Review
Dentistry, Oral Surgery & Medicine
Promphakkon Kulthanaamondhita, Chatvadee Kornsuthisopon, Suphalak Photichailert, Jeeranan Manokawinchoke, Phoonsuk Limraksasin, Thanaphum Osathanon
Summary: This systematic review explores the various functions of microRNAs (miRNAs) in regulating the behavior of dental pulp stem cells (DPSCs). miRNAs play a crucial role in modulating the stemness, differentiation, and inflammatory processes of DPSCs. Understanding these roles of miRNAs is important for the development of new therapeutics in regenerative dental medicine, and miRNA technology could revolutionize the future of regenerative endodontics.
JOURNAL OF ENDODONTICS
(2022)
Article
Cell Biology
Edward J. Calabrese, Evgenios Agathokleous, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese
Summary: This study represents the first assessment of hormetic dose responses by human dental pulp stem cells, focusing on cell renewal and differentiation. The study found that hormetic dose responses are commonly observed in this model, involving a wide range of chemicals including pharmaceuticals, dietary supplements/extracts from medicinal plants, and endogenous agents. The study evaluated the mechanistic foundations, study design considerations, and therapeutic implications of the hormetic dose responses in hDPSCs.
AGEING RESEARCH REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Wang Wang, Jiangling Sun, Ghazal Aarabi, Ulrike Peters, Frank Fischer, Jan Klatt, Martin Gosau, Ralf Smeets, Thomas Beikler
Summary: The study evaluated the effects of TCH on DPSCs. DPSC cells were sequestered and cell proliferation and migration abilities decreased at TCH concentrations higher than 250 μg/ml. Osteogenic and adipogenic differentiation abilities of DPSCs were inhibited at TCH concentrations higher than 50 μg/ml. The expression of osteogenic genes, lipogenic genes, and PPARγ were down-regulated in these conditions.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Junkai Zeng, Ming Chen, Yeqing Yang, Buling Wu
Summary: A total of 496 novel lncRNAs were identified in hDPSCs under hypoxia, with 45 of them being differentially expressed. A key novel lncRNA named HRL-SC was found to promote the proliferation and migration of hDPSCs through the PI3K/AKT signaling pathway.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Engineering, Biomedical
Jay R. K. Samal, Vignesh K. Rangasami, Sumanta Samanta, Oommen P. Varghese, Oommen P. Oommen
Summary: Studies have shown that culturing MSCs in a low oxygen environment can upregulate stem cell markers and promote cell proliferation in an undifferentiated state. However, there is ambiguity in the results due to differences in oxygen gradients and culture conditions among different studies. This progress report focuses on conflicting findings related to the application of hypoxic conditions for improving MSC proliferation or differentiation, aiming to decipher the factors influencing MSC characteristics under hypoxia.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Chiyu Li, Fanqi Meng, Zhijie Yang, Jiang Peng, Yuwei Guo, Jing Na, Qiusheng Shi, Yu Liu, Yu Wang, Lisha Zheng, Yubo Fan
Summary: A micropattern-based system is developed to train dental pulp stem cells and enhance their stemness and differentiation potential. Micropatterns remodel cellular structures, induce immature mitochondrial state, and activate specific signaling pathways to enhance stemness. In vivo implantation proves the effectiveness of this approach in promoting nerve regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Y. Han, M. Koohi-Moghadam, Q. Chen, L. Zhang, H. Chopra, J. Zhang, W. L. Dissanayaka
Summary: Stabilization of HIF-1 alpha enhances the survival of stem cells from human exfoliated deciduous teeth (SHED) and promotes dental pulp regeneration. This method reduces cell apoptosis, enhances vascularization and dentin formation, and modulates multiple target genes and signaling pathways.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Cell & Tissue Engineering
Mohammed Zayed, Koichiro Iohara, Hideto Watanabe, Mami Ishikawa, Michiyo Tominaga, Misako Nakashima
Summary: The study found that hypoxia-preconditioned DPSCs (hpDPSCs) have advantages in proliferation rate and stemness, making them a potential effective source for pulp regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Baoyu Li, Xuehong Xian, Xinwei Lin, Luo Huang, Ailin Liang, Hongwei Jiang, Qimei Gong
Summary: Hypoxia enhances the angiogenic potential of dental pulp stem cell exosomes (Exos) and partially alters their proteome profile. Lysyl oxidase-like 2 (LOXL2) is likely involved in hypoxia-preconditioned DPSC-Exos mediated angiogenesis.
Article
Biochemistry & Molecular Biology
Cristina- Bucchi, Ella Ohlsson, Josep Maria de Anta, Melanie Woelflick, Kerstin Galler, Maria Cristina Manzanares-Cespedes, Matthias Widbiller
Summary: Pluripotent stem cells derived from the amnion show the ability to adhere to dentin and mineralize in vitro, but exhibit unfavorable proliferation behavior and fail to undergo odontoblastic transition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Shilpa Bhandi, Ahmed Al Kahtani, Mohammed Mashyakhy, Loai Alsofi, Prabhadevi C. Maganur, Satish Vishwanathaiah, Luca Testarelli, Andrea Del Giudice, Deepak Mehta, Nishant Vyas, Vikrant R. Patil, A. Thirumal Raj, Shankargouda Patil
Summary: The CoCl2 treatment-induced hypoxic environment can modulate the secretory profile of dental pulp stem cells (DPSCs) and alter the levels of growth factors and cytokines, which in turn affect the maintenance of stemness.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Begona M. Bosch, Enrique Salero, Raquel Nunez-Toldra, Alfonso L. Sabater, F. J. Gil, Roman A. Perez
Summary: The failure of corneal endothelium cell monolayer is a major reason for corneal transplantation. This study proposes the use of dental pulp stem cells as an autologous cell source to reconstruct the corneal endothelium cell monolayer, bypassing ethical issues and limited clinical applications. Through a two-step differentiation protocol, dental pulp stem cells were successfully converted into corneal endothelial-like cells, demonstrating the potential for patient-derived cell therapies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhongjun Liu, Siwei Li, Shuaimei Xu, Nu Er Bi Ya Bu Du Xi Ku, Jun Wen, Xiongqun Zeng, Xiaoqing Shen, Pingping Xu
Summary: In this study, the expression profiles of circRNAs in DPSC osteo/odontogenic differentiation were analyzed. The results showed that circ_0005044 and FOSL1 were upregulated, while miR-296-3p was downregulated in this process. Knocking down circ_0005044 or overexpressing miR-296-3p significantly inhibited osteogenesis. The circ_0005044/miR-2964-3p/FOSL1 axis regulates DPSC osteo/odontogenic differentiation, suggesting potential molecular targets for dental-pulp complex regeneration.
DNA AND CELL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Seyedeh Sareh Hendi, Leila Gholami, Massoud Saidijam, Roghayeh Mahmoudi, Ali Asghar Arkian, Hengameh Bakhtiyar, Nasrin Haji Hasani, Saeid Afshar
Summary: The study found a significant positive effect of laser irradiation on cell proliferation under different nutritional conditions, but no statistically significant stimulatory effect on gene expression levels. Further research is needed to obtain an ideal irradiation setup to improve the proliferation and differentiation of inflamed dental pulp stem cells.
REGENERATIVE MEDICINE
(2022)
Article
Cell & Tissue Engineering
Mohamed Elashry, Mebrie Kinde, Michele C. Klymiuk, Asmaa Eldaey, Sabine Wenisch, Stefan Arnhold
Summary: In this study, it was found that exposure to hypoxia enhanced the proliferation and motility of skeletal muscle-derived stem cells, promoted the differentiation of muscle and adipocytes, and improved the efficiency of myoblast differentiation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Nanoscience & Nanotechnology
Daikelly Iglesias Braghirolli, Fernanda Zamboni, Erson A. X. Acasigua, Patricia Pranke
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2015)
Article
Polymer Science
Michele Greque de Morais, Christopher Stillings, Roland Dersch, Markus Rudisile, Patricia Pranke, Jorge Alberto Vieira Costa, Joachim Wendorff
POLIMEROS-CIENCIA E TECNOLOGIA
(2015)
Article
Biotechnology & Applied Microbiology
Michele Greque de Morais, Christopher Stillings, Roland Dersch, Markus Rudisile, Patricia Pranke, Jorge Alberto Vieira Costa, Joachim Wendorff
BIOMED RESEARCH INTERNATIONAL
(2015)
Review
Pharmacology & Pharmacy
Laura E. Sperling, Karina P. Reis, Patricia Pranke, Joachim H. Wendorff
DRUG DISCOVERY TODAY
(2016)
Article
Pharmacology & Pharmacy
Flavio Fonseca Veras, Isabel Roggia, Patricia Pranke, Claudio Nunes Pereira, Adriano Brandelli
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2016)
Article
Dentistry, Oral Surgery & Medicine
Stefanie Bressan Werle, Pedro Chagastelles, Patricia Pranke, Luciano Casagrande
CLINICAL ORAL INVESTIGATIONS
(2019)
Review
Pharmacology & Pharmacy
Daniela Steffens, Daikelly I. Braghirolli, Natasha Maurmann, Patricia Pranke
DRUG DISCOVERY TODAY
(2018)
Review
Biophysics
Agata Paim, Isabel C. Tessaro, Nilo S. M. Cardozo, Patricia Pranke
JOURNAL OF BIOLOGICAL PHYSICS
(2018)
Review
Biology
Agata Paim, Nilo S. M. Cardozo, Isabel C. Tessaro, Patricia Pranke
MATHEMATICAL BIOSCIENCES
(2018)
Review
Pharmacology & Pharmacy
Daikelly I. Braghirolli, Daniela Steffens, Patricia Pranke
DRUG DISCOVERY TODAY
(2014)
Article
Polymer Science
Guilherme Canete Vebber, Patricia Pranke, Claudio Nunes Pereira
JOURNAL OF APPLIED POLYMER SCIENCE
(2014)
Review
Chemistry, Multidisciplinary
Michele Greque de Morais, Vilasia Guimaraes Martins, Daniela Steffens, Patricia Pranke, Jorge Alberto Vieira da Costa
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2014)
Article
Cell & Tissue Engineering
Patricia Pranke, Pedro Chagastelles, Laura E. Sperling
STEM CELLS AND DEVELOPMENT
(2014)
Article
Engineering, Chemical
Agata Paim, Nilo S. M. Cardozo, Patricia Pranke, Isabel C. Tessaro
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
(2019)
Article
Dentistry, Oral Surgery & Medicine
Engku Nasiha Engku Ngah Sayuddin, Muhammad Taher, Mohd Hafiz Arzmi, Nor Aszlitah Burhanudin, Muhamad Ashraf Rostam
Summary: This article reviews the role of podoplanin in oral cancer and its potential as a therapeutic agent. High expression of podoplanin has been observed in oral cancer and pre-cancerous lesions, suggesting that inhibitors targeting podoplanin could be effective in treating oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Doris Haydee Rosero Salazar, Sydney Honnlee, Zi-Jun Liu
Summary: This study analyzed the dynamics and coordination of oropharyngeal muscles during natural chewing and swallowing, revealing the key role of palatal and pharyngeal muscles in chewing and the simultaneous changes in muscle activity and respiratory cycle during these processes.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Junkang Quan, Yang Liu, Lingli Ji, Yuming Zhao, Shuguo Zheng
Summary: This study identified a new DLX3 gene mutation in a Chinese family with enamel dysplasia and found that this mutation may affect ameloblast differentiation by inhibiting the transcriptional activity of Amelx/Odam/Klk4, thereby interfering with enamel formation.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Viviane Martins dos Santos Ribeiro, Mauricio Gonsalves da Costa Sousa, Paula Ribeiro Garcia, Lucas Souza dos Santos, Eliza Carla Barroso Duarte, Jose Raimundo Correa, Carlos Alberto Labate, Thais Regiani Cataldi, Rosiane Andrade da Costa, Marcelo Henrique Soller Ramada, Juliana Lott de Carvalho, Taia Maria Berto Rezende
Summary: This study compared the structural and proteomic architecture of decellularized human dental pulp using two different protocols. The results showed that the ECM preserved in the MG protocol was more intact. Proteomic analysis revealed that the MG protocol maintained around 69.56% of the proteins identified in the untreated pulp tissue, while the SG protocol only maintained 28.26%.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Jinjin Lu, Lixin Zhang, Ningxin Zhu, Dan Wang, Fei Xie, Man Qin, Yuanyuan Wang
Summary: The study investigated the effects of varying glucose concentrations on the proliferation and senescence of SHED and hBMSC. It was found that high glucose levels promoted proliferation in both cell types, but delayed senescence in SHED through autophagy inhibition and accelerated senescence in hBMSC. Additionally, the glycolysis in SHED was enhanced under high glucose culture conditions compared to hBMSC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Luciana O. Almeida, Luan Cesar Silva, Carolina Emerick, Juliana Amorim dos Santos, Rogerio M. Castilho, Cristiane H. Squarize
Summary: This study found that the loss of PTEN signaling increases the population of HNSCC CSCs, which can be targeted by rapamycin. However, a deficiency in mTORC2 can lead to problematic selection of the parasphere CSC subtype.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Elham Mohebbi, Zainab Alimoradi, Laura S. Rozek, Azadeh Mohebbi, Elahe Jafari
Summary: This study conducted a systematic review and meta-analysis to investigate the risk of head and neck cancer among opium users. The findings showed a significant correlation between opium use and the development of head and neck cancers, particularly lip and oral cavity cancers and laryngeal cancer. This highlights the importance of further research and targeted preventive measures to address this concerning association.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Antonio Alexandre Coelho, Rute Romao Carvalho, Ana Luiza Muniz, Andre Alves Crispim, Anderson Maia Meneses, Carla Welch da Silva, Dayrine Silveira de Paula, Ana Paula Negreiros Nunes Alves, Fabricio Bitu Sousa, Paulo Goberlanio de Barros Silva
Summary: The study aimed to evaluate the role of CD20 + cells in the healing process of oral traumatic ulcers (OTU) in rats. The results showed that blocking CD20 + cells with anti-CD20 rituximab (RTX) reduced cell migration, acute inflammation, and wound healing in OTU.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Meimei Cui, Jinling Cheng, Huijuan Cheng, Ming Zhao, Dan Zhou, Min Zhang, Jingjing Jia, Limei Luo
Summary: This study explored the characteristics of human papillomavirus (HPV) in oropharyngeal carcinoma (OPC) and found that high-risk HPV infection is common in OPC patients, with higher prevalence in North America, Oceania, and Europe. Females and older patients are more susceptible to infection. Tonsil and base of tongue are the most frequent sites of infection. This study provides important theoretical basis for the prevention and treatment of OPC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyue Guan, Chen Shi, Yuting Wang, Yani He, Yingxue Li, Yao Yang, Wenli Mu, Wenlan Li, Tiezhou Hou
Summary: The study revealed that Gremlin1 expression levels are significantly increased in periapical lesions and may be positively correlated with IL-18 levels. Blocking Gremlin1 can significantly suppress bone resorption loss and restrain inflammatory status by affecting the activation levels of phosphorylated-CREB, ICAM-1, VCAM-1, IL-18.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Giliano Nicolini Verzeletti, Eduardo Jose Gaio, Keilla Gomes Machado, Tobias Rauber Spuldaro, Clarissa Favero Demeda, Rafaele Frassini, Andre Felipe Streck, Sidnei Moura E. Silva, Cassiano Kuchenbecker Rosing, Joao Antonio Pegas Henriques, Mariana Roesch-Ely
Summary: This study investigates the effects of D. anceps seaweed on ligature-induced experimental periodontitis in rats. The results show that D. anceps can modulate the inflammatory response and have potential therapeutic effects for periodontitis.
ARCHIVES OF ORAL BIOLOGY
(2024)
