Article
Chemistry, Multidisciplinary
Guo Ye, Dekui Song, Junjie Song, Yan Zhao, Nan Liu
Summary: Wearable electronics have had a significant impact on human life, particularly in areas such as health monitoring and human-machine interfacing. However, the rapid development of these devices has also led to a significant increase in electronic waste, posing a threat to ecological systems. This study presents a fully biodegradable and biocompatible ionotronic skin made from natural polyelectrolytes derivatives, which exhibits high ionic conductivity and good compliance with the skin while completely degrading within a short period of time. The application of this novel material in transient measurement of electrophysiology has shown promising results, specifically in accurately recording action potentials and degrading without any residue. This research provides important insights for the design of future ionotronic materials for transient electronics.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Jerika A. Chiong, Helen Tran, Yangju Lin, Yu Zheng, Zhenan Bao
Summary: The field of wearable and implantable skin-inspired devices is rapidly growing interest in the consumer market, with a focus on developing environmentally-friendly electronics using recyclable, biodegradable, and biocompatible polymer technologies to mitigate the adverse impact on the environment and human health. Through advancements in molecular design, processing parameters, and fabricating techniques, there is a potential for economic growth and increased efficiency in these devices, which aim to enhance human-environment interaction levels.
Review
Materials Science, Multidisciplinary
Joshua Tropp, Jonathan Rivnay
Summary: The field of bioelectronics utilizes the optoelectronic properties of synthetic materials to interact with living systems, offering new possibilities for medical treatments. Conjugated polymers present an alternative design space for mechanically and physiochemically compatible electroactive materials, but face challenges in terms of biodegradability and biocompatibility.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Review
Green & Sustainable Science & Technology
Won Bae Han, Seung Min Yang, Kaveti Rajaram, Suk-Won Hwang
Summary: This review discusses the research progress on biocompatible and biodegradable polymer composite systems with electrical/mechanical functions, emphasizing the potential applicability of inorganic elements in conductive composites. It also highlights key issues and challenges to overcome, such as corrosion and oxidation of inorganic metals and improving the electrical performance of composite systems.
ADVANCED SUSTAINABLE SYSTEMS
(2022)
Review
Chemistry, Multidisciplinary
Shuo Chen, Zekai Wu, Chengzhen Chu, Yufeng Ni, Rasoul Esmaeely Neisiany, Zhengwei You
Summary: Biodegradable electronics are a crucial bio-friendly solution for e-waste management, sustainable development, and emerging implantable devices. Elastic electronics with human tissue-like mechanical characteristics are essential for human-related applications. The convergence of biodegradability and elasticity has opened up new possibilities for wearable and implantable electronics. This review clarifies the concepts of biodegradable and elastic electronics, discusses degradation mechanisms in polymeric materials, summarizes various biodegradable elastomers and gels, and examines their molecular design, modification, processing, and device fabrication, as well as current challenges and future directions.
Article
Biochemistry & Molecular Biology
Vladislav V. Istratov, Valerii A. Vasnev, Galy D. Markova
Summary: This study focused on synthesizing biodegradable and biocompatible amphiphilic polymers by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The research investigated the impact of the ratio of hydrophilic to hydrophobic organosilicon structures on the biological activity of macromolecules, as well as the influence of polymer structure on critical micelle concentrations and aggregation stability of emulsions. Additionally, the study explored how polymer structures affected antifungal activity and seed germination stimulation.
Article
Green & Sustainable Science & Technology
Seunghyeon Lee, Yeongbeom Hong, Bong Sup Shim
Summary: Plastics, especially electronic waste and microplastics, are currently posing challenging environmental issues. Superworms' ingestion behavior towards plastics provides an innovative approach to reduce plastic pollution. The study demonstrates that the biodegradable MMT/PEDOT:PSS composites have versatile multifunctionalities and open up new possibilities for eco-friendly applications using electronic materials.
ADVANCED SUSTAINABLE SYSTEMS
(2022)
Review
Materials Science, Multidisciplinary
Deying Kong, Kaiyuan Zhang, Jingjing Tian, Lan Yin, Xing Sheng
Summary: This article provides an overview of recent progress in the development of biocompatible and biodegradable light-emitting materials and devices, including molecular dyes, proteins, and inorganic particles with photoluminescence, material systems with unusual optical properties, and electroluminescent materials and devices with potential for full biodegradation. These advancements are envisioned to offer unique capabilities for a wide range of biomedical applications, from biological sensing and modulation to clinical diagnostics and therapy.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Nanoscience & Nanotechnology
J. Li, J. Liu, W. Huo, J. Yu, X. Liu, M. J. Haslinger, M. Muehlberger, P. Kulha, X. Huang
Summary: Biodegradable electronics with the ability to disintegrate and dissolve in liquids have promising applications in healthcare and consumer electronics. Printing technology has the potential to produce complex electronic components with improved yield and throughput. However, achieving a fully printed biodegradable system with complex electronic components is still a challenge. This article summarizes the state-of-the-art techniques in printing biodegradable electronic devices and provides insights into the development of biodegradable inks and pastes suitable for printing. It also discusses the challenges and future trends in printing biodegradable electronics.
MATERIALS TODAY NANO
(2022)
Article
Chemistry, Multidisciplinary
Jae-Young Bae, Eun-Ji Gwak, Gyeong-Seok Hwang, Hae Won Hwang, Dong-Ju Lee, Jong-Sung Lee, Young-Chang Joo, Jeong-Yun Sun, Sang Ho Jun, Myoung-Ryul Ok, Ju-Young Kim, Seung-Kyun Kang
Summary: Biodegradable electronics are sustainable disposable devices using fully biodegradable metallic glass film for stretchable and flexible electrodes. They show high elastic strain, enhanced stretchability, and good performance in electronic components and energy harvesting applications.
Article
Materials Science, Multidisciplinary
Kyung-Sub Kim, Jaeyoung Yoo, Jun-Seok Shim, Young-In Ryu, Suyeon Choi, Ju-Yong Lee, Hyuck Mo Lee, Jahyun Koo, Seung-Kyun Kang
Summary: The article introduces a biodegradable conductive paste composed of molybdenum microparticles and PBAT, demonstrating excellent mechanical flexibility and conductivity. The paste dissolves moderately in phosphate buffer saline, achieving complete biodegradability and a programmable lifecycle. The use of tetraglycol enhances elongation and conductivity performance of the paste.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Chemistry, Multidisciplinary
Jinho Kim, Congqi Yang, Taehyun Yun, Seohyun Woo, Hwajoong Kim, Mugeun Lee, Minji Jeong, Hyeji Ryu, Namjung Kim, Seongjun Park, Jaehong Lee
Summary: A biocompatible and biodegradable fiber electrode with high electrical conductivity and mechanical robustness is developed in this study. The fiber electrode incorporates a large amount of Mo microparticles into a biodegradable PCL fiber scaffold in a concentrated manner. It exhibits remarkable electrical performance, mechanical strength, bending stability, and durability, and shows potential for various applications.
Review
Polymer Science
Maurine Naliaka Andanje, James Wamai Mwangi, Bruno Roberts Mose, Sandro Carrara
Summary: There is a growing interest in developing biodegradable polymers to address the environmental impact of petroleum-based synthetic polymers. Bioplastics, derived from renewable resources, are identified as a potential alternative to conventional plastics. Additive manufacturing, or 3D printing, offers flexibility in material selection and can be used for manufacturing parts from bioplastics. However, challenges exist in printing biocomposites from plant biomass, such as warping and poor mechanical properties. This paper aims to review the technology of 3D printing using bioplastics and address the challenges faced in additive manufacturing with biocomposites.
Article
Polymer Science
Raluca Ioana Baron, Gabriela Biliuta, Vlad Socoliuc, Sergiu Coseri
Summary: Magnetic hydrogels composed of PVA/CO/MFs were prepared by a freeze-thaw technique, combining the renewability and biocompatibility of PVA and CO, as well as the magnetic properties of MFs. Thorough investigation showed excellent distribution of magnetic particles and CO in the PVA matrix, with superparamagnetic properties.
Review
Polymer Science
Shuo Chen, Yihan Wang, Lei Yang, Chengzhen Chu, Shichun Cao, Zhao Wang, Jiajia Xue, Zhengwei You
Summary: In this review, the recent progress in synthesis, process technologies, and biomedical applications of biodegradable elastomers is summarized. The emphasis is on the molecular design and processing strategies of biodegradable polyesters and polyurethanes, as well as the newly developed functionalities in biomedical applications. Future research directions, challenges, and potential solutions are discussed.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Cell Biology
Liangliang Liu, Junkang Wang, Jiaqi Zhang, Chaobo Huang, Zhaogang Yang, Yi Cao
Summary: The neurotoxicity of ZnO nanoparticles on 3D brain organoids was studied. High concentrations of ZnO nanoparticles were found to be cytotoxic to the organoids via defective autophagy and intracellular accumulation of Zn ions.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jian Zhao, He Cheng, Zhenhui Zhang, Yuan Liu, Jiangnan Song, Ting Liu, Yinna He, Alan Meng, Changlong Sun, Minmin Hu, Lei Wang, Guicun Li, Jianfeng Huang, Zhenjiang Li
Summary: In this study, semicoherent heterojunctions with rich Se vacancies were constructed as cathode to improve the rate capability of battery-type supercapacitors. The cathode exhibited large specific capacity, excellent cycle stability, and ultrahigh rate capability. Additionally, a high-performance hybrid supercapacitor was developed using N/S co-doped porous carbon as anode, showing high energy density and superior cycle performance.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Electrochemistry
Jing Huang, Mei Han, Peng Ji, Bo He, Xuansheng Feng, Ying Han, Kesheng Gao, Zeqing Miao, Changlong Sun, Jian Zhi, Lei Zhang, P. Chen
Summary: In this study, the introduction of mesopores in the beta-MnO2 cathode was shown to effectively address the issues of low capacity and poor cycling stability associated with manganese-based materials in RAZIBs. A novel strategy for optimizing the electrochemical performance of RAZIBs was provided through this structural modulation strategy.
ELECTROCHIMICA ACTA
(2022)
Article
Electrochemistry
Ying Han, Changlong Sun, Kesheng Gao, Shiqi Ding, Zeqing Miao, Jian Zhao, Zijiang Yang, Peng Wu, Jing Huang, Zhenjiang Li, Alan Meng, Lei Zhang, P. Chen
Summary: In this work, (Ga1-xZnx)(N1-xOx) (GaZnON) nanowire was in situ synthesized on a graphite layer to improve electrochemical performance in lithium-ion storage. The nanowire structure exhibited fast electron and ion transport with a large surface-to-volume ratio. The GaZnON nanowire anode showed enhanced capacity and stable performance in cycling tests.
ELECTROCHIMICA ACTA
(2022)
Article
Computer Science, Artificial Intelligence
Yongzhen Wang, Jun Lin, Sheng Bi, Changlong Sun, Luo Si, Xiaozhong Liu
Summary: This study presents an innovative approach to predict multiple chronic diseases using online shopping behaviors, leveraging an adaptive representation learning model and task-specific attention mechanism for feature sharing across tasks. The model addresses the lack of negative instances during training, demonstrating effectiveness in interpreting buying patterns of online shoppers with chronic diseases.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Shiyan Dong, Ye Bi, Xiangshi Sun, Yarong Zhao, Rongze Sun, Fei Hao, Yating Sun, Yifan Wang, Xuefeng Li, Weiye Deng, Xuan Liu, JongHoon Ha, Lirong Teng, Ping Gong, Jing Xie, Betty Y. S. Kim, Zhaogang Yang, Wen Jiang, Lesheng Teng
Summary: This study describes a TNBC-specific targeted liposomal formulation that effectively targets TNBC tumor cells through hyaluronic acid modification and has synergistic effects on inhibiting tumor cell proliferation and metastasis.
Article
Chemistry, Multidisciplinary
Jun Li, Chao Xue, Hao Wang, Shiyan Dong, Zhaogang Yang, Yuting Cao, Binan Zhao, Biao Cheng, Xianrui Xie, Xiumei Mo, Wen Jiang, Hengfeng Yuan, Jianfeng Pan
Summary: This study presents a strategy for manufacturing anisotropic hybrid nanofibrous composites that mimic the mechanical properties and hierarchical structures of tendons and ligaments. The hybrid nanofibrous composites show improved biodurability and biocompatibility, and after transplantation in vivo, they integrate with native tendons to promote tissue ingrowth and tendon regeneration. The optimized anisotropic hybrid nanofibrous composites also lead to more significant deposition of tendon-associated extracellular matrix proteins during tendon repair.
Article
Pharmacology & Pharmacy
Lixia Ma, Yue Zhou, Jia Zhang, Xi Yuan, Yimeng Zhao, Wei Gu, Jinhuo Pan, Zhaogang Yang, Tulin Lu, Guojun Yan
Summary: This study explores the dissolution mechanism and absorption process of compound Danshen tablets and compound Danshen capsules in vitro. Real-time cell-based assay technology was used to evaluate the dissolution and absorption of the multi-component solid preparations. The study establishes a comprehensive evaluation method for cell biology of compound Danshen solid preparations and a synchronous evaluation system of dissolution and absorption in vitro.
Article
Engineering, Environmental
Changlong Sun, Yan-Jie Wang, Dan Liu, Baizeng Fang, Wei Yan, Jiujun Zhang
Summary: In this study, gallium nitride nanoparticles were successfully synthesized and combined with nitrogen-doped graphene. The results show that the composite material exhibits excellent reversible capacity and cycling stability. Analysis reveals that the interfacial coupled chemical bonds can control and tailor the interfacial interaction. This structural engineering strategy opens up new opportunities for achieving high-performance lithium ion storage with traditional electrode materials.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Electrochemistry
Kesheng Gao, Zeqing Miao, Ying Han, Dazhi Li, Wei Sun, Meng Zhang, Alan Meng, Changlong Sun, Zhenjiang Li
Summary: A new anode material, Co-GeZn1.7ON1.8, was designed and synthesized through a solid state reaction method. The introduction of cobalt greatly increased the achievable capacity and resulted in outstanding electrochemical performance.
ELECTROCHIMICA ACTA
(2023)
Review
Immunology
Huan Zhang, Simiao Wang, Man Sun, Yaxin Cui, Jianming Xing, Lesheng Teng, Zhifang Xi, Zhaogang Yang
Summary: Exosomes have emerged as promising drug delivery vehicles for cancer immunotherapy due to their biocompatibility, low toxicity, and immunogenicity. Various strategies, such as modulation of the tumor microenvironment, immune checkpoint blockades, and cancer vaccines, have shown excellent therapeutic effects. Additionally, clinical trials of Exosome-based drug delivery systems further support their potential as drug carriers for cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Huan Zhang, Jie Yang, Rongze Sun, Songren Han, Zhaogang Yang, Lesheng Teng
Summary: In recent years, microfluidic technology has provided unique opportunities for the production of nano drug delivery systems (NDDSs) due to the miniaturization of the fluidic environment. Microfluidics improves the controllability and uniformity of NDDSs, resulting in narrow particle size distribution and high drug-loading capacity. This review comprehensively summarizes the fundamentals, synthesis, and industrialization of microfluidics-based NDDSs, and discusses the challenges and prospects for future development.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Engineering, Biomedical
Yi You, Yu Tian, Zhaogang Yang, Junfeng Shi, Kwang Joo Kwak, Yuhao Tong, Andreanne Poppy Estania, Jianhong Cao, Wei-Hsiang Hsu, Yutong Liu, Chi-Ling Chiang, Benjamin R. Schrank, Kristin Huntoon, DaeYong Lee, Ziwei Li, Yarong Zhao, Huan Zhang, Thomas D. Gallup, JongHoon Ha, Shiyan Dong, Xuefeng Li, Yifan Wang, Wen-Jing Lu, Eman Bahrani, Ly James Lee, Lesheng Teng, Wen Jiang, Feng Lan, Betty Y. S. Kim, Andrew S. Lee
Summary: The study found that extracellular vesicles (EVs) produced through cellular nanoporation can safely and effectively translate genetic material into functional proteins. In mice with photoaged skin, EVs carrying mRNA encoding for collagen induced collagen-protein grafts and reduced wrinkle formation. Intradermal delivery of mRNA-loaded EVs through a microneedle array resulted in prolonged and more uniform synthesis and replacement of collagen in the dermis. Intradermal delivery of EV-based COL1A1 mRNA may be an effective protein-replacement therapy for treating photoaged skin.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Oncology
Qing Zhu, Yixuan Zhang, Mo Li, Ying Zhang, Huan Zhang, Jiayi Chen, Zhaoyang Liu, Peng Yuan, Zhaogang Yang, Xiaobing Wang
Summary: This study identifies the important role of miR-124-3p in metastasis of non-small cell lung cancer (NSCLC) and reveals that miR-124-3p suppresses metastasis through extracellular exosome transport and intracellular PI3K/AKT signaling in NSCLC. These findings provide new insights toward a better understanding of NSCLC metastasis and suggest miR-124-3p as a potential treatment biomarker for NSCLC.
BIOMARKER RESEARCH
(2023)
Article
Chemistry, Physical
Fukun Ma, Shengjing Guan, Dan Liu, Zhimeng Liu, Yongfu Qiu, Changlong Sun, Yan-Jie Wang
Summary: Ge-GaZnON, a Ge-doped GaZnON material, was prepared by a solid state reaction method and its lithium-ion storage performance was studied. After 200 cycles, the capacity of the Ge-GaZnON anode reached 805.9 mAh g-1, much higher than that of the pristine GaZnON anode. Ge doping improved the stability, reaction resistance, and charge transfer kinetics of the lithiation/delithiation processes.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)