Multiple Endocrine Neoplasia Type 1 (MEN1): An Update and the Significance of Early Genetic and Clinical Diagnosis

Could the Less-Than Subtotal Parathyroidectomy Be an Option for Treating Young Patients With Multiple Endocrine Neoplasia Type 1-Related Hyperparathyroidism?

(2019) Fabio Luiz de Menezes Montenegro et al.   Frontiers in Endocrinology

Management of MEN1 Related Nonfunctioning Pancreatic NETs

(2018) Sjoerd Nell et al.   ANNALS OF SURGERY

Early and Late Complications After Surgery for MEN1-related Nonfunctioning Pancreatic Neuroendocrine Tumors

(2018) Sjoerd Nell et al.   ANNALS OF SURGERY

Parathyroid carcinoma in multiple endocrine neoplasm type 1 syndrome: case report and systematic literature review

(2018) Giovanna Di Meo et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Current and emerging therapies for PNETs in patients with or without MEN1

(2018) Morten Frost et al.   Nature Reviews Endocrinology

Genotype-phenotype pancreatic neuroendocrine tumor relationship in multiple endocrine neoplasia type 1 patients: A 23-year experience at a single institution

(2018) Ioannis Christakis et al.   SURGERY

Questions and Controversies About Parathyroid Pathophysiology in Children With Multiple Endocrine Neoplasia Type 1

(2018) Stephen J. Marx et al.   Frontiers in Endocrinology

Gastrinomas

(2018) Jeffrey A. Norton et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Total and Subtotal Parathyroidectomy in Young Patients With Multiple Endocrine Neoplasia Type 1-Related Primary Hyperparathyroidism: Potential Post-surgical Benefits and Complications

(2018) Francesco Tonelli et al.   Frontiers in Endocrinology

The Importance of an Early and Accurate MEN1 Diagnosis

(2018) Joanne M. de Laat et al.   Frontiers in Endocrinology

When Parathyroidectomy Should Be Indicated or Postponed in Adolescents With MEN1-Related Primary Hyperparathyroidism

(2018) Francesca Marini et al.   Frontiers in Endocrinology

Intraoperative Decision-Making and Technical Aspects of Parathyroidectomy in Young Patients With MEN1 Related Hyperparathyroidism

(2018) Priscilla F. Nobecourt et al.   Frontiers in Endocrinology

Management impact: effects on quality of life and prognosis in MEN1

(2017) Francesca Marini et al.   ENDOCRINE-RELATED CANCER

The future: surgical advances in MEN1 therapeutic approaches and management strategies

(2017) S M Sadowski et al.   ENDOCRINE-RELATED CANCER

The future: diagnostic and imaging advances in MEN1 therapeutic approaches and management strategies

(2017) Jerena Manoharan et al.   ENDOCRINE-RELATED CANCER

The future: genetics advances in MEN1 therapeutic approaches and management strategies

(2017) Sunita K Agarwal   ENDOCRINE-RELATED CANCER

MEN1-Dependent Breast Cancer: Indication for Early Screening? Results From the Dutch MEN1 Study Group

(2017) Rachel S. van Leeuwaarde et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Utility of FDG-PET Imaging for Risk Stratification of Pancreatic Neuroendocrine Tumors in MEN1

(2017) Elena R. Kornaczewski Jackson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Whole-genome landscape of pancreatic neuroendocrine tumours

(2017) Aldo Scarpa et al.   NATURE

Prognostic value of WHO grade in pancreatic neuro-endocrine tumors in Multiple Endocrine Neoplasia type 1: Results from the DutchMEN1 Study Group

(2017) Elfi B. Conemans et al.   PANCREATOLOGY

Operative intervention for primary hyperparathyroidism offers greater bone recovery in patients with sporadic disease than in those with multiple endocrine neoplasia type 1–related hyperparathyroidism

(2017) Angelica M. Silva et al.   SURGERY

Histologically Proven Bronchial Neuroendocrine Tumors in MEN1: A GTE 51-Case Cohort Study

(2017) P. Lecomte et al.   WORLD JOURNAL OF SURGERY

MEN1 redefined, a clinical comparison of mutation-positive and mutation-negative patients

(2016) Joanne M. de Laat et al.   BMC Medicine

Utility of chromogranin A, pancreatic polypeptide, glucagon and gastrin in the diagnosis and follow-up of pancreatic neuroendocrine tumours in multiple endocrine neoplasia type 1 patients

(2016) Wei Qiu et al.   CLINICAL ENDOCRINOLOGY

Localization of Insulinoma Using 68Ga-DOTATATE PET/CT Scan

(2016) Pavel Nockel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Impact of Delay in Diagnosis in Outcomes in MEN1: Results From the Dutch MEN1 Study Group

(2016) Rachel S. van Leeuwaarde et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Prospective Study of 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography for Detecting Gastro-Entero-Pancreatic Neuroendocrine Tumors and Unknown Primary Sites

(2016) Samira M. Sadowski et al.   JOURNAL OF CLINICAL ONCOLOGY

ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors

(2016) M. Falconi et al.   NEUROENDOCRINOLOGY

Unilateral Clearance for Primary Hyperparathyroidism in Selected Patients with Multiple Endocrine Neoplasia Type 1

(2016) Wouter P. Kluijfhout et al.   WORLD JOURNAL OF SURGERY

Multiple endocrine neoplasia type 1 (MEN1): An update of 208 new germline variants reported in the last nine years

(2016) Paola Concolino et al.   Cancer Genetics

Clinical Features, Treatments, and Outcomes of Patients with Thymic Carcinoids and Multiple Endocrine Neoplasia Type 1 Syndrome at MD Anderson Cancer Center

(2016) Ioannis Christakis et al.   Hormones & Cancer

Better Survival But Changing Causes of Death in Patients With Multiple Endocrine Neoplasia Type 1

(2015) Jeffrey A. Norton et al.   ANNALS OF SURGERY

Unraveling the intrafamilial correlations and heritability of tumor types in MEN1: a Groupe d'étude des Tumeurs Endocrines study

(2015) J Thevenon et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Prognostic role of theCDNK1BV109G polymorphism in multiple endocrine neoplasia type 1

(2015) Luisa Circelli et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Long-Term Natural Course of Pituitary Tumors in Patients With MEN1: Results From the DutchMEN1 Study Group (DMSG)

(2015) Joanne M. de Laat et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

MEN1 Disease Occurring Before 21 Years Old: A 160-Patient Cohort Study From the Groupe d'étude des Tumeurs Endocrines

(2015) P. Goudet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Localization of Hidden Insulinomas with 68Ga-DOTA-Exendin-4 PET/CT: A Pilot Study

(2015) K. Antwi et al.   JOURNAL OF NUCLEAR MEDICINE

Results of 68Gallium-DOTATATE PET/CT Scanning in Patients with Multiple Endocrine Neoplasia Type 1

(2015) Samira M. Sadowski et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Bronchopulmonary Neuroendocrine Neoplasms and Their Precursor Lesions in Multiple Endocrine Neoplasia Type 1

(2015) Detlef K. Bartsch et al.   NEUROENDOCRINOLOGY

Multiple Endocrine Neoplasia

(2015) Jeffrey A. Norton et al.   Surgical Oncology Clinics of North America

Thymic and Bronchial Carcinoid Tumors in Multiple Endocrine Neoplasia Type 1: The Mayo Clinic Experience from 1977 to 2013

(2015) Naykky Singh Ospina et al.   Hormones & Cancer

Challenges and controversies in management of pancreatic neuroendocrine tumours in patients with MEN1

(2015) Christopher J Yates et al.   Lancet Diabetes & Endocrinology

Thoracic and duodenopancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1: natural history and function of menin in tumorigenesis

(2014) C R C Pieterman et al.   ENDOCRINE-RELATED CANCER

Association between the p27 rs2066827 variant and tumor multiplicity in patients harboring MEN1 germline mutations

(2014) Viviane C Longuini et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Higher Risk of Aggressive Pancreatic Neuroendocrine Tumors in MEN1 Patients With MEN1 Mutations Affecting the CHES1 Interacting MENIN Domain

(2014) Detlef K. Bartsch et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Natural Course and Survival of Neuroendocrine Tumors of Thymus and Lung in MEN1 Patients

(2014) Joanne M. de Laat et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Recommandations pour la prise en charge de l’insulinome malin

(2014) Éric Baudin et al.   PRESSE MEDICALE

Higher risk of death among MEN1 patients with mutations in the JunD interacting domain: a Groupe d’étude des Tumeurs Endocrines (GTE) cohort study

(2013) Julien Thevenon et al.   HUMAN MOLECULAR GENETICS

Low Accuracy of Tumor Markers for Diagnosing Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1 Patients

(2013) Joanne M. de Laat et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Penetrance of Functioning and Nonfunctioning Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1 in the Second Decade of Life

(2013) Tatiana D. Gonçalves et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Causes of Death and Prognostic Factors in Multiple Endocrine Neoplasia Type 1

(2013) Tetsuhide Ito et al.   MEDICINE

Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4)

(2013) Rajesh V. Thakker   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Minimally invasive parathyroidectomy provides a conservative surgical option for multiple endocrine neoplasia type 1–primary hyperparathyroidism

(2013) Mark Versnick et al.   SURGERY

Menin: a scaffold protein that controls gene expression and cell signaling

(2013) Smita Matkar et al.   TRENDS IN BIOCHEMICAL SCIENCES

Utility of Intraoperative Parathyroid Hormone Monitoring in Patients with Multiple Endocrine Neoplasia Type 1-Associated Primary Hyperparathyroidism Undergoing Initial Parathyroidectomy

(2013) Naris Nilubol et al.   WORLD JOURNAL OF SURGERY

The role of transcervical thymectomy in patients with hyperparathyroidism

(2012) Kellen Welch et al.   AMERICAN JOURNAL OF SURGERY

Importance of Surveillance for Multiple Endocrine Neoplasia-1 and Surgery in Patients With Sporadic Zollinger–Ellison Syndrome

(2012) Maneesh H. Singh et al.   Clinical Gastroenterology and Hepatology

Surgical management of pancreatico-duodenal tumors in multiple endocrine neoplasia syndrome type 1

(2012) G Akerstrom et al.   Clinics

MENX and MEN4

(2012) NS Pellegata   Clinics

Pituitary tumors in patients with MEN1 syndrome

(2012) LV Syro et al.   Clinics

Biochemical, bone and renal patterns in hyperparathyroidism associated with multiple endocrine neoplasia type 1

(2012) DM Lourenço-Jr et al.   Clinics

Primary hyperparathyroidism in multiple endocrine neoplasia type 1: when to perform surgery?

(2012) F Giusti et al.   Clinics

Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1)

(2012) Rajesh V. Thakker et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription

(2012) Jing Huang et al.   NATURE

ENETS Consensus Guidelines for the Management of Patients with Liver and Other Distant Metastases from Neuroendocrine Neoplasms of Foregut, Midgut, Hindgut, and Unknown Primary

(2012) Marianne Pavel et al.   NEUROENDOCRINOLOGY

Surgical Management of Insulinomas in Multiple Endocrine Neoplasia Type 1

(2012) Francesco Giudici et al.   PANCREAS

The Negative Feedback-Loop between the Oncomir Mir-24-1 and Menin Modulates the Men1 Tumorigenesis by Mimicking the “Knudson’s Second Hit”

(2012) Ettore Luzi et al.   PLoS One

Surgery for a gastroenteropancreatic neuroendocrine tumor (GEPNET) in multiple endocrine neoplasia type 1

(2012) Kazuhiro Hanazaki et al.   SURGERY TODAY

Diagnosis and Treatment of Gastrinomas in Multiple Endocrine Neoplasia Type 1 (MEN-1)

(2012) Ursula Plöckinger   Cancers

Multiple endocrine neoplasia type 1 in Japan: establishment and analysis of a multicentre database

(2011) Akihiro Sakurai et al.   CLINICAL ENDOCRINOLOGY

Magnetic resonance imaging versus endoscopic ultrasonography for the detection of pancreatic tumours in multiple endocrine neoplasia type 1

(2011) Coralie Barbe et al.   DIGESTIVE AND LIVER DISEASE

Role of Multiple Endocrine Neoplasia Type 1 Mutational Analysis in Clinical Practice

(2011) Paul Newey et al.   Endocrine Practice

Gender-related differences in MEN1 lesion occurrence and diagnosis: a cohort study of 734 cases from the Groupe d'étude des Tumeurs Endocrines

(2011) P Goudet et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Adrenal involvement in MEN1. Analysis of 715 cases from the Groupe d'étude des Tumeurs Endocrines database

(2011) B Gatta-Cherifi et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Crystal Structure of Menin Reveals Binding Site for Mixed Lineage Leukemia (MLL) Protein

(2011) Marcelo J. Murai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenesis of pituitary tumors

(2011) Shlomo Melmed   Nature Reviews Endocrinology

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

Biochemically curative surgery for gastrinoma in multiple endocrine neoplasia type 1 patients

(2011) Masayuki Imamura   WORLD JOURNAL OF GASTROENTEROLOGY

The Optimal Surgical Treatment for Primary Hyperparathyroidism in MEN1 Patients: A Systematic Review

(2011) Jennifer M. J. Schreinemakers et al.   WORLD JOURNAL OF SURGERY

Multiple endocrine neoplasia type 1 (MEN1)

(2010) Rajesh V. Thakker   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Inherited pancreatic endocrine tumor syndromes: Advances in molecular pathogenesis, diagnosis, management, and controversies

(2010) Robert T. Jensen et al.   CANCER

Early-onset, progressive, frequent, extensive, and severe bone mineral and renal complications in multiple endocrine neoplasia type 1-associated primary hyperparathyroidism

(2010) Delmar M Lourenço et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Menin dynamics and functional insight: Take your partners

(2010) Katalin Balogh et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Clinical Use of Cinacalcet in MEN1 Hyperparathyroidism

(2010) V. J. Moyes et al.   International Journal of Endocrinology

Pituitary Tumors and Hyperplasia in Multiple Endocrine Neoplasia Type 1 Syndrome (MEN1): A Case-Control Study in a Series of 77 Patients Versus 2509 Non-MEN1 Patients

(2009) Jacqueline Trouillas et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Prospective Study of Surgery for Primary Hyperparathyroidism (HPT) in Multiple Endocrine Neoplasia-Type 1 and Zollinger-Ellison Syndrome

(2009) Jeffrey A. Norton et al.   ANNALS OF SURGERY

Bone mineral density analysis in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 after total parathyroidectomy

(2009) Flavia L. Coutinho et al.   CLINICAL ENDOCRINOLOGY

Surgical Approach in Hereditary Hyperparathyroidism

(2009) Francesco TONELLI et al.   ENDOCRINE JOURNAL

Multiple endocrine neoplasia type 1 (MEN1): Not only inherited endocrine tumors

(2009) Alberto Falchetti et al.   GENETICS IN MEDICINE

The MEN1 Gene and Pituitary Tumours

(2009) Sunita K. Agarwal et al.   Hormone Research in Paediatrics

Diagnostic challenges due to phenocopies: lessons from Multiple Endocrine Neoplasia type1 (MEN1)

(2009) Jeremy J. O. Turner et al.   HUMAN MUTATION

Sporadic and MEN1-Related Primary Hyperparathyroidism: Differences in Clinical Expression and Severity

(2009) Cristina Eller-Vainicher et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Asymptomatic Children with Multiple Endocrine Neoplasia Type 1 Mutations May Harbor Nonfunctioning Pancreatic Neuroendocrine Tumors

(2009) Paul J. Newey et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Localization of Insulinomas to Regions of the Pancreas by Intraarterial Calcium Stimulation: The NIH Experience

(2009) Jean-Marc Guettier et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rare Germline Mutations in Cyclin-Dependent Kinase Inhibitor Genes in Multiple Endocrine Neoplasia Type 1 and Related States

(2009) Sunita K. Agarwal et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Familial pituitary tumor syndromes

(2009) Marianne S. Elston et al.   Nature Reviews Endocrinology

Familial Parathyroid Tumors: Diagnosis and Management

(2009) Peter Stålberg et al.   WORLD JOURNAL OF SURGERY

Risk Factors and Causes of Death in MEN1 Disease. A GTE (Groupe d’Etude des Tumeurs Endocrines) Cohort Study Among 758 Patients

(2009) Pierre Goudet et al.   WORLD JOURNAL OF SURGERY

Thymic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1: A Comparative Study on 21 Cases Among a Series of 761 MEN1 from the GTE (Groupe des Tumeurs Endocrines)

(2009) Pierre Goudet et al.   WORLD JOURNAL OF SURGERY

Multiple endocrine neoplasia type 1 in Brazil: MEN1 founding mutation, clinical features, and bone mineral density profile

(2008) D M Lourenço et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Natural course of small adrenal lesions in multiple endocrine neoplasia type 1: an endoscopic ultrasound imaging study

(2008) S Schaefer et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

A Prospective Study of Gastric Carcinoids and Enterochromaffin-Like Cell Changes in Multiple Endocrine Neoplasia Type 1 and Zollinger-Ellison Syndrome: Identification of Risk Factors

(2008) Marc J. Berna et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The utility of routine transcervical thymectomy for multiple endocrine neoplasia 1-related hyperparathyroidism

(2008) Anathea C. Powell et al.   SURGERY

Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene

(2007) Manuel C. Lemos et al.   HUMAN MUTATION

Familial isolated primary hyperparathyroidism caused by mutations of the MEN1 gene

(2007) Fadil M Hannan et al.   Nature clinical practice. Endocrinology & metabolism