The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors

Biphasic regulation of InsP3receptor gating by dual Ca2+release channel BH3-like domains mediates Bcl-xLcontrol of cell viability

(2016) Jun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation

(2016) Marcos A. Carpio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Is BOK required for apoptosis induced by endoplasmic reticulum stress?

(2016) Yuniel Fernandez-Marrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Point Mutation in the Ubiquitin Ligase RNF170 That Causes Autosomal Dominant Sensory Ataxia Destabilizes the Protein and Impairs Inositol 1,4,5-Trisphosphate Receptor-mediated Ca2+Signaling

(2015) Forrest A. Wright et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gating machinery of InsP3R channels revealed by electron cryomicroscopy

(2015) Guizhen Fan et al.   NATURE

An interconnected hierarchical model of cell death regulation by the BCL-2 family

(2015) Hui-Chen Chen et al.   NATURE CELL BIOLOGY

BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress

(2015) Marcos A. Carpio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK

(2015) F Ke et al.   Cell Death & Disease

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2

(2015) Andrew R. Lavik et al.   Oncotarget

Regulating cell death at, on, and in membranes

(2014) Xiaoke Chi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity

(2014) R. W. Rooswinkel et al.   BLOOD

Many players in BCL-2 family affairs

(2014) Tudor Moldoveanu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Perilous journey: a tour of the ubiquitin–proteasome system

(2014) Gary Kleiger et al.   TRENDS IN CELL BIOLOGY

Parkin Sensitizes toward Apoptosis Induced by Mitochondrial Depolarization through Promoting Degradation of Mcl-1

(2014) Richard G. Carroll et al.   Cell Reports

Intracellular localization of the BCL-2 family member BOK and functional implications

(2013) N Echeverry et al.   CELL DEATH AND DIFFERENTIATION

A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1

(2013) Peng Wang et al.   CELLULAR SIGNALLING

The Bcl-2 Protein Family Member Bok Binds to the Coupling Domain of Inositol 1,4,5-Trisphosphate Receptors and Protects Them from Proteolytic Cleavage

(2013) Jacqualyn J. Schulman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Alpha-Helical Destabilization of the Bcl-2-BH4-Domain Peptide Abolishes Its Ability to Inhibit the IP3 Receptor

(2013) Giovanni Monaco et al.   PLoS One

Consequences of the combined loss of BOK and BAK or BOK and BAX

(2013) F Ke et al.   Cell Death & Disease

BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax

(2012) F Wilfling et al.   CELL DEATH AND DIFFERENTIATION

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice

(2012) F Ke et al.   CELL DEATH AND DIFFERENTIATION

BAG6/BAT3: emerging roles in quality control for nascent polypeptides

(2012) H. Kawahara et al.   JOURNAL OF BIOCHEMISTRY

Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: Role in Ca2+ signaling and disease

(2011) Clark W. Distelhorst et al.   CELL CALCIUM

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl

(2011) G Monaco et al.   CELL DEATH AND DIFFERENTIATION

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

(2011) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

RNF170 Protein, an Endoplasmic Reticulum Membrane Ubiquitin Ligase, Mediates Inositol 1,4,5-Trisphosphate Receptor Ubiquitination and Degradation

(2011) Justine P. Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Ubiquitin Ligase-Associated Chaperone Holdase Maintains Polypeptides in Soluble States for Proteasome Degradation

(2011) Qiuyan Wang et al.   MOLECULAR CELL

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

When worlds collide: IP3 receptors and the ERAD pathway

(2009) Richard J.H. Wojcikiewicz et al.   CELL CALCIUM

Alternative translation start sites and hidden coding potential of eukaryotic mRNAs

(2008) Alex V. Kochetov   BIOESSAYS

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Backrub-Like Backbone Simulation Recapitulates Natural Protein Conformational Variability and Improves Mutant Side-Chain Prediction

(2008) Colin A. Smith et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting Bcl-2-IP3 Receptor Interaction to Reverse Bcl-2's Inhibition of Apoptotic Calcium Signals

(2008) Yi-Ping Rong et al.   MOLECULAR CELL

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY