3D-QSAR, Docking, ADME/Tox studies on Flavone analogs reveal anticancer activity through Tankyrase inhibition

Virtual screening, Docking, ADMET and System Pharmacology studies on Garcinia caged Xanthone derivatives for Anticancer activity

(2018) Sarfaraz Alam et al.   Scientific Reports

Hyphenated 3D-QSAR statistical model-scaffold hopping analysis for the identification of potentially potent and selective sigma-2 receptor ligands

(2017) Giuseppe Floresta et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Diethyl-4,4ʹ-dihydroxy-8,3ʹ-neolign-7,7ʹ-dien-9,9ʹ-dionate exhibits antihypertensive activity in rats through increase in intracellular cGMP level and blockade of calcium channels

(2017) Arjun Singh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

3D-QSAR studies on Maslinic acid analogs for Anticancer activity against Breast Cancer cell line MCF-7

(2017) Sarfaraz Alam et al.   Scientific Reports

Synthesis of 3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)benzopyran-4-one derivatives as anticancer agents

(2016) Sarita Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer

(2016) Aastha Singh et al.   Chemical Biology & Drug Design

Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases

(2016) Amit Nathubhai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics

(2015) Yves Nkizinkiko et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases

(2015) Katerina Kumpan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Anti-Tubercular Agents from Glycyrrhiza glabra

(2015) Komal Kalani et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer

(2014) A. A. Chiappori et al.   ANNALS OF ONCOLOGY

Tankyrases: Structure, Function and Therapeutic Implications in Cancer

(2014) Teemu Haikarainen et al.   CURRENT PHARMACEUTICAL DESIGN

Tankyrases as drug targets

(2013) Lari Lehtiö et al.   FEBS Journal

Fragment-Based Ligand Design of Novel Potent Inhibitors of Tankyrases

(2013) E. Andreas Larsson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor

(2013) Michael D. Shultz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Tankyrase Inhibiting Flavones with Increased Potency and Isoenzyme Selectivity

(2013) Mohit Narwal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Screening and Structural Analysis of Flavones Inhibiting Tankyrases

(2013) Mohit Narwal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrases

(2013) Amit Nathubhai et al.   ACS Medicinal Chemistry Letters

Anti-cancer potential of flavonoids: recent trends and future perspectives

(2013) Priya Batra et al.   3 Biotech

A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice

(2012) J. Waaler et al.   CANCER RESEARCH

Drugging Wnt signalling in cancer

(2012) Paul Polakis   EMBO JOURNAL

[1,2,4]Triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: Antagonists of the Wnt Pathway That Inhibit Tankyrases 1 and 2 via Novel Adenosine Pocket Binding

(2012) Michael D. Shultz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

(2012) Jenna L. Riffell et al.   NATURE REVIEWS DRUG DISCOVERY

A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor

(2010) Yoko Yashiroda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

3D-QSAR in Drug Design - A Review

(2010) Jitender Verma et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

2D and 3D QSAR studies of the receptor binding affinity of progestins

(2010) Lea da Silva Veras et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Tankyrase function at telomeres, spindle poles, and beyond

(2007) Susan J. Hsiao et al.   BIOCHIMIE