BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation

The effects of a CCR3 inhibitor, AXP1275, on allergen-induced airway responses in adults with mild-to-moderate atopic asthma

(2018) G. M. Gauvreau et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells

(2018) Timotheus Y.F. Halim et al.   IMMUNITY

Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin

(2018) Sucai Liu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Coming of Age: CD96 Emerges as Modulator of Immune Responses

(2018) Hristo Georgiev et al.   Frontiers in Immunology

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization

(2018) Hyung-Geun Moon et al.   IMMUNITY

ICAM-1 controls development and function of ILC2

(2018) Ai-Hua Lei et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling

(2018) Bing Tian et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity

(2018) Martin D. Knolle et al.   Frontiers in Immunology

Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production

(2017) Laura Maggi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation

(2017) Kristina Johansson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator–inducible T-cell costimulator ligand interaction

(2017) Diamanda Rigas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Leukotriene C4 Potentiates IL-33–Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation

(2017) Sean J. Lund et al.   JOURNAL OF IMMUNOLOGY

Egr2 and 3 Inhibit T-bet–Mediated IFN-γ Production in T Cells

(2017) Randeep Singh et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells

(2017) Kangning Zhang et al.   JOURNAL OF IMMUNOLOGY

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

(2017) Antonia Wallrapp et al.   NATURE

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

(2017) Christoph S. N. Klose et al.   NATURE

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

(2017) Vânia Cardoso et al.   NATURE

A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma

(2017) Yang Zhang et al.   Scientific Reports

IL-13+ Type 2 Innate Lymphoid Cells Correlate with Asthma Control Status and Treatment Response

(2016) Yi Jia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cut to the chase: a review of CD26/dipeptidyl peptidase-4's (DPP4) entanglement in the immune system

(2016) C. Klemann et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

(2016) Steven G. Smith et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 innate lymphoid cells in induced sputum from children with severe asthma

(2016) Prasad Nagakumar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BATF Modulates the Th2 Locus Control Region and Regulates CD4+T Cell Fate during Antihelminth Immunity

(2016) Katherine Bao et al.   JOURNAL OF IMMUNOLOGY

Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway

(2016) Yong Yu et al.   NATURE

Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs

(2016) Jonathan S Silver et al.   NATURE IMMUNOLOGY

Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop

(2016) Makoto Kuwahara et al.   Nature Communications

Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut

(2015) Myung H. Kim et al.   IMMUNITY

ICOS:ICOS-Ligand Interaction Is Required for Type 2 Innate Lymphoid Cell Function, Homeostasis, and Induction of Airway Hyperreactivity

(2015) Hadi Maazi et al.   IMMUNITY

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung

(2015) E D Tait Wojno et al.   Mucosal Immunology

Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation

(2015) Ahmed Nadeem et al.   PHARMACOLOGICAL RESEARCH

Innate lymphoid cells: A new paradigm in immunology

(2015) G. Eberl et al.   SCIENCE

Batf is important for IL-4 expression in T follicular helper cells

(2015) Anupama Sahoo et al.   Nature Communications

Innate Lymphoid Cells in Inflammation and Immunity

(2014) Andrew N.J. McKenzie et al.   IMMUNITY

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

(2014) Christopher J. Oliphant et al.   IMMUNITY

Enhanced innate type 2 immune response in peripheral blood from patients with asthma

(2014) Kathleen R. Bartemes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

(2014) Luzheng Xue et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions

(2014) Christopher J Chan et al.   NATURE IMMUNOLOGY

IL-25-responsive, lineage-negative KLRG1hi cells are multipotential ‘inflammatory’ type 2 innate lymphoid cells

(2014) Yuefeng Huang et al.   NATURE IMMUNOLOGY

Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity

(2014) I. S. Okoye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-155 is essential for TH2-mediated allergen-induced eosinophilic inflammation in the lung

(2013) Carina Malmhäll et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell–driven immune responses in the setting of allergic asthma

(2013) Caroline Übel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation

(2013) Jan-Eric Turner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

(2013) Maryam Salimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of Signal Strength Switches Notch from an Inducer of T Cells to an Inducer of ILC2

(2013) Rebecca Gentek et al.   Frontiers in Immunology

IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation

(2012) Clare S. Hardman et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

BATF–JUN is critical for IRF4-mediated transcription in T cells

(2012) Peng Li et al.   NATURE

Transcription factor RORα is critical for nuocyte development

(2012) See Heng Wong et al.   NATURE IMMUNOLOGY

Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

(2012) H. S. Bandukwala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity

(2011) J. L. Barlow et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE