Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 51, Issue -, Pages 195-202Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2018.07.009
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Funding
- National Institutes of Health [R01 GM086487]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM086487] Funding Source: NIH RePORTER
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Many tail-anchored (TA) membrane proteins are targeted to and inserted into the endoplasmic reticulum (ER) by the 'guided entry of tail-anchored proteins' (GET) pathway. This post translational pathway uses transmembrane-domain selective cytosolic chaperones for targeting, and a dedicated membrane protein complex for insertion. The past decade has seen rapid progress towards defining the molecular basis of TA protein biogenesis by the GET pathway. Here we review the mechanisms underlying each step of the pathway, emphasizing recent structural work and highlighting key questions that await future studies.
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