Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse

Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1

(2018) Si-Hyung Lee et al.   FASEB JOURNAL

Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation

(2018) Jean-Marie Carpier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

(2018) Lakshmi Balagopalan et al.   Nature Communications

BLOC-1 is required for selective membrane protein trafficking from endosomes to primary cilia

(2017) William J. Monis et al.   JOURNAL OF CELL BIOLOGY

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT

(2016) Baerbel Keller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Finding the Golgi: Golgin Coiled-Coil Proteins Show the Way

(2016) Alison K. Gillingham et al.   TRENDS IN CELL BIOLOGY

A filter at the entrance of the Golgi that selects vesicles according to size and bulk lipid composition

(2016) Maud Magdeleine et al.   eLife

Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building Set

(2016) Anna Onnis et al.   Frontiers in Immunology

Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis

(2015) Jane C. Stinchcombe et al.   CURRENT BIOLOGY

The golgin GMAP-210 is required for efficient membrane trafficking in the early secretory pathway

(2015) P. Roboti et al.   JOURNAL OF CELL SCIENCE

Coupling of vesicle tethering and Rab binding is required for in vivo functionality of the golgin GMAP-210

(2015) Keisuke Sato et al.   MOLECULAR BIOLOGY OF THE CELL

IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo

(2015) Omar I. Vivar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orchestrating cytoskeleton and intracellular vesicle traffic to build functional immunological synapses

(2014) Helena Soares et al.   IMMUNOLOGICAL REVIEWS

Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system

(2014) F. Finetti et al.   JOURNAL OF CELL SCIENCE

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse

(2014) Kaushik Choudhuri et al.   NATURE

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor–independent TCR signaling hub

(2014) Romain Roncagalli et al.   NATURE IMMUNOLOGY

The specificity of vesicle traffic to the Golgi is encoded in the golgin coiled-coil proteins

(2014) M. Wong et al.   SCIENCE

Signaling at the immune synapse: vesicular trafficking takes the stage

(2013) Giulia Masi et al.   Cellular & Molecular Immunology

Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length

(2013) R. Ghossoub et al.   JOURNAL OF CELL SCIENCE

Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse

(2013) Helena Soares et al.   JOURNAL OF EXPERIMENTAL MEDICINE

VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites

(2013) Paola Larghi et al.   NATURE IMMUNOLOGY

End-binding protein 1 controls signal propagation from the T cell receptor

(2012) Noa B Martín-Cófreces et al.   EMBO JOURNAL

Cytokine Secretion by CD4+ T Cells at the Immunological Synapse Requires Cdc42-Dependent Local Actin Remodeling but Not Microtubule Organizing Center Polarity

(2012) K. Chemin et al.   JOURNAL OF IMMUNOLOGY

Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events

(2011) David J Williamson et al.   NATURE IMMUNOLOGY

CD4+ T-cell synapses involve multiple distinct stages

(2011) H. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

The immunological synapse: a focal point for endocytosis and exocytosis

(2010) Gillian M. Griffiths et al.   JOURNAL OF CELL BIOLOGY

T Cell Polarity at the Immunological Synapse Is Required for CD154-Dependent IL-12 Secretion by Dendritic Cells

(2010) M. Tourret et al.   JOURNAL OF IMMUNOLOGY

Activation of the Ancestral Polarity Regulator Protein Kinase C  at the Immunological Synapse Drives Polarization of Th Cell Secretory Machinery toward APCs

(2010) F. Bertrand et al.   JOURNAL OF IMMUNOLOGY

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Lethal Skeletal Dysplasia in Mice and Humans Lacking the Golgin GMAP-210

(2010) Patrick Smits et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse

(2010) M. A. Purbhoo et al.   Science Signaling

Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes

(2010) Romain Roncagalli et al.   Seminars in Immunopathology

Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms

(2009) Jesus Cardenas et al.   BMC BIOLOGY

Intraflagellar transport: it's not just for cilia anymore

(2009) Cosima T Baldari et al.   CURRENT OPINION IN CELL BIOLOGY

Loss of the LAT Adaptor Converts Antigen-Responsive T Cells into Pathogenic Effectors that Function Independently of the T Cell Receptor

(2009) Michael Mingueneau et al.   IMMUNITY

A Primary Role for Golgi Positioning in Directed Secretion, Cell Polarity, and Wound Healing

(2009) Smita Yadav et al.   MOLECULAR BIOLOGY OF THE CELL

Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse

(2009) Francesca Finetti et al.   NATURE CELL BIOLOGY

Asymmetric Tethering of Flat and Curved Lipid Membranes by a Golgin

(2008) G. Drin et al.   SCIENCE

The Golgin GMAP210/TRIP11 Anchors IFT20 to the Golgi Complex

(2008) John A. Follit et al.   PLoS Genetics