Harnessing Dendritic Cells for Poly (D,L-lactide-co-glycolide) Microspheres (PLGA MS)—Mediated Anti-tumor Therapy

Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape

(2017) Leisha A. Emens et al.   EUROPEAN JOURNAL OF CANCER

Nanoparticles for tumor immunotherapy

(2017) Xinlong Zang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Surgery Versus 5% Imiquimod for Nodular and Superficial Basal Cell Carcinoma: 5-Year Results of the SINS Randomized Controlled Trial

(2017) Hywel C. Williams et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Injectable formulations of poly(lactic acid) and its copolymers in clinical use

(2016) Anjali Jain et al.   ADVANCED DRUG DELIVERY REVIEWS

PLA micro- and nano-particles

(2016) Byung Kook Lee et al.   ADVANCED DRUG DELIVERY REVIEWS

Non-glycosidic compounds can stimulate both human and mouseiNKT cells

(2016) John-Paul Jukes et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Vaccine adjuvants as potential cancer immunotherapeutics

(2016) Burcu Temizoz et al.   INTERNATIONAL IMMUNOLOGY

Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying

(2016) Feng Wan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Orchestrating immune responses: How size, shape and rigidity affect the immunogenicity of particulate vaccines

(2016) Naomi Benne et al.   JOURNAL OF CONTROLLED RELEASE

Analysis of nanoparticle delivery to tumours

(2016) Stefan Wilhelm et al.   Nature Reviews Materials

Synthetic Nanoparticles for Vaccines and Immunotherapy

(2015) Darrell J. Irvine et al.   CHEMICAL REVIEWS

Sizing the optimal dimensions of a vaccine delivery system: a particulate matter

(2015) Bram Slütter et al.   Expert Opinion on Drug Delivery

Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease

(2015) Valerie L. Herrmann et al.   JOURNAL OF CONTROLLED RELEASE

In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma model

(2015) Joana M. Silva et al.   JOURNAL OF CONTROLLED RELEASE

Immunopotentiator-Loaded Polymeric Microparticles as Robust Adjuvant to Improve Vaccine Efficacy

(2015) Weifeng Zhang et al.   PHARMACEUTICAL RESEARCH

The STEAP1262-270peptide encapsulated into PLGA microspheres elicits strong cytotoxic T cell immunity in HLA-A*0201 transgenic mice-A new approach to immunotherapy against prostate carcinoma

(2015) Valerie L. Herrmann et al.   PROSTATE

Evaluation of nano spray drying as a method for drying and formulation of therapeutic peptides and proteins

(2015) Yusuf A. Haggag et al.   Frontiers in Pharmacology

Immune cell dysfunctions in breast cancer patients detected through whole blood multi-parametric flow cytometry assay

(2015) E. Verronèse et al.   OncoImmunology

Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses

(2015) Yusuf Dölen et al.   OncoImmunology

A Therapeutic Microparticle-Based Tumor Lysate Vaccine Reduces Spontaneous Metastases in Murine Breast Cancer

(2014) Brett P. Gross et al.   AAPS Journal

The Adjuvants Aluminum Hydroxide and MF59 Induce Monocyte and Granulocyte Chemoattractants and Enhance Monocyte Differentiation toward Dendritic Cells

(2014) A. Seubert et al.   JOURNAL OF IMMUNOLOGY

Poly(lactic acid) and poly(lactic-co-glycolic acid) particles as versatile carrier platforms for vaccine delivery

(2014) Vincent Pavot et al.   Nanomedicine

Biomaterials for Nanoparticle Vaccine Delivery Systems

(2014) Preety Sahdev et al.   PHARMACEUTICAL RESEARCH

Eliciting cytotoxic T-lymphocyte responses from synthetic vectors containing one or two epitopes in a C57BL/6 mouse model using peptide-containing biodegradable microspheres and adjuvants

(2014) R.M. Rubsamen et al.   VACCINE

CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so-Helpful

(2014) H.-J. Kim et al.   Cancer Immunology Research

Therapeutic In Situ Autovaccination against Solid Cancers with Intratumoral Poly-ICLC: Case Report, Hypothesis, and Clinical Trial

(2014) A. M. Salazar et al.   Cancer Immunology Research

Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant

(2013) Annina M. Hafner et al.   ADVANCED DRUG DELIVERY REVIEWS

Immune system targeting by biodegradable nanoparticles for cancer vaccines

(2013) Joana M. Silva et al.   JOURNAL OF CONTROLLED RELEASE

Effects of Microparticle Size and Fc Density on Macrophage Phagocytosis

(2013) Patricia Pacheco et al.   PLoS One

Vaccine adjuvant formulations: A pharmaceutical perspective

(2013) Luis A. Brito et al.   SEMINARS IN IMMUNOLOGY

Exploiting Endocytosis for Nanomedicines

(2013) A. Akinc et al.   Cold Spring Harbor Perspectives in Biology

NKT Cells as an Ideal Anti-Tumor Immunotherapeutic

(2013) Shin-ichiro Fujii et al.   Frontiers in Immunology

The endocytosis and intracellular fate of nanomedicines: Implication for rational design

(2013) Longfa Kou et al.   Asian Journal of Pharmaceutical Sciences

Induction of Potent Antigen-specific Cytotoxic T Cell Response by PLGA-nanoparticles Containing Antigen and TLR Agonist

(2013) Young-Ran Lee et al.   Immune Network

Biodegradable Particles as Vaccine Delivery Systems: Size Matters

(2012) Vijaya B. Joshi et al.   AAPS Journal

Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype

(2012) Stacey L. Demento et al.   BIOMATERIALS

PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses

(2012) Wenxue Ma et al.   International Journal of Nanomedicine

Coencapsulation of tumor lysate and CpG-ODN in PLGA-microspheres enables successful immunotherapy of prostate carcinoma in TRAMP mice

(2012) Marc Mueller et al.   JOURNAL OF CONTROLLED RELEASE

Targeting tumor antigens to dendritic cells using particulate carriers

(2012) Medha D. Joshi et al.   JOURNAL OF CONTROLLED RELEASE

Potential of NOD receptor ligands as immunomodulators in particulate vaccine carriers

(2012) Christian Wischke et al.   JOURNAL OF CONTROLLED RELEASE

PLGA-based nanoparticles: An overview of biomedical applications

(2012) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system

(2012) Erica Locatelli et al.   JOURNAL OF NANOPARTICLE RESEARCH

Adjuvant effect of microencapsulated NOD ligands studied in a human phagocytic cell line

(2012) Simi Mathew et al.   Journal of Applied Biomaterials & Functional Materials

Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations

(2011) Samar Hamdy et al.   ADVANCED DRUG DELIVERY REVIEWS

Enhanced Stimulation of Anti-Ovarian Cancer CD8+ T Cells by Dendritic Cells Loaded with Nanoparticle Encapsulated Tumor Antigen

(2011) Douglas J. Hanlon et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Dendritic Cells

(2011) Gerold Schuler   CANCER JOURNAL

Route of Administration Modulates the Induction of Dendritic Cell Vaccine-Induced Antigen-Specific T Cells in Advanced Melanoma Patients

(2011) W. J. Lesterhuis et al.   CLINICAL CANCER RESEARCH

Current adjuvants and new perspectives in vaccine formulation

(2011) Emanuele Montomoli et al.   Expert Review of Vaccines

The uptake of PLGA micro or nanoparticles by macrophages provokes distinct in vitro inflammatory response

(2011) Roberto Nicolete et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Tumor eradication by immunotherapy with biodegradable PLGA microspheres-an alternative to incomplete Freund's adjuvant

(2011) Marc Mueller et al.   INTERNATIONAL JOURNAL OF CANCER

Microencapsulation of inorganic nanocrystals into PLGA microsphere vaccines enables their intracellular localization in dendritic cells by electron and fluorescence microscopy

(2011) Christopher Schliehe et al.   JOURNAL OF CONTROLLED RELEASE

CD8- Dendritic Cells and Macrophages Cross-Present Poly(D,L-lactate-co-glycolate) Acid Microsphere-Encapsulated Antigen In Vivo

(2011) C. Schliehe et al.   JOURNAL OF IMMUNOLOGY

TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection

(2011) I. Jelinek et al.   JOURNAL OF IMMUNOLOGY

Vaccine therapy with sipuleucel-T (Provenge) for prostate cancer

(2011) Eddie Thara et al.   MATURITAS

Polymer nanoparticles: Preparation techniques and size-control parameters

(2011) J. Prasad Rao et al.   PROGRESS IN POLYMER SCIENCE

Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity

(2011) Sandra Morel et al.   VACCINE

Combination of immune stimulating adjuvants with poly(lactide-co-glycolide) microspheres enhances the immune response of vaccines

(2011) Aiala Salvador et al.   VACCINE

Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines

(2011) Anil Mahapatro et al.   JOURNAL OF NANOBIOTECHNOLOGY

CD4+ T-Cell Help in the Tumor Milieu Is Required for Recruitment and Cytolytic Function of CD8+ T Lymphocytes

(2010) R. Bos et al.   CANCER RESEARCH

Modulation of immune responses through direct activation of Toll-like receptors to T cells

(2010) G. Liu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Nano spray drying: A novel method for preparing protein nanoparticles for protein therapy

(2010) Sie Huey Lee et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro

(2010) Luis J. Cruz et al.   JOURNAL OF CONTROLLED RELEASE

Differential induction of inflammatory cytokines by dendritic cells treated with novel TLR-agonist and cytokine based cocktails: targeting dendritic cells in autoimmunity

(2010) Simon S Jensen et al.   Journal of Inflammation-London

Polymer nanoparticles containing tumor lysates as antigen delivery vehicles for dendritic cell–based antitumor immunotherapy

(2010) Shashi Prasad et al.   Nanomedicine-Nanotechnology Biology and Medicine

Biodegradable polymeric nanoparticles based drug delivery systems

(2009) Avnesh Kumari et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Concomitant delivery of a CTL-restricted peptide antigen and CpG ODN by PLGA microparticles induces cellular immune response

(2009) Stefan Fischer et al.   JOURNAL OF DRUG TARGETING

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity in a mouse model of melanoma

(2008) Robin Goforth et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation

(2008) Martijn S. Bijker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Specific and non-specific phagocytosis of ligand-grafted PLGA microspheres by macrophages

(2008) Nolwenn Brandhonneur et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Safety of MF59™ adjuvant

(2008) Viola Schultze et al.   VACCINE

Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8+ T cell-mediated anti-tumor immunity

(2008) Samar Hamdy et al.   VACCINE

TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses

(2008) Eva Schlosser et al.   VACCINE