Article
Multidisciplinary Sciences
Pankaj Ahluwalia, Meenakshi Ahluwalia, Ashis K. Mondal, Nikhil Sahajpal, Vamsi Kota, Mumtaz V. Rojiani, Amyn M. Rojiani, Ravindra Kolhe
Summary: This study identified a prognostic ECM gene signature in clear cell renal cell carcinoma, showing significant differences in expression between ECM-rich high-risk and ECM-poor low-risk patients. The high-risk group exhibited significant perturbations in kidney functions and higher infiltration of immunosuppressive T-reg and M2 macrophages. Further validation and exploration of this gene signature could lead to the development of novel therapeutic approaches.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Yanjing Li, Kexue Ge, Tingting Li, Run Cai, Yong Chen
Summary: This review highlights the recent progress in structural studies of histone lysine methyltransferases (HKMTs), which play important roles in regulating chromatin structure and gene expression. The focus is on representative HKMTs (H3K4, H3K27, H3K36, H3K79, and H4K20 methyltransferases) in complex with nucleosomes, with emphasis on understanding the molecular mechanisms of nucleosome recognition and trans-histone crosstalk by these enzymes. These structural studies shed light on the roles of HKMTs in tumorigenesis and provide a basis for developing novel therapeutic approaches targeting HKMTs in cancer.
Review
Cell Biology
Dawid Dorna, Jaroslaw Paluszczak
Summary: Epigenetic aberrations, including altered DNA methylation and histone modifications, are commonly found in head and neck squamous cell carcinomas (HNSCC). Histone lysine demethylases (KDMs) have been implicated in the pathogenesis of HNSCC and are potential therapeutic targets. These enzymes play a role in transcriptional regulation and various biological processes. Overexpression of KDMs in HNSCC affects cell proliferation, apoptosis, cell motility, and stemness.
Review
Biochemistry & Molecular Biology
Yao Zhang, Yanhua Mou, Jianjian Zhang, Chuanjian Suo, Hai Zhou, Min Gu, Zengjun Wang, Ruoyun Tan
Summary: This paper reviews the relationship between renal fibrosis and ferroptosis from the perspective of iron metabolism and lipid peroxidation. It summarizes some pharmaceuticals or chemicals associated with both ferroptosis and renal fibrosis. Additionally, other programmed cell death and ferroptosis in renal fibrosis are also reviewed for comparison and further investigation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Cell Biology
Ignacio J. Cardona-Benavides, Cristina de Ramon, Norma C. Gutierrez
Summary: This review summarizes the main genetic abnormalities in multiple myeloma and their therapeutic approaches, highlighting certain mutations as potential targets for personalized medicine.
Review
Nanoscience & Nanotechnology
Serge Moffett, Tze Chieh Shiao, Leila Mousavifar, Serge Mignani, Rene Roy
Summary: Despite progress in drug design against cancer, its cure remains a challenge. Safety and side effects need urgent addressing. Nanotechnology may be a solution to improve the efficacy of anti-cancer drugs.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Review
Health Care Sciences & Services
Grace Hey, Rohan Rao, Ashley Carter, Akshay Reddy, Daisy Valle, Anjali Patel, Drashti Patel, Brandon Lucke-Wold, Daniel Pomeranz Krummel, Soma Sengupta
Summary: Gliomas are aggressive and heterogeneous primary brain malignancies that are difficult to treat. Ligand-gated ion channels (LGICs) have been identified as valuable biomarkers and diagnostic tools in the pathogenesis of gliomas. Various LGICs, including P2X, SYT16, and PANX2, can be altered in glioma, disrupting neural homeostasis and worsening symptoms. LGICs, such as purinoceptors, glutamate-gated receptors, and Cys-loop receptors, are being targeted in clinical trials for potential therapeutic benefits in glioma diagnosis and treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Oncology
Gerardo Caruso, Rosamaria Ferrarotto, Antonello Curcio, Luisa Metro, Francesco Pasqualetti, Paola Gaviani, Valeria Barresi, Filippo Flavio Angileri, Maria Caffo
Summary: Meningiomas are common tumors of the central nervous system and often associated with decreased quality of life. Total resection is the preferred treatment method. Molecular alterations have been identified that may be responsible for grading, site, and prognosis. Recurrence rates are relatively high and current treatment options are insufficient. Further research is needed to understand the mechanisms of tumor formation and progression. Combination therapies targeting multiple molecular targets show promise as adjuvant treatments. Recent literature reviews provide insight into recent therapeutic treatments for meningiomas.
Article
Oncology
Nithya Krishnamurthy, Aaron M. Goodman, Donald A. Barkauskas, Razelle Kurzrock
Summary: The study revealed that mutations in the STK11 gene are closely associated with the malignancy and survival rates of tumors, especially when co-altered with KRAS. Patients with co-alterations of STK11 and KRAS in the pan-cancer setting had worse outcomes regardless of treatment type.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Clinical Neurology
Katrine M. Johannesen, Yuanyuan Liu, Mahmoud Koko, Cathrine E. Gjerulfsen, Lukas Sonnenberg, Julian Schubert, Christina D. Fenger, Ahmed Eltokhi, Maert Rannap, Nils A. Koch, Stephan Lauxmann, Johanna Krueger, Josua Kegele, Laura Canafoglia, Silvana Franceschetti, Thomas Mayer, Johannes Rebstock, Pia Zacher, Susanne Ruf, Michael Alber, Katalin Sterbova, Petra Lassuthova, Marketa Vlckova, Johannes R. Lemke, Konrad Platzer, Ilona Krey, Constanze Heine, Dagmar Wieczorek, Judith Kroell-Seger, Caroline Lund, Karl Martin Klein, P. Y. Billie Au, Jong M. Rho, Alice W. Ho, Silvia Masnada, Pierangelo Veggiotti, Lucio Giordano, Patrizia Accorsi, Christina E. Hoei-Hansen, Pasquale Striano, Federico Zara, Helene Verhelst, Judith S. Verhoeven, Hilde M. H. Braakman, Bert van der Zwaag, Aster V. E. Harder, Eva Brilstra, Manuela Pendziwiat, Sebastian Lebon, Maria Vaccarezza, Ngoc Minh Le, Jakob Christensen, Sabine Gronborg, Stephen W. Scherer, Jennifer Howe, Walid Fazeli, Katherine B. Howell, Richard Leventer, Chloe Stutterd, Sonja Walsh, Marion Gerard, Benedicte Gerard, Sara Matricardi, Claudia M. Bonardi, Stefano Sartori, Andrea Berger, Dorota Hoffman-Zacharska, Massimo Mastrangelo, Francesca Darra, Arve Vollo, M. Mahdi Motazacker, Phillis Lakeman, Mathilde Nizon, Cornelia Betzler, Cecilia Altuzarra, Roseline Caume, Agathe Roubertie, Philippe Gelisse, Carla Marini, Renzo Guerrini, Frederic Bilan, Daniel Tibussek, Margarete Koch-Hogrebe, M. Scott Perry, Shoji Ichikawa, Elena Dadali, Artem Sharkov, Irina Mishina, Mikhail Abramov, Ilya Kanivets, Sergey Korostelev, Sergey Kutsev, Karen E. Wain, Nancy Eisenhauer, Monisa Wagner, Juliann M. Savatt, Karen Muller-Schluter, Haim Bassan, Artem Borovikov, Marie-Cecile Nassogne, Anne Destree, An-Sofie Schoonjans, Marije Meuwissen, Marga Buzatu, Anna Jansen, Emmanuel Scalais, Siddharth Srivastava, Wen-Hann Tan, Heather E. Olson, Tobias Loddenkemper, Annapurna Poduri, Katherine L. Helbig, Ingo Helbig, Mark P. Fitzgerald, Ethan M. Goldberg, Timo Roser, Ingo Borggraefe, Tobias Brunger, Patrick May, Dennis Lal, Damien Lederer, Guido Rubboli, Henrike O. Heyne, Gaetan Lesca, Ulrike B. S. Hedrich, Jan Benda, Elena Gardella, Holger Lerche, Rikke S. Moller
Summary: This study provides detailed functional analyses and genotype-phenotype correlations in individuals carrying disease-causing variants in SCN8A. The results reveal the clinical phenotypes related to the functional effects and the correlation between the age at seizure onset, type of epilepsy, and the gain- or loss-of-function effects of SCN8A variants.
Article
Biochemistry & Molecular Biology
Adrian Sanchez-Fdez, Sofia Matilla-Almazan, Sofia Del Carmen, Mar Abad, Elena Arconada-Luque, Jaime Jimenez-Suarez, Luis Miguel Chinchilla-Tabora, Ma Jose Ruiz-Hidalgo, Ricardo Sanchez-Prieto, Atanasio Pandiella, Azucena Esparis-Ogando
Summary: Researchers have discovered that blocking the activity of MEK5 or ERK5 could help reduce the growth of sarcomas. The overexpression of ERK5 in human sarcomas is associated with worse survival outcomes for patients. This study is significant as it sheds light on the development process of sarcomas and provides new therapeutic opportunities.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Meng He, Fuyan Hu
Summary: This study investigated the role of transcription factors in regulating RNA-binding protein-alternative splicing interactions, identifying multiple TFs that can affect multiple ASEs. Six categories of TF-mediated transcriptional dysregulations were identified, regulatory networks were constructed, and pathway-enrichment analysis showed enrichment in pathways associated with cancer development. Survival analysis revealed some triplets were highly associated with survival rates, highlighting the importance of integrating TFs into alternative splicing regulatory networks in understanding their roles in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Konstantinos Kamposioras, Maria Vassilakopoulou, Alan Anthoney, Jorge Bariuoso, Davide Mauri, Was Mansoor, Vassilios Papadopoulos, Konstantinos Dimas
Summary: Caveolin-1 (CAV1) plays a significant role in gastrointestinal tumors and can affect tumor progression and patient survival outcome. However, there is still a lack of consensus regarding the specific functions and expression levels of CAV1 in tumors.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Oncology
Benoit Lhermitte, Thibaut Wolf, Marie Pierre Chenard, Andres Coca, Julien Todeschi, Francois Proust, Edouard Hirsch, Roland Schott, Georges Noel, Eric Guerin, Damien Reita, Agathe Chammas, Alexandra Salmon, Sophie Martin, Monique Dontenwill, Natacha Entz-Werle
Summary: Drugs targeting activating BRAF mutations have transformed the prognosis and treatment of MAPK-pathway-induced cancers. The better knowledge of the MAPK pathway's involvement in gliomagenesis offers hope in brain cancers where conventional therapies have produced disappointing results. This review summarizes the current literature regarding BRAF-altered gliomas, their molecular diagnosis, prognosis, associated molecular alterations, and potential treatment options.
Article
Oncology
Miner Yang, Gaowen Chen, Kunjie Gao, Yifeng Wang
Summary: Metabolic dysregulation in the tumor microenvironment significantly affects immune infiltration and responses. By constructing an immunometabolism gene set from TCGA, researchers identified three distinct immunometabolism subtypes in ovarian cancer, each with therapeutic and prognostic implications. The study provides new insights into the ovarian cancer microenvironment by proposing immunometabolism subtypes with prognostic relevance.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Shruti Sharma, Ujjawal Sharma
Summary: Exosomes, as important communicators between cells, play a crucial role in the protection and progression of cardiovascular diseases.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Oncology
Sanjeev K. K. Sharma, Subodh K. K. Yadav, Ujjawal Sharma, Pramod Avti, Satyavati Rana, Krishan L. L. Khanduja
Summary: The study aims to investigate the potential role of secretory phospholipase A2 (sPLA(2)) isozymes in tobacco condensate-induced colon damage. The effects of cigarette smoke condensate (CSC) on cell viability, reactive oxygen species (ROS), and gene expression of different sPLA(2) were evaluated. The findings suggest that specific sPLA(2) isozymes play a key role in controlling CSC-induced damage and may aid in the development of targeted therapeutic strategies.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Correction
Genetics & Heredity
Deeksha Pal, Ujjawal Sharma, Shrawan Kumar Singh, Rajendra Prasad
Review
Endocrinology & Metabolism
Bunty Sharma, Aman Kumar, Ujjawal Sharma, Deeksha Pal, Sourabh Prashar
Summary: The gut microbiota plays a crucial role in regulating the metabolic health of host organisms. Dysbiosis of the gut microflora can lead to the development of type 2 diabetes mellitus (T2DM), and the microbial composition can also influence the host organism's epigenetics and the involvement of the innate immune system. Understanding the connection between gut microbiota and T2DM is important for better understanding the disease.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Review
Neurosciences
Bunty Sharma, Deeksha Pal, Ujjawal Sharma, Aman Kumar
Summary: Mitochondria play a crucial role in providing energy and controlling apoptosis in neurons. Defective mitochondrial function is linked to neurodegenerative diseases such as Alzheimer's disease. Mitophagy, a quality control system, helps neurons maintain their health and functionality by removing damaged mitochondria. Dysfunction of mitochondria and dysregulated mitophagy are closely associated with the onset of Alzheimer's disease. Therapeutic approaches targeting mitophagy restoration could be used to prevent disease progression.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Uttam Sharma, Hardeep Singh Tuli, Vivek Uttam, Renuka Choudhary, Bunty Sharma, Ujjawal Sharma, Hridayesh Prakash, Aklank Jain
Summary: This review provides an overview of the current research progress on how microRNAs, long non-coding RNAs, and circular RNAs regulate Hedgehog and Hippo signaling pathways in various cancers, and their potential application as targets for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Oncology
Hardeep Singh Tuli, Prangya Rath, Abhishek Chauhan, Katrin Sak, Diwakar Aggarwal, Renuka Choudhary, Ujjawal Sharma, Kanupriya Vashishth, Sheetu Sharma, Manoj Kumar, Vikas Yadav, Tejveer Singh, Mukerrem Betul Yerer, Shafiul Haque
Summary: Luteolin, a common flavonoid, has shown promising anticancer properties by targeting various cellular processes to inhibit tumor growth and reverse medication resistance in cancer cells.
Review
Toxicology
Hardeep Singh Tuli, Jagjit Kaur, Kanupriya Vashishth, Katrin Sak, Ujjawal Sharma, Renuka Choudhary, Tapan Behl, Tejveer Singh, Sheetu Sharma, Adesh K. Saini, Kuldeep Dhama, Mehmet Varol, Gautam Sethi
Summary: ROS plays important roles in living organisms, with moderate levels affecting disease development and excessive levels leading to cell death. Current research is focused on using chemotherapy drugs and herbal agents to induce cancer cell death, while maintaining ROS homeostasis is crucial for cell development and survival.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Masrat Mohmad, Nivedita Agnihotri, Vikas Kumar, Ujjawal Sharma, Rakesh Kumar, Sadegh Kaviani, Ashish Kumar, Raj Kamal
Summary: A concise, ingenious and expedite extractive spectrophotometric procedure for the micro-level analysis of Pt(II) using the novel synthesized Ligand of flavonoids family, 3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one was elucidated by employing chelation as the basis of reaction between the two. The resulting brown coloured complex was extractable in non-aqueous organic solvents, the effectual and sensitive extraction and hence maximal colour intensity being exhibited in dichloromethane in the wavelength range 500-514 nm. To acquire a deeper knowledge of the complex's structural characteristics, theoretical investigations including Quantum theory of atoms in molecules and Natural bond orbital analysis were employed using Density functional theory calculations.
RESULTS IN CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Ajay Kumar, Bunty Sharma, Ujjawal Sharma, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Isha Rani, Seema Ramniwas, Satwinderjeet Kaur, Shafiul Haque, Hardeep Singh Tuli
Summary: Cucurbitacins, a class of secondary metabolites produced by the Cucurbitaceae family, have significant anticancer activity by inhibiting cell proliferation, invasion, and migration, inducing apoptosis, and encouraging cell cycle arrest. They also suppress the JAK-STAT3, Wnt, PI3K/Akt, and MAPK signaling pathways, which are essential for cancer cell survival and apoptosis. This study provides a comprehensive summary of potential molecular targets for cucurbitacins in suppressing various malignant processes.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Letter
Surgery
Nirmala Sehrawat, Ujjawal Sharma, Mukesh Yadav, Varruchi Sharma, Abhijit Dey, Talha B. Emran, Anil K. Sharma, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Pharmacology & Pharmacy
Priyanka Verma, Hemant Joshi, Tejveer Singh, Bunty Sharma, Ujjawal Sharma, Seema Ramniwas, Rashmi Rana, Madhu Gupta, Ginpreet Kaur, Hardeep Singh Tuli
Summary: Patients with glioblastoma and anaplastic astrocytoma are treated with temozolomide, which has been shown to increase patient survival but may also have negative immune-related effects. Flavonoids have antioxidant and chemo-preventive effects, and may reduce side effects of chemotherapy while increasing effectiveness. Exosomes have potential as drug carriers for cancer therapy due to their favorable biodistribution, biocompatibility, and low immunogenicity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Masrat Mohmad, Nivedita Agnihotri, Vikas Kumar, Mohammad Azam, Raj Kamal, Ashish Kumar, Ujjawal Sharma, Saleem Javed, Sambantham Muthu, Kim Min
Summary: A novel benzopyran-based platinum complex was prepared and studied using UV-visible spectrophotometry. The complexation between Pt(II) and HToC resulted in the formation of a stable binary yellow complex. The analytical results showed that the complex exhibits good sensitivity, versatility, and cost-effectiveness. DFT studies revealed the molecular geometry and other structural specifics of the complex. The complex demonstrated better antiproliferative potential, antimicrobial activity, and antioxidant capacity compared to the ligand.
Review
Dermatology
Ravi Kant Sharma, Manu Rashmi Sharma, Aneet Mahendra, Ujjawal Sharma, Simranjit Singh, Seema Ramniwas, Anil Kumar Sharma
Summary: Psoriasis is a prevalent chronic inflammatory skin condition caused by abnormal immune response. It not only affects the mental health of patients, but also leads to various systemic diseases. Artificial intelligence can play an important role in the early detection and management of psoriasis.
CURRENT DERMATOLOGY REPORTS
(2023)
