Leukotriene C4 Potentiates IL-33–Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation

Cysteinyl leukotriene E 4 activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D 2 and epithelial cytokines

(2017) Maryam Salimi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin-exacerbated respiratory disease

(2017) Jacqueline J. Eastman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic stromal lymphopoietin controls prostaglandin D 2 generation in patients with aspirin-exacerbated respiratory disease

(2016) Kathleen M. Buchheit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s

(2016) Jakob von Moltke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection

(2016) V S Pelly et al.   Mucosal Immunology

Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33

(2015) Christina A. Christianson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33

(2015) Susana Castanhinha et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene–Driven IL-33–Mediated Mast Cell Activation Pathway

(2015) Tao Liu et al.   JOURNAL OF IMMUNOLOGY

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

IL-33 promotes airway remodeling and is a marker of asthma disease severity

(2014) Zhi Guo et al.   JOURNAL OF ASTHMA

At the Bench: Understanding group 2 innate lymphoid cells in disease

(2014) Taylor A. Doherty   JOURNAL OF LEUKOCYTE BIOLOGY

Increased serum levels of interleukin 33 in patients with atopic dermatitis

(2014) Risa Tamagawa-Mineoka et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts

(2014) Yoshihide Kanaoka et al.   Allergy Asthma & Immunology Research

IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction

(2013) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production

(2013) Taylor A. Doherty et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification of GPR99 Protein as a Potential Third Cysteinyl Leukotriene Receptor with a Preference for Leukotriene E4Ligand

(2013) Yoshihide Kanaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-33 Markedly Activates Murine Eosinophils by an NF- B-Dependent Mechanism Differentially Dependent upon an IL-4-Driven Autoinflammatory Loop

(2013) C. Bouffi et al.   JOURNAL OF IMMUNOLOGY

IL-33 enhances proliferation and invasiveness of decidual stromal cells by up-regulation of CCL2/CCR2 via NF-κB and ERK1/2 signaling

(2013) Wen-Ting Hu et al.   MOLECULAR HUMAN REPRODUCTION

STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria

(2012) Taylor A. Doherty et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

IL-33 induces innate lymphoid cell–mediated airway inflammation by activating mammalian target of rapamycin

(2012) Robert J. Salmond et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cysteinyl Leukotriene 2 Receptor on Dendritic Cells Negatively Regulates Ligand-Dependent Allergic Pulmonary Inflammation

(2012) Nora A. Barrett et al.   JOURNAL OF IMMUNOLOGY

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33-LacZ Gene Trap Reporter Strain

(2012) M. Pichery et al.   JOURNAL OF IMMUNOLOGY

Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes

(2011) Nora A. Barrett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leukotriene E4 Activates Human Th2 Cells for Exaggerated Proinflammatory Cytokine Production in Response to Prostaglandin D2

(2011) L. Xue et al.   JOURNAL OF IMMUNOLOGY

IL-33-Responsive Lineage-CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs

(2011) K. R. Bartemes et al.   JOURNAL OF IMMUNOLOGY

IL-33 Mediates Inflammatory Responses in Human Lung Tissue Cells

(2010) A. Yagami et al.   JOURNAL OF IMMUNOLOGY

Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12receptor

(2009) Sailaja Paruchuri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system

(2008) Y. Kondo et al.   INTERNATIONAL IMMUNOLOGY

Leukotriene E4Activates Peroxisome Proliferator-activated Receptor γ and Induces Prostaglandin D2Generation by Human Mast Cells

(2008) Sailaja Paruchuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One