Multiscale Experimental and Computational Modeling Approaches to Characterize Therapy Delivery to the Heart from an Implantable Epicardial Biomaterial Reservoir

Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure

(2018) Yuki Ichihara et al.   BIOMATERIALS

Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings

(2018) Abraham R. Tzafriri et al.   JOURNAL OF CONTROLLED RELEASE

Fibrin Glue-aided, Instant Epicardial Placement Enhances the Efficacy of Mesenchymal Stromal Cell-Based Therapy for Heart Failure

(2018) Kazuya Kobayashi et al.   Scientific Reports

Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir

(2018) William Whyte et al.   Nature Biomedical Engineering

Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

(2018) Bohao Liu et al.   Nature Biomedical Engineering

Cardiac cell–integrated microneedle patch for treating myocardial infarction

(2018) Junnan Tang et al.   Science Advances

Delivery of drugs, growth factors, genes and stem cells via intrapericardial, epicardial and intramyocardial routes for sustained local targeted therapy of myocardial disease

(2017) Mikhail Maslov et al.   Expert Opinion on Drug Delivery

Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction

(2017) Vimal Ramjee et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiscale technologies for treatment of ischemic cardiomyopathy

(2017) Morteza Mahmoudi et al.   Nature Nanotechnology

Enhancing physiologic simulations using supervised learning on coarse mesh solutions

(2015) K. Kolandaivelu et al.   Journal of the Royal Society Interface

Epicardial FSTL1 reconstitution regenerates the adult mammalian heart

(2015) Ke Wei et al.   NATURE

Myocardial drug distribution generated from local epicardial application: Potential impact of cardiac capillary perfusion in a swine model using epinephrine

(2014) Mikhail Y. Maslov et al.   JOURNAL OF CONTROLLED RELEASE

The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction

(2013) Vahid Serpooshan et al.   BIOMATERIALS

Long-Term Functional Benefits of Epicardial Patches as Cell Carriers

(2013) Hadhami Hamdi et al.   CELL TRANSPLANTATION

Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

(2012) Wenda C. Carlyle et al.   JOURNAL OF CONTROLLED RELEASE

Intrapericardial Delivery of Gelfoam Enables the Targeted Delivery of Periostin Peptide after Myocardial Infarction by Inducing Fibrin Clot Formation

(2012) Brian D. Polizzotti et al.   PLoS One

Delivery of gelfoam-enabled cells and vectors into the pericardial space using a percutaneous approach in a porcine model

(2011) D Ladage et al.   GENE THERAPY

Local epicardial inotropic drug delivery allows targeted pharmacologic intervention with preservation of myocardial loading conditions

(2011) Mark A. Lovich et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Cell Delivery: Intramyocardial Injections or Epicardial Deposition? A Head-to-Head Comparison

(2009) Hadhami Hamdi et al.   ANNALS OF THORACIC SURGERY