Article
Nutrition & Dietetics
Jonas Laget, Irene Cortijo, Juliana H. H. Boukhaled, Karen Muyor, Flore Duranton, Bernard Jover, Fabrice Raynaud, Anne-Dominique Lajoix, Angel Argiles, Nathalie Gayrard
Summary: Obesity exacerbates renal inflammation and fibrosis in chronic kidney disease (CKD). Certain substances such as interleukin 11, dipeptidyl peptidase 4, and serpin 1 may directly affect the process of fibrosis.
Article
Endocrinology & Metabolism
Lauren K. Vasilakos, Baiba Steinbrekera, Donna A. Santillan, Mark K. Santillan, Debra S. Brandt, Daniel Dagle, Robert D. Roghair
Summary: Diabetes during pregnancy and chorioamnionitis are associated with increased levels of maternal insulin, leptin, and IL-6. While both leptin and IL-6 play roles in inflammation, they have contrasting effects on neurodevelopment. In a study of cord blood samples from 104 term infants, it was found that maternal diabetes increased levels of leptin and insulin, while chorioamnionitis was associated with elevated IL-6 levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Armando Pena, Micah L. Olson, Stephanie L. Ayers, Dorothy D. Sears, Sonia Vega-Lopez, Abigail T. Colburn, Gabriel Q. Shaibi
Summary: Obesity is linked to chronic inflammation and may increase the risk of type 2 diabetes in youth. This study investigated the relationship between inflammatory biomarkers and insulin sensitivity, beta-cell function, and response to lifestyle intervention in Latino youth with obesity. The findings showed that obesity-related inflammatory mediators were associated with T2D risk factors but were not affected by lifestyle intervention in Latino youth.
Article
Biochemistry & Molecular Biology
Saadia Zahid, Alcir L. L. Dafre, Antonio Currais, Jingting Yu, David Schubert, Pamela Maher
Summary: CMS121 has shown potential as a therapeutic option for metabolic disorders by protecting db/db mice from metabolic defects, reducing liver inflammation, and improving kidney damage markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Kyung Hee Hong, Min Young Um, Jiyun Ahn, Tae Youl Ha
Summary: This study investigated the effects of 6-gingerol on adiposity and obesity-induced inflammation in white adipose tissue of diet-induced obese mice. The results showed that 6-gingerol supplementation significantly reduced body weight, WAT mass, triglyceride, leptin, and insulin levels in HFD-fed mice. It also reduced adipogenesis-related transcription factors and lipogenesis-related genes in WAT. In addition, 6-gingerol increased adiponectin expression and decreased inflammatory adipokines and macrophage marker expression in WAT. In conclusion, 6-gingerol effectively alleviated adiposity and inflammation by regulating adipokines in diet-induced obese mice.
Review
Biochemistry & Molecular Biology
Sebastian Dommel, Matthias Bluher
Summary: Obesity is associated with adipose tissue dysfunction, leading to metabolic inflammation and increased immune cell infiltration, with CCL2 playing a crucial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Asma Mohammed Alyahya
Summary: This article discusses the role of adipokines in cardiovascular disease and its related risk factors, finding that progranulin has both protective and inflammatory effects.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Maki Murakoshi, Tomohito Gohda, Hiroko Sakuma, Terumi Shibata, Eri Adachi, Chiaki Kishida, Saki Ichikawa, Takeo Koshida, Nozomu Kamei, Yusuke Suzuki
Summary: High levels of PGRN and TNFR1 are associated with poor renal prognosis in patients with type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amgad Zaky, Sarah J. Glastras, May Y. W. Wong, Carol A. Pollock, Sonia Saad
Summary: Diabetic kidney disease is a progressive and challenging condition associated with the microbiota. Obesity and diabetes result in microbiota dysregulation, impacting health. Further research is needed to explore the role of microbiota in the development and treatment of DKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Sugania Malar Chinapayan, Shanggar Kuppusamy, Ning Yi Yap, Komathi Perumal, Glenda Gobe, Retnagowri Rajandram
Summary: Renal cell carcinoma is the most lethal genitourinary malignancy, and obesity is a risk factor for its development. This systematic review and meta-analysis found that visfatin and nesfatin-1 showed significant associations with RCC, indicating their potential role in the development and progression of the disease, as well as their potential diagnostic and prognostic capabilities.
Article
Geriatrics & Gerontology
Jeremy Raffin, Davide Angioni, Kelly Giudici, Philippe Valet, Geetika Aggarwal, Andrew D. Nguyen, John E. Morley, Sophie Guyonnet, Yves Rolland, Bruno Vellas, Philipe de Souto Barreto
Summary: This study aimed to investigate the associations between body mass index (BMI), physical activity (PA), and the adipokine progranulin (PGRN) in older adults. The results showed that higher PA levels were associated with lower PGRN concentrations in individuals without obesity, while the opposite pattern was found in obese individuals. In addition, BMI was positively associated with PGRN levels in highly active individuals.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiangli Zhao, Sadaf Hasan, Benjamin Liou, Yi Lin, Ying Sun, Chuanju Liu
Summary: The study found that PGRN deficiency leads to neuron loss and activation of microglia and astrocytes in aged mice. Several characteristic neurodegenerative disease markers, including alpha-synuclein, TDP-43, Tau, and beta-amyloid, were accumulated in the brain tissue of PGRN-deficient mice. Moreover, higher aggregation of lipofuscin was observed in the brain tissue of PGRN-deficient mice, and autophagy was also defective.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria D. Sanchez-Nino, Maria I. Ceballos, Sol Carriazo, Aranzazu Pintor-Chocano, Ana B. Sanz, Moin A. Saleem, Alberto Ortiz
Summary: The interaction between diabetes and Fabry disease may increase the severity of kidney damage by modulating the Gb3 synthesis pathway and downregulating kidney protective genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Xinzhi Li, Zhongyuan Ma, Yi Zhun Zhu
Summary: PVAT is a unique type of fat depot with local and systemic impacts, anatomically, developmentally, and functionally different from classical adipose tissues and from each other. The distinct origins and developmental trajectory of PVAT adipocytes potentially contribute to regional heterogeneity. PVAT communicates with neighboring vasculature by producing specific adipokines, vascular tone regulators, and extracellular vesicles in a given microenvironment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carlos Jimenez-Cortegana, German Ortiz-Garcia, Amalia Serrano, David Moreno-Ramirez, Victor Sanchez-Margalet
Summary: Atopic dermatitis is a common and complex chronic inflammatory skin disease, with increasing incidence in developed countries in recent years. Obesity, a global health issue on the rise, has been associated with diseases like atopic dermatitis. Research suggests that leptin, an important adipokine, may play a key role in the pathogenesis of atopic dermatitis.
Article
Endocrinology & Metabolism
L. C. Pinto, C. K. Kramer, J. L. Camargo, L. H. Canani, J. L. Gross, C. B. Leitao
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2020)
Article
Surgery
Michele de Souza Kraemer, Milene Moehlecke, Jakeline Rheinheimer, Luis Henrique Canani, Cristiane Bauermann Leitao, Bruna Bellincanta Nicoletto
SURGERY FOR OBESITY AND RELATED DISEASES
(2020)
Article
Multidisciplinary Sciences
Larissa Salomoni Carpes, Bruna Bellincanta Nicoletto, Luis Henrique Canani, Jakeline Rheinhemer, Daisy Crispim, Gabriela Correa Souza
Summary: Zonulin, a protein linked to various health conditions, was found to be increased in T2DM patients without renal disease, indicating impaired intestinal permeability. Its association with renal outcomes suggests its potential use as a disease monitoring marker, but further research is needed on the underlying mechanisms.
Review
Endocrinology & Metabolism
Freddy G. Eliaschewitz, Luis Henrique Canani
Summary: Oral semaglutide effectively reduces blood glucose and body weight in patients with T2D, demonstrating cardiovascular safety. Adverse events associated with oral semaglutide, like other GLP-1 RA drugs, are mainly related to the gastrointestinal tract.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Endocrinology & Metabolism
Cristine Dieter, Natalia Emerim Lemos, Nathalia Rodrigues de Faria Correa, Aline Rodrigues Costa, Luis Henrique Canani, Daisy Crispim, Andrea Carla Bauer
Summary: This study revealed an association between the ANGPT-2 rs2442598 A allele and risk for DR in T1DM patients, with the A/A genotype showing a significant association with DR risk.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2021)
Article
Endocrinology & Metabolism
Cristine Dieter, Natalia Emerim Lemos, Nathalia Rodrigues de Faria Correa, Felipe Mateus Pellenz, Luis Henrique Canani, Daisy Crispim, Andrea Carla Bauer
Summary: This study investigated the association between the rs759853 polymorphism in the AKR1B1 gene and diabetic kidney disease (DKD) in Brazilian patients with type 2 diabetes mellitus (T2DM). The results suggest that the A/A genotype of the rs759853 polymorphism is associated with an increased risk for DKD in this population.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)
Article
Endocrinology & Metabolism
Felipe Mateus Pellenz, Cristine Dieter, Guilherme Coutinho Kullmann Duarte, Luis Henrique Canani, Bianca Marmontel de Souza, Daisy Crispim
Summary: The TYK2 rs2304256 SNP is associated with protection against T1DM in a Southern Brazilian population, with the A allele showing a protective effect against the disease.
DIABETES & METABOLISM JOURNAL
(2021)
Review
Ophthalmology
Luis Fernando Castagnino Sesti, Renan Cesar Sbruzzi, Evelise Regina Polina, Douglas dos Santos Soares, Daisy Crispim, Luis Henrique Canani, Katia Goncalves dos Santos
Summary: The rs1617640 polymorphism in the EPO gene is suggestively associated with diabetic retinopathy (DR), particularly non-proliferative DR and DR in patients with type 1 diabetes (T1DM). However, no association is found between the rs507392 and rs551238 polymorphisms and DR.
Article
Endocrinology & Metabolism
Joao Roberto de Sa, Erika Bevilaqua Rangel, Luis Henrique Canani, Andrea Carla Bauer, Gustavo Monteiro Escott, Themis Zelmanovitz, Marcello Casaccia Bertoluci, Sandra Pinho Silveiro
Summary: The review on Diabetic Kidney Disease by SBD provides evidence-based guidelines for management with recommendations categorized by levels of evidence and degrees of agreement from panelists. Intensive glycemic control, blood pressure management, and the use of specific medications are essential for preventing advanced stages of DKD.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Peripheral Vascular Disease
Eloisa Toscan Massignam, Cristine Dieter, Tais Silveira Assmann, Guilherme Coutinho Kullmann Duarte, Andrea Carla Bauer, Luis Henrique Canani, Daisy Crispim
Summary: The ERBB3 and PA2G4 gene mutations were not found to be associated with T1DM. However, the ERBB3 rs705708 A allele was associated with a lower prevalence of diabetic retinopathy and arterial hypertension, as well as improved renal function.
MICROVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mariana Kras Borges Russo, Lucas Stahlhofer Kowalewski, Gabriella Richter da Natividade, Carlos Henrique de Lemos Muller, Helena Trevisan Schroeder, Patricia Martins Bock, Layane Ramos Ayres, Bernardo Urbano Cardoso, Caroline Zanotto, Julia Tsao Schein, Tatiana Helena Rech, Daisy Crispim, Luis Henrique Canani, Rogerio Friedman, Cristiane Bauermann Leitao, Fernando Gerchman, Mauricio Krause
Summary: In this study, it was found that patients with severe COVID-19 have elevated levels of plasma eHSP72 and a blunted HSR, regardless of the presence of diabetes. These results may explain the uncontrolled inflammation and the increased risk of developing type 2 diabetes after SARS-CoV-2 infection.
Article
Biochemistry & Molecular Biology
Cristine Dieter, Natalia Emerim Lemos, Eliandra Girardi, Denise Taurino Ramos, Felipe Mateus Pellenz, Luis Henrique Canani, Tais Silveira Assmann, Daisy Crispim
Summary: This study investigated the association of six lncRNA gene polymorphisms with diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). The study found that the rs3931283/PVT1 G/G genotype was associated with the risk of DKD and markers of renal function, while the rs7158663/MEG3 G/G genotype was associated with protection against severe DKD and better renal function.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Genetics & Heredity
Cristine Dieter, Leticia de Almeida Brondani, Natalia Emerim Lemos, Ariell Freires Schaeffer, Caroline Zanotto, Denise Taurino Ramos, Eliandra Girardi, Felipe Mateus Pellenz, Joiza Lins Camargo, Karla Suzana Moresco, Lucas Lima da Silva, Mariana Rauback Aubin, Mayara Souza de Oliveira, Tatiana Helena Rech, Luis Henrique Canani, Fernando Gerchman, Cristiane Bauermann Leitao, Daisy Crispim
Summary: Although age, sex, and comorbidities play a role in the severity of COVID-19, genetic polymorphisms in ACE1, ACE2, DPP9, IFIH1, IFNAR2, IFNL4, TLR3, TMPRSS2, and TYK2 also contribute to the variation in disease severity. This study found that specific genotypes and alleles in these genes are associated with increased risk of ICU admission and death in COVID-19 patients, especially among females and non-white individuals. Moreover, interactions between these polymorphisms further increase the risk of worse outcomes.
Article
Endocrinology & Metabolism
Cristine Dieter, Natalia Emerim Lemos, Nathalia Rodrigues de Faria Correa, Tais Silveira Assmann, Felipe Mateus Pellenz, Luis Henrique Canani, Leticia de Almeida Brondani, Andrea Carla Bauer, Daisy Crispim
Summary: This study investigated the association between SNPs in the TIE2 and ANGPT-1 genes and diabetic retinopathy (DR). The study included 603 patients with type 2 diabetes mellitus (T2DM) and DR as cases, and 388 patients with T2DM for more than 10 years without DR as controls. The results showed that certain genotypes and alleles of TIE2 and ANGPT-1 SNPs were associated with protection against DR in a Brazilian population.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Cristine Dieter, Natalia Emerim Lemos, Eliandra Girardi, Denise Taurino Ramos, Nathalia Rodrigues de Faria Correa, Luis Henrique Canani, Andrea Carla Bauer, Tais Silveira Assmann, Daisy Crispim
Summary: Long non-coding RNAs (lncRNAs) have a significant role in gene expression regulation and have been associated with various human diseases, including diabetes kidney disease (DKD). This study aimed to compare the expressions of lncRNAs MALAT1 and TUG1 in urine samples of type 1 diabetes mellitus (T1DM) patients with and without DKD. The results showed upregulation of MALAT1 in T1DM patients with DKD, suggesting its potential involvement in DKD development.
GENETICS AND MOLECULAR BIOLOGY
(2023)
