Article
Physiology
Eugenia B. Manukhina, Vadim E. Tseilikman, Maria V. Komelkova, Maxim S. Lapshin, Anna V. Goryacheva, Marina V. Kondashevskaya, Vladimir A. Mkhitarov, Svetlana S. Lazuko, Olga B. Tseilikman, Alexey P. Sarapultsev, Yulia A. Dmitrieva, Viktor K. Strizhikov, Olga P. Kuzhel, H. Fred Downey
Summary: This study found that 40% of rats exposed to traumatic stress developed experimental PTSD, exhibiting signs of cardiac injury. Conversely, resistant rats showed fewer cardiac injury markers. Reduced inflammation and oxidative stress, along with increased protective protein HSP70, were identified as factors that can mitigate cardiac damage in rats exposed to stress.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Physiology
Eugenia B. Manukhina, Vadim E. Tseilikman, Maria Komelkova, Maxim S. Lapshin, Anna Goryacheva, Marina Kondashevskaya, Vladimir A. Mkhitarov, Svetlana S. Lazuko, Olga B. Tseilikman, Alexey P. Sarapultsev, Yulia A. Dmitrieva, Viktor K. Strizhikov, Olga P. Kuzhel, H. Fred Downey
Summary: The study compared the effects of predator stress on cardiac injury mechanisms in PTSD-vulnerable and PTSD-resistant rats. The results showed that rats with PTSD developed multiple signs of cardiac injury, while PTSD-resistant rats were resistant to cardiac damage. Factors limiting cardiac injury in susceptible rats included reduced inflammation and oxidative stress, and increased protective heat shock protein 70.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Editorial Material
Psychology, Biological
Lisa M. Shin, Samuel R. Sommers
Summary: Increased exposure to media coverage of traumatic events is linked to greater symptoms of post-traumatic stress, especially in youth with specific patterns of brain activation that may make them more vulnerable to trauma.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Cardiac & Cardiovascular Systems
Yi-Han Lin, Maryann P. Platt, Ryan P. Gilley, David Brown, Peter H. Dube, Yanbao Yu, Norberto Gonzalez-Juarbe
Summary: This study found significant alterations in the cardiac proteome and phosphoproteome after pulmonary influenza infection, with viral particles persisting in the heart. Inhibition of necroptosis or prevention of mitochondrial damage may be potential therapeutic interventions to reduce cardiac damage during influenza infections.
CIRCULATION RESEARCH
(2021)
Editorial Material
Medicine, General & Internal
Ivana Sopek Merkas, Nenad Lakusic
Summary: Posttraumatic stress disorder (PTSD) can be triggered by acute coronary syndrome (ACS) and is associated with an increased risk of recurrent cardiovascular events and mortality. However, this subgroup of patients is not sufficiently recognized among clinicians who could offer specific therapeutic and rehabilitation approaches.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Lisa A. Brenner, Jeri E. Forster, Jaimie L. Gradus, Trisha A. Hostetter, Claire A. Hoffmire, Colin G. Walsh, Mary Jo Larson, Kelly A. Stearns-Yoder, Rachel Sayko Adams
Summary: This study aimed to identify the associations of military-related traumatic brain injury (TBI) with suicide and new-onset mental health conditions. The findings showed that soldiers with a history of TBI had higher rates of new-onset mental health conditions and were at greater risk of suicide. These results highlight the need for increased efforts to address the cumulative risk associated with multiple military-related exposures.
Article
Education, Scientific Disciplines
Katrin Jaradeh, Francesco Sergi, Coleen Kivlahan, Cesar Nava Gonzales, Mar Cury, Triveni DeFries
Summary: This study describes the implementation of trauma-informed care principles in a student-run asylum clinic, highlighting the importance of these principles in supporting individuals seeking asylum during forensic medical evaluations. The clinic completed 160 evaluations over a three-year period, with positive feedback from participants. Future research should focus on assessing secondary trauma and resilience within these clinics.
Review
Physiology
Jinsheng Lai, Chen Chen
Summary: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid produced by cytochrome P450 (CYP) epoxygenases, with beneficial effects against inflammation, fibrosis, and apoptosis in cardiovascular diseases. Studies have shown that increasing EET levels can protect against cardiovascular diseases such as hypertension, myocardial infarction, and heart failure. Therefore, upregulation of EETs may be a potential therapeutic strategy for cardiovascular diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Psychiatry
Carole E. Siegel, Eugene M. Laska, Ziqiang Lin, Mu Xu, Duna Abu-Amara, Michelle K. Jeffers, Meng Qian, Nicholas Milton, Janine D. Flory, Rasha Hammamieh, Bernie J. Daigle, Aarti Gautam, Kelsey R. Dean, Victor Reus, Owen M. Wolkowitz, Synthia H. Mellon, Kerry J. Ressler, Rachel Yehuda, Kai Wang, Leroy Hood, Francis J. Doyle, Marti Jett, Charles R. Marmar
Summary: The study identified two clinical subtypes of PTSD in veterans using machine learning methods and blood biomarkers, showing that one subtype (S2) had more severe symptoms compared to the other subtype (S1) and healthy controls. Multi-omic blood markers were effective in distinguishing between these subtypes and healthy controls, with methylation, micro RNA, and lactate markers showing a biological role in symptom severity.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Cardiac & Cardiovascular Systems
Roland von Kaenel, Jean-Paul Schmid, Rebecca E. Meister-Langraf, Juergen Barth, Hansjoerg Znoj, Ulrich Schnyder, Mary Princip, Aju P. Pazhenkottil
Summary: During acute coronary syndromes (ACS), the use of benzodiazepines may increase the risk of developing posttraumatic stress disorder symptoms, while morphine, beta-blockers, and antidepressants showed no predictive value in this study.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Steven H. Woodward, Stephen R. Baldassarri, Robert H. Pietrzak
Summary: Dog ownership is associated with lower cardiovascular and all-cause mortality, and is related to cardiometabolic diseases, but has a detrimental effect on conditions such as diabetes and stroke. Dog owners are generally younger and more active, while cat owners do not have these benefits. Dog owners have lower chances of developing hypertension and high cholesterol, and owning a dog can lower the risk of heart disease through exercise. However, in older veterans, dog ownership is associated with higher odds of diabetes and stroke.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Xiaonan Sun, Jalen Alford, Hongyu Qiu
Summary: Mitochondrial remodeling is crucial for maintaining normal cellular function and dysregulation can lead to complex diseases. Understanding the molecular basis and regulatory network of mitochondrial remodeling is important for elucidating the pathogenesis of cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychology, Multidisciplinary
Talea Cornelius, Joan A. Casey, Allan C. Just, Sebastian T. Rowland, Donald Edmondson
Summary: This study examined the effects of temperature and socioeconomic status (SES) on posttraumatic stress symptoms (PTSS) in patients with acute coronary syndrome (ACS). The results showed no association between temperature and PTSS, but a significant association between lower SES and PTSS. Therefore, early interventions in high-risk populations can improve mental and cardiovascular outcomes.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Behavioral Sciences
Reihaneh Ahmadi, Sama Rahimi-Jafari, Mahnaz Olfati, Nooshin Javaheripour, Farnoosh Emamian, Mohammad Rasoul Ghadami, Habibolah Khazaie, David C. Knight, Masoud Tahmasian, Amir A. Sepehry
Summary: Posttraumatic stress disorder (PTSD) is strongly associated with insomnia, and the prevalence of insomnia in PTSD patients is high. Screening and managing insomnia in PTSD patients are of great importance.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Medical Laboratory Technology
C. H. Geng, Y. U. F. A. N. Feng, Y. A. N. G. Yang, H. O. N. G. Q. I. N. Yang, Z. H. I. W. E. I. LI, Y. A. Q. I. N. Tang, J. I. N. G. Wang, H. O. N. G. M. E. Zhao
Summary: Cardiovascular disease, including heart failure (HF), is a leading cause of death globally. This study explored the link between asthma and HF, and found a higher prevalence of HF among asthmatic individuals. In animal models, asthma impaired heart function and aggravated cardiac remodeling. The study also identified the involvement of immunoglobulin E (IgE) and its receptor (Fc epsilon R1) in the adverse effects of asthma on the heart. Blockage of IgE-Fc epsilon R1 prevented asthma-induced decline of cardiac function and alleviated cardiac remodeling. These findings suggest the potential use of anti-IgE therapy in treating asthma complicated with heart conditions.
TRANSLATIONAL RESEARCH
(2022)
