Self-assembled 3D spheroids and hollow-fibre bioreactors improve MSC-derived hepatocyte-like cell maturation in vitro

Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study

(2016) Pedro F. Pinheiro et al.   ARCHIVES OF TOXICOLOGY

Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules

(2015) Farah Tasnim et al.   BIOMATERIALS

The Human Umbilical Cord Tissue-Derived MSC Population UCX® Promotes Early Motogenic Effects on Keratinocytes and Fibroblasts and G-CSF-Mediated Mobilization of BM-MSCs when Transplanted In Vivo

(2015) Joana P. Miranda et al.   CELL TRANSPLANTATION

Three-dimensional spheroid cell culture of umbilical cord tissue-derived mesenchymal stromal cells leads to enhanced paracrine induction of wound healing

(2015) Jorge M Santos et al.   Stem Cell Research & Therapy

Pluripotent stem cell-derived hepatocyte-like cells

(2014) R.E. Schwartz et al.   BIOTECHNOLOGY ADVANCES

Maturation of Induced Pluripotent Stem Cell Derived Hepatocytes by 3D-Culture

(2014) Richard L. Gieseck III et al.   PLoS One

Aggregate Culture of Human Embryonic Stem Cell-Derived Hepatocytes in Suspension Are an Improved In Vitro Model for Drug Metabolism and Toxicity Testing

(2014) Srikumar Sengupta et al.   TOXICOLOGICAL SCIENCES

UCX® cells: A primordial stem cell source for in vitro differentiation into hepatocyte-like cells (HLCs)

(2014) Madalena Cipriano et al.   TOXICOLOGY LETTERS

Re-evaluation of liver stem/progenitor cells

(2014) Naoki Tanimizu et al.   Organogenesis

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Decrease of Global Methylation Improves Significantly Hepatic Differentiation of Ad-MSCs: Possible Future Application for Urea Detoxification

(2013) C. Seeliger et al.   CELL TRANSPLANTATION

Spheroid Culture for Enhanced Differentiation of Human Embryonic Stem Cells to Hepatocyte-Like Cells

(2013) Kartik Subramanian et al.   STEM CELLS AND DEVELOPMENT

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

(2012) Kazuo Takayama et al.   BIOMATERIALS

Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies

(2012) Stefan A. Hoffmann et al.   BIOTECHNOLOGY AND BIOENGINEERING

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

Differentiated umbilical cord matrix stem cells as a newin vitromodel to study early events during hepatitis B virus infection

(2012) Massimiliano Paganelli et al.   HEPATOLOGY

Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacologicalin vitrostudies

(2012) Marc Lübberstedt et al.   Journal of Tissue Engineering and Regenerative Medicine

Hepatic Differentiation and Maturation of Human Embryonic Stem Cells Cultured in a Perfused Three-Dimensional Bioreactor

(2012) Louise Sivertsson et al.   STEM CELLS AND DEVELOPMENT

Application of Three-Dimensional Culture Conditions to Human Embryonic Stem Cell-Derived Definitive Endoderm Cells Enhances Hepatocyte Differentiation and Functionality

(2012) Thamil Selvee Ramasamy et al.   TISSUE ENGINEERING PART A

Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism

(2011) Jie Lin et al.   ARCHIVES OF TOXICOLOGY

Direct and Indirect Contribution of Human Embryonic Stem Cell–Derived Hepatocyte-Like Cells to Liver Repair in Mice

(2011) Dong–Hun Woo et al.   GASTROENTEROLOGY

In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor

(2011) Daniel Mueller et al.   Journal of Tissue Engineering and Regenerative Medicine

Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological In Vitro Studies

(2011) Katrin Zeilinger et al.   TISSUE ENGINEERING PART C-METHODS

Merging bioreactor technology with 3D hepatocyte-fibroblast culturing approaches: Improved in vitro models for toxicological applications

(2011) Sofia B. Leite et al.   TOXICOLOGY IN VITRO

Perfusion of 3D encapsulated hepatocytes-A synergistic effect enhancing long-term functionality in bioreactors

(2010) Rui M. Tostões et al.   BIOTECHNOLOGY AND BIOENGINEERING

5-azacytidine treatment reorganizes genomic histone modification patterns

(2010) Vitalina M. Komashko et al.   Epigenetics

In vitro hepatic differentiation of umbilical cord-derived mesenchymal stem cell

(2010) Hee-Hoon Yoon et al.   PROCESS BIOCHEMISTRY

Extending Hepatocyte Functionality for Drug-Testing Applications Using High-Viscosity Alginate–Encapsulated Three-Dimensional Cultures in Bioreactors

(2010) Joana P. Miranda et al.   TISSUE ENGINEERING PART C-METHODS

Differentiation of mesenchymal stromal cells derived from umbilical cord Wharton's jelly into hepatocyte-like cells

(2009) Ying-Nan Zhang et al.   CYTOTHERAPY

Properties of Hepatocyte-like Cell Clusters from Human Adipose Tissue-Derived Mesenchymal Stem Cells

(2009) Hanayuki Okura et al.   TISSUE ENGINEERING PART C-METHODS

Stem cell-derived hepatocytes and their use in toxicology

(2009) Christiane Guguen-Guillouzo et al.   TOXICOLOGY

Biochemical and molecular characterization of hepatocyte-like cells derived from human bone marrow mesenchymal stem cells on a novel three-dimensional biocompatible nanofibrous scaffold

(2008) Somaieh Kazemnejad et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Towards an Extended Functional Hepatocyte In Vitro Culture

(2008) Joana P. Miranda et al.   TISSUE ENGINEERING PART C-METHODS

Native Umbilical Cord Matrix Stem Cells Express Hepatic Markers and Differentiate Into Hepatocyte-like Cells

(2007) David Campard et al.   GASTROENTEROLOGY