Article
Biochemistry & Molecular Biology
Max A. Thorwald, Jose A. Godoy-Lugo, Ruben Rodriguez, Kimber L. Stanhope, James L. Graham, Peter J. Havel, Henry Jay Forman, Rudy M. Ortiz
Summary: The onset of type II diabetes increases the heart's susceptibility to oxidative damage due to inflammation and decreased antioxidant response. This study found that during the progression of T2DM, NF-kappa B related genes increase while Nrf2 genes are suppressed or unchanged, perpetuating inflammation and reducing the heart's ability to handle oxidative stress. These changes likely contribute to cardiovascular complications associated with diabetes.
Article
Environmental Sciences
Xinying Zhao, Alimire Abulikemu, Songqing Lv, Yi Qi, Junchao Duan, Jie Zhang, Rui Chen, Caixia Guo, Yanbo Li, Zhiwei Sun
Summary: Our study investigated the metabolic responses of lung bronchial epithelial cells (BEAS-2B) under silica nanoparticles (SiNPs) exposure using UPLC-MS-based metabolomics research. The results showed that even with low cytotoxicity, SiNPs disturbed global metabolism and perturbed five metabolic pathways, leading to oxidative stress, mitochondrial dysfunction, DNA damage, and membrane integrity rupture in BEAS-2B cells. This study provided novel insights into the mechanisms underlying SiNPs-induced pulmonary toxicity.
Review
Biochemistry & Molecular Biology
Gurjit Kaur Bhatti, Anshika Gupta, Paras Pahwa, Naina Khullar, Satwinder Singh, Umashanker Navik, Shashank Kumar, Sarabjit Singh Mastana, Arubala P. Reddy, P. Hemachandra Reddy, Jasvinder Singh Bhatti
Summary: Mitochondria, the powerhouses of cells, play a vital role in maintaining normal cell functioning and human health. Dysfunctional mitochondria can lead to various diseases, affecting organs with high energy demand. Drugs or compounds targeting mitochondria are considered effective and safe for treating these diseases.
BIOMEDICAL JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Tarun Pant, Nnamdi Uche, Matea Juric, Zeljko J. Bosnjak
Summary: Metabolic imbalances and persistent hyperglycemia in diabetes mellitus drive the production of reactive oxygen species (ROS), leading to vascular complications. Recent studies show that changes in long non-coding RNA (lncRNA) regulate mitochondrial function in oxidative stress. Mitochondria-targeted antioxidants (MTAs) have emerged as a promising therapeutic option for managing oxidative stress-induced diseases. This review discusses the potential of lncRNA as a diagnostic biomarker and regulator of oxidative stress in diabetes-associated vascular complications, as well as the use of MTAs in animal models and clinical trials.
Review
Biochemistry & Molecular Biology
Ramana Vaka, Evangeline Deer, Babbette LaMarca
Summary: Despite extensive research, the pathogenesis of preeclampsia (PE) remains unclear and lacks FDA-approved treatments. Mitochondrial oxidative stress has been identified as a crucial factor in PE development and holds potential as a target for therapy.
Review
Biochemistry & Molecular Biology
Anamaria Jurcau
Summary: With an aging population, the incidence of neurodegenerative diseases is on the rise, and current treatments primarily focus on symptom relief. Preventative measures such as a healthy lifestyle and avoidance of oxidative stress are recommended.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Annu Phogat, Jagjeet Singh, Vinay Malik, Vijay Kumar
Summary: This study aimed to evaluate the ameliorative potential of berberine (BBR) on acetamiprid (ACMP)-induced neurotoxicity. BBR significantly reduced oxidative stress and increased endogenous antioxidants in rat brain regions. It also protected against mitochondrial dysfunction caused by ACMP and modulated the expression of mitochondrial complexes.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria Carolina Jurcau, Felicia Liana Andronie-Cioara, Anamaria Jurcau, Florin Marcu, Delia Mirela Tit, Nicoleta Pascalau, Delia Carmen Nistor-Cseppento
Summary: Alzheimer's disease is a common form of dementia with increasing incidence and mortality rates. Current approved drugs for treatment have little effect on disease progression. Research has identified oxidative stress, mitochondrial dysfunction, and chronic neuroinflammation as key factors, pointing to potential therapeutic targets. Novel molecules and cell-based therapies have shown efficacy in vitro and animal models, but further research is needed for clinical translation.
Article
Biochemistry & Molecular Biology
Thomas B. Shea
Summary: This study reviews the various mechanisms of cognitive decline, neuronal function decrease, and neuronal loss, attributing these to oxidative stress. It suggests that a combination of compounds, rather than individual ones, is optimal for neuronal protection. Compounds providing antioxidant protection are particularly effective in delaying cognitive impairment in the early stages of Mild Cognitive Impairment and Alzheimer's disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yi-Hsuan Wu, Kuang-Shun Chueh, Shu-Mien Chuang, Cheng-Yu Long, Jian-He Lu, Yung-Shun Juan
Summary: The article mainly discusses the impact of overactive bladder syndrome (OAB) on quality of life, the relationship between oxidative stress and OAB, OAB animal models, and potential strategies for using plant antioxidants to treat OAB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jessica F. Hebert, Leslie Myatt
Summary: Obesity and gestational diabetes mellitus can lead to poor maternal and fetal outcomes due to impacts on placental function, particularly when there are changes in the maternal metabolic environment. Gender may influence the placental response. Preventing placental oxidative stress and mitochondrial dysfunction may improve pregnancy outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Jeong-Su Park, Nodir Rustamov, Yoon-Seok Roh
Summary: Chronic liver disease (CLD) is a global health issue that causes a significant number of deaths each year. Non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (ALD) are two distinct forms of CLD, but they both share oxidative stress as a common pathology. Mitochondria, which are vital for liver metabolism, are compromised in diseases like NAFLD, ALD, and liver fibrosis due to inflammation, toxins, and metabolic irregularities. Nuclear factor erythroid 2-related factor 2 (NRF2) emerges as a cellular protector that regulates antioxidant genes and maintains mitochondrial health. The synergy between NRF2 modulation and mitochondrial function provides new therapeutic potentials for CLD by preserving mitochondrial integrity against oxidative threats.
Article
Biochemistry & Molecular Biology
Wenfei Yu, Zhuxun Li, Wenjing Wu, Dandan Zhao, Chuanzhu Yan, Pengfei Lin
Summary: This study investigated the mechanisms underlying telbivudine-induced myopathy and found that it is associated with mitochondrial toxicity and impaired energy metabolism. This provides evidence supporting the common mechanism of NAs causing neuromyopathy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Toxicology
Xiaoqing Xu, Xiaohui Wang, Yaqin Yang, Irma Ares, Marta Martinez, Bernardo Lopez-Torres, Maria-Rosa Martinez-Larranaga, Xu Wang, Arturo Anadon, Maria-Aranzazu Martinez
Summary: This article reviews the effects of neonicotinoids on mitochondria and evaluates the protective effects of various active substances against neonicotinoid-induced toxicity. The research found that neonicotinoids can disrupt mitochondrial calcium ions homeostasis, inhibit mitochondrial respiration, and induce reactive oxygen species production, which leads to damage in non-target organisms. However, several active substances can protect against neonicotinoid-induced systemic toxicity by inhibiting oxidative signaling pathways, apoptosis, and lipid peroxidation. The article emphasizes the importance and urgency of developing neonicotinoid antidotes, with a focus on targeted mitochondrial antidotes.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Chemistry, Analytical
Premkumari Kumarathasan, Nazila Nazemof, Dalibor Breznan, Erica Blais, Hiroyuki Aoki, James Gomes, Renaud Vincent, Sadhna Phanse, Mohan Babu
Summary: This study evaluated the internalization and mitochondrial effects of silica nanoparticles (SiNPs) with different sizes and surface modifications. The findings suggest that physicochemical properties are determinants of SiNP exposure-related mitochondrial effects. Mitochondrial exposures combined with proteomic analysis can serve as a new approach in risk assessment, providing insights into related toxicity mechanisms.
Article
Multidisciplinary Sciences
Levent Albayrak, Vugar Ali Turksoy, Rovshan Khalilov, Aziz Eftekhari
Summary: The study aims to evaluate the levels of trace and heavy metals among COPD patients with acute exacerbation and their impact on the severity and mortality of the disease. The results showed that COPD patients with higher levels of heavy metals had more severe symptoms and higher mortality rates during acute exacerbation.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Pallavi Kishor Vawhal, Shailaja B. Jadhav, Sumit Kaushik, Kahnu Charan Panigrahi, Chandan Nayak, Humaira Urmee, Sharuk L. Khan, Falak A. Siddiqui, Fahadul Islam, Aziz Eftekhari, Abdullah R. Alzahrani, Mohd Fahami Nur Azlina, Md. Moklesur Rahman Sarker, Ibrahim Abdel Aziz Ibrahim
Summary: Recent research has shown that DPP-IV inhibitors can effectively treat type 2 diabetes. This study aimed to develop coumarin-based sulphonamides as potential DPP-IV inhibitors. Among the synthesized compounds, 6i and 6j exhibited the most potent DPP-IV inhibition.
Review
Oncology
Yasin Ahmadi, Javad Khalili Fard, Dlzar Ghafoor, Ali H. Eid, Amirhossein Sahebkar
Summary: In addition to lowering lipid levels, statins have various effects on apoptosis, angiogenesis, inflammation, senescence, and oxidative stress. The effects of statins vary depending on the cell context and the dosage used. High concentrations of statins tend to induce cytotoxic and cytostatic effects, while low concentrations can induce senescence or cytostatic impacts. In cancer cells, statins have been found to induce apoptosis or cell cycle arrest, anti-proliferative effects, and cause senescence, regardless of the concentration. However, the effects of statins on endothelial cells depend on the concentration, with micromolar concentrations causing cell senescence and apoptosis, while nanomolar concentrations have the opposite effect.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Mehmet Firat Baran, Cumali Keskin, Ayse Baran, Aziz Eftekhari, Sabina Omarova, Rovshan Khalilov, Mehmet Tevfik Adican, Gvozden Rosic, Dragica Selakovic, Mahmut Yildiztekin, Kadri Kurt, Canan Aytug Ava, Mehmet Nuri Atalar
Summary: The study aims to determine the chemical composition of Amygdalus communis (AC) leaf extract and investigate the antibacterial and cytotoxic properties of biosynthesized gold nanoparticles (AuNPs). LC-ESI/MS/MS was utilized to identify compounds involved in the synthesis of nanoparticles and their bioactivities. The AC-AuNPs exhibited a spherical shape, with a particle size below 100 nm and a face-centered cubic structure. Evaluation using MTT assay revealed that AC-AuNPs effectively inhibited the proliferation of CaCo-2 cells at concentrations ranging from 25 to 100 µg/mL. The AC-AuNPs also demonstrated strong antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, and Candida albicans. These results highlight the potential of biosynthesized AuNPs from AC leaf extract in antibacterial and anticancer applications.
Article
Biochemistry & Molecular Biology
Mehmet Firat Baran, Cumali Keskin, Ayse Baran, Abdulkerim Hatipoglu, Mahmut Yildiztekin, Selcuk Kucukaydin, Kadri Kurt, Hulya Hosgoren, Md. Moklesur Rahman Sarker, Albert Sufianov, Ozal Beylerli, Rovshan Khalilov, Aziz Eftekhari
Summary: This study focuses on the synthesis and characterization of silver nanoparticles (AgNPs) using Allium cepa peel and evaluates their antimicrobial, antioxidant, and anticholinesterase activities. The biosynthesized nanoparticles were characterized using various techniques, and their crystal size and zeta potential were determined. AC-AgNPs showed strong growth inhibitory activities against specific microorganisms, exhibited antioxidant properties, and demonstrated inhibitory effects on key enzymes. Overall, this eco-friendly and cost-effective method has potential applications in biomedicine and industry.
Article
Biochemistry & Molecular Biology
Aygun Nasibova, Rovshan Khalilov, Mahammad Bayramov, Islam Mustafayev, Aziz Eftekhari, Mirheydar Abbasov, Taras Kavetskyy, Gvozden Rosic, Dragica Selakovic
Summary: A study using EPR spectroscopy on grape snails exposed to gamma radiation found that radiation up to certain doses can induce magnetic properties in the organism. The body of the grape snail showed more generation of iron oxide magnetic nanoparticles compared to the shells. The levels of free radical signals and the EPR signal characterizing iron oxide magnetic nanoparticles varied depending on the dose of radiation. The study also highlighted the potential use of grape snails as bioindicators and analyzed the radionuclide composition and activities in different parts of the snails.
Editorial Material
Neurosciences
Dragica Selakovic, Daoud Ali, Aziz Eftekhari, Nemanja Jovicic, Gvozden Luka Rosic
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Neurosciences
Parvin Zulfugarova, Tayebeh Zivari-Ghader, Sevinj Maharramova, Elham Ahmadian, Aziz Eftekhari, Rovshan Khalilov, Vugar Ali Turksoy, Gvozden Rosic, Dragica Selakovic
Summary: The use of medicinal plants, such as Glycyrrhiza glabra L. (Licorice), has become popular due to their natural ingredients with fewer adverse effects and higher efficacy compared to synthetic alternatives. Licorice has been studied for its therapeutic effects on neural disorders like ischemic stroke, dementia, Alzheimer's disease, and Parkinson's disease, attributed to its HMGB inhibitory function, reactive oxygen scavenging, and anti-inflammatory activity. This review aims to summarize the evidence for the pharmacological effects of licorice and its active components on neurological disorders and the underlying signaling networks, based on papers published until January 2, 2023.
FRONTIERS IN NEUROSCIENCE
(2023)
Editorial Material
Chemistry, Multidisciplinary
Aziz Eftekhari, Rovshan Khalilov, Taras Kavetskyy, Cumali Keskin, Ram Prasad, Gvozden Luka Rosic
FRONTIERS IN CHEMISTRY
(2023)
Article
Energy & Fuels
Mehmet Firat Baran, Cumali Keskin, Ayse Baran, Kadri Kurt, Polat Ipek, Aziz Eftekhari, Rovshan Khalilov, Ismayil Fridunbayov, William C. Cho
Summary: Eco-friendly synthesis of metallic nanoparticles, particularly green-produced selenium nanoparticles, is highly significant for medicinal applications. The plant-mediated synthesis of selenium nanoparticles using waste from the outer skin of Pistachio vera fruit was successfully achieved and characterized. These biogenic nanoparticles showed potential in producing antimicrobial and/or anticancer medications.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Energy & Fuels
Polat Ipek, Mehmet Firat Baran, Ayse Baran, Abdulkerim Hatipoglu, Cumali Keskin, Mahmut Yildiztekin, Selcuk Kucukaydin, Hatice Becerekli, Kadri Kurt, Aziz Eftekhari, Irada Huseynova, Rovshan Khalilov, William C. Cho
Summary: The aim of this study is to develop a simple and eco-friendly method for the synthesis of gold nanoparticles (Au NPs) using extracts from Allium cepa red peel and investigate their antibacterial, antioxidant, and inhibitory effects on AChE and BChE enzymes.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Biochemistry & Molecular Biology
Soheila Montazersaheb, Sevda Jafari, Mutlu Dilsiz Aytemir, Elham Ahmadian, Mohammadreza Ardalan, Murat Zor, Aygun Nasibova, Amirabbas Monirifar, Sara Aghdasi
Summary: The study found that betanin combined with radiation therapy has a synergistic antitumor effect in prostate cancer. This indicates the potential use of betanin as a radiosensitizer agent.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Environmental Sciences
Abdulkerim Hatipoglu, Ayse Baran, Cumali Keskin, Mehmet Firat Baran, Aziz Eftekhari, Sabina Omarova, Dawid Janas, Rovshan Khalilov, Mehmet Tevfik Adican, Sevgi Irtegun Kandemir
Summary: In this study, plant-based silver nanoparticles were synthesized using white radish leaf extract and their antimicrobial and anticancer activities were evaluated. The results showed that the synthesized nanoparticles exhibited strong inhibition against pathogenic bacteria and cancer cell lines, indicating their promising potential in biomedical applications.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Elaheh Jabbari Hagh, Ali Mousavi, Seyyedeh Mina Hejazian, Mehdi Haghi, Samaneh Esfahanian, Elham Ahmadian, Sepideh Zununi Vahed, Mohammadreza Ardalan
Summary: The aim of this study was to investigate the impact of single nucleotide polymorphisms (SNPs) in CYP enzymes, MDR-1, and PXR genes on the metabolism rate of tacrolimus, acute graft rejection, and viral infections. The results showed that the CYP3A5*3 genotype variant had an influence on the metabolism rate of tacrolimus, but no significant association was found between these genes and viral infections or acute graft rejection.
ADVANCED PHARMACEUTICAL BULLETIN
(2023)
Review
Pharmacology & Pharmacy
Ladan Mafakher, Yasin Ahmadi, Javad Khalili Fard, Sajjad Yazdansetad, Sina Rezaei Gomari, Babak Elyasi Far
Summary: This article discusses the widespread use of alpha-amylase in the starch industry and introduces efficient strategies for immobilizing alpha-amylase. Due to the large size of its substrate, immobilization methods often decrease the enzyme's affinity for the substrate and its maximum reaction rate.
PHARMACEUTICAL SCIENCES
(2023)