ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis

Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality

(2017) David P W Rastall et al.   INTERNATIONAL IMMUNOLOGY

Gut microbiota and IBD: causation or correlation?

(2017) Josephine Ni et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development

(2017) Hua Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood

(2017) Sudhir K. Yadav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut Microbiome and Bone: to Build, Destroy, or Both?

(2017) Jing Yan et al.   Current Osteoporosis Reports

Subclinical gut inflammation in ankylosing spondylitis

(2016) Francesco Ciccia et al.   CURRENT OPINION IN RHEUMATOLOGY

The evidence for microbiome manipulation in inflammatory arthritis

(2016) Hannah Jethwa et al.   RHEUMATOLOGY

Functional defects in CD4+ CD25high FoxP3+ regulatory cells in ankylosing spondylitis

(2016) Huifang Guo et al.   Scientific Reports

Loss of bone strength in HLA-B27 transgenic rats is characterized by a high bone turnover and is mainly osteoclast-driven

(2015) Martina Rauner et al.   BONE

The intestinal microbiome in spondyloarthritis

(2015) Tejpal Gill et al.   CURRENT OPINION IN RHEUMATOLOGY

Autoimmune Disease-Associated Variants of Extracellular Endoplasmic Reticulum Aminopeptidase 1 Induce Altered Innate Immune Responses by Human Immune Cells

(2015) Yasser A. Aldhamen et al.   Journal of Innate Immunity

Inflammation in intervertebral disc degeneration and regeneration

(2015) M. Molinos et al.   Journal of the Royal Society Interface

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

(2015) Adrian Cortes et al.   Nature Communications

Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis

(2015) Mary-Ellen Costello et al.   Arthritis & Rheumatology

Cross-fostering immediately after birth induces a permanent microbiota shift that is shaped by the nursing mother

(2015) Joseph G Daft et al.   Microbiome

ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses

(2014) D. P. W. Rastall et al.   INTERNATIONAL IMMUNOLOGY

HLA-B27 and Human β2-Microglobulin Affect the Gut Microbiota of Transgenic Rats

(2014) Phoebe Lin et al.   PLoS One

β-Arrestin-1 Deficiency Protects Mice from Experimental Colitis

(2013) Taehyung Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens

(2013) Sergey S. Seregin et al.   AUTOIMMUNITY

Colitis-induced Bone Loss is Gender Dependent and Associated with Increased Inflammation

(2013) Regina Irwin et al.   INFLAMMATORY BOWEL DISEASES

Endoplasmic Reticulum Aminopeptidase-1 Functions Regulate Key Aspects of the Innate Immune Response

(2013) Yasser A. Aldhamen et al.   PLoS One

Global prevalence of ankylosing spondylitis

(2013) L. E. Dean et al.   RHEUMATOLOGY

The putative role of endoplasmic reticulum aminopeptidases in autoimmunity: Insights from genomic-wide association studies

(2012) Alessandra Fierabracci et al.   AUTOIMMUNITY REVIEWS

Genetics of spondyloarthritis—beyond the MHC

(2012) John D. Reveille   Nature Reviews Rheumatology

Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment

(2012) Eva Klingberg et al.   ARTHRITIS RESEARCH & THERAPY

Proinflammatory Th17 cells are expanded and induced by dendritic cells in spondylarthritis-prone HLA-B27-transgenic rats

(2011) Simon Glatigny et al.   ARTHRITIS AND RHEUMATISM

Extra-articular manifestations of ankylosing spondylitis: Prevalence, characteristics and therapeutic implications

(2011) Abdellah El Maghraoui   European Journal of Internal Medicine

Secretion of Endoplasmic Reticulum Aminopeptidase 1 Is Involved in the Activation of Macrophages Induced by Lipopolysaccharide and Interferon-γ

(2011) Yoshikuni Goto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Expansion of intestinal CD4+CD25highTreg cells in patients with ankylosing spondylitis: A putative role for interleukin-10 in preventing intestinal Th17 response

(2010) Francesco Ciccia et al.   ARTHRITIS AND RHEUMATISM

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway

(2010) S. Gregori et al.   BLOOD

IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

(2010) M. H. Zaki et al.   JOURNAL OF IMMUNOLOGY

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Discovertebral (Andersson) lesions of the spine in ankylosing spondylitis revisited

(2009) Johannes L. Bron et al.   CLINICAL RHEUMATOLOGY

Role of human leukocyte antigen-G in the induction of adaptive type 1 regulatory T cells

(2009) Silvia Gregori et al.   HUMAN IMMUNOLOGY