Both GSK-3β/CRMP2 and CDK5/CRMP2 Pathways Participate in the Protection of Dexmedetomidine Against Propofol-Induced Learning and Memory Impairment in Neonatal Rats

A Specific Role of Hippocampal NMDA Receptors and Arc Protein in Rapid Encoding of Novel Environmental Representations and a More General Long-Term Consolidation Function

(2019) Cameron M. Bye et al.   Frontiers in Behavioral Neuroscience

Calpain and JNK pathways participate in isoflurane – induced nucleus translocation of apoptosis-inducing factor in the brain of neonatal rats

(2018) Xue Han et al.   TOXICOLOGY LETTERS

Dexmedetomidine attenuates propofol-induce neuroapoptosis partly via the activation of the PI3k/Akt/GSK3β pathway in the hippocampus of neonatal rats

(2017) Jing Lv et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Neonatal Propofol Anesthesia Changes Expression of Synaptic Plasticity Proteins and Increases Stereotypic and Anxyolitic Behavior in Adult Rats

(2017) Desanka Milanovic et al.   NEUROTOXICITY RESEARCH

Neuroprotective effects of dexmedetomidine against hyperoxia-induced injury in the developing rat brain

(2017) Stefanie Endesfelder et al.   PLoS One

rno-miR-665 targets BCL2L1 (Bcl-xl) and increases vulnerability to propofol in developing astrocytes

(2016) Wen-Chong Sun et al.   JOURNAL OF NEUROCHEMISTRY

Dexmedetomidine Attenuates Neurotoxicity Induced by Prenatal Propofol Exposure

(2016) Jing Li et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY

Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats

(2016) YUJIE WANG et al.   Molecular Medicine Reports

Dexmedetomidine pretreatment attenuates propofol-induced neurotoxicity in neuronal cultures from the rat hippocampus

(2016) Yi Wei et al.   Molecular Medicine Reports

The Fas Ligand/Fas Death Receptor Pathways Contribute to Propofol-Induced Apoptosis and Neuroinflammation in the Brain of Neonatal Rats

(2016) Desanka Milanovic et al.   NEUROTOXICITY RESEARCH

Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus

(2016) Xiaohua Jin et al.   NEURAL PLASTICITY

Changes in the expression of collapsin response mediator protein-2 during synaptic plasticity in the mouse hippocampus

(2015) Keiichi Kadoyama et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Propofol Administration During Early Postnatal Life Suppresses Hippocampal Neurogenesis

(2015) Jing Huang et al.   MOLECULAR NEUROBIOLOGY

Propofol-induced rno-miR-665 targets BCL2L1 and influences apoptosis in rodent developing hippocampal astrocytes

(2015) Wen-Chong Sun et al.   NEUROTOXICOLOGY

CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation

(2015) Minghui Tan et al.   NEURAL PLASTICITY

Sevoflurane Induces Tau Phosphorylation and Glycogen Synthase Kinase 3β Activation in Young Mice

(2014) Guorong Tao et al.   ANESTHESIOLOGY

Both JNK and P38 MAPK pathways participate in the protection by dexmedetomidine against isoflurane-induced neuroapoptosis in the hippocampus of neonatal rats

(2014) Zhaoxia Liao et al.   BRAIN RESEARCH BULLETIN

Collapsin Response Mediator Protein 2 (CRMP2) Interacts withN-Methyl-d-aspartate (NMDA) Receptor and Na+/Ca2+Exchanger and Regulates Their Functional Activity

(2014) Tatiana Brustovetsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memory Enhancement by Targeting Cdk5 Regulation of NR2B

(2014) Florian Plattner et al.   NEURON

Dexmedetomidine Reduces Isoflurane-Induced Neuroapoptosis Partly by Preserving PI3K/Akt Pathway in the Hippocampus of Neonatal Rats

(2014) Yujuan Li et al.   PLoS One

Propofol and memory: a study using a process dissociation procedure and functional magnetic resonance imaging

(2013) X. Quan et al.   ANAESTHESIA

Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain

(2013) C. Creeley et al.   BRITISH JOURNAL OF ANAESTHESIA

Magnetic Resonance Spectroscopy as a tool to study the role of GABA in motor-cortical plasticity

(2013) Charlotte J. Stagg   NEUROIMAGE

NMDA receptors and memory encoding

(2013) Richard G.M. Morris   NEUROPHARMACOLOGY

Inhibition of aberrant cyclin-dependent kinase 5 activity attenuates isoflurane neurotoxicity in the developing brain

(2013) Wen-Yuan Wang et al.   NEUROPHARMACOLOGY

Repeated exposure to propofol potentiates neuroapoptosis and long-term behavioral deficits in neonatal rats

(2013) Deshui Yu et al.   NEUROSCIENCE LETTERS

The Role of Astrocytes in the Regulation of Synaptic Plasticity and Memory Formation

(2013) Yusuke Ota et al.   NEURAL PLASTICITY

Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury

(2012) Marc Schoeler et al.   BMC Neurology

Neonatal administration with dexmedetomidine does not impair the rat hippocampal synaptic plasticity later in adulthood

(2012) Kaori Tachibana et al.   PEDIATRIC ANESTHESIA

Long-term Differences in Language and Cognitive Function After Childhood Exposure to Anesthesia

(2012) C. Ing et al.   PEDIATRICS

Early Childhood Exposure to Anesthesia and Risk of Developmental and Behavioral Disorders in a Sibling Birth Cohort

(2011) Charles DiMaggio et al.   ANESTHESIA AND ANALGESIA

Isoflurane Neurotoxicity Is Mediated by p75NTR-RhoA Activation and Actin Depolymerization

(2010) Brian P. Lemkuil et al.   ANESTHESIOLOGY

Regional and Temporal Profiles of Calpain and Caspase-3 Activities in Postnatal Rat Brain following Repeated Propofol Administration

(2010) Desanka Milanovic et al.   DEVELOPMENTAL NEUROSCIENCE

Neuroprotective effects of a combination of dexmedetomidine and hypothermia after incomplete cerebral ischemia in rats

(2009) K. SATO et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats

(2009) Robert D. Sanders et al.   ANESTHESIOLOGY

Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria

(2009) Taku Ozaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Spatial Learning Impairment, Enhanced CDK5/p35 Activity, and Downregulation of NMDA Receptor Expression in Transgenic Mice Expressing Tau-Tubulin Kinase 1

(2009) S. Sato et al.   JOURNAL OF NEUROSCIENCE

Regulation of Hippocampal and Behavioral Excitability by Cyclin-Dependent Kinase 5

(2009) Ammar H. Hawasli et al.   PLoS One

Subanesthetic Doses of Propofol Induce Neuroapoptosis in the Infant Mouse Brain

(2008) Davide Cattano et al.   ANESTHESIA AND ANALGESIA

An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death

(2008) E Norberg et al.   CELL DEATH AND DIFFERENTIATION

Potential mechanism of cell death in the developing rat brain induced by propofol anesthesia

(2008) Vesna Pešić et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

GABAergic Mechanism of Propofol Toxicity in Immature Neurons

(2008) Sibel Kahraman et al.   JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY