A Novel Phytochemical, DIM, Inhibits Proliferation, Migration, Invasion and TNF-α Induced Inflammatory Cytokine Production of Synovial Fibroblasts From Rheumatoid Arthritis Patients by Targeting MAPK and AKT/mTOR Signal Pathway

Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12

(2018) Jingsong Yu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation

(2018) Thomas Karonitsch et al.   Cell Reports

3,3′-Diindolylmethane suppresses ovarian cancer cell viability and metastasis and enhances chemotherapy sensitivity via STAT3 and Akt signaling in vitro and in vivo

(2018) Minghua Zou et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Glycogen Metabolism and Rheumatoid Arthritis: The Role of Glycogen Synthase 1 in Regulation of Synovial Inflammation via Blocking AMP-Activated Protein Kinase Activation

(2018) Maohua Shi et al.   Frontiers in Immunology

Molecular targets, anti-cancer properties and potency of synthetic indole-3-carbinol derivatives

(2018) Mojgan Karimabad Noroozi et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Sonic Hedgehog Signaling Pathway Mediates Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via MAPK/ERK Signaling Pathway

(2018) Fang Liu et al.   Frontiers in Immunology

Anti-rheumatoid arthritis effects of traditional Chinese herb couple in adjuvant-induced arthritis in rats

(2017) Ting Pan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pathogenetic insights from the treatment of rheumatoid arthritis

(2017) Iain B McInnes et al.   LANCET

Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor

(2017) Ada Popolo et al.   SEMINARS IN CANCER BIOLOGY

RANTES/CCL5 Induces Collagen Degradation by Activating MMP-1 and MMP-13 Expression in Human Rheumatoid Arthritis Synovial Fibroblasts

(2017) Solomon A. Agere et al.   Frontiers in Immunology

Pharmacological Value of Murine Delayed-type Hypersensitivity Arthritis: A Robust Mouse Model of Rheumatoid Arthritis in C57BL/6 Mice

(2016) Sara Marie Atkinson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Old and new therapeutics for Rheumatoid Arthritis:in vivomodels and drug development

(2016) Samra Sardar et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Triptolide inhibits the migration and invasion of rheumatoid fibroblast-like synoviocytes by blocking the activation of the JNK MAPK pathway

(2016) Yanlong Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies

(2016) Cynthia A. Thomson et al.   NUTRITION REVIEWS

Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice

(2016) Stephanie M. Stanford et al.   Arthritis & Rheumatology

Genome-wide transcriptome analysis reveals inactivation of Wnt/β-catenin by 3,3′-diindolylmethane inhibiting proliferation of colon cancer cells

(2015) SUN-HEE LEEM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

3,3′-Diindolylmethane potentiates paclitaxel-induced antitumor effects on gastric cancer cells through the Akt/FOXM1 signaling cascade

(2015) HUA JIN et al.   ONCOLOGY REPORTS

3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling

(2015) Wen-Xue Li et al.   Oncotarget

Tanshinone IIA Induces Apoptosis in Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Blockade of the Cell Cycle in the G2/M Phase and a Mitochondrial Pathway

(2014) Ligang Jie et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis

(2014) B. Tong et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of cysteine-rich angiogenic inducer 61 in fibroblast-like synovial cell proliferation and invasion in rheumatoid arthritis

(2014) LI-GANG JIE et al.   Molecular Medicine Reports

3,3′-Diindolylmethane suppresses the growth of gastric cancer cells via activation of the Hippo signaling pathway

(2013) XIU JUAN LI et al.   ONCOLOGY REPORTS

Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells – a rheumatoid arthritis mouse model

(2013) Hareklea Markides et al.   Stem Cell Research & Therapy

Pharmacokinetic evaluation and In Vitro–In Vivo Correlation (IVIVC) of novel methylene-substituted 3,3′ diindolylmethane (DIM)

(2012) Apurva R Patel et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

3,3′-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppression and Treg induction

(2012) Zhen Huang et al.   MOLECULAR IMMUNOLOGY

Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors

(2012) Nunzio Bottini et al.   Nature Reviews Rheumatology

3,3'-Diindolylmethane suppresses growth of human esophageal squamous cancer cells by G1 cell cycle arrest

(2012) Soo Kim   ONCOLOGY REPORTS

Selective involvement of ERK and JNK mitogen-activated protein kinases in early rheumatoid arthritis (1987 ACR criteria compared to 2010 ACR/EULAR criteria): a prospective study aimed at identification of diagnostic and prognostic biomarkers as well as therapeutic targets

(2011) Daphne de Launay et al.   ANNALS OF THE RHEUMATIC DISEASES

Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells

(2011) Ji-Ae Shin et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

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(2010) Teresina Laragione et al.   MOLECULAR MEDICINE

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

3,3′-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice

(2009) Yoon Hee Kim et al.   INFLAMMATORY BOWEL DISEASES