BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals

A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity

(2019) David Fernández-Justel et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for the bypass of the major oxaliplatin–DNA adducts by human DNA polymerase η

(2019) Hala Ouzon-Shubeita et al.   BIOCHEMICAL JOURNAL

A novel mechanism of irinotecan targeting MDM2 and Bcl-xL

(2019) Boah Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

B-cell lymphoma 2 ovarian killer suppresses testicular cancer cell malignant behavior, but plays a role in platinum resistance

(2018) Jian Chu et al.   ANTI-CANCER DRUGS

Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK

(2018) Francine F.S. Ke et al.   CELL

The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer

(2018) Steven Carberry et al.   Cell Death & Disease

BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

(2018) Delphine Merino et al.   CANCER CELL

BOK displays cell death-independent tumor suppressor activity in non-small-cell lung carcinoma

(2017) Erika Moravcikova et al.   INTERNATIONAL JOURNAL OF CANCER

Uridine monophosphate synthetase enables eukaryoticde novoNAD+biosynthesis from quinolinic acid

(2017) Melanie R. McReynolds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU

(2017) Yan Yan et al.   MOLECULAR CANCER RESEARCH

Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling inC. elegans

(2016) Congwu Chi et al.   GENES & DEVELOPMENT

The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors

(2016) Jacqualyn J. Schulman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury

(2016) B. D'Orsi et al.   JOURNAL OF NEUROSCIENCE

A Review of the Evolution of Systemic Chemotherapy in the Management of Colorectal Cancer

(2015) Bengt Gustavsson et al.   Clinical Colorectal Cancer

BH3-only proteins: a 20-year stock-take

(2015) Marcel Doerflinger et al.   FEBS Journal

Placental autophagy regulation by the BOK-MCL1 rheostat

(2013) Manpreet Kalkat et al.   Autophagy

Intracellular localization of the BCL-2 family member BOK and functional implications

(2013) N Echeverry et al.   CELL DEATH AND DIFFERENTIATION

Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation

(2013) Thuc T. Le et al.   JOURNAL OF LIPID RESEARCH

A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators

(2013) Benjamin Szlyk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Consequences of the combined loss of BOK and BAK or BOK and BAX

(2013) F Ke et al.   Cell Death & Disease

Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer

(2012) M Griffith et al.   PHARMACOGENOMICS JOURNAL

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase

(2011) Kambiz N. Alavian et al.   NATURE CELL BIOLOGY

The Chemotherapeutic Drug 5-Fluorouracil Promotes PKR-Mediated Apoptosis in a p53- Independent Manner in Colon and Breast Cancer Cells

(2011) María Angel García et al.   PLoS One

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation

(2009) A. M. Jabbour et al.   BLOOD