Journal
JOURNAL OF IMMUNOLOGY
Volume 196, Issue 11, Pages 4447-4451Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1500383
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Funding
- Deutsche Forschungsgemeinschaft [SCHE692/3-1, SCHE692/4-1]
- Strategic Research Fund of the University of Dusseldorf
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Type I IFNs are critical in initiating protective antiviral immune responses, and plasmacytoid dendritic cells (pDCs) represent a major source of these cytokines. We show that only few pDCs are capable of producing IFN-beta after virus infection or CpG stimulation. Using IFN beta/YFP reporter mice, we identify these IFN-beta-producing cells in the spleen as a CCR9(+)CD9(-) pDC subset that is localized exclusively within the T/B cell zones. IFN-beta-producing pDCs exhibit a distinct transcriptome profile, with higher expression of genes encoding cytokines and chemokines, facilitating T cell recruitment and activation. These distinctive characteristics of IFN-beta-producing pDCs are independent of the type I IFNR-mediated feedback loop. Furthermore, IFN-beta-producing pDCs exhibit enhanced CCR7-dependent migratory properties in vitro. Additionally, they effectively recruit T cells in vivo in a peritoneal inflammation model. We define professional type I IFN-producing cells as a distinct subset of pDCs specialized in coordinating cellular immune responses.
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