and their relationship with diet

(2016) N.F. Agamia et al.   BRITISH JOURNAL OF DERMATOLOGY

The possible mechanisms of the human microbiome in allergic diseases

(2016) Kagan Ipci et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

Novel Strategies for Applied Metagenomics

(2016) Jessica M. Moore-Connors et al.   INFLAMMATORY BOWEL DISEASES

Proposal to reclassify Propionibacterium acnes type I as Propionibacterium acnes subsp. acnes subsp. nov. and Propionibacterium acnes type II as Propionibacterium acnes subsp. defendens subsp. nov.

(2016)   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

The natural history of cutaneous propionibacteria, and reclassification of selected species within the genus Propionibacterium to the proposed novel genera Acidipropionibacterium gen. nov., Cutibacterium gen. nov. and Pseudopropionibacterium gen. nov.

(2016) Christian F. P. Scholz et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Staphylococcal LTA-Induced miR-143 Inhibits Propionibacterium acnes-Mediated Inflammatory Response in Skin

(2016) Xiaoli Xia et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Different Propionibacterium acnes Phylotypes Induce Distinct Immune Responses and Express Unique Surface and Secreted Proteomes

(2016) Yang Yu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Guidelines of care for the management of acne vulgaris

(2016) Andrea L. Zaenglein et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

European evidence-based (S3) guideline for the treatment of acne - update 2016 - short version

(2016) A. Nast et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

A consensus-based practical and daily guide for the treatment of acne patients

(2016) H.P. Gollnick et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Systematic review of antibiotic resistance in acne: an increasing topical and oral threat

(2016) Timothy R Walsh et al.   LANCET INFECTIOUS DISEASES

Impact of Dietary Lipids on Colonic Function and Microbiota: An Experimental Approach Involving Orlistat-Induced Fat Malabsorption in Human Volunteers

(2016) Pamela Morales et al.   Clinical and Translational Gastroenterology

A cross-sectional pilot study of antibiotic resistance in Propionibacterium acnes strains in Indian acne patients using 16s-RNA polymerase chain reaction: A comparison among treatment modalities including antibiotics, benzoyl peroxide, and isotretinoin

(2016) Kabir Sardana et al.   INDIAN JOURNAL OF DERMATOLOGY

Strain-Level Differences in Porphyrin Production and Regulation in Propionibacterium acnes Elucidate Disease Associations

(2016) Tremylla Johnson et al.   mSphere

Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice

(2016) Mi-Ja Jung et al.   Scientific Reports

Strains of the Propionibacterium acnes type III lineage are associated with the skin condition progressive macular hypomelanosis

(2016) Emma Barnard et al.   Scientific Reports

The balance of metagenomic elements shapes the skin microbiome in acne and health

(2016) Emma Barnard et al.   Scientific Reports

MLST typing of antimicrobial-resistant Propionibacterium acnes isolates from patients with moderate to severe acne vulgaris

(2015) Lambros Giannopoulos et al.   ANAEROBE

Immune–microbiota interactions in health and disease

(2015) Noah W. Palm et al.   CLINICAL IMMUNOLOGY

Mechanistic target of rapamycin (mTOR) expression is increased in acne patients' skin

(2015) Giuseppe Monfrecola et al.   EXPERIMENTAL DERMATOLOGY

Dissecting the taxonomic heterogeneity within Propionibacterium acnes: proposal for Propionibacterium acnes subsp. acnes subsp. nov. and Propionibacterium acnes subsp. elongatum subsp. nov.

(2015) Itaru Dekio et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

South-East Asia study alliance guidelines on the management of acne vulgaris in South-East Asian patients

(2015) Chee Leok Goh et al.   JOURNAL OF DERMATOLOGY

Microorganisms inhabiting follicular contents of facial acne are not onlyPropionibacteriumbut alsoMalasseziaspp.

(2015) Narifumi Akaza et al.   JOURNAL OF DERMATOLOGY

Propionibacterium acnes Promotes Th17 and Th17/Th1 Responses in Acne Patients

(2015) Magdalena Kistowska et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vitamin B 12 modulates the transcriptome of the skin microbiota in acne pathogenesis

(2015) Dezhi Kang et al.   Science Translational Medicine

Regulation of lung immunity and host defense by the intestinal microbiota

(2015) Derrick R. Samuelson et al.   Frontiers in Microbiology

Prospective, Randomized, Open-Label Trial Comparing the Safety, Efficacy, and Tolerability of an Acne Treatment Regimen with and without a Probiotic Supplement and Minocycline in Subjects with Mild to Moderate Acne

(2015) Gordon W. Jung et al.   JOURNAL OF CUTANEOUS MEDICINE AND SURGERY

Clonality and Anatomic Distribution on the Skin of Antibiotic Resistant and Sensitive Propionibacterium acnes

(2014) H Lomholt et al.   ACTA DERMATO-VENEREOLOGICA

Microbiome, holobiont and the net of life

(2014) Emiliano Salvucci   CRITICAL REVIEWS IN MICROBIOLOGY

Relationship between the severity of acne vulgaris and antimicrobial resistance of bacteria isolated from acne lesions in a hospital in Japan

(2014) Keisuke Nakase et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Altered Mucus Glycosylation in Core 1 O-Glycan-Deficient Mice Affects Microbiota Composition and Intestinal Architecture

(2014) Felix Sommer et al.   PLoS One

Dialogue between skin microbiota and immunity

(2014) Y. Belkaid et al.   SCIENCE

Propionic acid and its esterified derivative suppress the growth of methicillin-resistant Staphylococcus aureus USA300

(2014) Y. Wang et al.   Beneficial Microbes

Comparative genomics reveals distinct host-interacting traits of three major human-associated propionibacteria

(2013) Tim N Mak et al.   BMC GENOMICS

Analysis of the Human Gut Microbiome and Association With Disease

(2013) Gary D. Wu et al.   Clinical Gastroenterology and Hepatology

Analysis of Facial Skin-Resident Microbiota in Japanese Acne Patients

(2013) Shigeki Numata et al.   DERMATOLOGY

Propionibacterium acnes Strain Populations in the Human Skin Microbiome Associated with Acne

(2013) Sorel Fitz-Gibbon et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Propionibacterium acnes Induces IL-1β Secretion via the NLRP3 Inflammasome in Human Monocytes

(2013) Min Qin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D

(2013) George W. Agak et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats

(2013) Feng-Ching Hsieh et al.   Nutrition & Metabolism

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

(2013) L. F. Eichenfield et al.   PEDIATRICS

Probiotic Bacteria Induce a ‘Glow of Health’

(2013) Tatiana Levkovich et al.   PLoS One

The Opportunistic Pathogen Propionibacterium acnes: Insights into Typing, Human Disease, Clonal Diversification and CAMP Factor Evolution

(2013) Andrew McDowell et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Pan-Genome and Comparative Genome Analyses of Propionibacterium acnes Reveal Its Genomic Diversity in the Healthy and Diseased Human Skin Microbiome

(2013) S. Tomida et al.   mBio

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Bacterial skin commensals and their role as host guardians

(2013) G.J.M. Christensen et al.   Beneficial Microbes

Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine

(2013) W. Bowe et al.   Beneficial Microbes

Analysis of Complete Genomes ofPropionibacterium acnesReveals a Novel Plasmid and Increased Pseudogenes in an Acne Associated Strain

(2013) Gabriela Kasimatis et al.   Biomed Research International

Susceptibility profiles of Propionibacterium acnes isolated from patients with acne vulgaris

(2013) Ioanna Grech   Journal of Global Antimicrobial Resistance

Loss of enteral nutrition in a mouse model results in intestinal epithelial barrier dysfunction

(2012) Yongjia Feng et al.   Annals of the New York Academy of Sciences

In Vitro evaluation of antibacterial activities and anti-inflammatory effects of Bifidobacterium spp. addressing acne vulgaris

(2012) Do-Kyung Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case-control study

(2012) A.C. Jahns et al.   BRITISH JOURNAL OF DERMATOLOGY

Bacterial identification and analytic challenges in clinical microbiome studies

(2012) J. Kirk Harris et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Malassezia globosa tends to grow actively in summer conditions more than other cutaneous Malassezia species

(2012) Narifumi AKAZA et al.   JOURNAL OF DERMATOLOGY

Systemic Isotretinoin Therapy Normalizes Exaggerated TLR-2-Mediated Innate Immune Responses in Acne Patients

(2012) Melanie C. Dispenza et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Increased hydrophobicity inMalasseziaspecies correlates with increased proinflammatory cytokine expression in human keratinocytes

(2012) Narifumi Akaza et al.   MEDICAL MYCOLOGY

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

An Expanded Multilocus Sequence Typing Scheme for Propionibacterium acnes: Investigation of ‘Pathogenic’, ‘Commensal’ and Antibiotic Resistant Strains

(2012) Andrew McDowell et al.   PLoS One

Compartmentalized Control of Skin Immunity by Resident Commensals

(2012) S. Naik et al.   SCIENCE

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Probiotic metabolites fromBacillus coagulansGanedenBC30TMsupport maturation of antigen-presenting cellsin vitro

(2012) Kathleen F Benson   WORLD JOURNAL OF GASTROENTEROLOGY

Epidemiologic Study ofMalasseziaYeasts in Acne Patients by Analysis of 26S rDNA PCR-RFLP

(2011) Young Chan Song et al.   Annals of Dermatology

Molecular analysis of the prevalent microbiota of human male and female forehead skin compared to forearm skin and the influence of make-up

(2011) T. Staudinger et al.   JOURNAL OF APPLIED MICROBIOLOGY

Diversity of the Human Skin Microbiome Early in Life

(2011) Kimberly A. Capone et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Antibiotic-resistantPropionibacterium acnesamong acne patients in a regional skin centre in Hong Kong

(2011) N.-M.T. Luk et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

The skin microbiome

(2011) Elizabeth A. Grice et al.   NATURE REVIEWS MICROBIOLOGY

Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

(2011) Whitney P Bowe et al.   Gut Pathogens

Detection of a new erm(X)-mediated antibiotic resistance in Egyptian cutaneous propionibacteria

(2010) T.S. El-Mahdy et al.   ANAEROBE

Small intestinal bacterial overgrowth in irritable bowel syndrome: are there any predictors?

(2010) Savio C Reddymasu et al.   BMC GASTROENTEROLOGY

GanedenBC30™ cell wall and metabolites: anti-inflammatory and immune modulating effects in vitro

(2010) Gitte S Jensen et al.   BMC IMMUNOLOGY

Proteomic identification of secreted proteins of Propionibacterium acnes

(2010) Carsten Holland et al.   BMC MICROBIOLOGY

Increased Incidence of Small Intestinal Bacterial Overgrowth During Proton Pump Inhibitor Therapy

(2010) Lucio Lombardo et al.   Clinical Gastroenterology and Hepatology

Report: In vitro antimicrobial susceptibility of Propionibacterium acnes isolated from acne patients in northern Mexico

(2010) Roger González et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Propionibacterium acnes Activates the IGF-1/IGF-1R System in the Epidermis and Induces Keratinocyte Proliferation

(2010) Olivia Isard et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles

(2010) Whitney P Bowe et al.   Lipids in Health and Disease

Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization

(2010) Tadayuki Iwase et al.   NATURE

Population Genetic Analysis of Propionibacterium acnes Identifies a Subpopulation and Epidemic Clones Associated with Acne

(2010) Hans B. Lomholt et al.   PLoS One

Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders

(2010) H.-K. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bifidobacterium longum lysate, a new ingredient for reactive skin

(2009) Audrey Guéniche et al.   EXPERIMENTAL DERMATOLOGY

Microbial community profiling for human microbiome projects: Tools, techniques, and challenges

(2009) M. Hamady et al.   GENOME RESEARCH

Gender-linked differences in human skin

(2009) Paolo U. Giacomoni et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Involvement of Propionibacterium acnes in the Augmentation of Lipogenesis in Hamster Sebaceous Glands In Vivo and In Vitro

(2009) Katsuhiro Iinuma et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Antimicrobial activity of enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect

(2009) Bong Seon Kang et al.   JOURNAL OF MICROBIOLOGY

Propionibacterium acnes colonization of the human shoulder

(2009) Amar Patel et al.   JOURNAL OF SHOULDER AND ELBOW SURGERY

New insights into the management of acne: An update from the Global Alliance to Improve Outcomes in Acne Group

(2009) Diane Thiboutot et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Milk Consumption and Acne—Is There a Link?

(2009) Wendy Marcason   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Oral Probiotic Control Skin Inflammation by Acting on Both Effector and Regulatory T Cells

(2009) Feriel Hacini-Rachinel et al.   PLoS One

Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla

(2009) M. A. Mahowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topographical and Temporal Diversity of the Human Skin Microbiome

(2009) E. A. Grice et al.   SCIENCE

Production of Superoxide Anions by Keratinocytes Initiates P. acnes-Induced Inflammation of the Skin

(2009) Philippe A. Grange et al.   PLoS Pathogens

Influence of substance-P on cultured sebocytes

(2008) Weon Ju Lee et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Skin microbiota: a source of disease or defence?

(2008) A.L. Cogen et al.   BRITISH JOURNAL OF DERMATOLOGY

Function of oleic acid on epidermal barrier and calcium influx into keratinocytes is associated withN-methyl d-aspartate-type glutamate receptors

(2008) Y. Katsuta et al.   BRITISH JOURNAL OF DERMATOLOGY

A diversity profile of the human skin microbiota

(2008) E. A. Grice et al.   GENOME RESEARCH

The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes Host-Microbe Homeostasis

(2008) C. Cosseau et al.   INFECTION AND IMMUNITY

A new phylogenetic group of Propionibacterium acnes

(2008) A. McDowell et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Milk consumption and acne in teenaged boys

(2008) Clement A. Adebamowo et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The influence of sex, handedness, and washing on the diversity of hand surface bacteria

(2008) N. Fierer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila

(2008) J.-H. Ryu et al.   SCIENCE