Low-density lipoprotein receptor-deficient hepatocytes differentiated from induced pluripotent stem cells allow familial hypercholesterolemia modeling, CRISPR/Cas-mediated genetic correction, and productive hepatitis C virus infection

Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants

(2018) Gemma F. Codner et al.   BMC BIOLOGY

CRISPR/Cas9 therapeutics for liver diseases

(2018) Rajagopal N. Aravalli et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Delivery approaches for CRISPR/Cas9 therapeutics in vivo: advances and challenges

(2018) D.C. Luther et al.   Expert Opinion on Drug Delivery

CRISPR/Cas9: at the cutting edge of hepatology

(2017) Francis P Pankowicz et al.   GUT

Entry and Release of Hepatitis C Virus in Polarized Human Hepatocytes

(2017) Sandrine Belouzard et al.   JOURNAL OF VIROLOGY

Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells

(2017) Jiayin Yang et al.   Stem Cell Reports

Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease

(2017) Kelsey E. Jarrett et al.   Scientific Reports

Lysophosphatidylcholine acyltransferase 1 is downregulated by hepatitis C virus: impact on production of lipo-viro-particles

(2016) Frauke Beilstein et al.   GUT

Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes

(2016) Thomas Touboul et al.   JOURNAL OF HEPATOLOGY

PCSK9 inhibitors in the prevention of cardiovascular disease

(2016) James Latimer et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus

(2016) Satomi Yamamoto et al.   PLoS Pathogens

Connexin 32-mediated cell-cell communication is essential for hepatic differentiation from human embryonic stem cells

(2016) Jinhua Qin et al.   Scientific Reports

Impact of LDL apheresis on aortic root atheroma in children with homozygous familial hypercholesterolemia

(2015) Bruno Lefort et al.   ATHEROSCLEROSIS

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

(2015) Melissa Baxter et al.   JOURNAL OF HEPATOLOGY

Restoration of Physiologically Responsive Low-Density Lipoprotein Receptor-Mediated Endocytosis in Genetically Deficient Induced Pluripotent Stem Cells

(2015) Venkat M. Ramakrishnan et al.   Scientific Reports

Transplantation of hESC-derived hepatocytes protects mice from liver injury

(2015) Laia Tolosa et al.   Stem Cell Research & Therapy

Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes

(2015) Kate Cameron et al.   Stem Cell Reports

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition

(2015) Laura Ordovás et al.   Stem Cell Reports

PCSK9 and LDLR degradation

(2014) Thomas A. Lagace   CURRENT OPINION IN LIPIDOLOGY

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society

(2014) M. Cuchel et al.   EUROPEAN HEART JOURNAL

Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells

(2014) Noushin Dianat et al.   HEPATOLOGY

Engrafted human stem cell–derived hepatocytes establish an infectious HCV murine model

(2014) Arnaud Carpentier et al.   JOURNAL OF CLINICAL INVESTIGATION

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society

(2013) B. G. Nordestgaard et al.   EUROPEAN HEART JOURNAL

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease

(2013) Daniel Felmlee et al.   Viruses-Basel

JD induced pluripotent stem cell-derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia

(2012) Max A. Cayo et al.   HEPATOLOGY

Disease-Corrected Hepatocyte-Like Cells from Familial Hypercholesterolemia-Induced Pluripotent Stem Cells

(2012) Faranak Fattahi et al.   MOLECULAR BIOTECHNOLOGY

Role of low-density lipoprotein receptor in the hepatitis C virus life cycle

(2011) Anna Albecka et al.   HEPATOLOGY

Functional analysis of LDLR promoter and 5′ UTR mutations in subjects with clinical diagnosis of familial hypercholesterolemia

(2011) Isabel De Castro-Orós et al.   HUMAN MUTATION

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Production of Infectious Hepatitis C Virus in Primary Cultures of Human Adult Hepatocytes

(2010) Philippe Podevin et al.   GASTROENTEROLOGY

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells

(2010) S. Tamir Rashid et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells

(2010) Arefeh Ghodsizadeh et al.   Stem Cell Reviews and Reports

The LDL Receptor

(2009) Joseph L. Goldstein et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Sequential processing of hepatitis C virus core protein by host cell signal peptidase and signal peptide peptidase: a reassessment

(2009) V. Pène et al.   JOURNAL OF VIRAL HEPATITIS

Apolipoprotein E on hepatitis C virion facilitates infection through interaction with low-density lipoprotein receptor

(2009) David M. Owen et al.   VIROLOGY

Efficient hepatocyte engraftment and long-term transgene expression after reversible portal embolization in nonhuman primates

(2008) Ibrahim Dagher et al.   HEPATOLOGY

Robust, Persistent Transgene Expression in Human Embryonic Stem Cells Is Achieved with AAVS1-Targeted Integration

(2007) Joseph R. Smith et al.   STEM CELLS