The rs75862629 minor allele in the endoplasmic reticulum aminopeptidases intergenic region affects human leucocyte antigen B27 expression and protects from ankylosing spondylitis in Sardinia

ERAP1/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han

(2018) W. Su et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Peptide Repertoire of HLA-B27 may include Ligands with Lysine at P2 Anchor Position

(2018) Shira Yair-Sabag et al.   PROTEOMICS

Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity

(2018) Brogan Yarzabek et al.   eLife

Genomic history of the Sardinian population

(2018) Charleston W. K. Chiang et al.   NATURE GENETICS

ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis

(2018) Yuliya Pepelyayeva et al.   Scientific Reports

An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes

(2018) Fabiana Paladini et al.   Scientific Reports

Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome

(2017) Adrian Martín-Esteban et al.   JOURNAL OF AUTOIMMUNITY

Pathogenesis of ankylosing spondylitis — recent advances and future directions

(2017) Vidya Ranganathan et al.   Nature Reviews Rheumatology

Overexpression of the Cytokine BAFF and Autoimmunity Risk

(2017) Maristella Steri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile

(2017) Aimee L. Hanson et al.   Arthritis & Rheumatology

Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view

(2016) José A. López de Castro et al.   MOLECULAR IMMUNOLOGY

Multi-modal Binding of a ‘Self’ Peptide by HLA-B*27:04 and B*27:05 Allelic Variants, but not B*27:09 or B*27:06 Variants: Fresh Support for Some Theories Explaining Differential Disease Association

(2016) Manish Kumar Rana et al.   PROTEIN JOURNAL

ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing

(2016) Hanna Chen et al.   Scientific Reports

ERAP2is associated with ankylosing spondylitis inHLA-B27-positive andHLA-B27-negative patients

(2015) Philip C Robinson et al.   ANNALS OF THE RHEUMATIC DISEASES

Endoplasmic reticulum aminopeptidase 1 and rheumatic disease

(2015) Tri M. Tran et al.   CURRENT OPINION IN RHEUMATOLOGY

Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2

(2015) Anastasia Mpakali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERp44 Exerts Redox-Dependent Control of Blood Pressure at the ER

(2015) Chihiro Hisatsune et al.   MOLECULAR CELL

'MHC-I-opathy'—unified concept for spondyloarthritis and Behçet disease

(2015) Dennis McGonagle et al.   Nature Reviews Rheumatology

Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis: Fig. 1

(2015) Tony J. Kenna et al.   RHEUMATOLOGY

ERAP1Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated With Predisposition to Spondyloarthritis

(2015) Félicie Costantino et al.   Arthritis & Rheumatology

Endoplasmic reticulum aminopeptidases: biochemistry, physiology and pathology

(2013) A. Hattori et al.   JOURNAL OF BIOCHEMISTRY

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

(2013) Adrian Cortes et al.   NATURE GENETICS

The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09

(2013) A. Cauli et al.   RHEUMATOLOGY

IRF1 and NF-kB Restore MHC Class I-Restricted Tumor Antigen Processing and Presentation to Cytotoxic T Cells in Aggressive Neuroblastoma

(2012) Silvia Lorenzi et al.   PLoS One

Evidence for malaria selection of a CR1 haplotype in Sardinia

(2011) R Kosoy et al.   GENES AND IMMUNITY

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

(2011) Zhiming Lin et al.   NATURE GENETICS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Balancing Selection Maintains a Form of ERAP2 that Undergoes Nonsense-Mediated Decay and Affects Antigen Presentation

(2010) Aida M. Andrés et al.   PLoS Genetics

The interplay between the geographic distribution of HLA-B27 alleles and their role in infectious and autoimmune diseases: A unifying hypothesis

(2009) Alessandro Mathieu et al.   AUTOIMMUNITY REVIEWS

HLA-B27 and Ankylosing Spondylitis geographic distribution as the result of a genetic selection induced by malaria endemic? A review supporting the hypothesis

(2008) Alessandro Mathieu et al.   AUTOIMMUNITY REVIEWS