Chimeric protein probes for C5a receptors through fusion of the anaphylatoxin C5a core region with a small-molecule antagonist

Leveraging the Knorr Pyrazole Synthesis for the Facile Generation of Thioester Surrogates for use in NCL

(2018) Dillon T. Flood et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical synthesis and structural analysis of guanylate cyclase C agonist linaclotide

(2018) Chenchen Chen et al.   CHINESE CHEMICAL LETTERS

Total synthesis of snake toxin α -bungarotoxin and its analogues by hydrazide-based native chemical ligation

(2018) Xiao-Qi Guo et al.   CHINESE CHEMICAL LETTERS

Synthetic studies toward human interleukin-5

(2018) Jinrong Liu et al.   CHINESE CHEMICAL LETTERS

Orthosteric and allosteric action of the C5a receptor antagonists

(2018) Heng Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis

(2018) Chen-Chen Chen et al.   Science China-Chemistry

Semi-synthesis of disulfide-linked branched tri-ubiquitin mimics

(2018) Yanyan Si et al.   Science China-Chemistry

Orthosteric and allosteric action of the C5a receptor antagonists

(2018) Heng Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chemical Protein Synthesis Enabled Mechanistic Studies on Molecular Recognition of K27-linked Ubiquitin Chains

(2018) Lei Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploring the Limits of Bivalency by DNA-Based Spatial Screening

(2018) Natali Dubel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Spatial Screening of Hemagglutinin on Influenza A Virus Particles: Sialyl-LacNAc Displays on DNA and PEG Scaffolds Reveal the Requirements for Bivalency Enhanced Interactions with Weak Monovalent Binders

(2017) Victor Bandlow et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Orthotopic patient-derived xenografts of paediatric solid tumours

(2017) Elizabeth Stewart et al.   NATURE

Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors

(2017) Robert E. Thompson et al.   Nature Chemistry

Potent peptidic fusion inhibitors of influenza virus

(2017) Rameshwar U. Kadam et al.   SCIENCE

Recent developments in peptide ligation independent of amino acid side-chain functional group

(2017) Jinhua Yang et al.   Science China-Chemistry

N-cap helix nucleation: methods and their applications

(2017) Dongyuan Wang et al.   Science China-Chemistry

Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily

(2016) Ho Yeung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Quasi-Racemic X-ray Structures of K27-Linked Ubiquitin Chains Prepared by Total Chemical Synthesis

(2016) Man Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monomer/Oligomer Quasi-Racemic Protein Crystallography

(2016) Shuai Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of Single α-to-β Residue Replacements on Structure and Stability in a Small Protein: Insights from Quasiracemic Crystallization

(2016) Dale F. Kreitler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical synthesis of histone H2A with methylation at Gln104

(2016) Qiaoqiao He et al.   Science China-Chemistry

Recent advances in the preparation of Fmoc-SPPS-based peptide thioester and its surrogates for NCL-type reactions

(2016) Hongxing Li et al.   Science China-Chemistry

Quasiracemate Crystal Structures of Magainin 2 Derivatives Support the Functional Significance of the Phenylalanine Zipper Motif

(2015) Zvi Hayouka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A functional role of Rv1738 inMycobacterium tuberculosispersistence suggested by racemic protein crystallography

(2015) Richard D. Bunker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expedient Total Synthesis of Small to Medium-Sized Membrane Proteins via Fmoc Chemistry

(2014) Ji-Shen Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural and functional characterization of human and murine C5a anaphylatoxins

(2014) Janus Asbjørn Schatz-Jakobsen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Genetically Encoded Chemical Probes in Cells Reveal the Binding Path of Urocortin-I to CRF Class B GPCR

(2013) Irene Coin et al.   CELL

Efficient chemical synthesis of human complement protein C3a

(2013) Artin Ghassemian et al.   CHEMICAL COMMUNICATIONS

Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography

(2013) Michal Avital-Shmilovici et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Daptomycin by Cyclization via a Chemoselective Serine Ligation

(2013) Hiu Yung Lam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical synthesis of proteins using peptide hydrazides as thioester surrogates

(2013) Ji-Shen Zheng et al.   Nature Protocols

Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency

(2013) K. Tharakaraman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergent Chemical Synthesis of Proteins by Ligation of Peptide Hydrazides

(2012) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C5a Receptor-Dependent Cell Activation by Physiological Concentrations of Desarginated C5a: Insights from a Novel Label-Free Cellular Assay

(2012) E. S. Reis et al.   JOURNAL OF IMMUNOLOGY

Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography

(2012) K. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Chemical Synthesis by Ligation of Peptide Hydrazides

(2011) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Solution structure of a unique C5a semi-synthetic antagonist: Implications in receptor binding

(2010) Xiaolu Zhang et al.   PROTEIN SCIENCE

Complement component 5a (C5a)

(2009) Helga D. Manthey et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Atomic-Level Mapping of Antibody Epitopes on a GPCR

(2009) Cheryl Paes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of universal antidotes to control aptamer activity

(2009) Sabah Oney et al.   NATURE MEDICINE

Structural study of Ac-Phe-[Orn-Pro-dCha-Trp-Arg], a potent C5a receptor antagonist, by NMR

(2008) Li Zhang et al.   BIOPOLYMERS

X-ray Structure of Snow Flea Antifreeze Protein Determined by Racemic Crystallization of Synthetic Protein Enantiomers

(2008) Brad L. Pentelute et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modulation of the antitumor immune response by complement

(2008) Maciej M Markiewski et al.   NATURE IMMUNOLOGY