Review
Pharmacology & Pharmacy
Zirong Pan, Guodong Ma, Linglei Kong, Guanhua Du
Summary: Stroke is an acute cerebrovascular disease caused by sudden rupture or blockage of blood vessels in the brain, and HIF-1 plays an important role in regulating various pathways in the pathological process. The roles of HIF-1 in stroke are controversial, involving factors such as ischemic time and degree, and its regulatory mechanisms include inflammation, autophagy, oxidative stress, and apoptosis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell Biology
Elena V. Mitroshina, Maria O. Savyuk, Evgeni Ponimaskin, Maria V. Vedunova
Summary: Hypoxia is a common pathological condition induced by various events, with the body's adaptation to it being crucial for health and disease. HIFs, a family of transcription factors, play a key role in cellular responses to hypoxia and are increasingly viewed as potential targets for treating a range of hypoxia-associated diseases. The role of HIFs in adaptation to hypoxia is universal across tissue types, including the CNS, where they are involved in regulating neurogenesis, nerve cell differentiation, and neuronal apoptosis, potentially offering new therapeutic opportunities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Min Kyung Park, Jun Ji, Keeok Haam, Tae-Hee Han, Seona Lim, Mi-Jung Kang, Soon Sung Lim, Hyun Seung Ban
Summary: Licochalcone A, a component of Glycyrrhiza uralensis, demonstrates potential as a therapeutic agent in hypoxic cancer cells by inhibiting HIF-1 alpha accumulation and mitochondrial respiration, leading to increased oxygen content and suppression of cancer cell viability.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Geriatrics & Gerontology
Yingjia Guo, Junpeng Zhou, Xianglong Li, Ying Xiao, Jingyao Zhang, Yutao Yang, Li Feng, Y. James Kang
Summary: Elderly rats show defective recovery from ischemic stroke possibly due to suppressed HIF-1 transcription activity. Overexpression of COMMD1 in aged rats leads to impaired HIF-1 transactivation and affects cerebral recovery.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Immunology
Qianyan He, Yinzhong Ma, Jie Liu, Dianhui Zhang, Jiaxin Ren, Ruoyu Zhao, JunLei Chang, Zhen-Ni Guo, Yi Yang
Summary: Ischemic stroke, caused by inadequate cerebrovascular blood and oxygen supply, poses a significant global health burden. HIF-1α, a key regulator of oxygen homeostasis, plays a critical role in various aspects of stroke pathophysiology and is an important target for potential therapeutic interventions. Further research into the differential regulation of HIF-1α in different cell types during ischemic stroke is crucial for understanding the disease mechanism and identifying novel treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Chao Fang, Lei Dai, Cun Wang, Chuanwen Fan, Yongyang Yu, Lie Yang, Hongxin Deng, Zongguang Zhou
Summary: Research showed that SCG2 expression was associated with the survival of CRC patients, and it exhibited anti-tumor and anti-angiogenesis effects by inhibiting HIF-1 alpha/VEGF activity.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Sajad Fakhri, Seyed Zachariah Moradi, Farahnaz Faraji, Leila Kooshki, Kassidy Webber, Anupam Bishayee
Summary: Tumor cells use multiple signaling mediators to escape hypoxia and promote angiogenesis and metastasis. HIF-1 plays a critical role in tumor conditions by stimulating target genes and dysregulated pathways in invasion and migration. Targeting the HIF-1 pathway and its cross-talk mediators may be a novel strategy for cancer prevention and treatment.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Immunology
Essa M. Sabi, Anuja Singh, Ziyad M. Althafar, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harrasi, Hosam M. Alqahtani, Simona Bungau
Summary: Rheumatoid arthritis is a chronic disease that affects millions of people worldwide and is closely associated with factors such as hypoxia and angiogenesis. This review will examine how hypoxia activates molecular pathways and how other pathways involving inflammatory signals develop and sustain synovitis in rheumatoid arthritis.
INFLAMMOPHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Subramanian Muthamil, Hyun Yong Kim, Hyun-Jun Jang, Ji-Hyo Lyu, Ung Cheol Shin, Younghoon Go, Seong-Hoon Park, Hee Gu Lee, Jun Hong Park
Summary: Cancer-associated cachexia (CAC) is a complex disorder characterized by weight loss due to muscle and adipose tissue atrophy. Cachexia is associated with decreased metabolic activity, imbalanced energy uptake-expenditure, catabolism, and inflammation. It is linked to various cancer types and causes more than 50% of cancer-related deaths worldwide. CAC in metastatic cancer patients occurs due to an imbalance between muscle protein synthesis and degradation, influenced by extracellular ligands and signaling pathways. Understanding the HIF-1 pathway and metabolic changes is crucial for developing novel cancer and cachexia therapies.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Integrative & Complementary Medicine
Lijuan Hu, Xiaoqing Xu, Xijuan Chen, Shuai Qiu, Qiuju Li, Dapeng Zhang, Feng Wang
Summary: In this study, it was investigated whether EGCG can decrease HIF-1α expression in pancreatic cancer cells. The results showed that EGCG reduced both the production and stability of HIF-1α, leading to decreased cell growth and tumor development. This study revealed the mechanism of EGCG inhibition in pancreatic cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Oncology
Lin Chen, Lei Bao, Yanling Niu, Jennifer E. Wang, Ashwani Kumar, Chao Xing, Yingfei Wang, Weibo Luo
Summary: This study identified a hypoxia-induced oncogenic lncRNA, named lncIHAT, which promoted survival, tumor growth, and lung metastasis of TNBC cells by regulating the expression of oncogenic genes PDK1 and ITGA6.
MOLECULAR CANCER RESEARCH
(2021)
Review
Plant Sciences
Dan-Li Hao, Jia-Meng Li, Ran Xie, Hai-Ru Huo, Xing-jiang Xiong, Feng Sui, Peng-qian Wang
Summary: Ischemic stroke (IS) is a global health issue, and traditional herbal medicine (THM) has shown potential in improving clinical outcomes and accelerating drug discovery. Clinical trials have demonstrated that THM combined with Western medicine can significantly improve neurological function defect scores, promote clinical total effective rate, and accelerate the recovery time of stroke with fewer adverse effects. These effects can be attributed to multiple mechanisms, including anti-inflammation, antioxidative stress, anti-apoptosis, brain blood barrier modulation, inhibition of platelet activation and thrombus formation, and promotion of neurogenesis and angiogenesis.
Article
Neurosciences
Nian Li, Xu Zhang, Jingwen Zhai, Jiangwen Yin, Ketao Ma, Ruixue Wang, Xinlei Qin, Yan Li, Xiwei Dong, Sheng Wang
Summary: The combination of isoflurane and Netrin-1 has been found to promote angiogenesis, improve neurological function, and reduce cerebral ischemic injury by activating the HIF-1 alpha-Netrin-1-UNC5B/VEGF cascade.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Dermatology
F. Toberer, H. A. Haenssle, M. Heinzel-Gutenbrunner, A. Enk, W. Hartschuh, P. Helmbold, H. Kutzner
Summary: The study highlights the crucial role of HIF-1α in MCC pathogenesis and suggests significant metabolic differences between McPyV(+) and McPyV(-) tumors.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Oncology
Yuan-rui Xu, An-long Wang, Ya-qing Li
Summary: Patients with chronic obstructive pulmonary disease (COPD) are at a higher risk of developing lung cancer due to chronic persistent inflammation and hypoxia, regardless of their smoking history. The role of hypoxia-inducible factor 1-alpha (HIF-1 alpha) in the crosstalk between inflammation and hypoxia is discussed, as it plays a crucial role in COPD progression to lung cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Jianjun Chu, Xiaoshan Yu, Shangshang Yang, Jianfeng Qiu, Qijun Wang
Summary: This paper proposes an evolutionary algorithm for neural network architecture search, introduces a novel indicator to measure population diversity, and suggests effective sampling and encoding strategies to optimize the search process. Experimental results demonstrate that the proposed method outperforms existing comparison methods.
COMPLEX & INTELLIGENT SYSTEMS
(2023)
Article
Business
Qiqi Wang, Xueling Fan, Jun Liu, Wenjing Cai
Summary: This study explores the shift of roles from help giver to help seeker among employees by investigating their help-giving and following help-seeking behavior. The study proposes two contradictory psychological processes, consistency and licensing, for employees to determine whether to seek help after giving help. The study differentiates between autonomous help-seeking and dependent help-seeking and suggests that help-giving has a stronger effect on dependent help-seeking. Leader respect is identified as a moderator to solve the opposite effects of help-giving on subsequent help-seeking. The results show that the negative (positive) relationship between help-giving and dependent help-seeking is mediated by personal reputation and reputation maintenance concerns, while the results regarding autonomous help-seeking are inconsistent. Leader respect weakens the positive relationship between help-giving and autonomous help-seeking in one study and strengthens the negative relationship in two studies. The study discusses theoretical implications for helping literature, self-regulation theory, and moral behavior research.
JOURNAL OF BUSINESS ETHICS
(2023)
Article
Chemistry, Multidisciplinary
Wei Liu, Shi-ou Zhu, Yu-lin Guo, Long-fang Tu, Yong-qi Zhen, Rong-yan Zhao, Liang Ou-Yang, Hiroshi Kurihara, Rong-Rong He, Bo Liu
Summary: Amyotrophic lateral sclerosis (ALS) is a common fatal neurodegenerative disease. The ULK1 activator BL-918 has shown therapeutic potential in treating ALS by inducing cytoprotective autophagy. This study provides further evidence of autophagic dysfunction in ALS pathogenesis.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Mathematics, Applied
Ting Li, Changying Liu, Bin Wang
Summary: In this paper, one-stage explicit trigonometric integrators for solving quasilinear wave equations are formulated and studied. The trigonometric integrators are used as the semidiscretization in time, while a spectral Galerkin method is employed for the discretization in space. It is shown that these integrators have second-order convergence in time and the result holds for the fully discrete scheme without requiring any CFL-type coupling.
Article
Chemistry, Physical
Feihan Yu, Wenxuan Wang, Yudong Li, Minshu Du, Feng Liu, Daxin Liang
Summary: A Fe species (Fe, Fe2O3)/TiO2 catalyst was designed to utilize photogenerated charges and holes, achieving high degradation rate and methane generation. It overcomes the limitations of TiO2 and shows great potential for application.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Thermodynamics
Dong Zhang, Haochun Zhang, Qi Wang, Wenbo Sun
Summary: This study investigates the entropy generation and thermal irreversibility analysis of liquid lead-bismuth eutectic (LBE) in an annular pipe. Computational fluid dynamics (CFD) technique is used to study the convective heat transfer performance. The results indicate that the best thermodynamic performance occurs under parabolic distributed heat flux.
JOURNAL OF THERMAL SCIENCE
(2023)
Article
Engineering, Aerospace
Zongyu Zhang, Qinghua Zeng, An Wang, Hongfu Wang
Summary: A model predictive control (MPC)-based compound control algorithm is proposed to suppress the anti-regulation characteristics of variable flow ducted rockets. A mathematical model is developed to analyze the anti-regulation, and a fused feedback variable is constructed to accurately predict the gas flow and the anti-regulation. Experimental results demonstrate that the proposed method achieves superior performance compared to previous methods in balancing the response rate and the anti-regulation of gas flow systems.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART G-JOURNAL OF AEROSPACE ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
De-Zhi Chen, Qi Wang, Rui-Run Chen, Shu Wang, Yan-Qing Su, Heng-Zhi Fu
Summary: Five Nb-16Si-20Ti-xMgO alloys were prepared, and the effect of MgO addition on their phase composition, microstructure evolution, and mechanical properties was examined. The results showed that MgO reacted with the Nb-Si-Ti alloy, leading to the substitution of Nb atoms by Mg atoms in the Nbss phase. The addition of 3.0 at% MgO transformed the hypoeutectic alloy into a hypereutectic alloy and resulted in a fine Nbss/alpha-Nb5Si3 eutectic structure. The Nb-16Si-20Ti-3MgO alloy exhibited the highest fracture toughness and compressive strength due to its Nbss phase content and Nbss/alpha-Nb5Si3 eutectic structure.
Article
Neurosciences
Hui-xian Yu, Si-hao Liu, Zhao-xia Wang, Chang-bin Liu, Pei Dai, Da-wei Zang
Summary: The study found that botulinum toxin type A injection can improve gait and posture control in patients with lower-limb spasticity post-stroke. It also improves motor functions and forefoot pressure in these patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Engineering, Aerospace
Hongfu Wang, Qinghua Zeng, An Wang, Zongyu Zhang, Weide Liu
Summary: This paper investigates the fault detection and isolation of pressure sensors in gas generators with double pressure feedback. Firstly, a Consistency Index is constructed based on the Principal Component Analysis (PCA) algorithm to evaluate the consistency of measured values. Secondly, the redundancy information of the system is used to estimate the pressure in the gas generator using Kalman's principle. Finally, the gap metric between measured pressure and estimated pressure is employed to characterize the health of the sensors.
INTERNATIONAL JOURNAL OF AEROSPACE ENGINEERING
(2023)
Article
Polymer Science
Guanghui Yang, Xin Ji
Summary: GF/MoS2/PTFE composites were produced with different molding pressures (50-70 MPa), and their mechanical and tribological properties were evaluated. The results showed that the properties of the composites varied depending on the molding pressure. At a molding pressure of 50 MPa, the composites displayed the best mechanical properties. The lowest wear rate and friction coefficient were observed at molding pressures of 60 MPa and 70 MPa, respectively. SEM analysis suggested that increased molding pressure led to greater residual stresses and surface furrows.
HIGH PERFORMANCE POLYMERS
(2023)
Article
Engineering, Mechanical
Changlin Liu, Suet To, Xuexiang Sheng, Jianfeng Xu
Summary: This paper explores the formation mechanism of crystal defects in single-crystal silicon during elliptical vibration cutting (EVC) using molecular dynamics simulation. The study finds that the cutting stage in EVC greatly influences the surface morphology, including elastic recovery and side flow. The preferred slip motion during subsurface damage formation is distinct in the extrusion and shear stage. The influence of cutting temperature and speed on crystal defects formation is also investigated, revealing the increase in proportion of Shockley partial dislocations at elevated temperature and the suppression of crystal defects generation with higher speed ratio.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2023)
Article
Computer Science, Interdisciplinary Applications
Changying Liu, Jiayin Li, Zhenqi Yang, Yumeng Tang, Kai Liu
Summary: In this paper, an energy-preserving collocation integrator is derived for solving hyperbolic Hamiltonian systems. Two specific high-order energy-preserving and symmetric integrators are presented by choosing collocation nodes as two and three Gauss-Legendre points, respectively. The convergence and symmetry of the constructed energy-preserving integrators are rigorously analyzed. Numerical results confirm the energy conservation property and accuracy of the proposed integrators.
MATHEMATICS AND COMPUTERS IN SIMULATION
(2023)
Article
Chemistry, Analytical
Rui Zhang, Jing Zhang, Qiqi Wang, Hehe Zhang
Summary: This paper proposes a DOIDS (Opportunistic Routing Intrusion Detection Scheme) based on the DBSCAN clustering algorithm for detecting routing attacks in UWSNs. By collecting energy consumption, forwarding, and link quality information as feature values and using the DBSCAN clustering algorithm to detect potential abnormal nodes. Finally, a decision function is defined according to the time decay function to determine whether the potential abnormal node is malicious.
Article
Green & Sustainable Science & Technology
Zihua Yin, Xi Lu, Shi Chen, Jiaxing Wang, Jie Wang, Johannes Urpelainen, Rachael Marie Fleming, Ye Wu, Kebin He
Summary: Electrification and power decarbonization are important for low-carbon energy transition, but their combined effects on CO2 emissions have not been fully understood. This study uses the LMDI model to analyze the effects of electrification and power decarbonization on CO2 emissions in China, the U.S., and the EU between 1997 and 2020. The results show that electrification and power decarbonization played a significant role in reducing CO2 emissions in these regions. However, there are differences in the driving factors of electrification and power decarbonization across the three regions. The study also suggests measures to accelerate electrification in the U.S. and the EU to achieve their 2030 climate targets.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
