Article
Obstetrics & Gynecology
Nicole Ziegler, Rudy Leon De Wilde
Summary: This study demonstrates that the use of 4DryField PH gel can significantly reduce the extent and severity of adhesions after surgery, with adhesiolysis surgery alone not sufficient. The results suggest that 4DryField PH gel may be a good approach to solving the adhesion problem in gynecologic surgery and further research in larger prospective randomized controlled trials is recommended to confirm the findings.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Seokhwan Bang, Young Hyo Choi, Seung-Ju Lee, Sung-Hoo Hong
Summary: This study compared the anti-adhesive effect of collagen type-I (COL) agent and hyaluronic acid-carboxymethylcellulose (HA/CMC) in laparoscopic and robotic radical prostatectomies. The results showed that both COL and HA/CMC were effective in preventing adhesion, and no significant adverse effects were observed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Xiaobo Bo, Jie Wang, Lingxi Nan, Yanlei Xin, Zhihui Gao, Changcheng Wang, Min Li, Sheng Shen, Han Liu, Xiaoling Ni, Tao Suo, Pinxiang Lu, Dexiang Zhang, Yueqi Wang, Houbao Liu
Summary: The study demonstrated that 3D laparoscopic common bile duct exploration could lead to significantly shorter operation time and less blood loss compared to 2D exploration, especially in patients with abdominal adhesions level 1 and 2.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Medicine, General & Internal
Afig Gojayev, Murathan Erkent, Huseyin Onur Aydin, Emre Karakaya, Sedat Yildirim, Gokhan Moray
Summary: This study retrospectively analyzed data from 830 patients undergoing surgical treatment for adhesive small bowel obstruction. The results showed that laparoscopic surgery had advantages over open surgery in terms of operation time, serious complications, mortality rate, gas out time, oral intake initiation time, and length of hospital stay. Therefore, laparoscopic surgery is a safe and effective treatment option for selected patients.
Article
Medicine, General & Internal
Sule Ozbilgin, Bahar Kuvaki, Hatice Keskin Simsek, Bahadir Saatli
Summary: This study demonstrates that gynecological laparoscopies can be performed without the use of neuromuscular blockers, and satisfactory conditions for ventilation and surgery can be achieved while using supraglottic airways. The results show that muscle relaxants are unnecessary when supraglottic airways are utilized in surgical procedures.
Article
Engineering, Biomedical
Ryo Mizuta, Yosuke Mizuno, Xi Chen, Yukari Kurihara, Tetsushi Taguchi
Summary: The developed surgical sealant effectively prevents postoperative adhesion on the large intestine surface. It demonstrates superior adhesion strength, inhibits albumin permeation, and effectively prevents penetration of fibroblast cells.
ACTA BIOMATERIALIA
(2021)
Article
Surgery
Zvi Ehrlich, Shirley S. Shapira, Gideon Sroka
Summary: This study compared the use of SurroundScope and standard angle laparoscope in laparoscopic cholecystectomy. The results showed that SurroundScope significantly reduced the number of entries to the field of view, increased the appearance ratio of tools and ports, and had fewer instances of camera removal due to smoke or fog. The conclusion is that SurroundScope improves the surgical workflow in laparoscopic cholecystectomy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Obstetrics & Gynecology
Iwaho Kikuchi, Mikio Momoeda, Takafumi Ujihira, Michiyo Iguchi, Kaori Koga, Mineto Morita
Summary: The aim of this study was to evaluate the safety and operability of GM142 adhesion barrier in patients undergoing surgery for benign gynecologic disease. The results showed that the barrier had a low incidence of adverse events and was easy to insert and position. No intestinal obstruction or gelatin-specific IgE antibodies were observed.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Surgery
Jinsoo Rhu, Gyu-Seong Choi, Jong Man Kim, Choon Hyuck David Kwon, Jae-Won Joh
Summary: This study analyzed the incidence and risk factors for surgical morbidities of laparoscopic living donors. The results showed that laparoscopic living donor surgery is safe for the majority of donors, and proper management can resolve critical complications. To minimize bile leakage, cautious surgical manipulation is needed for donors with complex hilar anatomy.
Article
Nanoscience & Nanotechnology
Hao Guo, Haifeng Shen, Juping Ma, Penghui Wang, Zheng Yao, Wenjie Zhang, Xiaoyan Tan, Bo Chi
Summary: In this study, an injectable shear-thinning hydrogel cross-linked through electrostatic interactions and hydrogen bonding was developed for preventing uncontrolled bleeding in endoscopic submucosal dissection surgery. The hydrogel exhibited excellent physical and biological properties, making it a promising material for endoscopic treatment of iatrogenic ulcers.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Obstetrics & Gynecology
Kensuke Sakai, Masaru Nakamura, Wataru Yamagami, Tatsuyuki Chiyoda, Yusuke Kobayashi, Hiroshi Nishio, Shigenori Hayashi, Hiroyuki Nomura, Fumio Kataoka, Eiichiro Tominaga, Kouji Banno, Daisuke Aoki
Summary: The study compared the efficacy of drainage following pelvic lymph node dissection in laparoscopic versus laparotomy cases. Results showed that routine drainage may not be necessary, especially in cases involving laparoscopic surgery. The study found a significantly lower prevalence of lymphocyst in the laparoscopy group compared to the laparotomy group.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Rana Mondal, Neha Jaiswal, Priya Bhave, Priyadarshi Mandal
Summary: This study retrospectively analyzed the hysteroscopic and laparoscopic findings in subfertile women and evaluated their association with tuberculosis. The study found that specific hysteroscopic and laparoscopic findings were predictive of tubercular manifestation, which can enhance diagnostic accuracy and guide clinical decision-making.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
A. C. Kaya, M. P. Radosa, J. S. M. Zimmermann, L. Stotz, S. Findeklee, A. Hamza, P. Sklavounos, F. Z. Takacs, G. Wagenpfeil, C. G. Radosa, E. F. Solomayer, J. C. Radosa
Summary: This study aimed to determine the incidence of intra- and postoperative complications of laparoscopic gynecological interventions and identified age, surgery duration, carbon dioxide use, and surgical indication as independent risk factors for intraoperative complications, while duration of surgery, carbon dioxide use, hemoglobin drop, and ASA status were identified as risk factors for postoperative complications. Overall, the study found a low incidence of complications, with specific risk factors identified for different types of complications.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Health Care Sciences & Services
Joseph J. Noh, Jung-Eun Jeon, Ji-Hee Jung, Tae-Joong Kim
Summary: This study compared the surgical outcomes of single-port access total laparoscopic hysterectomy (SPA-TLH) and hybrid robotic single-site hysterectomy (RSSH). A total of 64 patients underwent either hybrid RSSH or SPA-TLH for benign gynecologic disease. The results showed that there were no significant differences in surgical outcomes between the two groups, but the hybrid RSSH group had a shorter colpotomy time and a longer vaginal cuff closure time.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Sonia Lanzalaco, Xavier Sanchez, Carlos Aleman, Christine Weis, Kamelia A. Traeger, Pau Turon, Elaine Armelin
Summary: An innovative self- and pressure-adhesive biomedical implant has been developed in this study. Tissue adhesion is achieved by embedding a thermosensitive hydrogel into a substrate composed of knitted fibers. It was found that the inclusion of acrylamide-based comonomer significantly improved the bonding energy of the hydrogel. The results demonstrate the promising potential of this adhesive material.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Nutrition & Dietetics
Robert Thomas, Basma Greef, Alex McConnachie, Bethany Stanley, Madeleine Williams
Summary: The study found a small positive association between drinking tea and a reduced risk of prostate cancer among tea drinkers, but this does not support starting to drink tea for men who did not previously drink tea to reduce the risk. Further research is needed to determine whether tea is justified for future prospective nutritional intervention studies investigating prostate cancer prevention.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Adam Timmis, Panos Vardas, Nick Townsend, Aleksandra Torbica, Hugo Katus, Delphine De Smedt, Chris P. Gale, Aldo P. Maggioni, Steffen E. Petersen, Radu Huculeci, Dzianis Kazakiewicz, Victor de Benito Rubio, Barbara Ignatiuk, Zahra Raisi-Estabragh, Agnieszka Pawlak, Efstratios Karagiannidis, Roderick Treskes, Dan Gaita, John F. Beltrame, Alex McConnachie, Isabel Bardinet, Ian Graham, Marcus Flather, Perry Elliott, Elias A. Mossialos, Franz Weidinger, Stephan Achenbach
Summary: This report updates and expands upon the 2019 report, providing cardiovascular disease statistics for the 57 ESC member countries. The report highlights the determinants of CVD and the disparities among different countries.
EUROPEAN HEART JOURNAL
(2022)
Article
Endocrinology & Metabolism
Sophie Cassidy, Michael Trenell, Renae J. J. Stefanetti, Sarah J. J. Charman, Alison C. Barnes, Naomi Brosnahan, Louise McCombie, George Thom, Carl Peters, Sviatlana Zhyzhneuskaya, Wilma S. S. Leslie, Christopher Catt, Michael Catt, Alex McConnachie, Naveed Sattar, Falko F. F. Sniehotta, Michael E. J. Lean, Roy Taylor
Summary: In this study, randomization to weight loss plus maintenance intervention did not increase physical activity, although sleep parameters improved. Those who maintained >10% weight loss at 12 and 24 months had higher physical activity and reduced night-time waking.
Article
Biochemistry & Molecular Biology
Xilin Wu, Russell Senanayake, Emily Goodchild, Waiel A. Bashari, Jackie Salsbury, Claudia P. Cabrera, Giulia Argentesi, Samuel M. O'Toole, Matthew Matson, Brendan Koo, Laila Parvanta, Nick Hilliard, Vasilis Kosmoliaptsis, Alison Marker, Daniel M. Berney, Wilson Tan, Roger Foo, Charles A. Mein, Eva Wozniak, Emmanuel Savage, Anju Sahdev, Nicholas Bird, Kate Laycock, Istvan Boros, Stefan Hader, Victoria Warnes, Daniel Gillett, Anne Dawnay, Elizabeth Adeyeye, Alessandro Prete, Angela E. Taylor, Wiebke Arlt, Anish N. Bhuva, Franklin Aigbirhio, Charlotte Manisty, Alasdair McIntosh, Alexander McConnachie, J. Kennedy Cruickshank, Heok Cheow, Mark Gurnell, William M. Drake, Morris J. Brown
Summary: Primary aldosteronism (PA) caused by a unilateral aldosterone-producing adenoma is a common cause of hypertension. Adrenal surgery can provide a cure or significant improvement, but the invasive nature of the pre-surgical investigation limits the number of patients who can receive this treatment. This study compared the accuracy of a non-invasive test, [C-11]metomidate positron emission tomography computed tomography (MTO) scanning, with adrenal vein sampling (AVS) in predicting the success of surgery in patients with PA.
Article
Cardiac & Cardiovascular Systems
Leanne Mooney, Colette E. Jackson, Carly Adamson, Alex McConnachie, Paul Welsh, Rachel C. Myles, John J. V. McMurray, Pardeep S. Jhund, Mark C. Petrie, Ninian N. Lang
Summary: Circulating levels of interleukin-6 may identify patients at greater risk of adverse outcomes following hospitalization with heart failure with preserved ejection fraction.
CIRCULATION-HEART FAILURE
(2023)
Article
Neurosciences
Matthew Jamieson, Heather McClelland, Nicola Goudie, Jean McFarlane, Breda Cullen, Marilyn Lennon, Stephen Brewster, Bethany Stanley, Alex McConnachie, Jonathan Evans
Summary: Mobile phone reminding apps are useful for people with acquired brain injury to compensate for memory impairments. This pilot feasibility trial aimed to establish the feasibility of a randomized controlled trial comparing reminder apps in an ABI community treatment setting. The results showed that most participants could learn to use the apps and a larger trial would require 72 participants.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Public, Environmental & Occupational Health
K. Walker-Bone, G. J. Macfarlane, K. Burton, A. M. McConnachie, R. Zhang, G. T. Jones
Summary: Arm pain is a common problem in the workplace. Advicing workers to keep using their arms as much as possible leads to less disability at 6 months, especially for those who lift heavy weights or believe work caused their symptoms. Early physiotherapy, however, made no difference to disability outcomes. Similar results were seen amongst workers diagnosed with lateral epicondylitis.
OCCUPATIONAL MEDICINE-OXFORD
(2023)
Article
Cardiac & Cardiovascular Systems
Robert A. Sykes, Karla B. Neves, Rheure Alves-Lopes, Ilaria Caputo, Kirsty Fallon, Nigel B. Jamieson, Anna Kamdar, Assya Legrini, Holly Leslie, Alasdair McIntosh, Alex McConnachie, Andrew Morrow, Richard W. McFarlane, Kenneth Mangion, John McAbney, Augusto C. Montezano, Rhian M. Touyz, Colin Wood, Colin Berry
Summary: Post-COVID-19 conditions are associated with systemic vascular dysfunction, characterized by enhanced arterial constriction and reduced vasorelaxation. Histopathology revealed increased collagen abundance and phosphorylated myosin light chain in COVID-19 arteries. Upregulated gene pathways associated with extracellular matrix alteration and viral mRNA replication were also observed. Activation of Rho-kinase may serve as a novel therapeutic target for post-COVID-19 conditions.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Education, Special
C. A. Melville, C. Hatton, E. Beer, R. P. Hastings, S. -A. Cooper, N. McMeekin, D. Dagnan, K. Appleton, K. Scott, L. Fulton, R. S. P. Jones, A. McConnachie, R. Zhang, R. Knight, D. Knowles, C. Williams, A. Briggs, A. Jahoda
Summary: This study identified baseline variables, including anxiety, IQ, hearing impairment, depression severity, expectation of change, and therapy attendance, as predictors and moderators of outcome in psychological therapies for depression experienced by adults with IDs. These findings have important implications for tailoring therapeutic approaches in treating depression among adults with IDs.
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Robert Sykes, Andrew J. Morrow, Alex McConnachie, Anna Kamdar, C. Bagot, Hannah Bayes, Kevin G. Blyth, Michael Briscoe, Heeraj Bulluck, David Carrick, Colin Church, David Corcoran, C. Delles, Iain Findlay, Vivienne B. Gibson, Lynsey Gillespie, Douglas Grieve, Pauline Hall Barrientos, Antonia Ho, N. N. Lang, David J. Lowe, Vera Lennie, Peter MacFarlane, Kaithlin J. Mayne, Patrick Mark, Alasdair McIntosh, Ross McGeoch, Christopher McGinley, Connor Mckee, Sabrina Nordin, Alexander Payne, Alastair Rankin, Keith E. Robertson, Nicola Ryan, Giles H. Roditi, Naveed Sattar, David B. Stobo, Sarah Allwood-Spiers, Rhian Touyz, Gruschen Veldtman, Sarah Weeden, Stuart Watkins, Paul Welsh, Ryan Wereski, Kenneth Mangion, Colin Berry
Summary: This study investigated the associations of healthcare worker status with multisystem illness trajectory in hospitalized post-COVID-19 individuals. The results showed that healthcare workers had similar age, gender, and cardiovascular risk compared to non-healthcare workers, but had lower acute inflammation, milder illness severity, and shorter duration of hospital admission. Healthcare worker status was independently associated with the likelihood of myocarditis. Healthcare workers also had a higher rate of secondary care referrals.
Article
Medicine, General & Internal
Jesse Dawson, Michele Robertson, David Alexander Dickie, Phillip Bath, Kirsten Forbes, Terence Quinn, Niall M. Broom, Krishna Dani, Alex Doney, Graeme Houston, Kennedy R. Lees, Keith W. Muir, Allan Struthers, Matthew Walters, Mark Barber, Ajay Bhalla, Alan Cameron, Alexander Dyker, Paul Guyler, Ahamad Hassan, Mark T. Kearney, Breffni Keegan, Sekaran Lakshmanan, Mary Joan Macleod, Marc Randall, Louise Shaw, Ganesh Subramanian, David Werring, Alex McConnachie
Summary: This study investigated whether allopurinol could reduce the progression of white matter hyperintensity (WMH) and blood pressure after an ischaemic stroke or transient ischaemic attack (TIA). The results showed that allopurinol had no significant effect on the progression of WMH and blood pressure.
Article
Cardiac & Cardiovascular Systems
Kenneth Mangion, Andrew J. Morrow, Robert Sykes, Anna Kamdar, Catherine Bagot, George Bruce, Paul Connelly, Christian Delles, Vivienne B. Gibson, Lynsey Gillespie, Pauline Hall Barriento, Vera Lennie, Giles Roditi, Naveed Sattar, David Stobo, Sarah Allwood-Spiers, Alex McConnachie, Colin Berry
Summary: A study found sex differences in myocardial inflammation in female post-COVID-19 patients, who also reported worse outcomes at index admission and 28-60 days follow-up, although they had lower rates of cardiovascular hospitalization.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Joanna Osmanska, Katriona Brooksbank, Kieran F. Docherty, Stacy Robertson, Kirsty Wetherall, Alex McConnachie, Jerry Hu, Roy S. Gardner, Andrew L. Clark, Iain B. Squire, Paul R. Kalra, Pardeep S. Jhund, Pieter Muntendam, John J. McMurray, Mark C. Petrie, Ross T. Campbell
Summary: This study compared the bioavailability, pharmacokinetic and pharmacodynamic profiles between subcutaneous and intravenous furosemide, and described the use of a mini-pump for subcutaneous administration. The results showed that subcutaneous furosemide had similar bioavailability to intravenous furosemide, and administration via a patch pump was feasible and well tolerated.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Jessica Artico, Hunain Shiwani, James C. Moon, Miroslawa Gorecka, Gerry P. McCann, Giles Roditi, Andrew Morrow, Kenneth Mangion, Elena Lukaschuk, Mayooran Shanmuganathan, Christopher A. Miller, Amedeo Chiribiri, Sanjay K. Prasad, Robert D. Adam, Trisha Singh, Chiara Bucciarelli-Ducci, Dana Dawson, Daniel Knight, Marianna Fontana, Charlotte Manisty, Thomas A. Treibel, Eylem Levelt, Ranjit Arnold, Peter W. Macfarlane, Robin Young, Alex McConnachie, Stefan Neubauer, Stefan K. Piechnik, Rhodri H. Davies, Vanessa M. Ferreira, Marc R. Dweck, Colin Berry, John P. Greenwood
Summary: This study aimed to assess the presence, nature, and extent of myocardial damage in hospitalized patients with troponin elevation and COVID-19. The study found that patients with COVID-19 and elevated cardiac troponin levels had more ventricular impairment and myocardial scar compared to the control group. However, the proportion of myocarditis was low and scar pathogenesis was diverse.
Article
Rheumatology
L. Paul, M. T. Mcdonald, A. Mcconnachie, S. Siebert, E. H. Coulter
Summary: This study investigated the adherence and effects of an online physiotherapy program on individuals with axial spondyloarthritis (axSpA), as well as the factors influencing adherence. The study found that adherence decreased over the intervention period, and there was no association between adherence and baseline variables or demographics. Interviews revealed that support from others, routine, and perceived benefits positively influenced adherence, while lack of motivation, life events, and symptoms negatively affected adherence.
RHEUMATOLOGY INTERNATIONAL
(2023)