Article
Agriculture, Dairy & Animal Science
Luciana Mandrioli, Victorio Codotto, Giulia D'Annunzio, Enrico Volpe, Francesca Errani, Yoshinobu Eishi, Keisuke Uchida, Maria Morini, Giuseppe Sarli, Sara Ciulli
Summary: Pathological and microbiological investigations were conducted on ornamental cichlids, revealing the potential presence of Cutibacterium acnes and Mycobacterium spp. in the fish, posing potential health risks to humans.
Article
Multidisciplinary Sciences
B. Indu, Tallapragada Keertana, Sahu Ipsita, Uppada Jagadeeshwari, Chintalapati Sasikala, Chintalapati Venkata Ramana
Summary: The study focused on addressing yeast endobacteria, revealing a widespread and rich bacterial diversity among yeasts with most species yet to be cultivated. Findings demonstrate yeast as a thriving hub for bacterial communities, with successful reintroduction of selected bacteria into Candida tropicalis.
SCIENTIFIC REPORTS
(2021)
Review
Microbiology
Yoshinobu Eishi
Summary: The presence of Cutibacterium acnes in sarcoid granulomas indicates its potential involvement in granuloma formation. C. acnes is the only microorganism isolated from sarcoid lesions. Histopathologic analysis shows latent infection and intracellular proliferation of cell-wall-deficient C. acnes in some sarcoid lymph nodes, resulting in immune complex formation. Patients with sarcoidosis generally exhibit higher activation of T helper type 1 (Th1) immune responses to C. acnes compared to healthy individuals. Pulmonary granulomatosis caused by allergic immune response to C. acnes can be prevented by antimicrobial treatment, suggesting a role of C. acnes commensal in the lungs. C. acnes is the most commonly detected bacterium intracellularly in human peripheral lungs and mediastinal lymph nodes. Some sarcoidosis patients have increased levels of C. acnes-derived circulating immune complexes, indicating proliferation of C. acnes in affected organs. In individuals with hypersensitive Th1 immune responses to C. acnes, granulomas may form to contain the intracellular proliferation triggered by certain host-related or drug-induced conditions. Current clinical trials in cardiac sarcoidosis patients are evaluating combined treatment with steroids and antimicrobials during active disease, followed by continued antimicrobial therapy while tapering off steroids after disease remission.
Article
Microbiology
Miho Watanabe, Hisaya Kojima, Kunihiro Okano, Manabu Fukui
Summary: A novel strictly anaerobic chemoorganotrophic bacterium, Mahy22(T), isolated from a shallow brackish meromictic lake in Japan, showed unique morphology and growth conditions. Phylogenetic analysis based on the 16S rRNA gene placed the strain in a new genus, Mariniplasma anaerobium gen. nov., distinct from other Acholeplasma species.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yi-Hsien Shih, Donald Liu, Yen-Chou Chen, Ming-Hsuan Liao, Woan-Ruoh Lee, Shing-Chuan Shen
Summary: Nicotinamide (NAM) enhances the efficacy of tetracycline against Cutibacterium (C.) acnes and inhibits biofilm formation. The combination of NAM with deoxyribonuclease (DNase) I further strengthens its antibiofilm effect against C. acnes.
Article
Microbiology
Munusamy Madhaiyan, Shankar Sriram, Nedounsejian Kiruba, Venkatakrishnan Sivaraj Saravanan
Summary: Based on the analysis of phylogeny, overall genome-related indices, and phenotypic evidence, P. insulsa was proposed as a later heterotypic synonym of P. fungorum, and a subspecies relationship was suggested between P. terrae and P. steynii.
CURRENT MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Qiaoyun Jiang, Peixia Li, Jingru Qiu, Donghai Li, Guiling Li, Gang Shan
Summary: The development of safe and effective photosensitizers is crucial for improving photodynamic cancer therapy. In this study, a new redshift phenalenone derivative, SDU Red, was developed as a lysosome-targeting photosensitizer for triple-negative breast cancer therapy. SDU Red exhibited good photostability and a remarkable phototherapeutic index against triple-negative breast cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Riping Phang, Chun-Hung Lin
Summary: This review discusses the important task of large-scale glycan synthesis, especially the synthesis of Type-I and Type-II LacNAc. The article summarizes some efficient synthesis methods and solutions to long-standing problems, while pointing out the current restrictions and challenges in this field.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Oliver Brookes, Sonja Boland, Rene Lai Kuen, Dorian Miremont, Jamileh Movassat, Armelle Baeza-Squiban
Summary: Research on the development of an air-liquid interface model of alveolar epithelium incorporating features of type I and type II epithelial cells showed promising results in terms of cell morphology and barrier function. The coculture model demonstrated stable barrier properties similar to native alveolar epithelium, indicating its potential for representing a broader range of functions.
Article
Microbiology
Peixin Gao, Huibin Lu, Dorji Phurbu, Qinglong Wu, Peng Xing
Summary: Two novel species of the genus Cognataquiflexum were discovered from freshwater lakes on the Tibetan Plateau. Phylogenetic analysis and chemotaxonomic characteristics revealed their distinctiveness from other known species.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Microbiology
Waranya Butdee, Supattra Muangham, Duenrut Chonudomkul, Kannika Duangmal
Summary: A novel actinomycete strain RS10V-4T was classified as Streptomyces based on morphological, physiological, and chemotaxonomic properties. The strain showed high sequence similarity to Streptomyces noursei and was proposed as a new species, Streptomyces rhizoryzae sp. nov. Furthermore, the comparison of genome sequences and phenotypic features suggested that S. noursei and S. albulus should be classified as the same species.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2023)
Article
Microbiology
Jun-Ying Liu, Jian-Feng Zhang, Han-Lian Wu, Zhen Chen, Shu-Ying Li, Hong-Mei Li, Cui-Ping Zhang, Yuan-Qing Zhou, Can-Hua Lu
Summary: A strain of Gram-negative, aerobic, rod-shaped, motile bacterium, named RST, was isolated from tobacco bacterial wilt in Yuxi city of Yunnan province, China. This bacterium belongs to the genus Ralstonia and has a distinct fatty acid composition and polar lipid profile. Genome sequencing and comparative analysis revealed that it represents a novel species within the genus Ralstonia, named Ralstonia nicotianae sp. nov. The importance of this discovery is rated as 8 out of 10.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Thomas Hanke, Sebastian Mathea, Julia Woortman, Eidarus Salah, Benedict-Tilman Berger, Anthony Tumber, Risa Kashima, Akiko Hata, Bernhard Kuster, Susanne Mueller, Stefan Knapp
Summary: In this study, three highly selective LIMK1/2 inhibitors were characterized, providing potential candidate drugs for the treatment of diseases associated with LIMK dysregulation.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Engineering, Biomedical
Yuewen Yu, Shuang Wu, Le Zhang, Shidang Xu, Chunhui Dai, Shengming Gan, Ganfeng Xie, Guangxue Feng, Ben Zhong Tang
Summary: In this study, a cationization molecular engineering strategy was used to enhance the generation of reactive oxygen species (ROS) for efficient photodynamic therapy (PDT). The cationization process improved the aggregation-induced emission (AIE) feature, promoted intersystem crossing (ISC) processes, and increased charge transfer and separation ability, leading to the efficient production of ROS, particularly hydroxyl and superoxide radicals. Additionally, the cationic AIE photosensitizers also exhibited specific cancer cell mitochondrial targeting capability, which further improved the efficacy of PDT.
Article
Biotechnology & Applied Microbiology
Kazuhiro Umezawa, Hisaya Kojima, Yukako Kato, Manabu Fukui
Summary: In this study, a new species isolated from a hot spring microbial mat was identified as Dissulfurispira thermophila gen. nov., sp. nov. A reclassification of the Thermodesulfovibrio genus and proposed creation of new taxa at family and higher levels were also suggested based on phylogenetic analysis.
SYSTEMATIC AND APPLIED MICROBIOLOGY
(2021)
Article
Cell Biology
M. McKenna, M. McMenamin, A. McDowell
Article
Respiratory System
James A. Reihill, Michelle Moreland, Gavin E. Jarvis, Andrew McDowell, Gisli G. Einarsson, J. Stuart Elborn, S. Lorraine Martin
JOURNAL OF CYSTIC FIBROSIS
(2017)
Article
Orthopedics
S. Patrick, A. McDowell, A. Lee, A. Frau, U. Martin, E. Gardner, G. McLorinan, N. Eames
BONE & JOINT JOURNAL
(2017)
Review
Microbiology
Joseph McLaughlin, Steven Watterson, Alison M. Layton, Anthony J. Bjourson, Emma Barnard, Andrew McDowell
Review
Dermatology
A. McDowell, J. McLaughlin, A. M. Layton
Summary: Progressive macular hypomelanosis (PMH) is a skin condition characterized by symmetrically distributed hypopigmented macules on the trunk, possibly linked to the anaerobic skin bacterium Cutibacterium (formerly Propionibacterium) acnes. Recent studies suggest that subspecies elongatum of C. acnes may play a role in the pathophysiology of PMH.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Manu N. Capoor, Anna Konieczna, Andrew McDowell, Filip Ruzicka, Martin Smrcka, Radim Jancalek, Karel Maca, Michael Lujc, Fahad S. Ahmed, Christof Birkenmaier, Stefan Dudli, Ondrej Slaby
Summary: This study found that C. acnes can stimulate the expression of various inflammatory mediators and host molecules associated with pathological changes in disc tissue. Pre-treatment of cells with clindamycin significantly reduced the production of these pro-inflammatory mediators. The role of C. acnes in degenerative disc disease remains biologically credible and may involve individualized responses to infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Tetsuo Yamaguchi, Ulrich Costabel, Andrew McDowell, Josune Guzman, Keisuke Uchida, Kenichi Ohashi, Yoshinobu Eishi
Summary: Sarcoidosis may have multiple causative agents, including infectious and non-infectious factors. Research suggests that Mycobacterium tuberculosis and Propionibacterium acnes are the most common microorganisms involved in the development of sarcoidosis. Differential diagnosis and treatment of sarcoidosis may involve immunohistochemistry with specific antibodies to distinguish cases caused by different etiologies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Joseph McLaughlin, Istvan Nagy, Georgios Miliotis, Andrew McDowell
Summary: This study compared the discriminatory power of Single Locus Sequence Typing (SLST) and Multilocus Sequence Typing (MLST) methods for distinguishing subspecies of Cutibacterium acnes. The results showed that SLST had reduced discrimination on subspecies II and III, while MLST had the best results on subspecies I. By combining SLST with the camp2 gene sequence, a novel high-resolution Bilocus Sequence Typing (BLST) scheme was developed to improve differentiation of C. acnes isolates.
Letter
Dermatology
Andrew Mcdowell, Holger Bruggemann, Alison M. Layton
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Veterinary Sciences
Erin C. Coscia, Nader S. Abutaleb, Bradley Hostetter, Mohamed N. Seleem, Gert J. Breur, Robyn R. McCain, Christa J. Crain, Ondrej Slaby, Manu N. Capoor, Andrew McDowell, Fahad S. Ahmed, Viju Vijayanpillai, Sanjeev K. Narayanan, Michael F. Coscia
Summary: This study demonstrated the feasibility of safely injecting Cutibacterium acnes into sheep intervertebral discs for in vivo research. While bacterial growth was successful in the first set of discs, no growth was detected in the discs from the second set after six months, indicating potential bacterial clearance. Further studies are needed to investigate the pathogenic potential of C. acnes within infected discs.
VETERINARY SCIENCES
(2021)
Review
Microbiology
Andrew McDowell
Review
Pharmacology & Pharmacy
David S. Gibson, Stephen Drain, Catriona Kelly, Victoria McGilligan, Paula McClean, Sarah D. Atkinson, Elaine Murray, Andrew McDowell, Caroline Conway, Steven Watterson, Anthony J. Bjourson
EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT
(2017)
Article
Dermatology
Helene Omer, Andrew McDowell, Oleg A. Alexeyev
CLINICS IN DERMATOLOGY
(2017)
Article
Immunology
Yvonne Achermann, Jared Liu, Reinhard Zbinden, Patrick O. Zingg, Alexia Anagnostopoulos, Emma Barnard, Reto Sutter, Huiying Li, Andrew McDowell, Annelies S. Zinkernagel
CLINICAL INFECTIOUS DISEASES
(2018)