Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity
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Title
Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity
Authors
Keywords
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Journal
Scientific Reports
Volume 9, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-07-16
DOI
10.1038/s41598-019-46639-1
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Note: Only part of the references are listed.- Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase
- (2018) Tsukasa Okiyoneda et al. DEVELOPMENTAL CELL
- Therapeutic approaches to CFTR dysfunction: From discovery to drug development
- (2018) Hongyu Li et al. Journal of Cystic Fibrosis
- R560S: A class II CFTR mutation that is not rescued by current modulators
- (2018) Nikhil T. Awatade et al. Journal of Cystic Fibrosis
- F508del-CFTR is not corrected by thymosin α1
- (2018) Elizabeth Matthes et al. NATURE MEDICINE
- Reply to ‘F508del-CFTR is not corrected by thymosin α1’
- (2018) Luigina Romani et al. NATURE MEDICINE
- Structure-guided combination therapy to potently improve the function of mutant CFTRs
- (2018) Guido Veit et al. NATURE MEDICINE
- A novel triple combination of pharmacological chaperones improves F508del-CFTR correction
- (2018) Graeme W. Carlile et al. Scientific Reports
- VX-445–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
- (2018) Dominic Keating et al. NEW ENGLAND JOURNAL OF MEDICINE
- VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles
- (2018) Jane C. Davies et al. NEW ENGLAND JOURNAL OF MEDICINE
- High-throughput screening identifies FAU protein as a regulator of mutant cystic fibrosis transmembrane conductance regulator channel
- (2017) Valeria Tomati et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct Binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 Interface
- (2017) Rhea P. Hudson et al. MOLECULAR PHARMACOLOGY
- Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis
- (2017) Luigina Romani et al. NATURE MEDICINE
- Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770
- (2016) Martina Gentzsch et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor)
- (2016) Elizabeth Matthes et al. BRITISH JOURNAL OF PHARMACOLOGY
- A novel treatment of cystic fibrosis acting on-target: cysteamine plus epigallocatechin gallate for the autophagy-dependent rescue of class II-mutated CFTR
- (2016) A Tosco et al. CELL DEATH AND DIFFERENTIATION
- CFTR pharmacology
- (2016) Olga Zegarra-Moran et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Cystic fibrosis: a clinical view
- (2016) Carlo Castellani et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product
- (2016) Peter M. Haggie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations
- (2016) Gudio Veit et al. MOLECULAR BIOLOGY OF THE CELL
- New and emerging targeted therapies for cystic fibrosis
- (2016) Bradley S Quon et al. BMJ-British Medical Journal
- Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect
- (2016) Guido Veit et al. PLOS BIOLOGY
- New and emerging targeted therapies for cystic fibrosis
- (2016) Bradley S Quon et al. BMJ-British Medical Journal
- A modified thymosin alpha 1 inhibits the growth of breast cancer both in vitro and in vivo: suppressment of cell proliferation, inducible cell apoptosis and enhancement of targeted anticancer effects
- (2015) Xingzhen Lao et al. APOPTOSIS
- Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway
- (2015) Yan Guo et al. APOPTOSIS
- Origins of Cystic Fibrosis Lung Disease
- (2015) David A. Stoltz et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR
- (2015) Claire E. Wainwright et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation
- (2015) Valeria Tomati et al. Scientific Reports
- ΔF508 CFTR Surface Stability Is Regulated by DAB2 and CHIP-Mediated Ubiquitination in Post-Endocytic Compartments
- (2015) Lianwu Fu et al. PLoS One
- Some gating potentiators, including VX-770, diminish F508-CFTR functional expression
- (2014) G. Veit et al. Science Translational Medicine
- Potentiator ivacaftor abrogates pharmacological correction of F508 CFTR in cystic fibrosis
- (2014) D. M. Cholon et al. Science Translational Medicine
- Corrector VX-809 stabilizes the first transmembrane domain of CFTR
- (2013) Tip W. Loo et al. BIOCHEMICAL PHARMACOLOGY
- VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1
- (2013) Hong Yu Ren et al. MOLECULAR BIOLOGY OF THE CELL
- Mechanism-based corrector combination restores ΔF508-CFTR folding and function
- (2013) Tsukasa Okiyoneda et al. Nature Chemical Biology
- Novel pharmacological strategies to treat cystic fibrosis
- (2013) John W. Hanrahan et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Cystic Fibrosis Transmembrane Regulator Correctors and Potentiators
- (2013) S. M. Rowe et al. Cold Spring Harbor Perspectives in Medicine
- The CFTR Ion Channel: Gating, Regulation, and Anion Permeation
- (2013) T.-C. Hwang et al. Cold Spring Harbor Perspectives in Medicine
- Native ion mobility-mass spectrometry and related methods in structural biology
- (2012) A. Konijnenberg et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia
- (2012) Paolo Scudieri et al. JOURNAL OF PHYSIOLOGY-LONDON
- ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells
- (2011) Xuefeng Liu et al. AMERICAN JOURNAL OF PATHOLOGY
- NMR structure of human thymosin alpha-1
- (2011) Miguel-Angel Elizondo-Riojas et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Protein quality control at the plasma membrane
- (2011) Tsukasa Okiyoneda et al. CURRENT OPINION IN CELL BIOLOGY
- Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
- (2011) F. Van Goor et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CFTR: folding, misfolding and correcting the ΔF508 conformational defect
- (2011) Gergely L. Lukacs et al. TRENDS IN MOLECULAR MEDICINE
- c-Cbl Facilitates Endocytosis and Lysosomal Degradation of Cystic Fibrosis Transmembrane Conductance Regulator in Human Airway Epithelial Cells
- (2010) Siying Ye et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
- (2010) Alessandro Luciani et al. NATURE CELL BIOLOGY
- Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane
- (2010) T. Okiyoneda et al. SCIENCE
- A study of ion-neutral collision cross-section values for low charge states of peptides, proteins, and peptide/protein complexes
- (2009) Francisco A. Fernandez-Lima et al. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
- Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis
- (2009) Darren M Hutt et al. Nature Chemical Biology
- Biomolecule Analysis by Ion Mobility Spectrometry
- (2008) Brian C. Bohrer et al. Annual Review of Analytical Chemistry
- Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508
- (2008) Daisuke Morito et al. MOLECULAR BIOLOGY OF THE CELL
- Ion mobility–mass spectrometry analysis of large protein complexes
- (2008) Brandon T Ruotolo et al. Nature Protocols
- Adapting Proteostasis for Disease Intervention
- (2008) William E. Balch et al. SCIENCE
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