Article
Oncology
Diego Raimondo, Antonio Raffone, Agnese Virgilio, Stefano Ferla, Manuela Maletta, Daniele Neola, Antonio Travaglino, Roberto Paradisi, Alicia Hernandez, Emanuela Spagnolo, Virginia Garcia-Pineda, Jacopo Lenzi, Maurizio Guida, Paolo Casadio, Renato Seracchioli
Summary: This study compared the prevalence of molecular groups in endometrial cancer patients with and without coexistent adenomyosis, and found that the molecular signature does not appear to explain the better prognosis associated with coexistent adenomyosis in endometrial cancer patients.
Article
Oncology
Guillaume Beinse, Marie-Aude Le Frere Belda, Pierre-Alexandre Just, Nahina Bekmezian, Meriem Koual, Simon Garinet, Karen Leroy, Franck Letourneur, Adele Lusson, Claire Mulot, Delphine Le Corre, Marie Metairie, Nicolas Delanoy, Helene Blons, Claire Gervais, Catherine Durdux, Charles Chapron, Francois Goldwasser, Benoit Terris, Cecile Badoual, Valerie Taly, Pierre Laurent-Puig, Bruno Borghese, Anne-Sophie Bats, Jerome Alexandre
Summary: This study aimed to evaluate the classification ability of RNA sequencing (RNA-seq) for prognosis prediction in endometrial carcinoma (EC) patients. The results showed that RNA-seq can provide additional prognostic information beyond established classification systems and has potential applications in therapeutic strategies for EC.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Tzipi Braun, Shiraz Halevi, Rotem Hadar, Gilate Efroni, Efrat Glick Saar, Natahan Keller, Amnon Amir, Sharon Amit, Yael Haberman
Summary: Despite the rapid spread of COVID-19 around the world, a study on nasopharyngeal swab samples found that SARS-CoV-2 does not have a significant effect on the microbial community in the nasopharynx.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Kaiyou Fu, Yanrui Li, Jianyuan Song, Wangyu Cai, Wei Wu, Xiaohang Ye, Jian Xu
Summary: Lymph node metastasis is an important prognostic factor in endometrial cancer. By constructing a miRNA signature associated with LNM in EEC, the study showed high prediction accuracy. MiR-34c cluster may serve as a key biomarker for LNM in endometrial cancer.
FRONTIERS IN GENETICS
(2021)
Article
Chemistry, Physical
Gaurav Singh, Shrishti P. Pandey, Prabhat K. Singh
Summary: Sulfated cyclodextrins have been found to be potential candidates for producing host-induced guest aggregation with better properties than p-sulfonatocalixarenes. The size of the cavity in the host molecule plays a crucial role in the efficiency of host-induced guest aggregation.
Article
Biochemistry & Molecular Biology
Yang Jiao, Rui Geng, Zihang Zhong, Senmiao Ni, Wen Liu, Zhiqiang He, Shilin Gan, Qinghao Huang, Jinhui Liu, Jianling Bai
Summary: Four hypoxia-related genes were used to develop a prognostic model for endometrial cancer. NR3C1 amplification and IL-6 and SRPX suppressions were found in tumors. The high-risk group showed high stromal score and enriched infiltrated aDCs and B cells, supporting the hypothesis of an immune-deserted tumor. Hypoxia-related molecular subtypes of EC were identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Jinhui Liu, Yichun Wang, Huangyang Meng, Yin Yin, Hongjun Zhu, Tingting Ni
Summary: A signature of six ferroptosis-related genes was constructed and found to be an independent prognostic factor for UCEC. Patients in the low-risk group demonstrated higher expression of immune checkpoint molecules and tumor mutation burden, as well as sensitive responses to chemotherapy drugs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Konstantin A. Lusta, Anastasia V. Poznyak, Vasily N. Sukhorukov, Ilya I. Eremin, Irina I. Nadelyaeva, Alexander N. Orekhov
Summary: Since the end of the 20th century, it has been recognized that atherosclerosis is an inflammatory disease and the trigger for inflammation in the vascular walls is still uncertain. Numerous hypotheses have been proposed to explain the causes of atherogenesis, all supported by strong evidence. These causes include lipoprotein modification, oxidative transformation, shear stress, endothelial dysfunction, free radicals' action, homocysteinemia, diabetes mellitus, and decreased nitric oxide level. The latest hypothesis suggests the infectious nature of atherogenesis, with bacterial and viral infections possibly playing a role. This paper analyzes the existing hypotheses for atherogenesis and focuses on the contribution of bacterial and viral infections in the pathogenesis of atherosclerosis and cardiovascular disease.
Article
Chemistry, Physical
Laiyang Wei, Qi Bai, Xiaojiao Li, Ziyuan Liu, Chenruyuan Li, Yanhong Cui, Lin Shen, Chongqin Zhu, Weihai Fang
Summary: In this study, a stable monolayer ice structure called pZZMI was discovered by performing molecular dynamics simulations. This structure is formed by puckering the zigzag water chains of ZZMI in the direction perpendicular to the chains. Unlike other structures, each water molecule in pZZMI satisfies the ice rule and can form four hydrogen bonds.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Gastroenterology & Hepatology
Jessica Breton, Ceylan Tanes, Vincent Tu, Lindsey Albenberg, Sarah Rowley, Nina Devas, Rosa Hwang, Kelly Kachelries, Gary D. Wu, Robert N. Baldassano, Kyle Bittinger, Peter Mattei
Summary: The microbial community in children with perianal fistulising CD is different in composition and function compared to other CD patients and healthy children, highlighting the importance of understanding the microbiome in the perianal milieu for developing treatment strategies.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Oncology
Hoon Kim, Hyun Jung Kim, Hyeong Sik Ahn
Summary: This study investigated the association between endometriosis and the risks of endometrial hyperplasia and endometrial cancer. The results showed that women with endometriosis had significantly higher risks of developing endometrial hyperplasia and endometrial cancer.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Leila Adamyan, Yana Aznaurova, Assia Stepanian, Daniil Nikitin, Andrew Garazha, Maria Suntsova, Maxim Sorokin, Anton Buzdin
Summary: The study aims to develop a prototype gene expression biomarker for the diagnosis of endometriosis based on molecular signature differences. A unique gene signature was identified, showing high separation accuracy between samples with and without endometriosis.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Editorial Material
Genetics & Heredity
Nandita R. Garud
Summary: Nandita Garud discusses two influential papers by Hermisson and Pennings that offer a framework for determining whether adaptation should occur gradually or rapidly.
NATURE REVIEWS GENETICS
(2023)
Review
Cell Biology
Ewa Sikora, Anna Bielak-Zmijewska, Grazyna Mosieniak
Summary: Cellular senescence is a significant biological phenomenon that mainly participates in aging and aging-related diseases through secretion activity and cell cycle arrest. In this process, DNA damage, nuclear changes, and chromatin rearrangement play important roles.
AGEING RESEARCH REVIEWS
(2021)
Article
Medicine, General & Internal
Jiazhen Huang, Furong Du, Ning Wang
Summary: A 4-miRNA signature based on miR-31-5p, miR-34a-5p, miR-26a-1-3p and miR-4772-3p was developed to predict the prognosis of UCEC, showing high performance and independence in predicting risk and overall survival.
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez, Adi L. Tarca
Summary: This study aimed to determine the prevalence, characteristics, and clinical significance of angiogenic/antiangiogenic factor abnormalities in women with preeclampsia stratified according to gestational age at delivery. The results showed that patients with early preeclampsia had an abnormal angiogenic profile in virtually all cases, whereas only 50% of women with preeclampsia at term had such abnormalities. These findings have implications for future clinical care and research.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
Bo Hyun Yoon, Roberto Romero, Kyung Joon Oh, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Roberto Romero
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Tomi Kanninen, Eunjung Jung, Dahiana M. Gallo, Ramiro Diaz-Primera, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Mariachiara Bosco, Tinnakorn Chaiworapongsa
Summary: Preeclampsia and fetal growth disorders are pregnancy-specific conditions that share common pathophysiological mechanisms. This study suggests that the severity of the maternal inflammatory response is highest in patients with preeclampsia, while patients with an SGA fetus also show elevated inflammatory response.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero
Summary: This review examines the efficacy of vaginal progesterone (VP) in preventing preterm birth (PTB) in different subsets of high-risk women. The evidence suggests that VP is effective in reducing the risk of PTB and improving perinatal outcomes in certain groups, such as singleton gestations with a short cervix. However, further research is needed to determine its efficacy in other high-risk groups.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Nardhy Gomez-Lopez, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Dustyn Levenson, Adi L. Tarca
Summary: This study aimed to examine the differences in the anti-angiogenic state among women with eclampsia and severe preeclampsia, as well as the prevalence of abnormal angiogenic profiles in preterm and term eclampsia. The results showed that women with preterm eclampsia had a more severe anti-angiogenic state compared to those with severe preeclampsia. Furthermore, abnormal angiogenic profiles were more prevalent in preterm eclampsia than in term eclampsia.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Biochemical Research Methods
Valeria Garcia-Flores, Yi Xu, Errile Pusod, Roberto Romero, Roger Pique-Regi, Nardhy Gomez-Lopez
Summary: Single-cell RNA-sequencing (scRNA-seq) is a powerful tool to study cellular composition and interactions in complex tissues. This study presents a protocol for preparing high-quality single-cell suspensions from human placental tissues, including the basal plate, placental villi, and chorioamniotic membranes. The protocol includes tissue collection, tailored dissociation procedures, and cryopreservation of single-cell suspensions. The resulting suspensions are compatible with droplet-based scRNA-seq technology and exhibit high yield and viability. The entire process takes approximately 6 hours, with an additional 2 hours for thawing of cryopreserved single cells.
Article
Cell Biology
Valeria Garcia-Flores, Roberto Romero, Azam Peyvandipour, Jose Galaz, Errile Pusod, Bogdan Panaitescu, Derek Miller, Yi Xu, Li Tao, Zhenjie Liu, Adi L. Tarca, Roger Pique-Regi, Nardhy Gomez-Lopez
Summary: Preterm birth is a leading cause of perinatal morbidity and mortality worldwide, often resulting from preterm labor syndrome. Intra-amniotic infection has been identified as a primary cause of preterm labor, leading to premature activation of the parturition process in reproductive tissues. Using single-cell RNA sequencing, researchers created a comprehensive atlas of single-cell profiles in the murine uterus, decidua, and cervix during infection-induced preterm labor. The study revealed the impact of preterm labor on specific immune and non-immune cell subsets, identified shared and tissue-specific gene expression signatures, and determined cell-to-cell communication pathways involved in preterm labor. Comparisons with human uterine cell interactions highlighted conserved signaling pathways implicated in labor. This scRNA-seq data provides valuable insights into the cellular landscape and communication in reproductive tissues during preterm labor.
Article
Obstetrics & Gynecology
Mariachiara Bosco, Roberto Romero, Dahiana M. Gallo, Manaphat Suksai, Francesca Gotsch, Eunjung Jung, Piya Chaemsaithong, Adi L. Tarca, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Arun Meyyazhagan, Malek Al Qasem, Massimo P. Franchi, Lawrence I. Grossman, Siddhesh Aras, Tinnakorn Chaiworapongsa
Summary: This study aimed to determine the concentrations of CHCHD2/MNRR1 in amniotic fluid of pregnant women, women at term in labor, and those in preterm labor. The results showed that CHCHD2/MNRR1 is a physiological constituent of amniotic fluid in normal pregnancy, and its concentration increases in amniotic fluid associated with intra-amniotic infection during pregnancy, term labor, and preterm labor.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Kenichiro Motomura, Derek Miller, Jose Galaz, Tzu Ning Liu, Roberto Romero, Nardhy Gomez-Lopez
Summary: Progesterone, a sex steroid hormone, plays a crucial role in establishing and maintaining pregnancy. It modulates the maternal immune system to promote maternal-fetal tolerance and drive various physiological adaptations essential for pregnancy. This review provides an overview of the immunomodulatory functions of progesterone in different compartments during pregnancy, highlighting gaps in our understanding of the interactions between progesterone and maternal cellular immunity.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Meeting Abstract
Immunology
Nardhy Gomez-Lopez
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Editorial Material
Immunology
Nardhy Gomez-Lopez
TRENDS IN IMMUNOLOGY
(2023)
Article
Microbiology
Roberto Romero, Kevin R. Theis, Nardhy Gomez-Lopez, Andrew D. Winters, Jonathan J. Panzer, Huang Lin, Jose Galaz, Jonathan M. Greenberg, Zachary Shaffer, David J. Kracht, Tinnakorn Chaiworapongsa, Eunjung Jung, Francesca Gotsch, Jacques Ravel, Shyamal D. Peddada, Adi L. Tarca
Summary: There is debate regarding the link between the vaginal microbiota and pregnancy complications, especially spontaneous preterm birth, due to inconsistencies in study results, likely resulting from differences in sample sizes and cohort ethnicity. This study, which focuses on a predominantly African-American cohort, examines the associations between individual identity, gestational age, and other maternal characteristics with the composition of the vaginal microbiota throughout gestation resulting in term delivery, providing a robust foundational understanding of the vaginal microbiota in pregnancy.
MICROBIOLOGY SPECTRUM
(2023)
Article
Obstetrics & Gynecology
Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B. B. Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than, Adi L. L. Tarca
Summary: Approximately 47% of women with preterm labor deliver at term, but their infants are at higher risk for being small for gestational age and having neurodevelopmental disorders. This study tested the involvement of components of the insulin-like growth factor system in preterm labor and found higher levels of certain components in women with a history of preterm labor.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Nardhy Gomez-Lopez, Roberto Romero, Maria Fernanda Escobar, Javier Andres Carvajal, Maria Paula Echavarria, Ludwig L. Albornoz, Daniela Nasner, Derek Miller, Dahiana M. Gallo, Jose Galaz, Marcia Arenas-Hernandez, Gaurav Bhatti, Bogdan Done, Maria Andrea Zambrano, Isabella Ramos, Paula Andrea Fernandez, Leandro Posada, Tinnakorn Chaiworapongsa, Eunjung Jung, Valeria Garcia-Flores, Manaphat Suksai, Francesca Gotsch, Mariachiara Bosco, Nandor Gabor Than, Adi L. Tarca
Summary: In this study, the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was characterized. The findings revealed shared and pregnancy-specific proteomic changes in COVID-19 patients compared to controls, and the plasma proteome accurately identifies COVID-19 patients, even when they are asymptomatic. This study provides insight into the pathogenesis of COVID-19 and explains the more severe outcomes observed in pregnant women.
COMMUNICATIONS MEDICINE
(2023)