Lung tissue bioengineering for chronic obstructive pulmonary disease: overcoming the need for lung transplantation from human donors

Multivascular networks and functional intravascular topologies within biocompatible hydrogels

(2019) Bagrat Grigoryan et al.   SCIENCE

A Multicenter RCT of Zephyr® Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE)

(2018) Gerard J Criner et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

3D bioprinting of a corneal stroma equivalent

(2018) Abigail Isaacson et al.   EXPERIMENTAL EYE RESEARCH

Reinforced Electrospun Polycaprolactone Nanofibers for Tracheal Repair in an In Vivo Ovine Model

(2018) Jakob M. Townsend et al.   TISSUE ENGINEERING PART A

Production and transplantation of bioengineered lung into a large-animal model

(2018) Joan E. Nichols et al.   Science Translational Medicine

Cellular Reprogramming Using Protein and Cell-Penetrating Peptides

(2017) Bong Seo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interspecies organogenesis generates autologous functional islets

(2017) Tomoyuki Yamaguchi et al.   NATURE

Vision Loss after Intravitreal Injection of Autologous “Stem Cells” for AMD

(2017) Ajay E. Kuriyan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transplantation of bioengineered rat lungs recellularized with endothelial and adipose-derived stromal cells

(2017) Ryoichiro Doi et al.   Scientific Reports

Outcomes after lung transplantation

(2017) Gabriel Thabut et al.   Journal of Thoracic Disease

Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)

(2017) Mathew Suji Eapen et al.   Scientific Reports

Preliminary data on precision of QuantiFERON-TB Plus performance

(2016) David Gallagher et al.   EUROPEAN RESPIRATORY JOURNAL

3D printing of porous alginate/gelatin hydrogel scaffolds and their mechanical property characterization

(2016) Fu You et al.   International Journal of Polymeric Materials and Polymeric Biomaterials

The Registry of the International Society for Heart and Lung Transplantation: Thirty-third Adult Lung and Heart–Lung Transplant Report—2016; Focus Theme: Primary Diagnostic Indications for Transplant

(2016) Roger D. Yusen et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Giving new life to old lungs: methods to produce and assess whole human paediatric bioengineered lungs

(2016) Joan E. Nichols et al.   Journal of Tissue Engineering and Regenerative Medicine

Glioproliferative Lesion of the Spinal Cord as a Complication of “Stem-Cell Tourism”

(2016) Aaron L. Berkowitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema

(2016) J. Stolk et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Mesenchymal stem cells in the treatment of chronic lung disease

(2016) Sophie Wecht et al.   RESPIROLOGY

Comparative Decellularization and Recellularization of Wild-Type and Alpha 1,3 Galactosyltransferase Knockout Pig Lungs: A Model forEx VivoXenogeneic Lung Bioengineering and Transplantation

(2016) Joseph Platz et al.   TISSUE ENGINEERING PART C-METHODS

Combined Bone Marrow-Derived Mesenchymal Stromal Cell Therapy and One-Way Endobronchial Valve Placement in Patients with Pulmonary Emphysema: A Phase I Clinical Trial

(2016) Hugo Goulart de Oliveira et al.   Stem Cells Translational Medicine

3D printing of porous alginate/gelatin hydrogel scaffolds and their mechanical property characterization

(2016) Fu You et al.   International Journal of Polymeric Materials and Polymeric Biomaterials

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

The relationship between COPD and lung cancer

(2015) A.L. Durham et al.   LUNG CANCER

Global burden of COPD

(2015) José Luis López-Campos et al.   RESPIROLOGY

Avoiding Detrimental Human Immune Response Against Mammalian Extracellular Matrix Implants

(2015) Uri Galili   TISSUE ENGINEERING PART B-REVIEWS

Automated Decellularization of Intact, Human-Sized Lungs for Tissue Engineering

(2015) Andrew P. Price et al.   TISSUE ENGINEERING PART C-METHODS

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein

(2015) Agnes M. Azimzadeh et al.   XENOTRANSPLANTATION

Mesenchymal stem cells alleviate airway inflammation and emphysema in COPD through down-regulation of cyclooxygenase-2 via p38 and ERK MAPK pathways

(2015) Wen Gu et al.   Scientific Reports

Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development

(2015) Steven M. Hrycaj et al.   Cell Reports

Reprogramming with Small Molecules instead of Exogenous Transcription Factors

(2015) Tongxiang Lin et al.   Stem Cells International

Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels

(2015) T. J. Hinton et al.   Science Advances

Engineering alginate as bioink for bioprinting

(2014) Jia Jia et al.   Acta Biomaterialia

Enhanced Lung Epithelial Specification of Human Induced Pluripotent Stem Cells on Decellularized Lung Matrix

(2014) Sarah E. Gilpin et al.   ANNALS OF THORACIC SURGERY

Conversion of bone marrow mesenchymal stem cells into type II alveolar epithelial cells reduces pulmonary fibrosis by decreasing oxidative stress in rats

(2014) KUN HUANG et al.   Molecular Medicine Reports

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Mesenchymal stem cells: immune evasive, not immune privileged

(2014) James A Ankrum et al.   NATURE BIOTECHNOLOGY

Wnt5a through Noncanonical Wnt/JNK or Wnt/PKC Signaling Contributes to the Differentiation of Mesenchymal Stem Cells into Type II Alveolar Epithelial Cells In Vitro

(2014) Airan Liu et al.   PLoS One

All Roads Lead to Induced Pluripotent Stem Cells: The Technologies of iPSC Generation

(2014) Kejin Hu   STEM CELLS AND DEVELOPMENT

Meta-analysis of the independent and cumulative effects of multiple genetic modifications on pig lung xenograft performance during ex vivo perfusion with human blood

(2014) Donald G. Harris et al.   XENOTRANSPLANTATION

Porcine Endogenous Retroviruses in Xenotransplantation—Molecular Aspects

(2014) Magdalena Kimsa et al.   Viruses-Basel

A comparative study on collagen type I and hyaluronic acid dependent cell behavior for osteochondral tissue bioprinting

(2014) Ju Young Park et al.   Biofabrication

Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink

(2014) Falguni Pati et al.   Nature Communications

Differentiation of Mouse Induced Pluripotent Stem Cells Into Alveolar Epithelial Cells In Vitro for Use In Vivo

(2014) Qiliang Zhou et al.   Stem Cells Translational Medicine

The effects of storage and sterilization on de-cellularized and re-cellularized whole lung

(2013) Nicholas R. Bonenfant et al.   BIOMATERIALS

The 3D printing of gelatin methacrylamide cell-laden tissue-engineered constructs with high cell viability

(2013) Thomas Billiet et al.   BIOMATERIALS

A Placebo-Controlled, Randomized Trial of Mesenchymal Stem Cells in COPD

(2013) Daniel J. Weiss et al.   CHEST

Effects of freezing/thawing on the mechanical properties of decellularized lungs

(2013) Paula N. Nonaka et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Role of the Extracellular Matrix in Whole Organ Engineering

(2013) Denver M. Faulk et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells

(2013) Sarah X L Huang et al.   NATURE BIOTECHNOLOGY

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis

(2013) B. E. Rockich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs

(2013) H. Matsunari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production and Assessment of Decellularized Pig and Human Lung Scaffolds

(2013) Joan E. Nichols et al.   TISSUE ENGINEERING PART A

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors

(2012) Xiao-Jun Guan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

Clinical lung xenotransplantation - what donor genetic modifications may be necessary?

(2012) David K. C. Cooper et al.   XENOTRANSPLANTATION

Rapid 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds

(2012) L A Hockaday et al.   Biofabrication

Omnidirectional Printing of 3D Microvascular Networks

(2011) Willie Wu et al.   ADVANCED MATERIALS

Enhanced In Vivo Function of Bioartificial Lungs in Rats

(2011) Jeremy J. Song et al.   ANNALS OF THORACIC SURGERY

Human iPS cell-based therapy: Considerations before clinical applications

(2011) Ning Sun et al.   CELL CYCLE

Transplantation of alveolar type II cells stimulates lung regeneration during compensatory lung growth in adult rats

(2011) Hironobu Wada et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Unicentric study of cell therapy in chronic obstructive pulmonary disease/pulmonary emphysema

(2011) Ribeiro-Paes et al.   International Journal of Chronic Obstructive Pulmonary Disease

Cloning and functional characterization of pig CMP-N-acetylneuraminic acid hydroxylase for the synthesis ofN-glycolylneuraminic acid as the xenoantigenic determinant in pig–human xenotransplantation

(2010) Kwon-Ho Song et al.   BIOCHEMICAL JOURNAL

Transplantation of Human Embryonic Stem Cell–Derived Alveolar Epithelial Type II Cells Abrogates Acute Lung Injury in Mice

(2010) Dachun Wang et al.   MOLECULAR THERAPY

Paracrine Factors of Multipotent Stromal Cells Ameliorate Lung Injury in an Elastase-induced Emphysema Model

(2010) Ahmed M Katsha et al.   MOLECULAR THERAPY

Regeneration and orthotopic transplantation of a bioartificial lung

(2010) Harald C Ott et al.   NATURE MEDICINE

Tissue-Engineered Lungs for in Vivo Implantation

(2010) T. H. Petersen et al.   SCIENCE

Complement regulation in the GalT KO era

(2010) Shuji Miyagawa et al.   XENOTRANSPLANTATION

Porcine endogenous retrovirus and other viruses in xenotransplantation

(2009) Linda Scobie et al.   Current Opinion in Organ Transplantation

Multiple roles for Sox2 in the developing and adult mouse trachea

(2009) J. Que et al.   DEVELOPMENT

Survival impact of lung transplantation for COPD

(2009) S. Lahzami et al.   EUROPEAN RESPIRATORY JOURNAL

Tissue Engineering of Lung: The Effect of Extracellular Matrix on the Differentiation of Embryonic Stem Cells to Pneumocytes

(2009) Yuan-Min Lin et al.   TISSUE ENGINEERING PART A

Antibody-mediated xenograft injury: Mechanisms and protective strategies

(2009) Richard N. Pierson   TRANSPLANT IMMUNOLOGY

Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient

(2009) Ninette Amariglio et al.   PLOS MEDICINE