Article
Plant Sciences
Yu Wang, Xu Liu, Tingdong Hu, Xin Li, Yuru Chen, Guangxu Xiao, Juyang Huang, Yanxu Chang, Yan Zhu, Han Zhang, Ying Wang
Summary: The study demonstrated that pretreatment with Astragalus saponins could protect against experimental stroke by enhancing proliferation of NSCs through targeting Akt. These findings provide a basis for the development of novel strategies for stroke treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Edward J. Calabrese
Summary: This paper provides a detailed assessment of hormetic dose responses in adipose-derived stem cells (ADSCs) of animal models and humans, showing that hormetic dose responses are commonly reported for ADSCs and may have a determinant role in potential clinical applications.
PHARMACOLOGICAL RESEARCH
(2021)
Editorial Material
Cell & Tissue Engineering
Deepa Bhartiya
Summary: The tissue homeostasis of adult tissues is believed to be maintained by resident stem cells, but isolating these quiescent stem cells has proven difficult. Recent single-cell RNAseq studies have not been able to detect stem cells in several adult tissues, possibly because they were unknowingly discarded during processing.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ozlem Altundag, Hande Canpinar, Betul Celebi-Saltik
Summary: Methionine plays a critical role in the activity, self-renewal, and gene expression of stem cells. Different types of stem cells have varying responses to methionine metabolism, as well as differences in epigenetic regulation.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Kefei Nina Li, Tudorita Tumbar
Summary: Stem cells, particularly hair follicle stem cells, actively communicate with their microenvironment by sending out signals; the reconstruction of stem cell niches is crucial for skin homeostasis and regeneration; the interaction between hair follicle stem cells and their niches provides important insights into skin biology.
Review
Biochemistry & Molecular Biology
Pieter Jan Koopmans, Ahmed Ismaeel, Katarzyna Goljanek-Whysall, Kevin A. Murach
Summary: This article provides evidence for the role of miRNAs in controlling satellite cell function in adult skeletal muscle. It emphasizes the indispensability of miRNAs for satellite cell viability and the phases of myogenesis. The interplay between miRNAs and myogenic cell redox status, senescence, and communication to other muscle-resident cells during muscle adaptation is also discussed. Recent satellite cell miRNA profiling studies are summarized, and the need for novel genetic tools to further investigate miRNA control of satellite cell behavior in adult skeletal muscle in vivo is identified.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Oncology
Isabella Maria Mayer, Andrea Hoelbl-Kovacic, Veronika Sexl, Eszter Doma
Summary: Transplantation of adult hematopoietic stem cells is crucial for treating hematological disorders, while leukemic stem cells play a significant role in disease initiation and relapse. Understanding methods to maintain and expand hematopoietic cells, as well as isolate and enrich hematopoietic stem cells and leukemic stem cells, is essential for developing therapeutic strategies.
Review
Cell Biology
Jennifer Steens, Diana Klein
Summary: Stem cells have the unique ability to self-renew and differentiate into specialized cells. Adult stem cells exhibit limited differentiation capabilities determined by their tissue of origin. HOX genes, as master regulators of cell identity and fate, play a role in embryogenesis and maintaining positional identity. Understanding the regulation of HOX genes in stem cells may lead to advancements in regenerative medicine.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Claudia Curci, Angela Picerno, Nada Chaoul, Alessandra Stasi, Giuseppe De Palma, Rossana Franzin, Paola Pontrelli, Giuseppe Castellano, Giovanni B. Pertosa, Luigi Macchia, Vito Francesco Di Lorenzo, Carlo Sabba, Anna Gallone, Loreto Gesualdo, Fabio Sallustio
Summary: Studies have shown that Adult Renal Stem/Progenitor Cells (ARPCs) can regulate immune responses by inducing Tregs and DN T cell modulation, which play a crucial role in maintaining immune tolerance and preventing autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Zhiyuan Ji, Wei Guo, Xifeng Chen, Chunlian Wang, Kaijun Zhao
Summary: Executor (E) genes are a new type of plant resistance genes that activate expression and trigger hypersensitive response (HR) in plants by trapping TALEs released by pathogens. Utilizing E gene resistance plays a significant role in disease resistance breeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Amy Reilein, Helen Kogan, Rachel Misner, Karen Sophia Park, Daniel Kalderon
Summary: In adult Drosophila ovaries, the development of follicle stem cells and niche cells is regulated by signals from both anterior and posterior sources, leading to appropriate spatial organization through controlled proliferative expansion and establishment of signaling cues.
Review
Cell Biology
Yo Mabuchi, Chikako Okawara, Simon Mendez-Ferrer, Chihiro Akazawa
Summary: This study discusses the heterogeneous nature of mesenchymal cell populations, integrating single-cell analysis data to enhance understanding, while outlining the cell populations involved in the development of myeloproliferative neoplasms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yammy Yung, Emily Lee, Hiu-Tung Chu, Pui-Kwan Yip, Harinder Gill
Summary: Myeloproliferative neoplasms (MPNs) are hematopoietic stem cell disorders characterized by clonal myeloproliferation. Despite effective treatment, complete eradication of CML/MPN stem cells is rare. Novel agents and combination therapy have potential to target abnormal hematopoietic stem cells and the sustaining bone marrow microenvironment in CML and MPNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Fang Wang, Minghu Zhang, Yanling Hu, Meijuan Gan, Bo Jiang, Ming Hao, Shunzong Ning, Zhongwei Yuan, Xuejiao Chen, Xue Chen, Lianquan Zhang, Bihua Wu, Dengcai Liu, Lin Huang
Summary: This study investigated the combination of multiple resistance genes to increase the durability of wheat resistance to stripe rust. The results showed that a minimum of two-gene combinations can provide adequate resistance, and these combinations also showed resistance at the seedling stage.
Article
Plant Sciences
Anjan Kumar Pradhan, Neeraj Budhlakoti, Dwijesh Chandra Mishra, Pramod Prasad, S. C. Bhardwaj, Sindhu Sareen, M. Sivasamy, P. Jayaprakash, M. Geetha, R. Nisha, P. Shajitha, John Peter, Amandeep Kaur, Satinder Kaur, V. K. Vikas, Kuldeep Singh, Sundeep Kumar
Summary: We identified 20 reliable quantitative trait loci (QTLs) for seedling and adult plant resistance to stem rust in a association mapping panel of 400 germplasm accessions. Gene ontology analysis identified 21 potential candidate genes underlying these QTLs, including a leucine rich repeat receptor (LRR) and P-loop nucleoside triphosphate hydrolase. Four of the QTLs were validated using the KASP method, and these QTLs have the potential to be used in wheat improvement programs for developing disease resistant varieties.