The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy

Three cachexia phenotypes and the impact of fat-only loss on survival in FOLFIRINOX therapy for pancreatic cancer

(2018) Joshua K. Kays et al.   Journal of Cachexia Sarcopenia and Muscle

Cancer-associated cachexia

(2018) Vickie E. Baracos et al.   Nature Reviews Disease Primers

Circulating Activin A predicts survival in cancer patients

(2017) Audrey Loumaye et al.   Journal of Cachexia Sarcopenia and Muscle

Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle

(2017) Juha J. Hulmi et al.   Journal of Cachexia Sarcopenia and Muscle

Establishment and characterization of a novel murine model of pancreatic cancer cachexia

(2017) Katherine A. Michaelis et al.   Journal of Cachexia Sarcopenia and Muscle

Ethical guidelines for publishing in the journal of cachexia, sarcopenia and muscle: update 2017

(2017) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis

(2017) Akihiro Kita et al.   Journal of Cancer

UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses

(2017) Darshan S. Chandrashekar et al.   NEOPLASIA

ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass

(2017) Rafael Barreto et al.   Scientific Reports

Clinical Impact of Cystatin C/Cathepsin L and Follistatin/Activin A Systems in Breast Cancer Progression: A Preliminary Report

(2016) Gaetano Leto et al.   CANCER INVESTIGATION

Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

(2016) Justin L. Chen et al.   CANCER RESEARCH

Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma – A multi-institutional study

(2016) Mir Alireza Hoda et al.   EUROPEAN JOURNAL OF CANCER

Growth differentiating factor-15 (GDF-15): A potential biomarker and therapeutic target for cancer-associated weight loss

(2016) Lorena Lerner et al.   Oncology Letters

Activin A induces skeletal muscle catabolism via p38β mitogen-activated protein kinase

(2016) Hui Ding et al.   Journal of Cachexia Sarcopenia and Muscle

ActRII blockade protects mice from cancer cachexia and prolongs survival in the presence of anti-cancer treatments

(2016) Shinji Hatakeyama et al.   Skeletal Muscle

Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer

(2015) Yosuke Togashi et al.   CANCER LETTERS

Complete reversal of muscle wasting in experimental cancer cachexia: Additive effects of activin type II receptor inhibition and β-2 agonist

(2015) Míriam Toledo et al.   INTERNATIONAL JOURNAL OF CANCER

Role of Activin A and Myostatin in Human Cancer Cachexia

(2015) Audrey Loumaye et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Nonmuscle Tissues Contribution to Cancer Cachexia

(2015) Josep M. Argilés et al.   MEDIATORS OF INFLAMMATION

Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A

(2015) Moitri Basu et al.   Molecular Cancer

Development of Novel Activin-Targeted Therapeutics

(2015) Justin L Chen et al.   MOLECULAR THERAPY

Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling

(2015) Siyuan Xiong et al.   Oncotarget

Activin-βCmodulates cachexia by repressing the ubiquitin-proteasome and autophagic degradation pathways

(2015) Francesco Elia Marino et al.   Journal of Cachexia Sarcopenia and Muscle

Validation of the Consensus-Definition for Cancer Cachexia and evaluation of a classification model--a study based on data from an international multicentre project (EPCRC-CSA)

(2014) D. Blum et al.   ANNALS OF ONCOLOGY

Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer

(2014) Yosuke Togashi et al.   Molecular Cancer

Conversion of Human Pancreatic Acinar Cells Toward a Ductal-Mesenchymal Phenotype and the Role of Transforming Growth Factor β and Activin Signaling

(2014) Evelien De Waele et al.   PANCREAS

Pancreatic cancer cachexia: a review of mechanisms and therapeutics

(2014) Carlyn R. Tan et al.   Frontiers in Physiology

Intertwining of Activin A and TGFβ Signaling: Dual Roles in Cancer Progression and Cancer Cell Invasion

(2014) Holli Loomans et al.   Cancers

Non-invasive assessment of cardiac hemodynamics in patients with advanced cancer and with chronic heart failure: a pilot feasibility study

(2013) Stephan von Haehling et al.   Archives of Medical Science

Elevated expression of activins promotes muscle wasting and cachexia

(2013) Justin L. Chen et al.   FASEB JOURNAL

Circulating activin-A is elevated in patients with advanced multiple myeloma and correlates with extensive bone involvement and inferior survival; no alterations post-lenalidomide and dexamethasone therapy

(2012) E. Terpos et al.   ANNALS OF ONCOLOGY

Activin A StimulatesAKR1C3Expression and Growth in Human Prostate Cancer

(2012) Johannes Hofland et al.   ENDOCRINOLOGY

Activin-βcreduces reproductive tumour progression and abolishes cancer-associated cachexia in inhibin-deficient mice

(2012) Elspeth Gold et al.   JOURNAL OF PATHOLOGY

Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy

(2011) Enza Lonardo et al.   Cell Stem Cell

Generation of a Specific Activin Antagonist by Modification of the Activin A Propeptide

(2011) Yogeshwar Makanji et al.   ENDOCRINOLOGY

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Regulation of activin and inhibin in the adult testis and the evidence for functional roles in spermatogenesis and immunoregulation

(2011) Mark P. Hedger et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Altered expression of genes in adipose tissues associated with reduced fat mass in patients with pancreatic cancer

(2011) F. Haugen et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

(2010) Xiaolan Zhou et al.   CELL

Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia

(2009) Margaret E. Benny Klimek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS