Animal Models of PTSD: The Socially Isolated Mouse and the Biomarker Role of Allopregnanolone

Increased 5-HT2C receptor editing predisposes to PTSD-like behaviors and alters BDNF and cytokines signaling

(2019) Mathilde Règue et al.   Translational Psychiatry

Activation of PPAR-α by N-palmitoylethanolamine engages allopregnanolone biosynthesis to modulate emotional behavior

(2019) Andrea Locci et al.   BIOLOGICAL PSYCHIATRY

Animal models of post-traumatic stress disorder and novel treatment targets

(2019) Dario Aspesi et al.   BEHAVIOURAL PHARMACOLOGY

Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans

(2019) Jacob Raber et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress

(2018) Moriel Zelikowsky et al.   CELL

Endogenous neurosteroids influence synaptic GABAA receptors during postnatal development

(2018) D. Belelli et al.   JOURNAL OF NEUROENDOCRINOLOGY

Histone deacetylases mediate GABAA receptor expression, physiology, and behavioral maladaptations in rat models of alcohol dependence

(2018) John Peyton Bohnsack et al.   NEUROPSYCHOPHARMACOLOGY

27 ways to meet PTSD: Using the PTSD-checklist for DSM-5 to examine PTSD core criteria

(2018) C. Laurel Franklin et al.   PSYCHIATRY RESEARCH

PTSD in women is associated with a block in conversion of progesterone to the GABAergic neurosteroids allopregnanolone and pregnanolone measured in plasma

(2018) S.L. Pineles et al.   PSYCHONEUROENDOCRINOLOGY

Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials

(2018) Samantha Meltzer-Brody et al.   LANCET

Biomarkers for PTSD at the Interface of the Endocannabinoid and Neurosteroid Axis

(2018) Graziano Pinna   Frontiers in Neuroscience

Could a blood test for PTSD and depression be on the horizon?

(2018) Dario Aspesi et al.   Expert Review of Proteomics

Social isolation as a promising animal model of PTSD comorbid suicide: neurosteroids and cannabinoids as possible treatment options

(2018) Andrea Locci et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Modelling posttraumatic stress disorders in animals

(2018) Bibiana Török et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD

(2018) Ann M. Rasmusson et al.   PSYCHONEUROENDOCRINOLOGY

Open-label, proof-of-concept study of brexanolone in the treatment of severe postpartum depression

(2017) Stephen J. Kanes et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Ethanol Exposure Regulates Gabra1 Expression via Histone Deacetylation at the Promoter in Cultured Cortical Neurons

(2017) John Peyton Bohnsack et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Extinction of avoidance behavior by safety learning depends on endocannabinoid signaling in the hippocampus

(2017) Vincenzo Micale et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial

(2017) Stephen Kanes et al.   LANCET

Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum

(2017) Laura E Dichtel et al.   NEUROPSYCHOPHARMACOLOGY

Considering future pharmacotherapy for PTSD

(2017) Matthew J. Friedman et al.   NEUROSCIENCE LETTERS

Neuroactive steroids and PTSD treatment

(2017) Ann M. Rasmusson et al.   NEUROSCIENCE LETTERS

Social Isolation in Early versus Late Adolescent Mice Is Associated with Persistent Behavioral Deficits That Can Be Improved by Neurosteroid-Based Treatment

(2017) Andrea Locci et al.   Frontiers in Cellular Neuroscience

Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stress

(2016) Shane A. Perrine et al.   BEHAVIOURAL BRAIN RESEARCH

Stress-based animal models of depression: Do we actually know what we are doing?

(2016) Xin Yin et al.   BRAIN RESEARCH

Neurobiology of comorbid post-traumatic stress disorder and alcohol-use disorder

(2016) N. W. Gilpin et al.   GENES BRAIN AND BEHAVIOR

Neurosteroids and potential therapeutics: Focus on pregnenolone

(2016) Monique Vallée   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders

(2016) Ryan Shepard et al.   NEUROSCIENCE

Social isolation mediated anxiety like behavior is associated with enhanced expression and regulation of BDNF in the female mouse brain

(2016) Anita Kumari et al.   PHYSIOLOGY & BEHAVIOR

The epidemiology of post-traumatic stress disorder in Norway: trauma characteristics and pre-existing psychiatric disorders

(2016) Eva Lassemo et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

The epidemiology of DSM-5 posttraumatic stress disorder in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions-III

(2016) Risë B. Goldstein et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

Isolation Rearing Reduces Neuronal Excitability in Dentate Gyrus Granule Cells of Adolescent C57BL/6J Mice: Role of GABAergic Tonic Currents and Neurosteroids

(2016) Giuseppe Talani et al.   Frontiers in Cellular Neuroscience

Influence of daily social stimulation on behavioral and physiological outcomes in an animal model of PTSD

(2016) Shyam Seetharaman et al.   Brain and Behavior

Improving the Prediction of Treatment Response in Depression: Integration of Clinical, Cognitive, Psychophysiological, Neuroimaging, and Genetic Measures

(2016) Andrew H. Kemp et al.   CNS SPECTRUMS

Sex differences in the single prolonged stress model

(2015) Samantha M. Keller et al.   BEHAVIOURAL BRAIN RESEARCH

Abnormal Fear Memory as a Model for Posttraumatic Stress Disorder

(2015) Aline Desmedt et al.   BIOLOGICAL PSYCHIATRY

Benzodiazepines for PTSD

(2015) JEFFREY GUINA et al.   Journal of Psychiatric Practice

PTSD and Sexual Dysfunction in Men and Women

(2015) Rachel Yehuda et al.   Journal of Sexual Medicine

Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: Possible role of disrupted noradrenergic signaling

(2015) M.J. Skelly et al.   NEUROPHARMACOLOGY

Defeat stress in rodents: From behavior to molecules

(2015) Caroline Hammels et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Psychosocial predator-based animal model of PTSD produces physiological and behavioral sequelae and a traumatic memory four months following stress onset

(2015) Phillip R. Zoladz et al.   PHYSIOLOGY & BEHAVIOR

Psychopharmacological Strategies in the Management of Posttraumatic Stress Disorder (PTSD): What Have We Learned?

(2015) Nancy C. Bernardy et al.   Current Psychiatry Reports

Adolescent Social Isolation Does Not Lead to Persistent Increases in Anxiety- Like Behavior or Ethanol Intake in Female Long-Evans Rats

(2014) Tracy R. Butler et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Enduring Deficits in Brain Reward Function after Chronic Social Defeat in Rats: Susceptibility, Resilience, and Antidepressant Response

(2014) Andre Der-Avakian et al.   BIOLOGICAL PSYCHIATRY

Predator Exposure/Psychosocial Stress Animal Model of Post-Traumatic Stress Disorder Modulates Neurotransmitters in the Rat Hippocampus and Prefrontal Cortex

(2014) C. Brad Wilson et al.   PLoS One

Allopregnanolone modulation of HPA axis function in the adult rat

(2014) Giovanni Biggio et al.   PSYCHOPHARMACOLOGY

The effect of chronic phenytoin administration on single prolonged stress induced extinction retention deficits and glucocorticoid upregulation in the rat medial prefrontal cortex

(2014) Sophie A. George et al.   PSYCHOPHARMACOLOGY

5α-reductase type I expression is downregulated in the prefrontal cortex/Brodmann’s area 9 (BA9) of depressed patients

(2014) Roberto Carlos Agis-Balboa et al.   PSYCHOPHARMACOLOGY

Pregnenolone Can Protect the Brain from Cannabis Intoxication

(2014) Monique Vallée et al.   SCIENCE

A systematic review of the comorbidity between PTSD and alcohol misuse

(2014) Frances Debell et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

Ganaxolone improves behavioral deficits in a mouse model of post-traumatic stress disorder

(2014) Graziano Pinna et al.   Frontiers in Cellular Neuroscience

Differential effects of sertraline in a predator exposure animal model of post-traumatic stress disorder

(2014) C. Brad Wilson et al.   Frontiers in Behavioral Neuroscience

Targeting neurosteroidogenesis as therapy for PTSD

(2014) Graziano Pinna   Frontiers in Pharmacology

Changes in PTSD symptomatology and mental health during pregnancy and postpartum

(2013) Jane M. Onoye et al.   Archives of Womens Mental Health

Allopregnanolone Elevations Following Pregnenolone Administration Are Associated with Enhanced Activation of Emotion Regulation Neurocircuits

(2013) Rebecca K. Sripada et al.   BIOLOGICAL PSYCHIATRY

Comorbidity of posttraumatic stress disorder with alcohol dependence among US adults: Results from National Epidemiological Survey on Alcohol and Related Conditions

(2013) Carlos Blanco et al.   DRUG AND ALCOHOL DEPENDENCE

SSRIs and the female brain – potential for utilizing steroid-stimulating properties to treat menstrual cycle-linked dysphorias

(2013) Thelma Lovick   JOURNAL OF PSYCHOPHARMACOLOGY

Increased Voluntary Ethanol Consumption and Changes in Hippocampal Synaptic Plasticity in Isolated C57BL/6J Mice

(2013) Giuseppe Talani et al.   NEUROCHEMICAL RESEARCH

Social Deprivation Enhances VTA Synaptic Plasticity and Drug-Induced Contextual Learning

(2013) Leslie R. Whitaker et al.   NEURON

Adolescent social isolation enhances the plasmalemmal density of NMDA NR1 subunits in dendritic spines of principal neurons in the basolateral amygdala of adult mice

(2013) J.O. Gan et al.   NEUROSCIENCE

Differential effectiveness of tianeptine, clonidine and amitriptyline in blocking traumatic memory expression, anxiety and hypertension in an animal model of PTSD

(2013) Phillip R. Zoladz et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The role of allopregnanolone in depression and anxiety

(2013) Cornelius Schüle et al.   PROGRESS IN NEUROBIOLOGY

Neurosteroids as Therapeutic Leads in Psychiatry

(2013) Charles F. Zorumski et al.   JAMA Psychiatry

Animal models of post-traumatic stress disorder: face validity

(2013) Sonal Goswami et al.   Frontiers in Neuroscience

Neurobiological Sequelae of Witnessing Stressful Events in Adult Mice

(2012) Brandon L. Warren et al.   BIOLOGICAL PSYCHIATRY

Biological studies of post-traumatic stress disorder

(2012) Roger K. Pitman et al.   NATURE REVIEWS NEUROSCIENCE

Genetic Strain Differences in Learned Fear Inhibition Associated with Variation in Neuroendocrine, Autonomic and Amygdala Dendritic Phenotypes

(2012) Marguerite C Camp et al.   NEUROPSYCHOPHARMACOLOGY

On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment

(2012) Cristina A J Stern et al.   NEUROPSYCHOPHARMACOLOGY

Up-Regulation of Neurosteroid Biosynthesis as a Pharmacological Strategy to Improve Behavioural Deficits in a Putative Mouse Model of Post-Traumatic Stress Disorder

(2011) Graziano Pinna et al.   JOURNAL OF NEUROENDOCRINOLOGY

Isolation rearing-induced reduction of brain 5α-reductase expression: Relevance to dopaminergic impairments

(2011) Marco Bortolato et al.   NEUROPHARMACOLOGY

Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs?

(2011) C. Schüle et al.   NEUROSCIENCE

Helplessness: A systematic translational review of theory and evidence for its relevance to understanding and treating depression

(2011) Christopher R. Pryce et al.   PHARMACOLOGY & THERAPEUTICS

Neurosteroids reduce social isolation-induced behavioral deficits: a proposed link with neurosteroid-mediated upregulation of BDNF expression

(2011) Mauricio Nin   Frontiers in Endocrinology

Chronic social isolation and chronic variable stress during early development induce later elevated ethanol intake in adult C57BL/6J mice

(2010) Marcelo F. Lopez et al.   ALCOHOL

In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis

(2010) Graziano Pinna   BEHAVIOURAL PHARMACOLOGY

Substance use, childhood traumatic experience, and Posttraumatic Stress Disorder in an urban civilian population

(2010) Lamya Khoury et al.   DEPRESSION AND ANXIETY

Hippocampal microinfusion of oxytocin attenuates behavioral response to stress by means of dynamic interplay with the glucocorticoid-catecholamine responses

(2010) Hagit Cohen et al.   JOURNAL OF NEUROENDOCRINOLOGY

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders

(2010) Rainer Rupprecht et al.   NATURE REVIEWS DRUG DISCOVERY

Behavioral abnormality and pharmacologic response in social isolation-reared mice

(2009) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake

(2009) Graziano Pinna et al.   CURRENT OPINION IN PHARMACOLOGY

Single prolonged stress: toward an animal model of posttraumatic stress disorder

(2009) Shigeto Yamamoto et al.   DEPRESSION AND ANXIETY

Depression, anxiety, post-traumatic stress disorder and health-related quality of life and its association with social support in ambulatory prostate cancer patients

(2009) A. MEHNERT et al.   EUROPEAN JOURNAL OF CANCER CARE

Impaired Pavlovian fear extinction is a common phenotype across genetic lineages of the 129 inbred mouse strain

(2009) M. Camp et al.   GENES BRAIN AND BEHAVIOR

Extrasynaptic GABAA Receptors: Form, Pharmacology, and Function

(2009) D. Belelli et al.   JOURNAL OF NEUROSCIENCE

Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats

(2009) Lêda S.B. Garcia et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Translocator Protein (18 kD) as Target for Anxiolytics Without Benzodiazepine-Like Side Effects

(2009) Rainer Rupprecht et al.   SCIENCE

Early Social Isolation in Male Long-Evans Rats Alters Both Appetitive and Consummatory Behaviors Expressed During Operant Ethanol Self-Administration

(2008) Brian A. McCool et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Impaired Fear Extinction Learning and Cortico-Amygdala Circuit Abnormalities in a Common Genetic Mouse Strain

(2008) K. Hefner et al.   JOURNAL OF NEUROSCIENCE

Amygdala intercalated neurons are required for expression of fear extinction

(2008) Ekaterina Likhtik et al.   NATURE

Neurosteroid Biosynthesis Regulates Sexually Dimorphic Fear and Aggressive Behavior in Mice

(2008) Graziano Pinna et al.   NEUROCHEMICAL RESEARCH

Understanding the Pathophysiology of Postpartum Depression: Implications for the Development of Novel Treatments

(2008) Charles B. Nemeroff   NEURON

Neuropeptide S-Mediated Control of Fear Expression and Extinction: Role of Intercalated GABAergic Neurons in the Amygdala

(2008) Kay Jüngling et al.   NEURON

Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

(2008) Kazufumi Nagata et al.   NEUROPSYCHOPHARMACOLOGY

Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder

(2008) F. Pibiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Social Bonds and Posttraumatic Stress Disorder

(2007) Anthony Charuvastra et al.   Annual Review of Psychology

Changes in neuroactive steroid content during social isolation stress modulate GABAA receptor plasticity and function

(2007) Mariangela Serra et al.   BRAIN RESEARCH REVIEWS