Review
Cell Biology
Emily R. Frost, Gunes Taylor, Mark A. Baker, Robin Lovell-Badge, Jessie M. Sutherland
Summary: The development of ovaries or testes is crucial for reproductive competence, relying on key cell fate decisions and cell cycle regulation. The Cip/Kip family of CKIs in mouse gonad development plays significant roles, as highlighted by recent single-cell RNA sequencing studies showing their heterogeneity and new roles in controlling and maintaining female fertility.
GENES & DEVELOPMENT
(2021)
Article
Reproductive Biology
Dulama Richani, Robert B. Gilchrist
Summary: Oocytes are maintained in a state of meiotic arrest until ovulation is triggered. Manipulation of cyclic nucleotides such as cGMP and cAMP can influence meiotic arrest and improve oocyte developmental competence. Pre-IVM modulation of cGMP and/or cAMP has shown consistent improvement in oocyte developmental competence.
BIOLOGY OF REPRODUCTION
(2022)
Article
Genetics & Heredity
Fupeng Wang, Yawen Tang, Yijie Cai, Ran Yang, Zongyu Wang, Xiaodong Wang, Qianying Yang, Wenjing Wang, Jianhui Tian, Lei An
Summary: It has been found that retinoic acid plays a central role in governing oocyte meiosis initiation. In this study, it was also revealed that retinoic acid is involved in LH-induced resumption from oocyte meiotic arrest. The research further emphasized the importance of LH in this process.
Article
Cell Biology
Soo-Hyun Park, Pil-Soo Jeong, Ye Eun Joo, Hyo-Gu Kang, Min Ju Kim, Sanghoon Lee, Bong-Seok Song, Sun-Uk Kim, Seong-Keun Cho, Bo-Woong Sim
Summary: Luteolin, as an antioxidant, plays a significant protective role in the in vitro maturation of oocytes, improving rates of polar body extrusion and blastocyst formation, enhancing gene expression, reducing intracellular reactive oxygen species, and ameliorating cell organelle defects caused by oxidative stress. Additionally, luteolin improves developmental competence of in vitro-fertilized embryos and restores competencies decreased by oxidative stress, shedding light on the relationship between oxidative stress and oocyte maturation processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Xiaoyi Wang, Melissa E. Pepling
Summary: This article discusses the meiotic process of female mammalian oocytes during embryonic development, highlighting the events and mechanisms from meiotic prophase one to metaphase two. It emphasizes the importance of understanding the mechanisms regulating meiotic progression to improve treatments for female infertility, as errors in meiosis can lead to aneuploidy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Saffet Ozturk
Summary: This review comprehensively evaluates the molecular determinants of developmental and permanent arrests occurring in mammalian oocytes, and discusses potential approaches for inducing permanent arrests to obtain competent oocytes.
Review
Endocrinology & Metabolism
Zhenle Pei, Ke Deng, Congjian Xu, Shuo Zhang
Summary: This article summarizes the cellular and molecular mechanisms involved in oocyte development and maturation, including meiotic arrest and resumption, as well as cytoplasmic events associated with oocyte quality. Understanding these mechanisms is crucial for understanding the female reproductive system and for future research and potential treatment approaches.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Kaori Nozawa, Zian Liao, Yuhkoh Satouh, Ting Geng, Masahito Ikawa, Diana Monsivais, Martin M. Matzuk
Summary: Wee1-like protein kinase 2 (WEE2) is an oocyte-specific protein tyrosine kinase involved in the regulation of oocyte meiotic arrest. Knockout mouse models were developed to test the impact of Wee2 loss-of-function on female fertility. While a frameshift mutation had no effect, a larger deletion resulted in reduced litter size in homozygous Wee2 female knockout mice. Overall, loss of Wee2 had only minor effects on fertility in mice, suggesting alternative approaches should be considered for contraceptive development.
Article
Biochemistry & Molecular Biology
Anumegha Gupta, Surendra Kumar Trigun
Summary: This study describes the effects of Cilostamide on oocytes at different meiotic stages, showing that Cilostamide treatment promotes meiotic arrest by increasing cAMP and cGMP levels and modulating related regulatory factors.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Neurosciences
Cristina Perez-Ternero, Patrick N. Pallier, Jordi L. Tremoleda, Alessio Delogu, Cathy Fernandes, Adina T. Michael-Titus, Adrian J. Hobbs
Summary: The lack of C-type natriuretic peptide (CNP) in the central nervous system (CNS) impairs tight junction protein arrangement, increases blood-brain barrier (BBB) permeability, and leads to changes in motor coordination and late-onset seizures.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Pan Chang, Xiaomeng Zhang, Jing Zhang, Jianbang Wang, Xihui Wang, Man Li, Rui Wang, Jun Yu, Feng Fu
Summary: The levels of brain natriuretic peptide (BNP) increase during the early stages of diabetic cardiomyopathy (DCM) as a compensatory protection mechanism. BNP activates the NPRA-PKG-STAT3-Opa1 signaling pathway, promoting mitochondrial fusion, inhibiting mitochondrial oxidative stress, preserving mitochondrial respiratory capacity, and preventing the development of DCM.
Article
Multidisciplinary Sciences
Laleh Abbassi, Stephany El-Hayek, Karen Freire Carvalho, Wusu Wang, Qin Yang, Sofia Granados-Aparici, Rafael Mondadori, Vilceu Bordignon, Hugh J. Clarke
Summary: In the process of fertilization, the uncoupling of mature oocytes from somatic granulosa cells is necessary. The study revealed that activation of EGFR signaling in granulosa cells during ovulation triggers ERK-dependent loss of filopodia oocyte adhesion and Arp2/3 mediated retraction of granulosa cell filopodia.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Bi-Yun Luo, Xiang Fang, Cheng-Zhi Wang, Cheng-Jie Yao, Zhen Li, Xue-Ying He, Xin-Yi Xiong, Chi-Zhen Xie, Xing-Lin Lai, Zhen-Hua Zhang, Gao-Feng Qiu
Summary: In this study, two GnRH-like peptides were isolated and identified from the brain tissues of Chinese mitten crab. Immunolocalization showed the presence of these peptides in the brain, ovary, and hepatopancreas. The synthetic peptides were found to induce oocyte maturation. This study provides the first direct evidence of the existence of GnRH-like peptides in the crab and demonstrates their conserved role in oocyte maturation as a primitive neurohormone.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Endocrinology & Metabolism
Patrycja Straczynska, Krzysztof Papis, Emilia Morawiec, Michal Czerwinski, Zdzislaw Gajewski, Anita Olejek, Anna Bednarska-Czerwinska
Summary: In vitro fertilization (IVF) is an effective method for treating infertility. In vitro maturation (IVM) of oocytes can be an alternative to ovarian hyperstimulation. The development of the embryo depends on the maturity of the oocyte. The microenvironment of the ovarian follicle and maternal signals play a role in the growth and maturation of the oocyte.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Sihai Lu, Yaju Tang, Ru Yao, Rui Xu, Hui Zhang, Jie Liu, Yan Gao, Qiang Wei, Xiaoe Zhao, Jianpeng Liu, Bin Han, Meng-Hao Pan, Baohua Ma
Summary: This study suggests that FSH mediates meiotic arrest of oocytes in goat follicles through the promotion of 17-beta-estradiol synthesis and the expression of ER beta. Additionally, the E-2/ER signaling pathway prevents meiotic recovery of oocytes by inhibiting NPR2 expression and cGMP synthesis.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Endocrinology & Metabolism
Pei Xu, Bao-Yi Huang, Jia-Hui Zhan, Man-Ting Liu, Yang Fu, You-Qiang Su, Qing-Yuan Sun, Wei-Hua Wang, Dun-Jin Chen, Jian-Qiao Liu
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Article
Chemistry, Multidisciplinary
Hui Li, Liji You, Yufeng Tian, Jing Guo, Xianbao Fang, Chenmin Zhou, Lanying Shi, You-Qiang Su
Article
Biochemistry & Molecular Biology
Xiaolin Chen, Chengxiu Hu, Xing Fan, Yiying Wang, Qiannan Li, You-Qiang Su, Dai-Min Zhang, QianLu Yang, Anthony G. Passerini, ChongXiu Sun
Summary: mTOR inhibitors induce PKC-dependent endothelial MLC phosphorylation, contraction, and hyperpermeability that promote pneumonitis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Hongdao Zhang, Fengjuan Zhang, Qinghua Chen, Mingzhe Li, Xiaolong Lv, Yali Xiao, Zhaozhen Zhang, Li Hou, Yana Lai, Ying Zhang, Aihua Zhang, Shiqi Gao, Heling Fu, Wen Xiao, Jianli Zhou, Feiyang Diao, Aimin Shi, You-Qiang Su, Wentao Zeng, Ligang Wu, Jianmin Li
Summary: Piwi-interacting RNAs (piRNAs) are crucial for germ cell development in golden hamsters, with defects leading to disrupted reproductive function and embryonic arrest. The findings highlight the essential role of piRNAs in mammalian oogenesis and the potential for using golden hamsters as a model species for piRNA studies.
NATURE CELL BIOLOGY
(2021)
Article
Cell Biology
Hong Yin, Teng Zhang, Hao Wang, Xin Hu, Xuan Hou, Xianbao Fang, Yaoxue Yin, Hui Li, Lanying Shi, You-Qiang Su
Summary: The research reveals that EML1 plays a crucial role in controlling oocyte meiotic progression in mice, and its loss leads to abnormal oocytes unable to progress to the second meiotic division.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Shiwen Ni, Teng Zhang, Chenmin Zhou, Min Long, Xuan Hou, Liji You, Hui Li, Lanying Shi, You-Qiang Su
Summary: The formation of IMPDH cytoophidium in mouse ovaries affects oocyte meiosis and development competence, and treatment with IMPDH inhibitor in vitro shows similar effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
You-Qiang Su, Yaoxue Yin, Jing Guo, Xuhong Gong, Yufeng Tian, Lanying Shi
Summary: The coordinated development of germline and somatic compartments in a follicle is crucial for the formation of a functional oocyte. The bi-directional communication between the oocyte and granulosa cells plays a vital role in supporting the development and function of both compartments. MTOR, a serine/threonine kinase, is emerging as a major regulator of oocyte and follicle development, controlling various aspects of their development and function.
BIOLOGY OF REPRODUCTION
(2022)
Article
Cell Biology
Xiaoli Wei, Lanping Zheng, Yingpu Tian, Haibin Wang, Youqiang Su, Gensheng Feng, Chao Wang, Zhongxian Lu
Summary: In this study, the crucial roles of the tyrosine phosphatase SHP2 in modulating the proliferation and apoptosis of ovarian granulosa cells (GCs) were identified. SHP2 deficiency promoted GC proliferation and inhibited GC apoptosis, while SHP2 overexpression had the opposite effects. Furthermore, SHP2 was found to balance follicular development by suppressing PI3K/AKT signaling. This study provides a potential therapeutic target for the clinical treatment of follicle developmental dysfunction.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Article
Cell Biology
Feifei Yuan, Xiaoqiong Hao, Yanying Cui, Fuxin Huang, Xiao Zhang, Yanli Sun, Tiantian Hao, Zhijuan Wang, Wei Xia, Youqiang Su, Meijia Zhang
Summary: Germ cell division and differentiation require close contact and interaction with somatic cells. LH-EGFR signaling activates sphingosine kinases (SphK) in somatic cells, leading to the production of S1P. S1P acts as a functional transmitter of LH-EGFR signaling, inducing meiotic maturation in somatic cells and improving developmental competence in oocytes.
CELL DEATH & DISEASE
(2022)
Article
Biology
Zhijuan Wang, Hongwei Wei, Zhanying Wu, Xiaodan Zhang, Yanli Sun, Longwei Gao, Wenqing Zhang, You-Qiang Su, Meijia Zhang
Summary: This study reveals the molecular mechanism of the movement of mouse spermatozoa out of the isthmic reservoir in preparation for fertilization. It involves the expression of TGFB1, NPPC, and TGF-beta signaling in cumulus cells and ampullary epithelial cells. Oocyte-dependent and cumulus cell-derived TGFB1 plays a critical role in promoting sperm migration in the oviduct and subsequent fertilization.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hui Li, Hailian Zhao, Chunhui Yang, Ruibao Su, Min Long, Jinliang Liu, Lanying Shi, Yuanchao Xue, You-Qiang Su
Summary: Mammalian oogenesis relies on stored mRNAs for successful development, but how their fate is determined remains unclear. RNA-binding proteins (RBPs) are important regulators, but the full complement in oocytes is unknown. This study identified 1396 RBPs in mouse oocytes and found LSM14B to be an important RBP specific to oocytes, essential for oogenesis and proper translation of its bound mRNAs.
Article
Medicine, Research & Experimental
Hong Yin, Xuan Hou, Teng Zhang, Lanying Shi, You-Qiang Su
JOURNAL OF BIOMEDICAL RESEARCH
(2020)
Article
Oncology
Jiqiang Wang, Zhihui Liu, Qianru Sun, Shuang Xia, Jing Cui, Lan Yang, Liyou An, Jiaxin Zhang, Lei Su, Youqiang Su, Fuliang Du
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2019)
Article
Medicine, Research & Experimental
Guangyi Cao, Mingzhe Li, Hao Wang, Lanying Shi, You-Qiang Su
JOURNAL OF BIOMEDICAL RESEARCH
(2018)
