Recombinant α-Klotho Protein Alleviated Acute Cardiorenal Injury in a Mouse Model of Lipopolysaccharide-Induced Septic Cardiorenal Syndrome Type 5

Septic Cardiomyopathy

(2018) Sarah J. Beesley et al.   CRITICAL CARE MEDICINE

Cardiorenal syndrome in sepsis: A narrative review

(2018) Aditya Kotecha et al.   JOURNAL OF CRITICAL CARE

THE SEPTIC HEART Current Understanding of Molecular Mechanisms and Clinical Implications

(2018) Lukas Martin et al.   CHEST

The role of mitochondria in sepsis-induced cardiomyopathy

(2018) Giacomo Stanzani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice

(2018) Daniela Jou-Valencia et al.   CRITICAL CARE MEDICINE

Suppression of Apoptosis in Human Umbilical Vein Endothelial Cells (HUVECs) by Klotho Protein is Associated with Reduced Endoplasmic Reticulum Oxidative Stress and Activation of the PI3K/AKT Pathway

(2018) Wei Cui et al.   MEDICAL SCIENCE MONITOR

Intact FGF23 and α-klotho during acute inflammation/sepsis in CKD patients

(2016) Evangelia Dounousi et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Molecular Basis of Klotho: From Gene to Function in Aging

(2015) Yuechi Xu et al.   ENDOCRINE REVIEWS

Renal Production, Uptake, and Handling of Circulating  Klotho

(2015) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy

(2015) K. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ENDOPLASMIC RETICULUM STRESS IN SEPSIS

(2015) Mohammad Moshahid Khan et al.   SHOCK

Klotho has dual protective effects on cisplatin-induced acute kidney injury

(2013) Monica C. Panesso et al.   KIDNEY INTERNATIONAL

Klotho Suppresses Cardiomyocyte Apoptosis in Mice with Stress-Induced Cardiac Injury via Downregulation of Endoplasmic Reticulum Stress

(2013) Shuang Song et al.   PLoS One

Renal and Extrarenal Actions of Klotho

(2013) Ming Chang Hu et al.   SEMINARS IN NEPHROLOGY

Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart

(2012) Jian Xie et al.   Nature Communications

The Pathogenesis of Sepsis

(2011) Deborah J. Stearns-Kurosawa et al.   Annual Review of Pathology-Mechanisms of Disease

Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation

(2011) Y. Zhao et al.   DIABETES

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Inflammatory Cytokines TWEAK and TNF  Reduce Renal Klotho Expression through NF B

(2011) J. A. Moreno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective

(2010) Ming-Chang Hu et al.   KIDNEY INTERNATIONAL

Tumor Necrosis Factor and Interferon-γ Down-regulate Klotho in Mice With Colitis

(2009) Robert D. Thurston et al.   GASTROENTEROLOGY

Klotho Gene Delivery Prevents the Progression of Spontaneous Hypertension and Renal Damage

(2009) Yuhong Wang et al.   HYPERTENSION