Journal
INFLAMMATION
Volume 35, Issue 3, Pages 871-880Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-011-9388-3
Keywords
sepsis; vasoactive agents; inflammatory responses; oxygenation
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Funding
- Six Talent Summit Foundation of Jiangsu Province
- Changzhou Health Bureau Foundation
- Jinling Hospital Foundation
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This study aims to determine whether levosimendan combined with arginine vasopressin infusion supplemented with norepinephrine can improve hemodynamics and pulmonary dysfunction. The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group. Levosimendan combined with arginine vasopressin supplemented with norepinephrine infusion shows potential benefit in sepsis-induced acute lung injury by decreasing mean pulmonary artery pressure and attenuating inflammatory responses in the lung compared to norepinephrine infusion alone.
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