Review
Biochemistry & Molecular Biology
Victoria Campos-Pena, Pavel Pichardo-Rojas, Talia Sanchez-Barbosa, Emma Ortiz-Islas, Citlali Ekaterina Rodriguez-Perez, Pedro Montes, Gerardo Ramos-Palacios, Daniela Silva-Adaya, Rafael Valencia-Quintana, Jorge Francisco Cerna-Cortes, Danira Toral-Rios
Summary: The presence of insoluble aggregates of amyloid beta (A beta) in the brain is a hallmark of Alzheimer's disease, and it has been shown to contribute to extensive neuronal loss. The distribution and content of cholesterol in the membrane play an important role in the production and accumulation of A beta peptides, leading to dysfunction and neuronal death. The monomeric forms of A beta peptides can trigger changes in Tau phosphorylation and cognitive function through their internalization by specific receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
Andressa R. Pereira, Flavio M. Shimizu, Osvaldo N. Oliveira Jr
Summary: The composition of Langmuir monolayers, specifically the relative concentration of cholesterol, plays a crucial role in modulating the effects of the antineoplastic drug paclitaxel. The dependence on cholesterol concentration for these monolayers simulating lipid rafts is non-monotonic, affecting surface pressure and compressibility modulus differently. The physiological action of paclitaxel may vary depending on its interaction with membrane penetration or membrane elasticity changes.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Analytical
Minggang Tian, Yaru Sun, Xiuqi Kong, Baoli Dong
Summary: Studying the phase separation of ER membranes is crucial for understanding the fundamental biology of ER. However, NIR ratiometric imaging of ER phase behaviors has not been explored in living cells and diverse tissues. In this study, we developed a polarity-responsive NIR fluorescent probe to visualize the phase behavior in ER membranes and revealed different phase behaviors in different tissues.
ANALYTICAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Scott B. Hansen, Hao Wang
Summary: This article discusses the role of cholesterol in neuroinflammation and its relationship with cognitive function loss.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Neurosciences
Vladimir Rudajev, Jiri Novotny
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by the production and aggregation of amyloid beta, which leads to cell membrane disruption and cell death. Cholesterol, as a major component of cell membranes, plays a significant role in the progression of AD, although its effects are inconsistent.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Chemistry, Medicinal
Yash P. Singh, Harish Kumar
Summary: Alzheimer's disease is a chronic neurodegenerative disease associated with aging, characterized by progressive memory loss and cognitive impairment. The current clinical treatment options for AD are limited and the use of tryptamine and its analogs as multifunctional agents shows promise for AD therapy.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hongtao Du, Jinzhi Song, Fang Ma, Hongxin Gao, Xinyan Zhao, Renjun Mao, Xiaolong He, Yan Yan
Summary: This study synthesised and characterised a series of novel harmine derivatives as potential ligands for AD treatment. Compounds 13 and 17d showed exceptional neuroprotective effects and potent inhibition against AChE and A beta aggregation. Kinetic studies and molecular modelling confirmed the interaction of compound 13 with both CAS and PAS of AChE.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Siddhartha Banerjee, Mohtadin Hashemi, Karen Zagorski, Yuri L. Lyubchenko
Summary: The presence of cholesterol in lipid bilayers significantly enhances the aggregation process of Aβ42 at low concentrations, indicating that the lipid composition plays a crucial role in controlling the self-assembly of Aβ oligomers in cellular membranes.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Neurosciences
Maria Rosaria Tropea, Domenica D. Li Puma, Marcello Melone, Walter Gulisano, Ottavio Arancio, Claudio Grassi, Fiorenzo Conti, Daniela Puzzo
Summary: The deletion of alpha 7nAChR leads to impaired hippocampal synaptic plasticity and memory, along with an increase in Amyloid Precursor Protein expression and A beta levels, resembling classic features of Alzheimer's disease (AD).
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Nancy D. Asen, Ogadimma D. Okagu, Chibuike C. Udenigwe, Rotimi E. Aluko
Summary: This study explores the potential of peptides obtained from enzymatic digestion of pea protein as novel AChE-inhibitory agents in Alzheimer's disease management. The peptides were found to be able to change the conformation of AChE protein and inhibit its activity, making them promising candidates for more effective and safer AD treatments.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Maria Blaszczyk, Agata Koziol, Anna Palko-Labuz, Kamila Sroda-Pomianek, Olga Wesolowska
Summary: Cholesterol is an important component of mammalian cell membranes, and together with sphingomyelin, it forms lipid rafts, which play a role in signal transduction. Altered cholesterol levels are associated with various diseases. This study investigated compounds that affect cellular cholesterol homeostasis. These compounds were found to be cytotoxic to colon cancer cells and decreased cellular cholesterol levels. The interaction of these compounds with model membranes was visualized, and certain compounds were found to affect the size and shape of lipid domains. The importance of membrane interactions for the anticancer potency of these compounds, especially betulin derivatives, was suggested.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2023)
Article
Medicine, Research & Experimental
Sagheer Ahmed, Sidrah Tariq Khan, Muhammad Kazim Zargaham, Arif Ullah Khan, Saeed Khan, Abrar Hussain, Jalal Uddin, Ajmal Khan, Ahmed Al-Harrasi
Summary: Alzheimer's disease is the most common type of dementia affecting the later years of life and will be a major burden on the healthcare system. Despite scientific advancements, there are still no therapies available to stop or slow the progression of the disease. FDA has approved certain drugs for AD treatment, but research also suggests potential benefits from herbal compounds.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Shoaib Manzoor, Santosh Kumar Prajapati, Shreyasi Majumdar, Shilpi Khurana, Sairam Krishnamurthy, Nasimul Hoda
Summary: The phenyl sulfonyl-pyrimidine derivatives BS-10 and BS-22 have shown potential therapeutic effects in Alzheimer's disease by reducing memory impairment, inhibiting acetylcholinesterase activity, increasing acetylcholine levels, and exhibiting antioxidant properties.
Article
Biochemistry & Molecular Biology
Yurii A. Zolotarev, Vladimir A. Mitkevich, Stanislav I. Shram, Alexei A. Adzhubei, Anna P. Tolstova, Oleg B. Talibov, Alexander K. Dadayan, Nikolai F. Myasoyedov, Alexander A. Makarov, Sergey A. Kozin
Summary: The study showed that HAEE can cross the blood-brain barrier and interact directly with A beta, reducing cerebral amyloidogenesis in a mouse model of AD. This anti-amyloid effect is likely due to the interaction between HAEE and A beta species in the brain.
Article
Multidisciplinary Sciences
Hui -Lam Rachel Kwan, Zora Chui-Kuen Chan, Xinyi Bi, Justyna Kutkowska, Tomasz J. Proszynski, Chi Bun Chan, Chi Wai Lee
Summary: Junctional folds are unique membrane specializations that develop during the postnatal maturation of vertebrate neuromuscular junctions (NMJs). This study demonstrates the progressive development of membrane infoldings via nerve-independent, caveolin-3-dependent mechanisms and identifies their roles in AChR trafficking and redistribution during the structural maturation of NMJs.